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131], 'inhibition': [72, 210, 240], 'induction': [74, 198, 248], 'were': [77], 'analysed': [78], 'crystal': [81], 'violet': [82], 'assay,': [83], 'flow': [84], 'cytometry': [85], 'blotting': [88], 'apoptosis‐relevant': [90], 'proteins.': [91], 'The': [92, 171], 'effect': [93], 'combined': [95], 'chemotherapy': [101], 'or': [102, 179, 192], 'small‐interference': [103], 'RNA': [104], '(siRNA)': [105], 'targeting': [106], 'clusterin': [108], 'gene': [109], 'also': [111, 160], 'investigated.': [112], 'RESULTS': [113], 'Bispecific': [114], 'reduced': [116], 'cells': [123, 148, 175], 'dose‐dependent': [126], 'manner.': [127], 'There': [128], 'cell': [130], 'inhibition,': [132], 'increases': [133], 'sub‐G0–G1': [136], 'fraction,': [137], 'cleavage': [139], 'caspase‐3': [141], 'poly(ADP‐Ribose)': [143], 'polymerase': [144], 'proteins': [145], 'after': [149], 'treatment.': [152], 'Interestingly,': [153], '/': [155, 201], 'resulted': [161], 'down‐regulation': [164], 'Mcl‐1': [166], 'up‐regulation': [168], 'Bax.': [170, 222], 'sensitivity': [172], 'to': [176], 'mitoxantrone,': [177], 'docetaxel': [178], 'paclitaxel': [180], 'significantly': [182], 'increased,': [183], 'reducing': [184], '50%': [186], 'inhibitory': [187], 'concentration': [188], '45%,': [190], '80%': [191], '90%,': [193], 'respectively.': [194], 'Furthermore,': [195], 'apoptotic': [197], 'synergistically': [206], 'enhanced': [207], 'siRNA‐mediated': [209], 'clusterin,': [212], 'cytoprotective': [214], 'chaperone': [215], 'that': [216], 'interacts': [217], 'inhibits': [220], 'activated': [221], 'CONCLUSIONS': [223], 'These': [224], 'findings': [225], 'support': [226], 'concept': [228], 'targeted': [231], 'suppression': [232], 'family': [236], 'members': [237], 'multitarget': [239], 'strategies': [241], 'for': [242], 'cancer,': [244], 'through': [245], 'effective': [247], 'apoptosis.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022724778', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T22:13:52.956001', 'created_date': '2016-06-24'}