Title: Painful Na-channelopathies: an expanding universe
Abstract: •The universe of painful Na-channelopathies is expanding. •Na-channel mutations cause common painful neuropathies as well as rare genetic pain disorders. •Mutations of NaV1.8, as well as NaV1.7, can cause painful channelopathies. The universe of painful Na-channelopathies – human disorders caused by mutations in voltage-gated sodium channels – has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic. The universe of painful Na-channelopathies – human disorders caused by mutations in voltage-gated sodium channels – has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic.
Publication Year: 2013
Publication Date: 2013-07-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 64
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