Signaling by Higher Inositol Polyphosphates

Name: Work Video:
Duration: 3 min 30 s
Xavier Pesesse; Kuicheon Choi; Tong Zhang; Stephen B. Shears
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840, 870], 'cells.': [73, 210, 3350], 'Importantly,': [74, 211], 'this': [75, 85, 212, 222, 1176, 1479, 1721, 1843, 1869, 2322, 2362, 3141, 3157, 3394], 'does': [76, 213, 3363], 'not': [77, 105, 214, 242, 1685, 1794, 1802, 1860, 1889, 2272, 2331, 2380, 2561, 2657, 2720, 2766, 3200, 3242, 3330, 3337, 3413], 'involve': [78, 215], 'classical': [79, 216], 'agonists.': [80, 217], 'Instead,': [81, 218, 904], 'we': [82, 219, 1013, 1178, 1195, 1372, 1718, 1846, 1883, 2399], 'response': [87, 224, 1446, 1668, 1798, 2494], 'is': [88, 225, 1036, 1156, 1382, 1458, 1473, 1482, 1603, 1731, 1888, 2306, 2358, 2379, 2413, 2468, 2684, 2759, 2773, 3053, 3205, 3248, 3314, 3323, 3377, 3410, 3431, 3501], 'novel': [90, 227], 'consequence': [91, 228, 2383], 'activation': [94, 231, 1887, 2737, 3190, 3222, 3296], 'ERK1/2': [96, 233, 1967, 2112, 2718], 'p38MAPα/β': [98, 235], 'kinases': [99, 236, 2764], 'by': [100, 237, 595, 795, 811, 945, 951, 975, 1318, 1368, 1374, 1507, 1596, 1812, 1862, 1897, 1909, 1999, 2106, 2333, 2374, 2546, 2641, 2671, 2700, 2715, 2940, 3039, 3170, 3175, 3179, 3188, 3223, 3304, 3326, 3331, 3379, 3472], 'hyperosmotic': [101, 118, 238, 255, 1154, 1369, 1591, 1654, 1676, 1898, 2676, 2983, 3327, 3334, 3434], 'stress.': [102, 239, 1027, 1899], 'JNK': [103, 240, 1805, 1854, 1858, 1886], 'did': [104, 241, 1684, 1793, 2271], 'participate': [106, 243], 'regulating': [108, 245, 592], 'levels.': [110, 247, 3310], 'Identification': [111, 248], 'as': [114, 251, 1054, 1056, 1211, 1235, 1323, 1337, 1339, 1660, 2423, 2425, 3043], 'sensor': [116, 253], 'stress': [119, 256, 1155, 1390, 1556, 1592, 1607, 1655, 1704, 1730, 1911, 2677, 2984, 3328, 3335], 'opens': [120, 257, 3506], 'new': [123, 260, 2747, 3509], 'area': [124, 261, 3510], 'research': [126, 263, 3512], 'for': [127, 264, 1000, 1891, 2390, 2749, 2997, 3233, 3424, 3513], 'studies': [128, 265, 1387], 'into': [129, 266, 1388, 2428, 3004], 'activities': [132, 269, 1232], 'higher': [134, 271, 1395, 3492], 'phosphates.': [136, 273], 'Pivotal': [274], 'signaling': [277, 1727, 2728, 2744, 3006, 3320], 'functions': [278, 783], '1The': [281], 'abbreviations': [282, 346], 'used': [283, 347], 'are:': [284, 348], 'PP-InsP5,': [285, 349], 'diphosphoinositol': [286, 298, 314, 350, 362, 378, 1562, 2188], 'pentakisphosphate;': [287, 293, 351, 357], 'DN,': [288, 352], 'dominant': [289, 353, 2405], 'negative;': [290, 354], 'InsP5,': [291, 355], 'InsP6,': [294, 358], 'hexakisphosphate;': [296, 360], 'PP-InsP4,': [297, 361], 'tetrakisphosphate;': [299, 302, 363, 366], '[PP]2-InsP4,': [300, 364], 'PtdIns(4,5)P2,': [303, 367, 2993], 'phosphatidylinositol': [304, 307, 368, 371], '4,5-bisphosphate;': [305, 369], 'PtdIns(3,4,5)P3,': [306, 370], '3,4,5-trisphosphate;': [308, 372], 'PIPKH,': [309, 373], 'polyphosphoinositide': [310, 374], 'kinase': [311, 340, 375, 404, 1231, 1807, 1905, 2180, 2194, 2232, 2269, 2318, 2348, 2377, 2409, 2430, 2462, 2712, 2751, 3221, 3360, 3373], 'homolog;': [312, 376], 'DIPP,': [313, 377], 'polyphosphate': [315, 379], 'phosphohydrolase;': [316, 380], 'PH,': [317, 381], 'pleckstrin': [318, 382], 'homology;': [319, 383], 'HEK,': [320, 384], 'human': [321, 385], 'embryonic': [322, 386], 'kidney;': [323, 387], 'ERK,': [324, 388], 'extracellular': [325, 389, 1488, 3382], 'signal-regulated': [326, 339, 390, 403], 'kinase;': [327, 334, 341, 391, 398, 405], 'MAP,': [328, 392], 'mitogen-activated': [329, 336, 393, 400], 'protein;': [330, 394], 'JNK,': [331, 395], 'c-Jun': [332, 396], 'NH2-terminal': [333, 397], 'MEK,': [335, 399], 'protein': [337, 401, 488, 2729, 2858, 3052], 'kinase/extracellular': [338, 402], 'EGF,': [342, 406], 'epidermal': [343, 407], 'growth': [344, 408], 'factor.1The': [345], 'factor.': [409], 'their': [413, 424, 446, 1703, 3406], 'highly': [414], 'negative': [415, 2406], 'electrostatic': [416, 2796], 'potential': [417], 'considerable': [420], 'free': [421], 'energy': [422, 553], 'hydrolysis': [425, 3174], '(for': [426], 'review,': [427], 'see': [428, 2170], 'Ref.': [429, 742, 1975, 2054, 3259], '1Shears': [430], 'S.B.': [431, 497, 605, 851, 956, 982, 1217, 1244, 1522, 1542, 2870], 'Biochem.': [432, 830, 852, 957, 1067, 1130, 1165, 1350, 1543, 3449], 'J.': [433, 500, 534, 608, 633, 829, 853, 958, 984, 1068, 1115, 1119, 1166, 1219, 1245, 1275, 1287, 1351, 1524, 1544, 1745, 1762, 1819, 1923, 2066, 2127, 2440, 2526, 2589, 2618, 2873, 2907, 3109, 3264], '2004;': [434, 854, 2129, 2443], '377:': [435, 855], '265-280Crossref': [436, 856], 'PubMed': [437, 481, 511, 545, 575, 619, 644, 671, 706, 730, 772, 834, 857, 962, 988, 1072, 1139, 1170, 1223, 1256, 1355, 1528, 1548, 1633, 1749, 1773, 1835, 1929, 1947, 1991, 2070, 2132, 2451, 2535, 2596, 2628, 2835, 2851, 2884, 2918, 2973, 3020, 3086, 3120, 3270, 3458], 'Scopus': [438, 482, 512, 546, 576, 620, 645, 672, 707, 731, 773, 835, 858, 963, 989, 1073, 1140, 1171, 1224, 1257, 1356, 1529, 1634, 1750, 1774, 1836, 1930, 1948, 1992, 2071, 2133, 2452, 2597, 2629, 2836, 2852, 2885, 2919, 2974, 3021, 3087, 3121, 3271, 3459], '(159)': [439, 859], 'Google': [440, 484, 514, 548, 578, 622, 647, 674, 709, 733, 775, 837, 860, 965, 991, 1075, 1123, 1142, 1173, 1226, 1259, 1358, 1531, 1549, 1636, 1752, 1776, 1838, 1932, 1950, 1994, 2073, 2135, 2454, 2536, 2599, 2631, 2838, 2854, 2887, 2921, 2976, 3023, 3089, 3123, 3273, 3461], 'Scholar).': [441, 549, 579, 734, 838, 861, 966, 992, 1076, 1143, 1174, 1227, 1260, 1359, 1550, 1637, 1839, 1951, 1995, 2136, 2455, 2922, 2977, 3024, 3124], 'The': [442, 799, 1028, 1804, 1900, 2012, 2090, 2137, 2229, 2339, 2456], 'former': [443], 'attribute': [444], 'facilitates': [445], 'functionally': [447, 893, 2785], 'significant': [448, 894, 2343, 2555, 2651, 2786, 3404], 'binding': [449], 'PH': [451, 2804, 2998], '(2Luo': [452, 677, 2806, 2944, 3057], 'H.R.': [453, 560, 678, 715, 744, 1618, 2807, 2945, 3058], 'Huang': [454, 464, 679, 689, 745, 755, 2586, 2808, 2818, 2946, 2956, 3059, 3069], 'Y.E.': [455, 680, 746, 2809, 2947, 3060], 'Chen': [456, 681, 747, 2810, 2948, 3061], 'J.C.': [457, 682, 748, 2433, 2811, 2949, 3062], 'Sairardi': [458, 683, 749, 2812, 2950, 3063], 'A.': [459, 529, 533, 562, 652, 667, 684, 717, 750, 1238, 1620, 2058, 2813, 2902, 2906, 2951, 3064, 3104, 3108], 'Iijima': [460, 685, 751, 2814, 2952, 3065], 'M.': [461, 686, 752, 1741, 1761, 2056, 2060, 2577, 2815, 2953, 3066], 'Ye': [462, 567, 687, 722, 753, 1625, 2816, 2954, 3067], 'K.': [463, 568, 688, 723, 754, 1536, 1626, 2817, 2955, 3068], 'Y.': [465, 523, 690, 756, 2585, 2604, 2819, 2896, 2957, 3070, 3098], 'Nagata': [466, 565, 691, 720, 757, 1623, 2820, 2958, 3071], 'E.': [467, 566, 692, 721, 758, 1624, 2515, 2608, 2821, 2959, 3072], 'Devreotes': [468, 693, 759, 2822, 2960, 3073], 'P.': [469, 694, 760, 2064, 2610, 2823, 2961, 3074], 'Snyder': [470, 569, 659, 695, 724, 761, 1241, 1627, 2824, 2962, 3075], 'S.H.': [471, 570, 660, 696, 725, 762, 1242, 1628, 2825, 2963, 3076], 'Cell.': [472, 697, 763, 2591, 2826, 2964, 3077], '2003;': [473, 698, 764, 1120, 1545, 1827, 1926, 2827, 2965, 3078, 3267], '114:': [474, 699, 765, 2828, 2966, 3079], '559-572Abstract': [475, 700, 766, 2829, 2967, 3080], 'Full': [476, 478, 506, 508, 540, 542, 614, 616, 639, 641, 701, 703, 767, 769, 1251, 1253, 1768, 1770, 1830, 1832, 1986, 1988, 2446, 2448, 2532, 2623, 2625, 2830, 2832, 2879, 2881, 2913, 2915, 2968, 2970, 3081, 3083, 3115, 3117], 'Text': [477, 479, 507, 509, 541, 543, 615, 617, 640, 642, 702, 704, 768, 770, 1252, 1254, 1769, 1771, 1831, 1833, 1987, 1989, 2447, 2449, 2533, 2624, 2626, 2831, 2833, 2880, 2882, 2914, 2916, 2969, 2971, 3082, 3084, 3116, 3118], 'PDF': [480, 510, 544, 618, 643, 705, 771, 1255, 1772, 1834, 1990, 2450, 2534, 2627, 2834, 2883, 2917, 2972, 3085, 3119], '(163)': [483, 708, 774, 2837, 2975, 3088], 'Scholar)': [485, 776, 1753, 2074, 2537, 2632], 'domains': [489, 2805, 2859, 2999], '(3Ye': [490, 598, 2863], 'W.': [491, 531, 599, 2864, 2904, 3106], 'Ali': [492, 600, 2865], 'N.': [493, 601, 1103, 2866], 'Bembenek': [494, 602, 1515, 2867], 'M.E.': [495, 603, 1516, 2868], 'Shears': [496, 604, 955, 981, 1216, 1243, 1521, 1541, 2869], 'Lafer': [498, 606, 2871], 'E.M.': [499, 607, 2872], 'Biol.': [501, 535, 609, 634, 1246, 1763, 1826, 1925, 2441, 2527, 2592, 2874, 2908, 3110, 3266], 'Chem.': [502, 536, 610, 635, 1247, 1764, 2442, 2528, 2875, 2909, 3111], '1995;': [503, 611, 2876], '270:': [504, 612, 2877], '1564-1568Abstract': [505, 613, 2878], '(160)': [513, 621, 2886], 'Scholar,': [515, 1124, 1532, 2600, 2839, 2888, 3090], '4Couchman': [516, 2889, 3091], 'J.R.': [517, 2890, 3092], 'Vogt': [518, 2891, 3093], 'S.': [519, 666, 1107, 2587, 2602, 2612, 2892, 3094], 'Lim': [520, 522, 2893, 2895, 3095, 3097], 'S.-T.': [521, 2894, 3096], 'Oh': [524, 2897, 3099], 'E.-S.': [525, 2898, 3100], 'Prestwich': [526, 2899, 3101], 'G.D.': [527, 2900, 3102], 'Theibert': [528, 2901, 3103], 'Lee': [530, 2903, 3105], 'Woods': [532, 2905, 3107], '2002;': [537, 572, 668, 727, 1630, 1983, 2848, 2910, 3017, 3112], '277:': [538, 2911, 3113], '49296-49303Abstract': [539, 2912, 3114], '(48)': [547, 2920, 3122], 'Additionally,': [550], 'high': [552], 'phosphate': [554], 'groups': [555], 'may': [556, 788, 2101, 2314, 3339, 3389], 'phosphorylate': [557], 'proteins': [558, 597, 1616, 2571, 2790, 3003], '(5Luo': [559, 714, 1617], 'Saiardi': [561, 716, 1619], 'Yu': [563, 718, 1621], 'H.': [564, 719, 1109, 1113, 1622, 2517], 'Biochemistry.': [571, 726, 1629], '41:': [573, 728, 1631], '2509-2515Crossref': [574, 729, 1632], '(67)': [577, 732, 1635], 'These': [580, 1586, 2298, 3292, 3351], 'effects': [581, 1587], 'believed': [583], 'underlie': [585], 'roles': [587], 'clathrin': [593], 'assembly': [594], 'adaptor': [596], 'Scholar),': [623, 648, 675, 710, 1777, 2855, 3274, 3462], 'apoptosis': [624], '(6Morrison': [625], 'B.H.': [626], 'Bauer': [627], 'J.A.': [628], 'Kalvakolanu': [629], 'D.V.': [630], 'Lindner': [631], 'D.J.': [632, 2439, 2513], '2001;': [636, 1136, 3455], '276:': [637], '24965-24970Abstract': [638], '(137)': [646], 'trafficking': [650, 3442], '(7Saiardi': [651], 'Sciambi': [653], 'C.': [654, 821, 1302, 2583], 'McCaffery': [655], 'J.M.': [656, 1111, 1977], 'Wendland': [657], 'B.': [658, 1938], 'Proc.': [661], 'Natl.': [662], 'Acad.': [663], 'Sci.': [664, 1982], 'U.': [665, 823], '99:': [669], '14206-14211Crossref': [670], '(148)': [673], 'chemotaxis': [676], 'repair': [713, 1099], 'It': [735, 862, 1381, 1472, 2412, 2722, 3430], 'also': [737, 1079, 1196, 1847, 2076, 2760], 'been': [738, 866, 901, 916, 1005, 2119, 3037], 'pointed': [739], 'out': [740], '(e.g.': [741], '2Luo': [743], 'important': [781, 2415, 2995], 'currently': [784], 'attributed': [785], 'InsP6': [787, 1228, 2231, 2317, 2935], 'vivo': [790], 'be': [791, 874, 1366, 1810, 1895, 2102, 2691, 2987, 3390, 3470], 'more': [792], 'effectively': [793], 'performed': [794], 'Dictyostelids': [800], 'have': [801, 842, 915, 1391, 3154], 'uniquely': [802], 'exploited': [803], 'physico-chemical': [805], 'properties': [806], 'diphosphates': [810, 1364, 2780], 'synthesizing': [812], 'near-millimolar': [813], 'these': [816, 889, 2480, 2924, 3150, 3464], 'molecules': [817], '(8Laussmann': [818], 'T.': [819], 'Pikzack': [820], 'Thiel': [822], 'Mayr': [824], 'G.W.': [825], 'Vogel': [826], 'G.': [827], 'Eur.': [828], '2000;': [831, 1248, 1765, 2593], '267:': [832], '2447-2451Crossref': [833], '(35)': [836], 'However,': [839, 896, 1601, 1857], 'cells': [841, 1149, 1421, 1450, 1453, 1954, 2044, 2283, 2295, 2311, 2355, 2403, 2664, 3167], '300-fold': [843], 'lower': [844, 2292], '(1Shears': [850], 'therefore': [864, 2723, 2986], 'generally': [865], 'anticipated': [867], 'that,': [868], 'cells,': [871], 'there': [872, 1481, 2496, 3126], 'should': [873, 1557], 'substantial,': [875, 997], 'stimulus-dependent': [876, 908], 'increases': [877, 2370, 3415], 'elevate': [886, 1188, 1558, 1877, 3308, 3488], 'polyphosphates': [890], 'threshold.': [895], 'such': [898, 1322], 'phenomenon': [899], 'previously.': [903], 'only': [905], 'quite': [906], 'small': [907], 'changes': [909, 1046, 1329], 'turnover': [914, 3204, 3313], 'reported,': [917], 'each': [920], 'case': [921], 'result': [923, 2159], 'was': [924, 1859, 1873, 1997, 2098, 2290, 2330, 2713], 'decrease': [926, 971, 2326], 'rather': [927], 'than': [928, 2293], 'an': [929, 1037, 1498, 1609, 2156, 3050, 3341, 3355, 3502], 'increase': [930, 1495, 1580, 1714, 2006, 2084, 2937], 'pyrophosphates.': [936, 3429], 'For': [937], 'example,': [938], 'depletion': [939], 'endoplasmic': [941], 'reticulum': [942], 'Ca2+': [943], 'stores': [944], 'thapsigargin': [946], 'transiently': [947, 2401], 'decreases': [948], '50%': [952, 2672], '(9Glennon': [953], 'M.C.': [954], '1993;': [959, 2529], '293:': [960], '583-590Crossref': [961], '(97)': [964], 'Activation': [967], 'β-adrenergic': [969], 'receptors': [970], '40%': [978], '(10Safrany': [979, 1214], 'S.T.': [980, 1215, 1510], 'EMBO': [983, 1218, 1523, 1744, 2065], '1998;': [985, 1220, 1525, 1746], '17:': [986, 1221, 1526, 1747], '1710-1716Crossref': [987, 1222], '(55)': [990, 1225], 'This': [993, 1996, 2683], 'absence': [994, 2340], 'regulatory': [998, 3422], 'context': [999, 3423], 'addressed': [1006], 'current': [1009], 'study,': [1010, 1845], 'which': [1012, 1371], 'selected': [1014], 'biological': [1016], 'paradigm': [1017], 'fundamental': [1019], 'widespread': [1021], 'significance,': [1022], 'namely,': [1023], 'defense': [1024], 'against': [1025], 'osmotic': [1026, 1031, 1082, 1314, 1555, 1910], 'maintenance': [1029], 'balance': [1032], 'across': [1033, 1062, 1345], 'plasma': [1034, 1063, 1346], 'membranes': [1035, 1064, 1347], 'ongoing': [1038, 2307], 'burden': [1040], 'face': [1043], 'controlled': [1045, 1328], 'both': [1048, 1331, 1559, 3298, 3466], 'cell': [1049, 1332, 3365], 'size': [1050, 1333], 'hydration': [1053], 'well': [1055, 1338, 2424, 3249], 'exchange': [1057, 1340], 'metabolites': [1059, 1342], 'ions': [1061, 1344], '(11Häussinger': [1065, 1163, 1348], 'D.': [1066, 1126, 1128, 1164, 1349, 2521, 3445, 3447], '1996;': [1069, 1167, 1352], '313:': [1070, 1168, 1353], '697-710Crossref': [1071, 1169, 1354], '(495)': [1074, 1172, 1357], 'There': [1077, 2772], 'clinically': [1080], 'relevant': [1081], 'challenges': [1083, 1315], 'can': [1085, 1187, 1491, 1809, 2781, 2936, 3436, 3469, 3486], 'impose': [1086], 'strain': [1087], 'upon': [1088, 2167, 2350, 2543, 2638, 2678, 2753, 3239, 3287], 'cytoskeleton,': [1090], 'perturb': [1091], 'chromatin': [1092], 'structure,': [1093], 'damage': [1094, 3437], 'DNA,': [1095], 'inhibit': [1097], '(12Chiasson': [1100], 'J.L.': [1101], 'Aris-Jilwan': [1102], 'Belanger': [1104], 'R.': [1105, 1739, 2062], 'Bertrand': [1106], 'Beauregard': [1108], 'Ekoe': [1110], 'Fournier': [1112], 'Havrankova': [1114], 'Can.': [1116], 'Med.': [1117], 'Assoc.': [1118], '168:': [1121], '859-866PubMed': [1122], '13Kültz': [1125], 'Chakravarty': [1127, 3446], 'Comp.': [1129, 3448], 'Physiol.': [1131, 1135, 2128, 3450, 3454], 'A': [1132, 1441, 3451], 'Mol.': [1133, 2590, 3452], 'Integr.': [1134, 3453], '130:': [1137, 3456], '421-428Crossref': [1138, 3457], '(40)': [1141, 3460], 'One': [1144], 'way': [1145], 'examine': [1147], 'how': [1148, 1720, 3362], 'sense': [1150], 'adapt': [1152, 1402], 'add': [1158], 'sorbitol': [1159, 1186, 1398, 1457, 1606, 1663, 1800, 1815, 1852, 1865, 1872, 2031, 2166, 2493, 2542, 2637], 'medium': [1162], 'In': [1175, 1840, 2923, 3477], 'report,': [1177], 'addition': [1182, 1376, 2927], '0.2': [1184, 1378, 1405, 1455, 1863], 'm': [1185, 1379, 1406, 1456, 1662, 1814, 1851, 1864], '25-fold,': [1193], 'study': [1197], 'molecular': [1199], 'mechanisms': [1200, 1710], 'involved.': [1203], 'Cellular': [1204], 'phosphates': [1208], 'were': [1209, 1233, 1645, 2497, 3127, 3168], 'determined': [1210, 2699], 'assayed': [1234], '(15Saiardi': [1237], 'Caffrey': [1239, 1511], 'J.J.': [1240, 1512], '275:': [1249, 1766], '24686-24692Abstract': [1250], '(155)': [1258], 'Several': [1261], 'colleagues': [1262], 'kindly': [1263], 'supplied': [1264], 'following': [1266, 1554, 2982], 'cDNA': [1267, 2410], 'constructs:': [1268], 'DN-p38α': [1269, 2568], 'DN-p38β': [1271, 2570], 'pCDNA3': [1273], '(Dr.': [1274, 1286, 1301], 'Han,': [1276], 'Scripps': [1277], 'Research': [1278], 'Institute,': [1279], 'La': [1280], 'Jolla,': [1281], 'CA),': [1282], 'PIPKH': [1283, 3198], 'pCMV2': [1285], 'Chang,': [1288], 'Beth': [1289], 'Israel': [1290], 'Deaconess': [1291], 'Medical': [1292], 'Center,': [1293], 'Boston,': [1294], 'MA),': [1295], 'DN-ERK1': [1296, 2507], 'DN-ERK2': [1298, 2510], 'pCMV5': [1300], 'Der,': [1303], 'University': [1304], 'North': [1306], 'Carolina).': [1307], 'Cells': [1308, 1401], 'constantly': [1310], 'adapting': [1311], 'brought': [1316], 'on': [1317, 3354], 'normal': [1319], 'activities,': [1321], 'breakdown': [1325], 'macromolecules,': [1327], 'hydration,': [1336], 'investigated': [1361], 'whether': [1362, 3049], 'might': [1365, 1723, 2182], 'regulated': [1367, 3315, 3471], 'stress,': [1370], 'introduced': [1373], 'sorbitol.': [1380], 'notable': [1383], 'earlier': [1386, 1844], 'hyperosomotic': [1389], 'frequently': [1392], 'employed': [1393], 'much': [1394], 'doses': [1396], '(0.5–0.7': [1399], 'm).': [1400], 'successfully': [1403], 'sorbitol,': [1407], 'since': [1408, 3463], 'it': [1409, 1602, 2025, 2097, 3275, 3376, 3409], 'failed': [1410], 'even': [1411, 2308, 2929, 3245], 'after': [1412], '24': [1413], 'h': [1414], 'affect': [1416, 2273, 3440], 'viability': [1417], 'either': [1419, 1781, 2286, 3163], 'HEK': [1420, 1452], '(101': [1422], '±': [1423, 1435, 1569, 2197, 2207, 2215, 2235, 2245, 2253], '2%)': [1424], 'DDT1': [1427, 1448, 2662], 'MF2': [1428, 1449, 2663], 'vas': [1429], 'deferens': [1430], 'smooth': [1431], 'muscle': [1432], 'line': [1433], '(96': [1434], '1%)': [1436], 'compared': [1437], 'non-sorbitol': [1439], 'controls.': [1440, 2228, 2266], 'novel,': [1442], 'immediate': [1443], 'selective': [1445], 'dramatic': [1460], 'elevation': [1461], 'levels,': [1464, 1717, 2169], 'range': [1467], '10–25-fold': [1469], '(Fig.': [1470, 1584, 1656, 1669, 1696, 1855, 1866, 1880, 1912, 1969, 2010, 2051, 2088, 2113, 2296, 2312, 2337, 2356, 2548, 2643, 2681, 3256, 3290], '1).': [1471], 'worth': [1474], 'emphasizing': [1475], 'novelty': [1477], 'observation;': [1480], 'previous': [1484], 'report': [1485], 'any': [1487, 2342, 2498, 2554, 2650, 3398, 3478], 'diphosphate.': [1500], 'Both': [1501], 'hydrolyzed': [1506], 'DIPPs': [1508], '(14Safrany': [1509], 'Yang': [1513], 'X.': [1514, 1538, 2573], 'Moyer': [1517], 'M.B.': [1518], 'Burkhart': [1519], 'W.A.': [1520], '6599-6607Crossref': [1527], '(138)': [1530], '16Hua': [1533], 'L.V.': [1534], 'Hidaka': [1535], 'Pesesse': [1537], 'Barnes': [1539], 'L.D.': [1540], '373:': [1546], '81-89Crossref': [1547], 'Any': [1551], 'DIPP': [1552], 'inhibition': [1553, 3171, 3180], 'polyphosphates.': [1563], 'On': [1564], 'contrary,': [1566], '26': [1568], '4%': [1570], '(n': [1571, 2221, 2259], '=': [1572, 2222, 2260], '8)': [1573], 'drop': [1574], 'accompanies': [1577], 'sorbitol-dependent': [1579, 1713, 2005, 2083, 2325], '1A).': [1585], 'consistent': [1589], 'elevating': [1593], 'activating': [1597], 'kinase.': [1600, 2393], 'possible': [1604], 'inhibits': [1608], '[PP]2-InsP4-specific': [1610, 1613], 'phosphatase': [1611], 'phosphorylation': [1614, 1968, 2048], 'Time': [1638], 'course': [1639], 'data': [1640, 2299, 3293, 3401], 'indicated': [1641], 'elevated': [1646, 3277], 'within': [1647, 1690], '5–10': [1648], 'min': [1649], 'initiation': [1652], '1B).': [1657], 'As': [1658], 'little': [1659], '0.05': [1661], 'promoted': [1664], 'severalfold': [1666], '1C).': [1670, 1881], 'Within': [1671], 'minutes': [1672], 'terminating': [1674], 'challenge,': [1677], 'declined': [1680], 'exponentially,': [1681], 'although': [1682], 'they': [1683], 'return': [1686], 'pre-activated': [1688], '2-h': [1692], 'experimental': [1693], 'time': [1694], 'frame': [1695], '1D);': [1697], 'instead,': [1698], "cell's": [1700], 'memory': [1701], 'history': [1705], 'persisted.': [1706], 'To': [1707, 2394], 'assess': [1708], 'underlying': [1711], 'considered': [1719], 'enzyme': [1722], 'interface': [1724], 'entities.': [1728], 'Hyperosomotic': [1729], 'known': [1732, 3250], 'activate': [1734, 2111, 3252], 'Ser/Thr': [1735], 'phosphoprotein': [1736, 1756], 'phosphatases': [1737, 1757], '(17Meier': [1738], 'Thelen': [1740], 'Hemmings': [1742], 'B.A.': [1743], '7294-7303Crossref': [1748], '(147)': [1751], 'Tyr': [1755], '(18Hresko': [1758], 'R.C.': [1759], 'Mueckler': [1760], '18114-18120Abstract': [1767], '(17)': [1775], 'but': [1778, 2856, 3396], 'inhibitors': [1779, 1958, 2023, 2181, 2270, 2336, 2349, 2378], 'pathway': [1782, 1808, 2463, 3321, 3374], '(20': [1783], 'nm': [1784, 3185], 'okadaic': [1785], 'acid': [1786], '10': [1788, 2203, 2210, 2241, 2248, 3176], 'μm': [1789, 2145, 2153, 2204, 2211, 2219, 2242, 2249, 2257, 3177], 'phenylarsine': [1790], 'oxide,': [1791], 'respectively)': [1792], 'modify': [1795], '(data': [1801, 2560, 2656, 2719, 3199, 3241], 'shown).': [1803, 2562, 2658, 2721, 3201, 3243], 'MAP': [1806, 1904, 2179, 2268, 2347, 2376, 2408, 2429, 2461, 2750, 2763, 3220, 3359, 3372], 'activated': [1811, 1853, 1861, 1908, 3325], '0.5': [1813, 1850], '(19Bagowski': [1816], 'C.P.': [1817], 'Besser': [1818], 'Frey': [1820], 'C.R.': [1821], 'Ferrell': [1822], 'Jr.,': [1823], 'J.E.': [1824], 'Curr.': [1825], '13:': [1828], '315-320Abstract': [1829], '(117)': [1837], 'agreement': [1841], 'found': [1848, 2704], '2A).': [1856], '2A),': [1867], 'yet': [1868, 3318], 'dose': [1870], 'sufficient': [1874, 3306], 'maximally': [1876], 'Thus,': [1882, 3202], 'conclude': [1884], 'necessary': [1890], 'increased': [1896], 'ERK': [1901, 2303, 2734, 3253, 3299], 'p38': [1903, 2150, 3255, 3301], 'pathways': [1906], '2,': [1913, 1970], 'B': [1914, 1971], 'C,': [1916, 1973], 'Refs.': [1918], '20Cowan': [1919, 3260], 'K.J.': [1920, 3261], 'Storey': [1921, 3262], 'K.B.': [1922, 3263], 'Exp.': [1924, 3265], '206:': [1927, 3268], '1107-1115Crossref': [1928, 3269], '(471)': [1931, 3272], 'Scholar': [1933], '21Galcheva-Gargova': [1935], 'Z.': [1936, 2606], 'Derijard': [1937], 'Wu': [1939], 'I.H.': [1940], 'Davis': [1941], 'R.J.': [1942, 2614], 'Science.': [1943], '1994;': [1944], '265:': [1945], '806-808Crossref': [1946], '(531)': [1949], 'Pretreatment': [1952, 2042], 'MEK': [1957, 2022, 2142, 2335, 2477, 2502], 'U0126': [1959, 2039, 2250], '(10': [1960, 2152, 3231], 'μm)': [1961, 1965], 'PD098059': [1963, 2220, 2258, 2287], '(50': [1964, 2144], 'inhibited': [1966, 2047], '22English': [1976], 'Cobb': [1978, 2524], 'M.H.': [1979, 2525], 'Trends': [1980], 'Pharmacol.': [1981], '23:': [1984], '40-45Abstract': [1985], '(389)': [1993], 'accompanied': [1998], '45–50%': [2001], 'reduction': [2002, 2386], '3A).': [2011, 2089, 2172], 'similarity': [2013], 'results': [2016, 2033], 'obtained': [2017], 'two': [2019, 2481], 'structurally': [2020], 'unrelated': [2021], 'makes': [2024], 'unlikely': [2026], 'reversal': [2028, 2161], 'effect': [2032, 2093, 2117, 2164, 2344, 2540, 2556, 2635, 2652, 2674, 2688, 3238, 3286], 'from': [2034, 3370], 'unsuspected': [2035], 'nonspecific': [2036], 'actions': [2037, 2752, 3426], 'PD098059.': [2041], 'SB203580': [2046, 2095], 'p38α/β': [2050], '2C': [2052], '23Goedert': [2055], 'Cuenda': [2057], 'Craxton': [2059], 'Jakes': [2061], 'Cohen': [2063], '1997;': [2067, 2620], '16:': [2068], '3563-3571Crossref': [2069], '(356)': [2072], 'elicited': [2077], '23%': [2079], 'attenuation': [2080, 2367, 2490], 'relatively': [2091], 'mild': [2092], 'when': [2096, 2200, 2238, 2557, 2564, 2653, 3375], 'added': [2099, 2558, 2654], 'alone': [2100, 2559, 2655], 'part': [2104], 'explained': [2105], 'its': [2107, 2736], 'ability': [2108], 'non-specifically': [2110, 2183], '3A);': [2114], 'similar': [2116], 'noted': [2120], '(24Liu': [2122], 'Q.': [2123], 'Hofmann': [2124], 'P.A.': [2125], 'Am.': [2126], '286:': [2130], 'H2204-H2212Crossref': [2131], '(142)': [2134], 'co-application': [2138], 'single': [2141], 'inhibitor': [2143, 2151, 2397], 'PD098059)': [2146], 'together': [2147], 'SB203580)': [2154], 'yielded': [2155], 'approximately': [2157, 2685], 'additive': [2158], '(80%': [2160], 'Fig.': [2171, 3281], 'eliminated': [2174], 'possibility': [2176], 'block': [2184, 2459], 'synthesis': [2185, 2275, 3193], 'polyphosphates:': [2189], 'native': [2190, 2710], 'preparations': [2191], 'showed': [2195, 2233], '103': [2196, 2214], '2%': [2198, 2216, 2246], 'activity': [2199, 2237, 2304, 2707], 'incubated': [2201, 2239], 'SB203580,': [2205, 2243], '105': [2206, 2244], '3%': [2208], 'U0126,': [2212], '50': [2218, 2256], '3),': [2223], 'relative': [2225, 2263], 'vehicle': [2227, 2265], 'recombinant': [2230], '97': [2234], '6%': [2236], '96': [2252], '5%': [2254], '3–4),': [2261], 'Although': [2267], 'vitro,': [2277], 'level': [2279], 'treated': [2284], 'UO1276': [2289], '25%': [2291], 'control': [2294, 3145, 3164], '3B).': [2297, 2338], 'suggest': [2300], 'resting': [2310], '2B)': [2313], 'weakly': [2315], 'enhance': [2316], 'activity.': [2319], 'Consistent': [2320], 'explanation,': [2323], 'reversed': [2332], 'sorbitol-treated': [2354, 3166], '3B)': [2357], 'additional': [2360, 3387], 'interest;': [2361, 2762], 'observation': [2363, 3504], 'indicates': [2364], 'sorbitol-mediated': [2369], 'secondary': [2382], 'substrate': [2388], 'supply': [2389], 'substantiate': [2395], 'experiments,': [2398], 'next': [2400], 'transfected': [2402], '(DN)': [2407], 'constructs.': [2411], 'first': [2414], 'note': [2417], 'environmental': [2419], 'stresses': [2420], 'provide': [2421], '"lateral"': [2422], '"top-down"': [2426], 'input': [2427, 2500], 'responses': [2431], '(25Harrison': [2432], 'Zyla': [2434], 'T.R.': [2435], 'Bardes': [2436], 'E.S.': [2437], 'Lew': [2438], '279:': [2444], '2616-2622Abstract': [2445], '(68)': [2453], 'DN-ERK': [2457], 'constructs': [2458, 2669], 'at': [2464, 2941], 'point': [2466], 'downstream': [2469, 2732, 3316], 'site': [2472], 'action': [2474], 'inhibitors,': [2478], 'so': [2479, 3380], 'empirical': [2482], 'approaches': [2483], 'could': [2484, 2690], 'yield': [2485], 'quantitatively': [2486], 'different': [2487], 'degrees': [2488], 'if': [2495], 'lateral': [2499], 'between': [2501, 3028], 'ERK.': [2504], 'When': [2505], 'co-expressed,': [2506, 2565], '(K71R)': [2508], '(K52R)': [2511], '(26Robbins': [2512], 'Zhen': [2514], 'Owaki': [2516], 'Vanderbilt': [2518], 'C.A.': [2519], 'Ebert': [2520], 'Geppert': [2522], 'T.D.': [2523], '268:': [2530], '5097-5106Abstract': [2531], 'reduced': [2538, 2633, 2670], '30%': [2547, 2642], '4).': [2549, 2644, 2682], 'Neither': [2550], 'DN': [2551, 2647, 2668], 'construct': [2552, 2648], 'had': [2553, 2649, 3236, 3284], 'Also': [2563], 'TGY-to-AGF': [2567], '(27Wang': [2572], 'McGowan': [2574], 'C.H.': [2575], 'Zhao': [2576], 'He': [2578], 'L.': [2579], 'Downey': [2580], 'J.S.': [2581], 'Fearns': [2582], 'Wang': [2584], 'Han': [2588, 2617], '20:': [2594], '4543-4552Crossref': [2595], '(237)': [2598], '28Huang': [2601], 'Jiang': [2603], 'Li': [2605], 'Nishida': [2607], 'Mathias': [2609], 'Lin': [2611], 'Ulevitch': [2613], 'Nemerow': [2615], 'G.R.': [2616], 'Immunity.': [2619], '6:': [2621], '739-749Abstract': [2622], '(212)': [2630], 'Again,': [2645], 'neither': [2646], 'Transient': [2659], 'transfection': [2660, 2696], 'four': [2667], 'maximum': [2687], 'anticipated,': [2692], 'given': [2693], 'limited': [2695], 'efficiency': [2697], '(50%;': [2698], 'GFP': [2701], 'co-transfection).': [2702], 'unaffected': [2714, 3169], 'recombinant,': [2716], 'phosphorylated': [2717], 'seems': [2724], 'likely': [2725], 'another': [2727, 2994, 3319], 'lies': [2731], 'mediates': [2735], 'accumulation.': [2741], 'Nevertheless,': [2742], 'offers': [2745], 'repertoire': [2748], 'physiology.': [2755], 'Its': [2756], 'unusual': [2757], 'nature': [2758], 'do': [2765], 'typically': [2767], 'recruit': [2768, 3002], 'diffusible': [2769], 'messengers.': [2771], 'growing': [2775], 'appreciation': [2776], 'bind': [2782], 'manner': [2787], 'certain': [2789], 'through': [2791, 3194], 'largely': [2792], 'delocalized': [2793], '(i.e.': [2794], 'nonspecific)': [2795], 'interactions,': [2797], 'most': [2798], 'notably': [2799], 'majority': [2802], '29Lemmon': [2840], 'M.A.': [2841, 3010], 'Ferguson': [2842, 3011], 'K.M.': [2843, 3012], 'Abrams': [2844, 3013], 'C.S.': [2845, 3014], 'FEBS': [2846, 3015], 'Lett.': [2847, 3016], '513:': [2849, 3018], '71-76Crossref': [2850, 3019], '(214)': [2853, 3022], 'certainly': [2861], 'involved': [2862], 'circumstances,': [2925], 'just': [2930], 'pyrophosphate': [2932, 3139], 'group': [2933], 'ligand': [2938, 2996], 'affinity': [2939], 'least': [2942], '30–100-fold': [2943], 'Elevations': [2978], 'would': [2985, 3142], 'expected': [2988], 'increasingly': [2990], 'compete': [2991], 'helps': [3001], 'multimeric': [3005, 3151], 'complexes': [3007], '(signalosomes)': [3008], '(29Lemmon': [3009], 'Indeed,': [3025], 'dynamic': [3026], 'competition': [3027], 'soluble': [3029], 'membrane-bound': [3033], 'lipids': [3035], 'shown': [3038], 'others': [3040], 'act': [3042], 'logic': [3045], 'gate': [3046], 'determine': [3048], 'inositide-binding': [3051], 'recruited': [3054], 'signalosomes': [3056], 'If': [3125], 'autonomous': [3128], 'spatio-temporal': [3129], 'regulation': [3130], 'competing': [3136], 'lipid': [3137, 3210], 'ligands,': [3140], 'facilitate': [3143], 'stimulus-specific': [3144], 'over': [3146], 'membership': [3148], 'complexes.': [3152], 'evidence': [3155], 'metabolic': [3158], 'autonomy;': [3159], 'PtdIns(4,5)P2': [3173], 'U73122,': [3178], 'PI': [3182], '3-kinases': [3183], 'with100': [3184], 'wortmannin,': [3186], 'specific': [3189, 3368, 3497], 'PtdIns(3,4,5)P3': [3192], 'transient': [3195], 'overexpression': [3196], 'completely': [3206], 'independent': [3207], 'turnover.': [3211], 'Of': [3212], 'importance': [3213], 'subject': [3216], 'specificity,': [3219], 'inflammatory': [3225], 'cytokine': [3226], 'tumor': [3227], 'necrosis': [3228], 'factor': [3229], 'α': [3230], 'ng/ml': [3232], '30': [3234], 'min)': [3235], 'Furthermore,': [3244], 'though': [3246], 'EGF': [3247], '5': [3257], 'barely': [3276], '(0.7-fold;': [3280], '5)': [3282], '5).': [3291], 'indicate': [3294], 'not,': [3303], 'themselves,': [3305], 'Perhaps': [3311], 'selectively': [3324], 'EGF.': [3332], 'Alternately,': [3333], '(but': [3336], 'EGF)': [3338], 'attenuate': [3340], 'inhibitory': [3342], 'process': [3343], 'normally': [3345], 'constrains': [3346], 'accumulation': [3348], 'questions': [3352], 'touch': [3353], 'enigma': [3356], 'pervades': [3358], 'research:': [3361], 'elicit': [3366], 'output': [3369], 'utilized': [3378], 'stimulii?': [3385], 'Much': [3386], 'work': [3388], 'required': [3391], 'solve': [3393], 'problem,': [3395], 'case,': [3399, 3479], 'our': [3400, 3480], 'still': [3403], 'demonstration': [3407, 3481], 'stress-dependent': [3411], 'agonist-initiated': [3414], 'provides': [3420], 'intriguing': [3432], 'shock': [3435], '(13Kültz': [3444], '(see': [3475], 'Introduction).': [3476], 'polyphosphates,': [3494], 'acute': [3499], 'manner,': [3500], 'unprecedented': [3503], 'inositide': [3514], 'signaling.': [3515], 'Download': [3516], '.pdf': [3517], '(.01': [3518], 'MB)': [3519], 'Help': [3520], 'pdf': [3522], 'files': [3523]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022494306', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T00:52:34.558174', 'created_date': '2016-06-24'}
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