Publication Information

{'id': 'https://openalex.org/W2022386942', 'doi': 'https://doi.org/10.1074/jbc.m803493200', 'title': 'A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes', 'display_name': 'A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes', 'publication_year': 2008, 'publication_date': '2008-06-01', 'ids': {'openalex': 'https://openalex.org/W2022386942', 'doi': 'https://doi.org/10.1074/jbc.m803493200', 'mag': '2022386942', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18515798', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2475699'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m803493200', 'pdf_url': 'http://www.jbc.org/article/S0021925819547305/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819547305/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039059766', 'display_name': 'Chao‐Po Lin', 'orcid': 'https://orcid.org/0000-0002-1457-1635'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chao-Po Lin', 'raw_affiliation_strings': ['Department of Pharmacology, University of Medicine and Dentistry of New Jersey—Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Medicine and Dentistry of New Jersey—Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107460507', 'display_name': 'Yi Ban', 'orcid': 'https://orcid.org/0000-0002-7644-9686'}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yi Ban', 'raw_affiliation_strings': ['Rutgers, The State University of New Jersey [New Brunswick]'], 'affiliations': [{'raw_affiliation_string': 'Rutgers, The State University of New Jersey [New Brunswick]', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103562235', 'display_name': 'Yi Lisa Lyu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yi Lisa Lyu', 'raw_affiliation_strings': ['Rutgers, The State University of New Jersey [New Brunswick]'], 'affiliations': [{'raw_affiliation_string': 'Rutgers, The State University of New Jersey [New Brunswick]', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108099110', 'display_name': 'Shyamal D. Desai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I75420490', 'display_name': 'Louisiana State University Health Sciences Center New Orleans', 'ror': 'https://ror.org/01qv8fp92', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I75420490']}, {'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shyamal D. Desai', 'raw_affiliation_strings': ['Louisiana State University Health Sciences Center', 'Rutgers - The State University of New Jersey, New Brunswick'], 'affiliations': [{'raw_affiliation_string': 'Louisiana State University Health Sciences Center', 'institution_ids': ['https://openalex.org/I75420490']}, {'raw_affiliation_string': 'Rutgers - The State University of New Jersey, New Brunswick', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057145998', 'display_name': 'Leroy F. Liu', 'orcid': 'https://orcid.org/0000-0001-9396-763X'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leroy F. Liu', 'raw_affiliation_strings': ['Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New jersey 08854'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New jersey 08854', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.284, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 112, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '283', 'issue': '30', 'first_page': '21074', 'last_page': '21083'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9822, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lactacystin', 'display_name': 'Lactacystin', 'score': 0.5603577}, {'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.4730013}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.42644942}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.7356149}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.6280466}, {'id': 'https://openalex.org/C2776148510', 'wikidata': 'https://www.wikidata.org/wiki/Q6468907', 'display_name': 'Lactacystin', 'level': 4, 'score': 0.5603577}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.54021543}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.5253289}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.50571966}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.4730013}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44170147}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4414188}, {'id': 'https://openalex.org/C158456008', 'wikidata': 'https://www.wikidata.org/wiki/Q412639', 'display_name': 'DNA supercoil', 'level': 4, 'score': 0.4337594}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.42644942}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4106755}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39892977}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3270839}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.27805996}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.2387174}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020552', 'descriptor_name': 'Comet Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m803493200', 'pdf_url': 'http://www.jbc.org/article/S0021925819547305/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2475699', 'pdf_url': 'https://europepmc.org/articles/pmc2475699?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18515798', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m803493200', 'pdf_url': 'http://www.jbc.org/article/S0021925819547305/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1508099272', 'https://openalex.org/W1514540426', 'https://openalex.org/W1536538430', 'https://openalex.org/W1549846058', 'https://openalex.org/W1553801822', 'https://openalex.org/W1705636341', 'https://openalex.org/W193931596', 'https://openalex.org/W1989302474', 'https://openalex.org/W1991182906', 'https://openalex.org/W2008962151', 'https://openalex.org/W2009885625', 'https://openalex.org/W2013499751', 'https://openalex.org/W2016599680', 'https://openalex.org/W2022811243', 'https://openalex.org/W2027955308', 'https://openalex.org/W2029134404', 'https://openalex.org/W2040234559', 'https://openalex.org/W2040829831', 'https://openalex.org/W2044142379', 'https://openalex.org/W2046770300', 'https://openalex.org/W2052036700', 'https://openalex.org/W2056441912', 'https://openalex.org/W2061510201', 'https://openalex.org/W2062445688', 'https://openalex.org/W2072358340', 'https://openalex.org/W2077927459', 'https://openalex.org/W2078835140', 'https://openalex.org/W2084060660', 'https://openalex.org/W2085712777', 'https://openalex.org/W2085901921', 'https://openalex.org/W2113301783', 'https://openalex.org/W2118553080', 'https://openalex.org/W2119186872', 'https://openalex.org/W2123273708', 'https://openalex.org/W2124624490', 'https://openalex.org/W2126350892', 'https://openalex.org/W2127144150', 'https://openalex.org/W2127236494', 'https://openalex.org/W2130307677', 'https://openalex.org/W2132600317', 'https://openalex.org/W2135072453', 'https://openalex.org/W2146274229', 'https://openalex.org/W2149451232', 'https://openalex.org/W2160948762', 'https://openalex.org/W2169349050', 'https://openalex.org/W2169602273', 'https://openalex.org/W2394674068', 'https://openalex.org/W4236530034'], 'related_works': ['https://openalex.org/W4383550996', 'https://openalex.org/W4362068865', 'https://openalex.org/W4230809382', 'https://openalex.org/W3172974747', 'https://openalex.org/W261027724', 'https://openalex.org/W2415754750', 'https://openalex.org/W2414342434', 'https://openalex.org/W2132427641', 'https://openalex.org/W2046256887', 'https://openalex.org/W1985114772'], 'abstract_inverted_index': {'Reversible': [0, 225], 'topoisomerase': [1, 226, 452, 460, 519], 'I': [2, 227, 453], '(Top1)-DNA': [3, 228], 'cleavage': [4, 47, 79, 190, 205, 210, 229, 272, 304, 415, 430, 435, 703, 755, 806, 829, 871, 984, 1030, 1092, 1140, 1345, 1494, 1543, 1625, 1656, 1688, 1764, 3014, 3382, 3666], 'complexes': [5, 48, 191, 211, 230, 273, 416, 436, 704, 756, 807, 830, 872, 985, 1031, 1093, 1346, 1495, 1544, 1626, 1689, 1765, 3383, 3667], 'are': [6, 231, 831, 873, 997, 1229, 1268, 1681, 3043, 3497, 4228], 'the': [7, 63, 69, 75, 97, 127, 145, 158, 170, 176, 201, 214, 232, 288, 294, 300, 322, 352, 370, 383, 395, 401, 426, 439, 574, 584, 588, 749, 980, 993, 1005, 1026, 1062, 1068, 1076, 1085, 1132, 1137, 1144, 1147, 1151, 1165, 1264, 1266, 1271, 1275, 1326, 1341, 1454, 1505, 1546, 1554, 1605, 1614, 1621, 1632, 1647, 1652, 1675, 1684, 1703, 1706, 1716, 1727, 1733, 1750, 1760, 1774, 1896, 2137, 2175, 2197, 2211, 2236, 2277, 2311, 2341, 2435, 2462, 2499, 2566, 2623, 2809, 2817, 2882, 2950, 2997, 3004, 3096, 3372, 3378, 3389, 3426, 3433, 3461, 3470, 3479, 3511, 3517, 3557, 3595, 3603, 3656, 3697, 3709, 3738, 3747, 3778, 3818, 3914, 3946, 4001, 4006, 4022, 4074, 4108, 4134, 4151, 4195, 4221, 4231, 4238], 'key': [8, 233], 'DNA': [9, 42, 100, 118, 234, 267, 325, 343, 451, 577, 585, 689, 833, 876, 887, 977, 987, 1009, 1016, 1156, 1214, 1348, 1628, 1636, 1691, 2807, 2992, 3007, 3017, 3325, 3375, 3427, 3436, 3491, 3527, 3561, 3589, 3600, 3623, 3629, 3659, 3669, 3760, 3839, 4077, 4116, 4143, 4184, 4253, 4272], 'lesion': [10, 235], 'induced': [11, 236, 3328, 3984, 4014, 4121, 4175], 'by': [12, 105, 126, 237, 330, 351, 578, 836, 1403, 1702, 1835, 2090, 2113, 2156, 2292, 2328, 2357, 2510, 2538, 2563, 2628, 2636, 2651, 2741, 2751, 2827, 2855, 2886, 2896, 2922, 2937, 2968, 2978, 3095, 3329, 3388, 3495, 3510, 3696, 3708, 3732, 3913, 4000, 4067, 4122], 'anticancer': [13, 238, 662], 'camptothecins': [14, 239, 663, 740], '(e.g.': [15, 25, 240, 250, 664, 675], 'topotecan': [16, 241], 'and': [17, 38, 41, 51, 108, 120, 135, 175, 194, 242, 263, 266, 276, 333, 345, 360, 400, 419, 666, 685, 687, 724, 751, 776, 839, 889, 1004, 1136, 1150, 1160, 1226, 1234, 1291, 1441, 1453, 1504, 1663, 1671, 1679, 1711, 1732, 1768, 1821, 1928, 1955, 1977, 2035, 2052, 2067, 2071, 2101, 2107, 2127, 2267, 2365, 2376, 2394, 2434, 2519, 2622, 2673, 2678, 2755, 2768, 2786, 2918, 2940, 2982, 3009, 3029, 3048, 3111, 3129, 3187, 3249, 3320, 3536, 3563, 3576, 3602, 3608, 3615, 3625, 3715, 3782, 3834, 3852, 3920, 3931, 3942, 3961, 3974, 4005, 4083, 4103, 4130, 4139, 4236, 4242, 4259, 4276], 'irinotecan)': [18, 243], 'as': [19, 21, 244, 246, 668, 670, 699, 1218, 1781, 1856, 2002, 2465, 2569, 3093, 3386], 'well': [20, 245, 659, 669, 792, 3338], 'structurally': [22, 247, 672], 'perturbed': [23, 248, 673], 'DNAs': [24, 249, 674], 'oxidatively': [26, 251], 'damaged': [27, 252], 'DNA,': [28, 30, 32, 34, 36, 40, 253, 255, 257, 259, 261, 265], 'UV-irradiated': [29, 254], 'alkylated': [31, 256], 'uracil-substituted': [33, 258], 'mismatched': [35, 260], 'gapped': [37, 262], 'nicked': [39, 264], 'with': [43, 268, 881, 885, 1011, 1395, 1444, 1674, 1938, 1964, 1974, 2043, 2092, 2095, 2142, 2149, 2158, 2169, 2217, 2378, 2396, 2506, 2512, 2521, 2534, 2540, 2599, 2653, 2757, 2803, 2821, 2846, 2857, 2869, 2906, 2924, 2984, 3240, 3655, 3976, 4186, 4204, 4212, 4230], 'abasic': [44, 269, 678], 'sites).': [45, 270], 'Top1': [46, 60, 72, 78, 93, 114, 153, 189, 204, 209, 271, 285, 297, 303, 318, 339, 378, 414, 429, 434, 700, 754, 805, 828, 870, 983, 1029, 1091, 1139, 1344, 1449, 1451, 1493, 1503, 1542, 1624, 1655, 1659, 1687, 1763, 2557, 2559, 2722, 2832, 2866, 2934, 2938, 3381, 3665, 3846, 3862, 3940], 'arrest': [49, 192, 274, 417, 1006, 1145, 1496, 3748], 'transcription': [50, 193, 275, 418, 890, 1339, 1400, 1406, 1436, 1497, 1678, 3010, 3471, 3564, 3626, 3710, 3750, 3833, 3930, 4002, 4082, 4138, 4203, 4241], 'trigger': [52, 277], 'transcription-dependent': [53, 278, 1445, 1622], 'degradation': [54, 202, 279, 427, 1447, 1501, 1540, 2560], 'of': [55, 71, 77, 99, 117, 147, 160, 164, 172, 178, 203, 208, 216, 280, 296, 302, 324, 342, 372, 385, 389, 397, 403, 428, 433, 441, 576, 583, 590, 746, 753, 804, 975, 982, 1007, 1028, 1061, 1078, 1089, 1146, 1154, 1167, 1236, 1263, 1274, 1343, 1393, 1405, 1435, 1448, 1457, 1502, 1508, 1541, 1616, 1646, 1649, 1654, 1686, 1695, 1705, 1708, 1718, 1729, 1735, 1762, 1773, 1776, 1840, 1852, 1902, 2050, 2065, 2186, 2210, 2220, 2235, 2565, 2609, 2638, 2641, 2656, 2681, 2732, 2761, 2778, 2806, 2849, 2860, 2874, 2909, 2927, 2949, 2961, 3000, 3006, 3087, 3098, 3134, 3374, 3380, 3435, 3508, 3520, 3559, 3622, 3749, 3799, 3832, 3844, 4024, 4081, 4110, 4154, 4179, 4183, 4197, 4202, 4210, 4223, 4240], 'Top1,': [56, 281, 459, 518], 'a': [57, 141, 185, 196, 222, 282, 366, 410, 421, 447, 591, 744, 1079, 1127, 1155, 1161, 1261, 1335, 1617, 1696, 1712, 1754, 1960, 2075, 2119, 2391, 2397, 2548, 2553, 2629, 2674, 2861, 3050, 3130, 3282, 3337, 3797, 4111, 4176, 4217, 4257], 'phenomenon': [58, 283], 'termed': [59, 284], 'down-regulation.': [61, 154, 286, 379, 1724], 'In': [62, 155, 287, 380, 1124, 1323, 1604, 3689], 'current': [64, 289, 1606], 'study,': [65, 290], 'we': [66, 291, 1608, 3901], 'have': [67, 139, 292, 364, 742, 1238, 3176, 3774, 3858, 4268], 'investigated': [68, 293, 3634], 'role': [70, 295, 974, 1615, 1648], 'down-regulation': [73, 298, 2833, 2867, 3863, 3941], 'in': [74, 187, 213, 299, 412, 438, 597, 706, 758, 979, 1067, 1143, 1245, 1340, 1398, 1620, 1651, 1752, 1759, 1935, 1959, 1979, 2040, 2074, 2109, 2115, 2118, 2249, 2281, 2294, 2315, 2330, 2345, 2359, 2374, 2406, 2865, 2899, 3011, 3022, 3026, 3032, 3077, 3090, 3192, 3254, 3273, 3298, 3301, 3365, 3377, 3438, 3441, 3501, 3549, 3565, 3591, 3617, 3627, 3635, 3641, 3681, 3765, 3769, 3790, 3837, 3907, 3965, 3980, 3988, 4017, 4099, 4141, 4160, 4164, 4171, 4220, 4244, 4248, 4256, 4262, 4278, 4282], 'repair': [76, 220, 301, 445, 1559, 1770, 3585], 'complexes.': [80, 206, 305, 431, 1657, 2726, 3752], 'Using': [81, 306], 'quiescent': [82, 307, 1638, 3051, 3274, 3636, 3682, 3770, 3908, 4104, 4166, 4249], '(serum-starved)': [83, 308, 1639], 'human': [84, 309, 1909, 3036], 'WI-38': [85, 310, 1640, 1913, 1923, 2145, 3001, 3039, 3041, 3080, 3256, 3277, 3303, 3443, 3503, 3551, 3593, 3637, 3683, 3771, 3792, 3909, 4105, 4167, 4264], 'cells,': [86, 311, 1003, 3304, 3594, 3967, 4106], 'camptothecin': [87, 312], '(CPT)': [88, 313], 'was': [89, 166, 314, 391, 989, 1699, 1779, 1832, 1893, 1914, 2192, 2204, 2214, 2239, 2404, 2450, 2459, 2561, 2620, 2713, 2738, 2878, 2956, 3244, 3262, 3293, 3309, 3456, 3674, 3694, 3809, 3911, 3998, 4065, 4146], 'shown': [90, 167, 315, 392, 1240, 1667, 3076, 3245, 3263, 3457, 3640, 3675, 3776, 3810, 3859, 3979, 4170], 'to': [91, 157, 168, 200, 316, 382, 393, 425, 698, 1000, 1075, 1241, 1325, 1334, 1552, 1610, 1668, 1740, 2136, 2195, 2881, 2958, 3045, 3106, 3246, 3264, 3458, 3587, 3599, 3605, 3663, 3676, 3728, 3746, 3811, 4095, 4149], 'induce': [92, 317, 3247, 3265, 3649, 3677, 3729, 4096], 'down-regulation,': [94, 115, 319, 340, 1660, 3847], 'which': [95, 188, 320, 413, 1753, 3848], 'paralleled': [96, 321], 'induction': [98, 116, 323, 341], 'single-strand': [101, 326, 491, 550, 841], 'breaks': [102, 327, 842], '(SSBs)': [103, 328, 843], '(assayed': [104, 329], 'comet': [106, 331, 2131, 2275, 2309, 2401, 3513], 'assays)': [107, 332], 'ATM': [109, 121, 179, 334, 346, 404, 1664, 1736, 3188, 3250, 3271, 3307, 3318, 3541, 3567, 3577, 3611, 3679, 3692, 3730, 3742, 3767, 3788, 3804, 3807, 3814, 3819, 3826, 3840, 3905, 3943, 3963, 3986, 3996, 4059, 4063, 4097, 4119, 4157, 4246], 'autophosphorylation': [110, 122, 335, 347, 1665, 1737, 3189, 3251, 3308, 3319, 3542, 3578, 3680, 3693, 3731, 3743, 3789, 3808, 3827, 3841, 3906, 3944, 3964, 3987, 3997, 4064, 4098, 4120], '(at': [111, 336, 1925], 'Ser-1981).': [112, 337], 'Interestingly,': [113, 338], 'SSBs': [119, 174, 218, 344, 399, 443, 1557, 1662, 1731], 'were': [123, 348, 1642, 1666, 1738, 1825, 1848, 1933, 1972, 1993, 2038, 2062, 2081, 2105, 2133, 2147, 2167, 2246, 2279, 2313, 2343, 2371, 2388, 2437, 2504, 2531, 2545, 2625, 2634, 2748, 2771, 2789, 2801, 2819, 2844, 2894, 2904, 2935, 2975, 3020, 3632, 3972], 'all': [124, 349], 'abolished': [125, 350, 3786, 3824, 3999], 'proteasome': [128, 161, 353, 386, 1439, 1650, 1680, 3779, 3800, 3835, 4007, 4084, 4140, 4211, 4243], 'inhibitor': [129, 354, 2676, 2916, 3821], 'MG132.': [130, 355, 4009], 'Furthermore,': [131, 356, 4118], 'studies': [132, 357, 3175, 3857, 4267], 'using': [133, 358, 739, 2452, 2547, 2808, 3425], 'immunoprecipitation': [134, 359, 2828], 'dominant-negative': [136, 361], 'ubiquitin': [137, 362], 'mutants': [138, 363], 'suggested': [140, 365, 991, 1491, 4269], 'specific': [142, 367, 802, 1713, 4135], 'requirement': [143, 368, 1714, 3798, 3831, 3928, 4136], 'for': [144, 151, 219, 369, 376, 444, 1084, 1558, 1644, 1683, 1715, 1722, 1984, 2086, 2152, 2162, 2181, 2270, 2285, 2301, 2324, 2336, 2353, 2362, 2383, 2444, 2603, 2717, 2720, 2743, 2823, 2970, 3341, 3546, 3802, 3929, 3938, 4114, 4137], 'assembly': [146, 371, 1717], 'Lys-48-linked': [148, 373, 1719], 'polyubiquitin': [149, 374, 1720], 'chains': [150, 375, 1721], 'CPT-induced': [152, 173, 377, 398, 1090, 1661, 1723, 1730, 3016, 3291, 3306, 3331, 3362, 3439, 3462, 3480, 3490, 3526, 3540, 3566, 3574, 3588, 3610, 3628, 3691, 3741, 3766, 3787, 3803, 3806, 3825, 3838, 3845, 3861, 3904, 3939, 3995, 4058, 4115, 4142, 4245, 4271], 'contrast': [156, 381], 'effect': [159, 384, 1024, 3477, 3519, 4193], 'inhibition,': [162, 387], 'inactivation': [163, 388], 'PARP1': [165, 390, 1744], 'increase': [169, 394], 'amount': [171, 396, 1027, 1728, 2185], 'level': [177, 402, 1734, 3133], 'autophosphorylation.': [180, 405, 3568, 3805], 'Together,': [181, 406, 1746, 4087], 'these': [182, 407, 1747, 3241, 4088], 'results': [183, 212, 408, 437, 1397, 1748, 3315, 3487, 3570, 3754, 4089, 4227, 4233], 'support': [184, 409, 1749], 'model': [186, 411, 1083, 1751, 3393], 'activate': [195, 420], 'ubiquitin-proteasome': [197, 422, 1618, 1697, 1755], 'pathway': [198, 423, 1619, 1698, 1756], 'leading': [199, 424], 'Degradation': [207, 432], 'exposure': [215, 440], 'Top1-concealed': [217, 442, 840, 1556], 'through': [221, 446, 587, 800, 878], 'PARP1-dependent': [223, 448], 'process.': [224, 449], 'Eukaryotic': [450], '(Top1)': [454], '3The': [455, 514], 'abbreviations': [456, 515], 'used': [457, 516], 'are:': [458, 517], 'I;': [461, 520], 'DRB,': [462, 521, 3524, 4004], '5,6-dichloro-1-β-d-ribobenzimidazole;': [463, 522], 'APH,': [464, 523, 3430, 3521], 'aphidicolin;': [465, 524], 'MG132,': [466, 525, 4071], 'carbobenzoxy-l-leucyl-l-leucyl-l-leucinal;': [467, 526], 'Ub,': [468, 527], 'ubiquitin;': [469, 528], 'ATM,': [470, 529, 1221], 'ataxia': [471, 530], 'telangiectasia': [472, 531], 'mutated;': [473, 532], 'PARP1,': [474, 533], 'poly(ADP-ribose)': [475, 534], 'polymerase': [476, 535, 1459, 1510], 'family,': [477, 536], 'member': [478, 537], '1;': [479, 483, 538, 542], 'TDP1,': [480, 539], 'tyrosyl-DNA': [481, 540], 'phosphodiesterase': [482, 541], 'MEF,': [484, 543], 'mouse': [485, 544, 2000, 2060, 3969, 3989, 4018], 'embryonic': [486, 545, 1996], 'fibroblast;': [487, 546], 'CPT,': [488, 547, 4123], 'camptothecin;': [489, 548], 'SSB,': [490, 549], 'break;': [492, 495, 551, 554], 'DSB,': [493, 552], 'double-strand': [494, 553, 1157], 'DMEM,': [496, 555], "Dulbecco's": [497, 556], 'modified': [498, 557], "Eagle's": [499, 558], 'medium;': [500, 559], 'E1,': [501, 560], 'ubiquitin-activating': [502, 561], 'enzyme;': [503, 562], 'E3,': [504, 563], 'ubiquitin-protein': [505, 564], 'isopeptide': [506, 565], 'ligase;': [507, 566], 'HA,': [508, 567], 'hemagglutinin;': [509, 568], '3-AB,': [510, 569], '3-aminobenzamide;': [511, 570], 'DIQ,': [512, 571], '1,5-dihydroxyisoquinoline.': [513, 572], 'catalyzes': [573], 'breakage/reunion': [575], 'transiently': [579], 'nicking': [580], 'one': [581], 'strand': [582], 'duplex,': [586], 'formation': [589, 1153, 1707, 1775, 3364, 4023, 4153], 'reversible': [592, 692, 869, 1138], 'Top1-DNA': [593, 693, 1162, 2725, 3013], 'covalent': [594, 694, 2724], 'complex': [595, 1943, 2100], '(reviewed': [596, 705, 757, 1244], 'Refs.': [598, 707, 759], '1Wang': [599], 'J.C.': [600, 613], 'Annu.': [601, 631, 645, 712, 764], 'Rev.': [602, 615, 632, 646, 713, 728, 765, 780, 1250], 'Biochem.': [603, 647], '1996;': [604], '65:': [605], '635Crossref': [606], 'PubMed': [607, 622, 638, 651, 719, 733, 771, 785, 825, 861, 926, 968, 1255, 1372, 1387, 1429, 1483, 1534, 1582, 1806, 1878, 2029, 2427, 2493, 2594, 2706, 3072, 3124, 3169, 3234, 3357, 3895, 4051], 'Scopus': [608, 623, 639, 652, 720, 734, 772, 786, 927, 969, 1256, 1373, 1388, 1430, 1484, 1535, 1583, 1807, 1879, 2030, 2428, 2494, 2595, 2707, 3125, 3170, 3235, 3358, 3896, 4052], '(2063)': [609], 'Google': [610, 625, 641, 654, 722, 736, 774, 788, 826, 862, 902, 929, 942, 959, 971, 1045, 1058, 1105, 1122, 1180, 1197, 1210, 1258, 1289, 1308, 1321, 1375, 1390, 1432, 1486, 1537, 1585, 1602, 1809, 1881, 2032, 2430, 2496, 2597, 2709, 3073, 3127, 3151, 3172, 3237, 3360, 3405, 3422, 3898, 4054], 'Scholar,': [611, 626, 642, 903, 930, 943, 960, 1046, 1106, 1181, 1198, 1309, 1376, 1586, 3152, 3406], '2Wang': [612], 'Nat.': [614, 727, 779, 1249], 'Mol.': [616, 920, 1366, 1423, 1477, 1528, 1576, 1800, 2588, 3889], 'Cell': [617, 1907, 3164], 'Biol.': [618, 817, 853, 922, 1368, 1425, 1479, 1530, 1578, 1802, 1868, 2019, 2483, 2590, 2696, 3064, 3165, 3224, 3891, 4041], '2002;': [619], '3:': [620], '430-440Crossref': [621], '(1879)': [624], '3Li': [627, 708, 760], 'T.K.': [628, 709, 761, 1590], 'Liu': [629, 710, 762, 814, 850, 895, 918, 935, 952, 1051, 1098, 1115, 1173, 1190, 1203, 1282, 1314, 1364, 1379, 1421, 1475, 1526, 1574, 1595, 1798, 1861, 2016, 2420, 2480, 2586, 2693, 3144, 3161, 3398, 3415, 3887, 4038], 'L.F.': [630, 711, 763, 815, 851, 896, 919, 936, 953, 1052, 1099, 1116, 1174, 1191, 1204, 1283, 1315, 1365, 1380, 1422, 1476, 1527, 1575, 1596, 1799, 1862, 2017, 2421, 2481, 2587, 2694, 3145, 3162, 3399, 3416, 3888, 4039], 'Pharmacol.': [633, 714, 766], 'Toxicol.': [634, 715, 767], '2001;': [635, 648, 716, 768, 1599, 2698], '41:': [636, 717, 769], '53-77Crossref': [637, 718, 770], '(470)': [640, 721, 773], '4Champoux': [643], 'J.J.': [644, 3346], '70:': [649], '369-413Crossref': [650], '(2164)': [653], 'Scholar).': [655, 737, 789, 827, 863, 972, 1059, 1123, 1211, 1259, 1322, 1391, 1433, 1487, 1538, 1603, 1810, 1882, 2033, 2497, 2710, 3074, 3173, 3238, 3423, 3899, 4055], 'It': [656, 790, 864, 1488], 'has': [657, 865, 1073, 1331, 1489, 1549], 'been': [658, 866, 1239, 1490, 1550], 'established': [660, 793], 'that': [661, 794, 868, 995, 1492, 1677, 1887, 3178, 3290, 3317, 3489, 3573, 3658, 3725, 3740, 3756, 3777, 3860, 3903, 3948, 3957, 4073, 4091, 4270], 'irinotecan': [665], 'topotecan)': [667], 'various': [671, 2150, 2824], 'UV': [676], 'adducts,': [677], 'sites,': [679], 'base': [680], 'mismatches,': [681], 'uracil': [682], 'incorporation,': [683], 'nicks': [684], 'gaps,': [686], 'oxidized': [688], 'lesions)': [690], 'stabilize': [691], 'complexes,': [695, 3015], 'often': [696], 'referred': [697], 'cleavable': [701], 'or': [702, 1014, 2831, 2986, 4208], 'Scholar': [723, 775], '5Pommier': [725, 777, 1247], 'Y.': [726, 778, 1039, 1248, 1302, 2419, 2686, 3222], 'Cancer.': [729, 781, 1251], '2006;': [730, 782, 1252, 2021, 2485, 4043], '6:': [731, 783, 1253], '789-802Crossref': [732, 784, 1254], '(1584)': [735, 787, 1257], 'Studies': [738, 1898, 3424], '(CPTs)': [741], 'generated': [743, 1066], 'wealth': [745], 'information': [747], 'on': [748, 1025, 1438, 2502, 2552, 2715, 2841, 2996, 3478, 3525, 3813, 3866, 4194], 'structure': [750], 'biology': [752], 'is': [791, 1442, 1757, 3336, 3661, 3744, 3762, 3842, 3849, 3864, 4079, 4093, 4128, 4274], 'CPTs': [795, 996], 'exert': [796], 'their': [797, 801, 837, 879], 'antitumor': [798], 'activity': [799, 1440, 3801, 3816, 3836], 'stabilization': [803], '(6Hsiang': [808, 844], 'Y.H.': [809, 845, 892, 1095, 1170, 3141, 3395], 'Hertzberg': [810, 846], 'R.': [811, 847, 951, 1114, 1189, 3414], 'Hecht': [812, 848], 'S.': [813, 849], 'J.': [816, 852, 964, 1378, 1867, 2018, 2482, 2692, 2695, 3062, 3063, 3116, 3120, 3163, 3223, 4040], 'Chem.': [818, 854, 1869, 2020, 2484, 2697, 3065, 3225, 4042], '1985;': [819, 855, 3166], '260:': [820, 856], '14873-14878Abstract': [821, 857], 'Full': [822, 858, 1873, 1875, 2024, 2026, 2488, 2490, 2701, 2703, 3069, 3229, 3231, 3352, 3354, 4046, 4048], 'Text': [823, 859, 1874, 1876, 2025, 2027, 2489, 2491, 2702, 2704, 3070, 3230, 3232, 3353, 3355, 4047, 4049], 'PDF': [824, 860, 1877, 2028, 2492, 2705, 3071, 3233, 3356, 4050], 'unique': [832], 'lesions,': [834], 'characterized': [835, 3339], 'reversibility': [838], 'hypothesized': [867], 'processed': [874], 'into': [875, 986, 1347, 1627, 1690, 1766, 3384, 3668], 'damage': [877, 988, 1215, 1349, 3018, 3326, 3630, 4078, 4273], 'interactions': [880], 'cellular': [882], 'machineries': [883], 'associated': [884], 'active': [886, 976, 1008], 'replication': [888, 978, 1010, 1064, 1071, 1080, 1134, 1148, 3008, 3376, 3390, 3428, 3437, 3451, 3562, 3601, 3607, 3624, 3660, 3698], '(7Hsiang': [891, 1094, 1169, 3394], 'Lihou': [893, 1096, 1171, 3396], 'M.G.': [894, 1097, 1172, 3397], 'Cancer': [897, 937, 954, 1040, 1053, 1100, 1117, 1175, 1192, 1205, 1284, 1303, 1316, 1597, 2422, 3146, 3400, 3417], 'Res.': [898, 938, 955, 1041, 1054, 1101, 1118, 1176, 1193, 1285, 1304, 1317, 1383, 1598, 2423, 3147, 3401, 3418], '1989;': [899, 1042, 1102, 1177, 1305, 3402], '49:': [900, 1043, 1103, 1178, 1306, 3403], '5077-5082PubMed': [901, 1104, 1179, 3404], '8Desai': [904], 'S.D.': [905, 1351, 1408, 1462, 1513, 1561, 1588, 1785, 1860, 2573, 2688, 3874], 'Zhang': [906, 1352, 1409, 1463, 1514, 1562, 1786, 2574, 3875], 'H.': [907, 1200, 1353, 1410, 1464, 1515, 1563, 1787, 2575, 3198, 3876], 'Rodriguez-Bauman': [908, 1354, 1411, 1465, 1516, 1564, 1591, 1788, 2576, 3877], 'A.': [909, 947, 1110, 1185, 1355, 1412, 1466, 1517, 1565, 1592, 1789, 2005, 2469, 2577, 3212, 3216, 3410, 3878, 4027], 'Yang': [910, 1356, 1413, 1467, 1518, 1566, 1790, 2578, 3879], 'J.M.': [911, 1035, 1298, 1357, 1414, 1468, 1519, 1567, 1791, 2579, 3880], 'Wu': [912, 1358, 1415, 1469, 1520, 1568, 1792, 2580, 3142, 3881], 'X.': [913, 1359, 1416, 1470, 1521, 1569, 1793, 2581, 3882], 'Gounder': [914, 1360, 1417, 1471, 1522, 1570, 1794, 2582, 3883], 'M.K.': [915, 1361, 1418, 1472, 1523, 1571, 1795, 2583, 3884], 'Rubin': [916, 1362, 1419, 1473, 1524, 1572, 1593, 1796, 2584, 3885], 'E.H.': [917, 1363, 1420, 1474, 1525, 1573, 1594, 1797, 2585, 3886], 'Cell.': [921, 1367, 1424, 1478, 1529, 1577, 1801, 2589, 3348, 3890], '2003;': [923, 1369, 1426, 1480, 1531, 1579, 1803, 2591, 3226, 3892], '23:': [924, 1370, 1427, 1481, 1532, 1580, 1804, 2592, 3893], '2341-2350Crossref': [925, 1371, 1428, 1482, 1533, 1581, 1805, 2593, 3894], '(123)': [928, 1374, 1431, 1485, 1536, 1584, 1808, 2596, 3897], '9Tsao': [931], 'Y.P.': [932, 945, 1108, 1183, 1279, 3408], "D'Arpa": [933, 1201, 1280, 1865], 'P.': [934, 1048, 1202, 1281, 1311, 1866, 3118], '1992;': [939, 1286], '52:': [940, 1287], '1823-1829PubMed': [941, 1288], '10Tsao': [944, 1107, 1182, 3407], 'Russo': [946, 1109, 1184, 3409], 'Nyamuswa': [948, 1111, 1186, 3411], 'G.': [949, 1112, 1187, 3412], 'Silber': [950, 1113, 1188, 3413], '1993;': [956, 1119, 1194, 3419], '53:': [957, 1120, 1195, 3420], '5908PubMed': [958, 1121, 1196, 3421], '11Shao': [961], 'R.G.': [962], 'EMBO': [963, 3119], '1999;': [965], '18:': [966, 3350], '1397-1406Crossref': [967], '(303)': [970], 'The': [973, 1693, 1883, 2078, 2103, 2200, 2244, 2369, 2386, 2400, 2432, 2529, 2542, 2711, 2746, 2799, 2892, 2973, 3450, 3723, 3830, 3926], 'processing': [981, 1342, 1623, 1653, 1685, 1761, 3012, 3379], 'initially': [990], 'from': [992, 1635, 1827, 1850, 1895, 1916, 1995, 2439, 2723, 2773, 2791, 4057], 'observations': [994], 'exquisitely': [998], 'cytotoxic': [999], 'S': [1001, 1086], 'phase': [1002, 1273], 'aphidicolin': [1012], '(APH)': [1013], 'other': [1015], 'synthesis': [1017, 3872, 3916, 4185], 'inhibitors': [1018, 2151], 'abolishes': [1019], 'CPT': [1020, 1232, 1396, 2161, 2822, 2989, 3179, 3243, 3261, 3646, 3673, 3958, 3983, 4092, 4174, 4251], 'cytotoxicity': [1021, 1088], 'without': [1022], 'any': [1023, 3650], '(12Holm': [1032, 1295], 'C.': [1033, 1050, 1296, 1313, 3114, 3204, 3344], 'Covey': [1034, 1297], 'Kerrigan': [1036, 1299, 2410], 'D.': [1037, 1300, 1864], 'Pommier': [1038, 1301, 3221], '6365-6368PubMed': [1044, 1307], "13D'Arpa": [1047, 1310], 'Beardmore': [1049, 1312], '1990;': [1055, 1207, 1318], '50:': [1056, 1319], '6919PubMed': [1057, 1320], 'Analysis': [1060], 'aberrant': [1063], 'intermediates': [1065], 'SV40': [1069], 'cell-free': [1070], 'system': [1072], 'led': [1074], 'suggestion': [1077], 'fork': [1081, 1135, 1149, 3391], 'collision': [1082, 1129, 1168, 1547, 3392], 'phase-specific': [1087], 'this': [1125], 'model,': [1126], 'polarity-specific': [1128], 'occurs': [1130, 1771], 'between': [1131], 'advancing': [1133], 'complex,': [1141], 'resulting': [1142], 'concomitant': [1152], 'break': [1158], '(DSB)': [1159], 'cross-link': [1163], 'at': [1164, 1270, 1545, 2083, 2123, 2178, 2230, 2288, 2298, 2304, 2333, 2440, 2781, 3109, 3184, 3190, 3252], 'site': [1166], '14Zhang': [1199], 'Cells.': [1206], '2:': [1208], '23-27PubMed': [1209], 'Indeed,': [1212, 3281, 3505], 'many': [1213], 'signals,': [1216], 'such': [1217], 'phosphorylated': [1219], 'RPA,': [1220], 'Chk1,': [1222], 'Chk2,': [1223], 'p53,': [1224], 'NF-κB,': [1225], 'H2AX': [1227, 3182], '(γ-H2AX)': [1228, 3186], 'detected': [1230], 'upon': [1231, 1743, 3054], 'treatment,': [1233], 'most': [1235], 'them': [1237], 'be': [1242, 1669, 1741, 3107, 3951], 'replication-dependent': [1243, 1327, 3498], 'Ref.': [1246, 2407], 'As': [1260, 3075, 3639, 3978, 4169], 'consequence': [1262], 'collision,': [1265], 'cells': [1267, 1394, 1641, 1924, 1931, 1971, 2037, 2104, 2146, 2166, 2370, 2443, 2500, 2530, 2624, 2800, 2818, 2839, 3042, 3081, 3194, 3257, 3278, 3370, 3444, 3552, 3684, 3793, 3910], 'arrested': [1269], 'G2/M': [1272], 'cell': [1276, 1292, 1885, 1911, 2079, 2202, 2212, 2883, 3102, 3137], 'cycle': [1277, 3103], '(9Tsao': [1278], 'Scholar)': [1290, 2598, 3128], 'death': [1293], 'ensues': [1294], 'addition': [1324, 2637], 'processing,': [1328], 'accumulating': [1329], 'evidence': [1330, 1612], 'also': [1332, 3288, 3515, 3633, 3736, 3775, 3850, 4147], 'pointed': [1333], 'second': [1336], 'mechanism': [1337, 4113], 'involving': [1338], '(8Desai': [1350, 1407, 1461, 1512, 1560, 1784, 2572, 3873], '15Wu': [1377], 'Nucleic': [1381], 'Acids': [1382], '1997;': [1384, 1870], '25:': [1385], '4181-4186Crossref': [1386], '(132)': [1389], 'Treatment': [1392], 'rapid': [1399], 'arrest,': [1401], 'followed': [1402, 2089, 2112, 2155, 2291, 2327, 2356, 2509, 2537, 2650, 2740, 2826, 2854, 2885, 2921, 2967], 'recovery': [1404], 'Recovery': [1434], 'depends': [1437], 'correlated': [1443], 'proteasomal': [1446, 1500], '(termed': [1450], 'down-regulation)': [1452], 'largest': [1455, 1506], 'subunit': [1456, 1507], 'RNA': [1458, 1509], 'II': [1460, 1511], 'elongation,': [1498], 'triggering': [1499], 'Proteasomal': [1539], 'sites': [1548], 'speculated': [1551], 'expose': [1553], 'otherwise': [1555], '16Desai': [1587], 'Li': [1589], '61:': [1600], '5926-5932PubMed': [1601], 'studies,': [1607], 'seek': [1609], 'provide': [1611], 'supporting': [1613], 'SSBs.': [1629, 1777], 'To': [1630, 3954, 4281], 'eliminate': [1631], 'complication': [1633], 'arising': [1634], 'replication,': [1637, 3761], 'employed': [1643], 'analysis': [1645, 2449, 2834], 'Like': [1658], 'transcription-': [1670, 3851, 3960, 4129, 4275], 'proteasome-dependent,': [1672, 4131], 'consistent': [1673, 3654, 4229], 'notion': [1676, 3657], 'required': [1682], 'damage.': [1692, 4117, 4144], 'involvement': [1694, 3373, 3434, 3558, 4239], 'further': [1700, 3431, 3955, 4132], 'supported': [1701], 'demonstration': [1704], 'Top1-ubiquitin': [1709], 'conjugates': [1710], 'By': [1725, 3468, 3532, 3671, 4010], 'contrast,': [1726, 3469, 3533, 3672, 4011], 'found': [1739], 'increased': [1742], 'inactivation.': [1745], 'involved': [1758, 3764], 'SSBs,': [1767], 'PARP1-mediated': [1769], 'downstream': [1772], 'Immunoblotting—Immunoblotting': [1778], 'performed': [1780, 2134, 2451, 2460, 2714, 4148], 'described': [1782, 1857, 2003, 2466, 2570], 'previously': [1783, 2467, 2571], 'Antibodies': [1811], 'against': [1812], 'p-Ser-1981-ATM': [1813], '(p': [1814], 'denotes': [1815], 'phosphorylation)': [1816], '(Upstate': [1817], 'Immunochemicals),': [1818], 'γ-H2AX': [1819, 3248, 3292, 3321, 3332, 3335, 3363, 3440, 3463, 3481, 3575, 3652, 4016], '(Upstate),': [1820], 'p-Tyr15-cdc2': [1822], '(Cell': [1823, 2515], 'Signaling)': [1824, 2516], 'purchased': [1826], 'commercial': [1828], 'sources.': [1829], 'Anti-hTop2α': [1830], 'antibody': [1831, 1890, 2514, 2526], 'kindly': [1833], 'provided': [1834], 'Dr.': [1836, 2774, 2792], 'Jaulang': [1837], 'Hwang': [1838, 2691], '(Institute': [1839], 'Molecular': [1841], 'Biology,': [1842], 'Academia': [1843], 'Sinica,': [1844], 'Taiwan).': [1845], 'Anti-Top1': [1846], 'antibodies': [1847], 'obtained': [1849, 1894, 1915, 2438, 2772, 2790], 'sera': [1851], 'Scleroderma': [1853], '70': [1854], 'patients': [1855], 'before': [1858], '(25Desai': [1859], 'Vazquez-Abad': [1863], '272:': [1871], '24159Abstract': [1872], '(227)': [1880], 'hybridoma': [1884], 'line': [1886, 1912], 'produces': [1888], 'monoclonal': [1889], '12G10': [1891], '(α-tubulin)': [1892], 'Developmental': [1897], 'Hybridoma': [1899], 'Bank': [1900], '(University': [1901, 2777], 'Iowa,': [1903], 'Iowa': [1904], 'City,': [1905], 'IA).': [1906], 'Culture—The': [1908], 'fibroblast': [1910], 'American': [1917], 'Type': [1918], 'Culture': [1919], 'Collection': [1920], '(Manassas,': [1921], 'VA).': [1922], 'passages': [1926], '18-23)': [1927], 'HeLa': [1929, 2034], 'TetOn': [1930], '(Clontech)': [1932], 'cultured': [1934, 1978, 2039, 2501, 3089], 'DMEM': [1936, 1980, 2041, 2093], 'supplemented': [1937, 2042, 2094], '10%': [1939, 2044, 2096, 2190, 2268, 3027], 'FetalPlex': [1940, 2045, 2097], 'animal': [1941, 2046, 2098], 'serum': [1942, 1968, 1983, 2047, 2099, 3055, 3092], '(Gemini': [1944], 'Bio-Products,': [1945], 'West': [1946], 'Sacramento,': [1947], 'CA),': [1948], 'l-glutamine': [1949], '(2': [1950, 4214], 'mm),': [1951], 'penicillin': [1952], '(100': [1953, 1957], 'units/ml),': [1954], 'streptomycin': [1956], 'μg/ml)': [1958], '37': [1961, 2084, 2124, 2179, 2231], '°C': [1962, 2085, 2180], 'incubator': [1963, 2122], '5%': [1965, 2120], 'CO2.': [1966], 'For': [1967, 1987, 2273, 2307, 2945], 'starvation,': [1969], 'then': [1970, 2072, 2193, 2215, 2247, 2372, 2520, 2532, 2626, 2749, 2879, 2976], 'washed': [1973, 2533], 'serum-free': [1975], 'medium': [1976, 2188], 'containing': [1981], '0.2%': [1982, 3033, 3091], '72': [1985, 3085], 'h.': [1986, 2164, 2272, 2385], 'neuronal': [1988], 'culture,': [1989], 'mixed': [1990, 2216, 2905], 'cortical': [1991, 3970, 3990, 4019], 'neurons': [1992, 3971, 4102], 'isolated': [1994, 3973], 'day': [1997, 2058], '17.5': [1998], 'C57BL/6': [1999], 'embryos': [2001, 2061], '(23Zhang': [2004, 2468, 4026], 'Lyu': [2006, 2470, 4028], 'Y.L.': [2007, 2409, 2471, 4029], 'Lin': [2008, 2412, 2472, 4030], 'C.P.': [2009, 2413, 2473, 4031], 'Zhou': [2010, 2474, 4032], 'N.': [2011, 2475, 4033], 'Azarova': [2012, 2414, 2476, 4034], 'A.M.': [2013, 2415, 2477, 4035], 'Wood': [2014, 2478, 4036], 'L.M.': [2015, 2479, 4037], '281:': [2022, 2486, 4044], '35997-36003Abstract': [2023, 2487, 4045], '(108)': [2031, 2495, 4053], 'V79': [2036], 'complex.': [2048], 'Isolation': [2049], 'parp1+/-': [2051], 'parp1-/-': [2053], 'Mouse': [2054], 'Embryonic': [2055], 'Fibroblasts': [2056], '(MEFs)—Embryonic': [2057], '12.5': [2059], 'dissected': [2063], 'free': [2064], 'brains': [2066], 'livers,': [2068], 'finely': [2069], 'minced,': [2070], 'suspended': [2073], 'trypsin-EDTA': [2076], 'solution.': [2077], 'suspensions': [2080], 'incubated': [2082], '5': [2087, 2182, 2325, 2354, 2667], 'min,': [2088, 2154, 2326, 2355], 'termination': [2091], 'glutamine/penicillin/streptomycin.': [2102], 'pelleted': [2106], 'resuspended': [2108], 'fresh': [2110], 'medium,': [2111], 'culturing': [2114], 'plastic': [2116], 'plates': [2117], 'CO2': [2121], '°C.': [2125, 2232], 'Neutral': [2126], 'Alkaline': [2128, 2632], 'Comet': [2129], 'Assays—The': [2130], 'assays': [2132], 'according': [2135], 'Trevigen': [2138], 'CometAssay™': [2139], 'kit': [2140], 'protocol': [2141, 2464], 'slight': [2143, 2600], 'modifications.': [2144], 'pretreated': [2148], '30': [2153, 2286, 2363, 2925, 2959], 'co-treatment': [2157], '25': [2159], 'μm': [2160], '1': [2163, 2271, 2321, 2384, 2642, 2670], 'Treated': [2165], 'trypsinized': [2168], '0.005%': [2170], 'trypsin': [2171, 2198], '(50×': [2172], 'lower': [2173, 3721], 'than': [2174, 3300], 'normal': [2176], 'concentration)': [2177], 'min.': [2183, 2338, 2745, 2972], 'Equal': [2184], 'drug-free': [2187], '(with': [2189], 'serum)': [2191, 3028, 3034, 3276, 3446], 'added': [2194, 2880, 2957], 'quench': [2196], 'activity.': [2199], 'final': [2201], 'density': [2203], 'approximately': [2205, 3311], '10,000': [2206], 'cells/ml.': [2207], '50': [2208, 2233, 2664, 2947], 'μl': [2209, 2219, 2234, 2608, 2640, 2655, 2731, 2848, 2859, 2873, 2908, 2926, 2948, 2960], 'suspension': [2213], '500': [2218], '0.5%': [2221], 'low': [2222], 'melting': [2223], 'point': [2224], 'agarose': [2225, 2930, 2943], '(Invitrogen)': [2226], '(in': [2227], 'phosphate-buffered': [2228, 2535], 'saline)': [2229], 'cell/agarose': [2237], 'mixture': [2238], 'transferred': [2240], 'onto': [2241], 'glass': [2242], 'slides.': [2243], 'slides': [2245, 2278, 2312, 2342], 'immersed': [2248, 2280, 2314, 2344], 'prechilled': [2250], 'lysis': [2251, 2612, 2852], 'buffer': [2252, 2297, 2317, 2332, 2347, 2613, 2660, 2737, 2863, 2877, 2955], '(2.5': [2253], 'm': [2254, 2349, 2643], 'NaCl,': [2255], '100': [2256, 2442, 2607, 2730], 'mm': [2257, 2260, 2319, 2322, 2615, 2618, 2646, 2662, 2665, 2668, 2671], 'EDTA,': [2258, 2672], '10': [2259, 2744, 2971, 3921], 'Tris,': [2261, 2350, 2647], 'pH': [2262, 2351, 2648], '10.0,': [2263], '1%': [2264], 'Triton': [2265], 'X-100,': [2266], 'Me2SO)': [2269], 'neutral': [2274, 3512], 'assay,': [2276, 2310], '1×': [2282, 2295], 'TBE': [2283, 2296], '(Tris/Borate/EDTA)': [2284], 'min': [2287, 2303, 2364, 2719], 'room': [2289, 2305], 'temperature,': [2290], 'electrophoresis': [2293, 2329, 2754, 2981], '0.8': [2299], 'V/cm': [2300], '8-10': [2302], 'temperature.': [2306], 'alkaline': [2308, 2316, 2331, 2567, 2611, 2851], '(300': [2318], 'NaOH,': [2320, 2616], 'EDTA)': [2323, 2619], '0.5': [2334], 'volt/cm': [2335], '20': [2337, 2718, 2814], 'After': [2339, 2727], 'electrophoresis,': [2340], 'neutralization': [2346, 2856, 2862], '(0.4': [2348], '7.5)': [2352], 'dehydration': [2358], '70%': [2360], 'alcohol': [2361], 'air': [2366], 'drying': [2367], 'overnight.': [2368], 'rehydrated': [2373], 'H2O': [2375], 'stained': [2377], '0.2': [2379], 'μg/ml': [2380], 'ethidium': [2381], 'bromide': [2382], 'images': [2387, 2544], 'visualized': [2389], 'under': [2390], 'fluorescence': [2392, 2543, 2555], 'microscope': [2393], 'captured': [2395, 2546], 'CCD': [2398, 2549], 'camera.': [2399], 'tail': [2402], 'moment': [2403], 'defined': [2405], '48Lyu': [2408], 'J.E.': [2411], 'Tsai': [2416], 'Y.C.': [2417], 'Ban': [2418], '2007;': [2424], '67:': [2425], '8839-8846Crossref': [2426], '(452)': [2429], 'Scholar.': [2431], 'mean': [2433], 'S.E.': [2436], 'least': [2441], 'each': [2445, 2604, 3547], 'treatment': [2446, 2889], 'group.': [2447], 'Statistical': [2448], 'two-tailed': [2453], 'unpaired': [2454], "Student's": [2455], 't': [2456], 'test.': [2457], 'Immunocytochemistry—Immunocytochemistry': [2458], 'following': [2461], 'standard': [2463], 'Briefly,': [2498, 2602], 'coverslips': [2503], 'fixed': [2505], '3.7%': [2507], 'paraformaldehyde': [2508], 'incubation': [2511], 'anti-p-Ser-1981-ATM': [2513], '(1:500': [2517], 'dilution)': [2518], 'an': [2522, 2610, 2850, 2900], 'appropriate': [2523], 'Cy3-conjugated': [2524], 'secondary': [2525], '(Jackson': [2527], 'Immunoresearch).': [2528], 'saline': [2536], 'counterstaining': [2539], '4′,6′-diamino-2-phenylindole.': [2541], 'camera': [2550], 'mounted': [2551], 'Zeiss': [2554], 'microscope.': [2556], 'Down-regulation—CPT-induced': [2558], 'monitored': [2562], 'immunoblotting': [2564, 4232], 'lysates': [2568, 2633, 2893], 'modification.': [2601], '35-mm': [2605], 'dish,': [2606], '(200': [2614], '2': [2617], 'added,': [2621, 2739], 'scraped': [2627], 'rubber': [2630], 'policeman.': [2631], 'neutralized': [2635], '16': [2639], 'HCl,': [2644], '600': [2645], '8.0,': [2649], 'mixing': [2652], '13': [2654], '10×': [2657, 2875], 'S7': [2658, 2683, 2876, 2887], 'nuclease': [2659, 2684, 2728, 2888], '(50': [2661], 'MgCl2,': [2663], 'CaCl2,': [2666], 'dithiothreitol,': [2669], 'protease': [2675, 2915], 'mixture)': [2677], '60': [2679, 2872], 'units': [2680], 'staphylococcal': [2682], '(30Mao': [2685], 'Desai': [2687], 'Ting': [2689], 'C.Y.': [2690], '276:': [2699], '40652-40658Abstract': [2700], '(160)': [2708], 'digestion': [2712], 'ice': [2716], 'releasing': [2721], 'digestion,': [2729], '6×': [2733, 2951], 'SDS': [2734, 2752, 2952, 2979], 'gel': [2735, 2753, 2953, 2980], 'sample': [2736, 2954], 'boiling': [2742, 2969], 'samples': [2747, 2974], 'analyzed': [2750, 2977], 'immunoblotted': [2756, 2983], 'anti-hTop1': [2758, 2985], 'antibodies.': [2759, 2988], 'Transfection': [2760], 'HA-tagged': [2762], 'Mutant': [2763], 'Ubiquitin': [2764], 'cDNAs—HA-Ub,': [2765], 'K48R-Ub,': [2766], 'K29R-Ub,': [2767], 'K63R-Ub': [2769], 'plasmids': [2770, 2788], 'Cam': [2775], 'Patterson': [2776], 'North': [2779], 'Carolina': [2780], 'Chapel': [2782], 'Hill,': [2783], 'NC).': [2784], 'HA-K48-only-Ub,': [2785], 'HA-K63-only-Ub': [2787], 'Vishva': [2793], 'M.': [2794], 'Dixit': [2795], '(Genentech': [2796], 'Inc.,': [2797], 'CA).': [2798], 'transfected': [2802], '1.5-3': [2804], 'μg': [2805], 'PolyFect': [2810], 'transfection': [2811], 'reagent': [2812], '(Qiagen).': [2813], 'h': [2815, 3086], 'post-transfection,': [2816], 'treated': [2820, 3975], 'time,': [2825], '(see': [2829, 2835], 'below)': [2830], 'above).': [2836], 'Immunoprecipitation—For': [2837], 'immunoprecipitation,': [2838], 'growing': [2840], '60-mm': [2842], 'dishes': [2843], 'lysed': [2845], '400': [2847], 'buffer,': [2853, 2914], '75': [2858], '(described': [2864], 'assay)': [2868], 'brief': [2870, 2897], 'sonication.': [2871], 'lysates,': [2884], '(180': [2890], 'units).': [2891], 'cleared': [2895], 'centrifugation': [2898], 'Eppendorf': [2901], 'centrifuge.': [2902], 'Supernatants': [2903], '550': [2907], '2×': [2910], 'radioimmune': [2911, 2962], 'precipitation': [2912, 2963], 'assay': [2913, 2964, 3514], 'mixture,': [2917], 'phenylmethylsulfonyl': [2919], 'fluoride,': [2920], 'clarifying': [2923], 'protein': [2928, 2941, 3871, 3915, 3936], 'L-conjugated': [2929, 2942], 'beads': [2931], '(Santa': [2932], 'Cruz).': [2933], 'immunoprecipitated': [2936], 'antiserum': [2939], 'beads.': [2944], 'immunoblotting,': [2946], 'buffer-washed': [2965], 'beads,': [2966], 'anti-HA': [2987], 'Induces': [2990, 4252], 'Distinct': [2991], 'Damage': [2993], 'Signals': [2994], 'Depending': [2995], 'Growth': [2998], 'State': [2999], 'Cells—To': [3002], 'study': [3003, 3285], 'roles': [3005, 3621], 'signals': [3019], 'measured': [3021], 'both': [3023, 3181, 3534, 3560, 3606, 4100], 'proliferating': [3024, 3255, 3302, 3442, 3502, 3550, 3592], '(cultured': [3025, 3031], 'nonproliferating': [3030, 3299, 3791, 3966], 'primary': [3035], 'lung': [3037], 'fibroblasts,': [3038], 'cells.': [3040, 3504, 3638, 3772, 4168, 4250, 4280], 'known': [3044, 3105], 'cease': [3046], 'proliferation': [3047, 3083, 3138], 'enter': [3049], 'G0/G1': [3052], 'state': [3053], 'starvation': [3056], '(17Dimri': [3057], 'G.P.': [3058], 'Hara': [3059], 'E.': [3060], 'Campisi': [3061], '1994;': [3066], '269:': [3067], '16180-16186Abstract': [3068], 'Fig.': [3078, 3448, 3466, 3484, 3530, 3554, 3642, 3719, 3924, 3981, 4161, 4172], '1a,': [3079], 'ceased': [3082], 'after': [3084], 'being': [3088, 3597], 'evidenced': [3094, 3494], 'lack': [3097], 'p-Tyr-15': [3099], 'cdc2': [3100], '(a': [3101, 3136], 'marker': [3104, 3340], 'elevated': [3108], 'G1/S': [3110], 'S/G2)': [3112], '(18Norbury': [3113], 'Blow': [3115], 'Nurse': [3117], '1991;': [3121], '10:': [3122], '3321-3329Crossref': [3123], '(398)': [3126], 'much': [3131], 'reduced': [3132, 3297, 3707], 'Top2α': [3135], 'marker)': [3139], '(19Hsiang': [3140], 'H.Y.': [3143], '1988;': [3148], '48:': [3149], '3230-3235PubMed': [3150], '20Earnshaw': [3153], 'W.C.': [3154], 'Halligan': [3155], 'B.': [3156], 'Cooke': [3157], 'C.A.': [3158], 'Heck': [3159], 'M.M.': [3160], '100:': [3167], '1706Crossref': [3168], '(589)': [3171], 'Previous': [3174, 3856], 'demonstrated': [3177], 'induces': [3180, 3959], 'phosphorylation': [3183], 'Ser-139': [3185], 'Ser-1981': [3191, 3253, 4155], 'tumor': [3193], '(21Furuta': [3195], 'T.': [3196], 'Takemura': [3197], 'Liao': [3199], 'Z.-Y.': [3200], 'Aune': [3201], 'G.J.': [3202], 'Redon': [3203], 'Sedelnikova': [3205], 'O.A.': [3206], 'Pilch': [3207], 'D.R.': [3208], 'Rogakou': [3209], 'E.P.': [3210], 'Celeste': [3211], 'Chen': [3213], 'H.T.': [3214], 'Nussenzweig': [3215], 'Aladjem': [3217], 'M.I.': [3218], 'Bonner': [3219], 'W.M.': [3220], '278:': [3227], '20303-20312Abstract': [3228], '(384)': [3236], 'Consistent': [3239], 'observations,': [3242], '(Fig.': [3258, 3279, 3286, 3685, 3701, 3734, 3794, 3828, 3854, 4085, 4234], '1b).': [3259], 'However,': [3260, 4200], 'little': [3266], 'γ-H2AX,': [3267], 'but': [3268, 3367, 3499, 3522, 3705, 3758, 3868, 3933, 3992, 4124], 'relatively': [3269], 'robust': [3270, 3678, 3985], 'autophosphorylation,': [3272, 4060], '(0.2%': [3275], '1c).': [3280], 'dose': [3283], 'dependence': [3284], '1d)': [3287], 'showed': [3289, 3902], 'greatly': [3294, 3706], '(over': [3295], '300-fold)': [3296], 'whereas': [3305], 'only': [3310], '10-fold': [3312], 'reduced.': [3313], 'These': [3314, 3486, 3569, 3753, 4226], 'suggest': [3316, 3488, 3572, 3755, 4237], 'may': [3322, 3579, 3950], 'represent': [3323, 3580], 'distinct': [3324], 'responses': [3327, 3586, 3631], 'CPT.': [3330, 3977], 'Is': [3333, 3613], 'Replication-dependent—Because': [3334], 'DSBs': [3342, 3492, 3509, 3528, 4025], '(22Thiriet': [3343], 'Hayes': [3345], 'Mol': [3347], '2005;': [3349], '617-622Abstract': [3351], '(187)': [3359], 'Scholar),': [3361], 'proliferating,': [3366], 'not': [3368, 3523, 3648, 3759, 3869, 3934, 4125], 'quiescent,': [3369], 'suggests': [3371, 3945], 'DSBs,': [3385], 'predicted': [3387], 'inhibitor,': [3429, 3452, 3472, 3699, 3917, 4003, 4008], 'confirmed': [3432, 3516], '(10%': [3445], '(supplemental': [3447, 3465, 3483, 3529, 3553, 3923], 'S1a).': [3449, 3485], 'APH': [3453, 3535, 3700, 4187], '(10': [3454, 4188], 'μm),': [3455], 'largely': [3459, 3785], 'abolish': [3460], 'signal': [3464, 3482], 'S1).': [3467], 'DRB': [3473, 3537, 3712, 4069, 4205], 'had': [3474, 4190], 'essentially': [3475], 'no': [3476, 4191], '(as': [3493], 'γ-H2AX)': [3496], 'transcription-independent': [3500], 'direct': [3506], 'measurement': [3507], 'inhibitory': [3518], 'S1b).': [3531], 'partially': [3538], 'inhibited': [3539, 4066], '(approximately': [3543], '2-5-fold': [3544], 'reduction': [3545, 4219], 'inhibitor)': [3548], 'S1a),': [3555], 'suggesting': [3556, 3796, 4072, 4107], 'again': [3571], 'two': [3581], 'separate,': [3582], 'albeit': [3583], 'overlapping,': [3584], 'lesions': [3590], 'former': [3596], 'linked': [3598], 'latter': [3604], 'transcription.': [3609], 'Autophosphorylation': [3612], 'Transcription-': [3614, 4258], 'Proteasome-dependent': [3616, 4260], 'Nonproliferating': [3618], 'Cells—The': [3619, 4265], 'differential': [3620], '2a': [3643], '(middle': [3644], 'row),': [3645], 'did': [3647], 'detectable': [3651], 'signal,': [3653], 'needed': [3662], 'process': [3664], 'DSBs.': [3670], '2a,': [3686], 'top': [3687], 'row).': [3688], 'addition,': [3690], 'unaffected': [3695, 3912], '2b,': [3702, 3720], 'upper': [3703], 'panels),': [3704], 'inhibitors,': [3711, 3780], '(150': [3713, 4206], 'μm)': [3714, 3922, 4189, 4207, 4215], 'α-amanitin': [3716, 3726], '(5': [3717], 'μg/ml;': [3718], 'panels).': [3722], 'fact': [3724], 'fails': [3727], 'itself': [3733], '2b)': [3735], 'excludes': [3737], 'possibility': [3739, 3947], 'due': [3745], 'elongation': [3751], 'transcription,': [3757, 3867], 'primarily': [3763], 'activation': [3768, 4247], 'We': [3773], 'MG132': [3781, 4213], 'PS-341': [3783], '(bortezomib),': [3784], '2a),': [3795], 'depend': [3812], 'kinase': [3815], 'because': [3817], 'kinase-specific': [3820], 'KU-55933': [3822], 'completely': [3823], '2a).': [3829], 'reminiscent': [3843], 'proteasome-dependent': [3853, 3962, 4277], '2d).': [3855], 'dependent': [3865], 'new': [3870, 3935], 'Here,': [3900], 'cycloheximide': [3918], '(1': [3919], 'S2).': [3925], 'similar': [3927], 'proteasome,': [3932], 'synthesis,': [3937], 'they': [3949], 'related': [3952], 'phenomena.': [3953], 'confirm': [3956], 'post-mitotic': [3968, 4101], '2c,': [3982], 'neurons,': [3991, 4020], 'minimal': [3993], 'γ-H2AX.': [3994], 'hydrogen': [4012, 4061, 4075, 4126], 'peroxide': [4013], 'remarkable': [4015], 'indicating': [4021], 'Different': [4056], 'peroxide-induced': [4062, 4076], 'neither': [4068], 'nor': [4070], 'independent': [4080], '2c).': [4086], 'demonstrate': [4090], 'able': [4094], 'presence': [4109], 'replication-independent': [4112], 'peroxide,': [4127], 'demonstrating': [4133], 'Immunocytochemistry': [4145], 'examine': [4150], 'possible': [4152], 'autophosphorylated': [4156], '(labeled': [4158], 'p-ATM': [4159, 4180, 4198, 4224], '3)': [4162], 'foci': [4163], 'CPT-treated': [4165], '3,': [4173], 'large': [4177], 'number': [4178, 4196, 4222], 'foci.': [4181, 4199, 4225], 'Inhibition': [4182], 'significant': [4192], 'inhibition': [4201, 4209], 'caused': [4216], 'dramatic': [4218], '2)': [4235], 'Single-strand': [4254], 'Breaks': [4255], 'Manner': [4261], 'Quiescent': [4263], 'above': [4266], 'nonproliferative': [4279]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022386942', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-12T01:52:11.650851', 'created_date': '2016-06-24'}