Title: Functional Significance of the Effects of Neurotransmitters on the Na<sup>+</sup>,K<sup>+</sup>‐ATPase System
Abstract: Abstract: The aim of the present experiments was to study the effects of the neurotransmitters acetylcholine, noradrenaline, 5‐hydroxytryptamine, and dopamine on the Na + ,K + ‐ATPase of rat brain synaptosomal fractions. It is shown that dopamine at low concentrations specifically inhibits the Na + ,K + ‐ATPase of synaptic membranes from the brain regions rich in dopaminergic endings, but has no effect on the synaptosomal Na + ,K + ‐ATPase from the other parts of brain. Acetylcholine and noradrenaline have similar specific effects on Na + ,K + ‐ATPase from cholinergic and adrenergic synaptosomes. The Na + ,K + ‐ATPases of synaptic membranes from the different brain regions, characterised by different distributions of cholinergic, adrenergic, and 5‐hydroxytrypta‐minergic endings, show different reactions with neurotransmitters. These data indicate a functional significance of the effects of the neurotransmitters on the synaptosomal Na + ,K + ‐ATPase.
Publication Year: 1984
Publication Date: 1984-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 21
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot