Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2022380234', 'doi': 'https://doi.org/10.1038/ncb0504-386', 'title': 'Fatal liaisons of p53 with Bax and Bak', 'display_name': 'Fatal liaisons of p53 with Bax and Bak', 'publication_year': 2004, 'publication_date': '2004-04-30', 'ids': {'openalex': 'https://openalex.org/W2022380234', 'doi': 'https://doi.org/10.1038/ncb0504-386', 'mag': '2022380234', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15122264'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncb0504-386', 'pdf_url': 'https://www.nature.com/articles/ncb0504-386.pdf', 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/ncb0504-386.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078485478', 'display_name': 'Jean‐Luc Perfettini', 'orcid': 'https://orcid.org/0000-0002-2427-2604'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-Luc Perfettini', 'raw_affiliation_strings': ['the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France'], 'affiliations': [{'raw_affiliation_string': 'the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France', 'institution_ids': ['https://openalex.org/I2801843802', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054733198', 'display_name': 'Romano T. Kroemer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210127540', 'display_name': 'Nerviano Medical Sciences', 'ror': 'https://ror.org/038mzt421', 'country_code': 'IT', 'type': 'company', 'lineage': ['https://openalex.org/I4210127540']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Romano T. Kroemer', 'raw_affiliation_strings': ['Molecular Modeling and Design, Pharmacia, Viale Pasteur 10, Nerviano, 20014, MI, Italy'], 'affiliations': [{'raw_affiliation_string': 'Molecular Modeling and Design, Pharmacia, Viale Pasteur 10, Nerviano, 20014, MI, Italy', 'institution_ids': ['https://openalex.org/I4210127540']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075296559', 'display_name': 'Guido Kroemer', 'orcid': 'https://orcid.org/0000-0002-9334-4405'}, 'institutions': [{'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Guido Kroemer', 'raw_affiliation_strings': ['the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France'], 'affiliations': [{'raw_affiliation_string': 'the Apoptosis, Cancer & Immunity Laboratory associated with the National League against Cancer, CNRS-UMR8125, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France', 'institution_ids': ['https://openalex.org/I2801843802', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.961586, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '5', 'first_page': '386', 'last_page': '388'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.60498095}, {'id': 'https://openalex.org/keywords/apoptosis', 'display_name': 'Apoptosis', 'score': 0.552566}, {'id': 'https://openalex.org/keywords/p53', 'display_name': 'p53', 'score': 0.546085}, {'id': 'https://openalex.org/keywords/negative-regulator', 'display_name': 'Negative regulator', 'score': 0.45616964}], 'concepts': [{'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.750932}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.74700904}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.60498095}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5898804}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5170044}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49681857}, {'id': 'https://openalex.org/C3017707949', 'wikidata': 'https://www.wikidata.org/wiki/Q2138797', 'display_name': 'Negative regulator', 'level': 3, 'score': 0.45616964}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20814088}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18522274}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.12876919}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019253', 'descriptor_name': 'Proto-Oncogene Proteins c-bcl-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010539', 'descriptor_name': 'Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050998', 'descriptor_name': 'bcl-2 Homologous Antagonist-Killer Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051028', 'descriptor_name': 'bcl-2-Associated X Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncb0504-386', 'pdf_url': 'https://www.nature.com/articles/ncb0504-386.pdf', 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15122264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/ncb0504-386', 'pdf_url': 'https://www.nature.com/articles/ncb0504-386.pdf', 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1550247880', 'https://openalex.org/W1616121322', 'https://openalex.org/W1968305129', 'https://openalex.org/W1976720365', 'https://openalex.org/W1984547206', 'https://openalex.org/W2028171591', 'https://openalex.org/W2063669247', 'https://openalex.org/W2072188392', 'https://openalex.org/W2075230059', 'https://openalex.org/W2099113454', 'https://openalex.org/W2116145077', 'https://openalex.org/W2122400112', 'https://openalex.org/W2155235678', 'https://openalex.org/W2160345685', 'https://openalex.org/W2168084973'], 'related_works': ['https://openalex.org/W4362398353', 'https://openalex.org/W4361919412', 'https://openalex.org/W4298044808', 'https://openalex.org/W4253469166', 'https://openalex.org/W4247906184', 'https://openalex.org/W4213473406', 'https://openalex.org/W2777068447', 'https://openalex.org/W2139802109', 'https://openalex.org/W2080413140', 'https://openalex.org/W1860759659'], 'abstract_inverted_index': {'p53': [0, 28], 'can': [1], 'induce': [2], 'apoptosis': [3], 'through': [4, 32], 'its': [5], 'well': [6, 19], 'defined': [7, 20], 'role': [8], 'as': [9], 'a': [10, 17], 'regulator': [11], 'of': [12], 'transcription,': [13], 'but': [14], 'also': [15], 'by': [16], 'less': [18], 'transcription-independent': [21], 'mechanism.': [22], 'Two': [23], 'recent': [24], 'studies': [25], 'demonstrate': [26], 'that': [27], 'mediates': [29], 'mitochondrial': [30], 'permeabilization': [31], 'direct': [33], 'physical': [34], 'interactions': [35], 'with': [36], 'the': [37], 'pro-apoptotic': [38], 'Bcl-2': [39], 'family': [40], 'members,': [41], 'Bax': [42], 'and': [43], 'Bak.': [44]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022380234', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-17T15:26:55.963214', 'created_date': '2016-06-24'}