Title: current concepts of synaptic structure and function
Abstract: Annals of the New York Academy of SciencesVolume 183, Issue 1 p. 5-20 current concepts of synaptic structure and function George B. Koelle, George B. Koelle department of pharmacology, medical school, university of pennsylvania philadelphia, pa. 19104Search for more papers by this author George B. Koelle, George B. Koelle department of pharmacology, medical school, university of pennsylvania philadelphia, pa. 19104Search for more papers by this author First published: September 1971 https://doi.org/10.1111/j.1749-6632.1971.tb30738.xCitations: 32AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat references 1 Couteaux, R. 1947. contribution à l'étude de la synapse myoneurale; buisson de kühne et plaque motrice. rev. canad. biol. 6: 563–711. Google Scholar 2 Couteaux, R. & J. Taxi. 1952. recherches histochimiques sur la distribution des activités cholinestérasiques au niveau de la synapse myoneurale. arch. anat. micr. morph. exp. 41: 352–392. Google Scholar 3 Robertson, J. D. 1956. some features of the ultrastructure of reptilian skeletal muscle. j. biophys. biochem. cytol. 2: 369–392. 10.1083/jcb.2.4.369 CASPubMedWeb of Science®Google Scholar 4 Csillik, B. 1965. functional structure of the postsynaptic membrane in the myoneural junction. akadémiai kiadó. budapest , hungary . Google Scholar 5 Andersson-cedergren, E. 1959. ultrastructure of motor end plate and sarcoplasmic components of mouse skeletal muscle fiber. j. ultrastruct. res. (suppl.) 1: 1. Google Scholar 6 Koelle, G. B. 1968. functional anatomy of synaptic transmission. anesthesiology 29: 643–653. 10.1097/00000542-196807000-00006 CASPubMedWeb of Science®Google Scholar 7 De robertis, E. 1964. histophysiology of synapses and neurosecretion. the macmillan co. new york , n. y . Google Scholar 8 Eccles, J. C. 1964. the physiology of synapses. springer-verlag. berlin ; academic press, new york. 10.1007/978-3-642-64950-9 Google Scholar 9 Koelle, G. B. 1970. neurohumoral transmission and the autonomic nervous system. in the pharmacological basis of therapeutics. L. S. Goodman & A. Gilman, eds.: 402–441. the macmillan co. new york , n. y . Google Scholar 10 Katz, B. 1969. the release of neural transmitter substances. charles c thomas. springfield , ill . PubMedGoogle Scholar 11 Hubbard, J. I. 1970. mechanism of transmitter release. in progress in biophysics and molecular biology. J. A. V. Butler & D. Noble, eds. pergamon press. oxford & new york . Google Scholar 12 Koelle, G. B. 1962. a new general concept of the neurohumoral functions of acetyl-choline and acetylcholinesterase. j. pharm. pharmacol. 14: 65–90. 10.1111/j.2042-7158.1962.tb11057.x CASPubMedWeb of Science®Google Scholar 13 Burn, J. H. & M. J. Rand. 1959. sympathetic postganglionic mechanism. nature (london) 184: 163–165. 10.1038/184163a0 Web of Science®Google Scholar 14 Koelle, G. B. 1951. the elimination of enzymatic diffusion artifacts in the histochemical localization of cholinesterases and a survey of their cellular distributions. j. pharmacol. exp. therap. 103: 153–171. CASPubMedWeb of Science®Google Scholar 15 Koelle, G. B. 1955. the histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. j. pharmacol. exp. therap. 114: 167–184. CASPubMedWeb of Science®Google Scholar 16 Koelle, G. B. & E. C. Steiner. 1956. the cerebral distributions of a tertiary and a quaternary anticholinesterase agent following intravenous and intraventricular injection. j. pharmacol. exp. therap. 118: 420–434. CASPubMedWeb of Science®Google Scholar 17 Koelle, G. B. 1957. histochemical demonstration of reversible anticholinesterase action at selective cellular sites in vivo. j. pharmacol. exp. therap. 120: 488–503. CASPubMedWeb of Science®Google Scholar 18 Mcisaac, R. J. & G. B. Koelle. 1959. comparison of the effects of inhibition of external, internal, and total acetylcholinesterase upon ganglionic transmission. j. pharmacol. exp. therap. 126: 9–20. CASPubMedWeb of Science®Google Scholar 19 Koelle, W. A. & G. B. Koelle. 1959. the localization of external or functional acetylcholinesterase at the synapses of autonomic ganglia. j. pharmacol. exp. therap. 126: 1–8. CASPubMedWeb of Science®Google Scholar 20 Sawyer, C. H. & W. H. Hollinshead. 1945. cholinesterases in sympathetic fibers and ganglia. j. neurophysiol. 8: 137–153. 10.1152/jn.1945.8.3.137 CASWeb of Science®Google Scholar 21 Gromadzki, C. G. & G. B. Koelle. 1965. the effect of axotomy on the acetylcholinesterase of the superior cervical ganglion of the cat. biochem. pharmacol. 14: 1745–1754. 10.1016/0006-2952(65)90264-9 CASPubMedWeb of Science®Google Scholar 22 Volle, R. L. & G. B. Koelle. 1961. the physiological role of acetylcholinesterase (ache) in sympathetic ganglia. j. pharmacol. exp. therap. 133: 223–240. CASPubMedWeb of Science®Google Scholar 23 Ogston, A. B. 1955. removal of acetylcholine from a limited volume by diffusion. j. physiol. (london) 128: 222–223. 10.1113/jphysiol.1955.sp005300 CASPubMedWeb of Science®Google Scholar 24 Abrahams, V. C., G. B. Koelle & P. Smart. 1957. histochemical demonstration of cholinesterases in the hypothalamus of the dog. j. physiol. (london) 139: 137–144. 10.1113/jphysiol.1957.sp005881 CASPubMedWeb of Science®Google Scholar 25 Koelle, G. B. & C. N. Geesey. 1961. localization of acetylcholinesterase in the neurohypophysis and its functional implications. proc. soc. exp. biol. 106: 625–628. 10.3181/00379727-106-26423 CASPubMedWeb of Science®Google Scholar 26 Gerschenfeld, H. M, J. H. Tramezzani & E. De robertis. 1960. ultrastructure and function in neurohypophysis of the toad. endocrinology 66: 741–762. 10.1210/endo-66-5-741 CASPubMedWeb of Science®Google Scholar 27 Cauna, N., N. T. Naik, D. B. Leaming & P. Alberti. 1961. the distribution of cholinesterases in the autonomic ganglia of man and of some mammals. histochemistry of cholinesterase, symposium, basel, 1960. bibliotheca anat. 2: 90–96. Google Scholar 28 Matsumura, M. & G. B. Koelle. 1961. the nature of synaptic transmission in the superior cervical ganglion following reinnervation by the afferent vagus. j. pharmacol. exp. therap. 134: 28–46. CASPubMedWeb of Science®Google Scholar 29 Douglas, W. W., D. W. Lynwood & R. W. Straub. 1960. on the excitant effect of acetylcholine on structures in the preganglionic trunk of the cervical sympathetic: with a note on the anatomical complexities of the region. j. physiol. (london) 153: 250–264. 10.1113/jphysiol.1960.sp006533 CASPubMedWeb of Science®Google Scholar 30 Dolivo, M. & G. B. Koelle. unpublished data. Google Scholar 31 Masland, R. L. & R. S. Wigton. 1940. nerve activity accompanying fasciculation produced by prostigmine. j. neurophysiol. 3: 269–275. 10.1152/jn.1940.3.3.269 CASWeb of Science®Google Scholar 32 Feng, T. P. & T. H. Li. 1941. studies on the neuromuscular junction. xxiii. a new aspect of the phenomena of eserine potentiation and posttetanic facilitation in mammalian muscle. chinese j. physiol. 16: 37–56. Google Scholar 33 Riker, W. F., J. Roberts, F. G. Standaert & H. Fujimoru. 1957. the motor nerve terminal as the primary focus for drug-induced facilitation of neuromuscular transmission. j. pharmacol. exp. therap. 121: 286–312. CASPubMedWeb of Science®Google Scholar 34 Elfvin, L.-g. 1963. the ultrastructure of the superior cervical sympathetic ganglion of the cat. ii. the structure of the preganglionic end fibers and the synapses as studied by serial sections. j. ultrastruct. res. 8: 441–476. 10.1016/S0022-5320(63)80049-0 Web of Science®Google Scholar 35 Katz, B. 1966. nerve, muscle, and synapse.: 151–152. mcgraw-hill. new york , n. y . Google Scholar 36 Dempsher. J. & W. K. Riker. 1957. the role of acetylcholine in virus-infected sympathetic ganglia. j. physiol. (london) 139: 145–156. 10.1113/jphysiol.1957.sp005882 CASPubMedWeb of Science®Google Scholar 37 Koketsu, K. & S. Nishi. 1968. cholinergic receptors at sympathetic preganglionic nerve terminals. j. physiol. 196: 293–310. 10.1113/jphysiol.1968.sp008508 CASPubMedWeb of Science®Google Scholar 38 Ginsborg, B. L. & S. Guerrero. 1964. on the action of depolarizing drugs on sympathetic ganglion cells of the frog. j. physiol. (london) 172: 189–206. 10.1113/jphysiol.1964.sp007412 CASPubMedWeb of Science®Google Scholar 39 Pilar, G. 1969. effect of ach on pre- and postsynaptic elements of avian ciliary ganglion synapses. fed. proc. 28(2): 670. Web of Science®Google Scholar 40 Ciani, S. & C. Edwards. 1963. the effect of acetylcholine on neuromuscular transmission in the frog. j. pharmacol. exp. therap. 142: 21–23. CASPubMedWeb of Science®Google Scholar 41 Hubbard, J. L, R. F. Schmidt & T. Yokota. 1965. the effect of acetylcholine upon mammalian motor nerve terminals. j. physiol. 181: 810–829. 10.1113/jphysiol.1965.sp007799 CASPubMedWeb of Science®Google Scholar 42 Takeshige, C. & R. L. Volle. 1963. cholinoceptive sites in denervated sympathetic ganglia. j. pharmacol. exp. therap. 141: 206–213. CASPubMedWeb of Science®Google Scholar 43 Fleisch, J. H., W. Flacke & R. A. Gillis. 1969. nicotinic and muscarinic receptors in the cardiac sympathetic ganglia of the dog. j. pharmacol. exp. therap. 168: 106–115. CASPubMedWeb of Science®Google Scholar 44 Dolivo, M. & G. B. Koelle. 1970. properties of nicotinic and muscarinic receptors of isolated rat ganglion. experientia 26: 679. Web of Science®Google Scholar 45 Eccles, J. C., R. M. Eccles & F. Magni. 1961. central inhibitory action attributable to presynaptic depolarization produced by muscle afferent volleys. j. physiol. (london) 159: 147–166. 10.1113/jphysiol.1961.sp006798 CASPubMedWeb of Science®Google Scholar 46 Cannon, W. B. & A. Rosenbleuth. 1936. the sensitization of a sympathetic ganglion by preganglionic denervation. am. j. physiol. 116: 408–413. Web of Science®Google Scholar 47 Chien, S. 1960. supersensitivity of denervated superior cervical ganglion to acetylcholine. am. j. physiol. 198: 949–954. CASPubMedWeb of Science®Google Scholar 48 Brücke, F.th. v. 1938. the response of a denervated ganglion to acetylcholine. j. physiol. 91: 375–393. 10.1113/jphysiol.1938.sp003566 PubMedGoogle Scholar 49 Mckinstry, D. N. & G. B. Koelle. 1967. acetylcholine release from the cat superior cervical ganglion by carbachol. j. pharmacol. exp. therap. 157(2): 319–327. CASPubMedWeb of Science®Google Scholar 50 Brimblecombe, R. W. & J. V. Sutton. 1968. the ganglion-stimulating effects of some ammo-acid esters. brit. j. pharmacol. 34: 358–369. 10.1111/j.1476-5381.1968.tb07057.x CASPubMedWeb of Science®Google Scholar 51 Green, R. D. 1969. the effect of denervation on the sensitivity of the superior cervical ganglion of the pithed cat. j. pharmacol. exp. therap. 167: 143–150. CASPubMedWeb of Science®Google Scholar 52 Vickerson, F. H. L. & D. R. Varma. 1969. effects of denervation on the sensitivity of the superior cervical ganglion of the cat to acetylcholine and mcn-a-343. can. j. physiol. pharmacol. 47: 255–259. 10.1139/y69-046 CASPubMedWeb of Science®Google Scholar 53 Brown, D. A. 1969. responses of normal and denervated cat superior cervical ganglia to some stimulant compounds. j. physiol. 201: 225–236. 10.1113/jphysiol.1969.sp008752 CASPubMedWeb of Science®Google Scholar 54 Hancock, J. C. & R. L. Volle. 1970. stimulation by carbachol and tetramethyl-ammonium ions of intact and denervated sympathetic ganglia. life sci. 9: 1–10. 10.1016/0024-3205(70)90217-1 Google Scholar 55 Mckinstry, D. N., E. Koenig, W. A. Koelle & G. B. Koelle. 1963. the release of acetylcholine from sympathetic ganglion by carbachol. relationship to the functional significance of the localization of acetylcholinesterase. can. j. biochem. physiol. 41: 2599–2609. 10.1139/o63-290 CASPubMedWeb of Science®Google Scholar 56 Mckinstry, D. N. & G. B. Koelle. 1967. effects of drugs on acetylcholine release from the cat superior cervical ganglion by carbachol and by preganglionic stimulation. j. pharmacol. exp. therap. 157: 328–336. CASPubMedWeb of Science®Google Scholar 57 Harvey, A. M. & F. C. Macintosh. 1940. calcium and synaptic transmission in a sympathetic ganglion. j. physiol. (london) 97: 408–416. 10.1113/jphysiol.1940.sp003818 CASPubMedWeb of Science®Google Scholar 58 Paton, W. D. M. & E. J. Zaimis. 1951. paralysis of autonomic ganglia by methonium salts. brit. j. pharmacol. 6: 155–168. 10.1111/j.1476-5381.1951.tb00631.x CASPubMedWeb of Science®Google Scholar 59 Matthews, E. K. & J. P. Quilliam. 1964. effects of central depressant drugs upon acetylcholine release. brit. j. pharmacol. 22: 415–440. 10.1111/j.1476-5381.1964.tb02047.x CASPubMedWeb of Science®Google Scholar 60 Matthews, E. K. 1966. the presynaptic effects of quaternary ammonium compounds on the acetylcholine metabolism of a sympathetic ganglion. brit. j. pharmacol. 26: 552–566. 10.1111/j.1476-5381.1966.tb01836.x CASPubMedWeb of Science®Google Scholar 61 Birks, R. & F. C. Macintosh. 1961. acetylcholine metabolism of a sympathetic ganglion. can. j. biochem. physiol. 39: 787–827. 10.1139/o61-081 CASWeb of Science®Google Scholar 62 Collier, B. & H. S. Katz. 1970. the release of acetylcholine by acetylcholine in the cat's superior cervical ganglion. brit. j. pharmacol. 39(2): 428–438. 10.1111/j.1476-5381.1970.tb12905.x CASPubMedWeb of Science®Google Scholar 63 Macintosh, F. C. 1963. synthesis and storage of acetylcholine in nervous tissue. can. j. biochem. physiol. 41: 2555–2571. 10.1139/o63-288 CASPubMedWeb of Science®Google Scholar 64 Douglas, W. W. & A. M. Poisner. 1964. stimulus-secretion coupling in a neurosecretory organ: the role of calcium in the release of vasopressin from the neurohypophysis. j. physiol. 172: 1–18. 10.1113/jphysiol.1964.sp007399 CASPubMedWeb of Science®Google Scholar 65 Anichkov, S. V. & A. A. Belous. 1947. the effect of acetylcholine and nicotine upon the neurohypophysis. fixiol. zh. 33: 6. (in russian.). Google Scholar 66 Belous, A. A. 1950. the effect of acetylcholine and nicotine upon secretion of the isolated neurohypophysis. farmakol. toksikol. 13: 1. (in russian.). Google Scholar 67 Burn, J. H. & M. J. Rand. 1965. acetylcholine in adrenergic transmission. ann. rev. pharmacol. 5: 163–182. 10.1146/annurev.pa.05.040165.001115 CASPubMedWeb of Science®Google Scholar 68 Ferry, C. B. 1966. cholinergic link hypothesis in adrenergic neuroeffector transmission. physiol. rev. 46: 420–456. CASPubMedWeb of Science®Google Scholar 69 Jacobowitz, D. & G. B. Koelle. 1965. histochemical correlations of acetylcholinesterase and catecholamines in postganglionic autonomic nerves of the cat, rabbit, and guinea pig. j. pharmacol. exp. therap. 148(2): 225–237. CASPubMedWeb of Science®Google Scholar 70 Wilson, H. & J. P. Long. 1959. the effect of hemicholinium (hc-3) at various peripheral cholinergic transmitting sites. arch. intern. pharmacodyn. 70: 343–352. Google Scholar 71 Gardiner, J. E. & J. W. Thompson. 1961. lack of evidence for a cholinergic mechanism in sympathetic transmission. nature (london) 191: 86. 10.1038/191086a0 CASPubMedWeb of Science®Google Scholar 72 Jacobowitz, D., P. Johnson, I. Kitchner & G. B. Koelle. 1965. the effect of hemicholinium (hc-3) on sympathetic transmission at the nictitating membrane of the rabbit. brit. j. pharmacol. 25: 527–533. 10.1111/j.1476-5381.1965.tb02070.x CASPubMedWeb of Science®Google Scholar 73 Arya, P. C. & O. D. Gulati. 1968. cholinergic link hypothesis and sympathetic transmission at the nictitating membrane of the dog. brit. j. pharmacol. 33: 413–425. 10.1111/j.1476-5381.1968.tb00491.x CASPubMedWeb of Science®Google Scholar 74 Koelle, G. B. 1963. cytological distributions and physiological functions of cholinesterases. in cholinesterases and anticholinesterase agents. handb. exp. pharmak. (suppl. 15). G. B. Koelle, ed.: 187–298. springer-verlag. berlin , Germany . 10.1007/978-3-642-99875-1_6 Google Scholar 75 Thoenen, H., J. P. Tranzer, H. Hürlimann & W. Haefely. 1966. untersuchungen zur frage eines cholinergischen gliedes in der postganglionären sympathischen transmission. helv. physiol. acta 24: 229–246. CASPubMedWeb of Science®Google Scholar 76 Ehinger, B., B. Falck & B. Sporrong. 1970. possible axo-axonal synapses between peripheral adrenergic and cholinergic nerve terminals. z. zellforsch. 107: 508–521. 10.1007/BF00335438 CASPubMedWeb of Science®Google Scholar 77 Richardson, K. C. 1964. the fine structure of the albino rabbit iris with special reference to the identification of adrenergic and cholinergic nerves and nerve endings in its intrinsic muscles. am. j. anat. 114: 173–205. 10.1002/aja.1001140202 CASPubMedWeb of Science®Google Scholar 78 Merrillees, N. C. R., B. Burnstock & M. Holman. 1963. correlation of fine structure and physiology for the innervation of smooth muscle in the guinea-pig vas deferens. j. cell biol. 19: 529–550. 10.1083/jcb.19.3.529 CASPubMedWeb of Science®Google Scholar 79 Koelle, G. B., J. S. Friedenwald, L. Wolfand & R. A. Allen. 1952. localization of specific cholinesterase in ocular tissues of the cat. am. j. ophthalmol. 35: 1580–1584. 10.1016/0002-9394(52)91445-1 CASPubMedWeb of Science®Google Scholar 80 Nichols, C. W. & G. B. Koelle. 1968. comparison of the localization of acetylcholinesterase and non-specific cholinesterase activities in mammalian and avian retinas. j. comp. neurol. 133: 1–16. 10.1002/cne.901330102 CASPubMedWeb of Science®Google Scholar 81 Churchill, J. A., H. F. Schuknecht & R. Doran. 1956. acetylcholinesterase activity in the cochlea. laryngoscope 66: 1–15. 10.1288/00005537-195601000-00001 CASPubMedGoogle Scholar 82 Mckinstry, D. N. & G. B. Koelle. 1967. inhibition of release of acetylcholine by strychnine and its implications regarding transmission by the olivo-cochlear bundle. nature (london) 213: 505–506. 10.1038/213505a0 CASPubMedWeb of Science®Google Scholar 82a Fex, A. 1968. efferent inhibition in the cochlea by the olivo-cochlear bundle. in hearing mechanisms in vertebrates. ciba found. sympos. A. V. S. Renk & J. Knight, eds.: 169–186. little, brown & co., boston , mass . 10.1002/9780470719657.ch9 Google Scholar 83 Erulkar, S. D., C. W. Nichols, M. B. Popp & G. B. Koelle. 1968. renshaw elements: localization and acetylcholinesterase content. j. histochem. cytochem. 16: 128–135. 10.1177/16.2.128 CASPubMedWeb of Science®Google Scholar 84 Koelle, G. B. 1969. significance of acetylcholinesterase in central synaptic transmission. fed. proc. 28(1): 95–100. CASPubMedWeb of Science®Google Scholar 85 Davis, R. & G. B. Koelle. 1967. electron microscopic localization of acetylcholinesterase and nonspecific cholinesterase at the neuromuscular junction by the gold-thiocholine and gold-thiolacetic acid methods. j. cell. biol. 34: 157–171. 10.1083/jcb.34.1.157 CASPubMedWeb of Science®Google Scholar 86 Koelle, G. B., R. Davis & M. Devlin. 1968. acetyl disulfide, (ch3cos)2, and bis-(thioacetoxy) aurate (i) complex, au(ch3cos)-2, histochemical substrates of unusual properties with acetylcholinesterase. j. histochem. cytochem. 16: 754–764. 10.1177/16.12.754 CASPubMedWeb of Science®Google Scholar 87 Koelle, G. B., R. Davis & E. G. Smyrl. 1970. new findings concerning the localization by electron microscopy of acetylcholinesterase in autonomic ganglia. in international symposium in histochemistry of nervous transmission. helsinki, 1970. in press. Google Scholar 88 Davis, R. & G. B. Koelle. electron microscopic localization of acetylcholinesterase in antonomic ganglia of the cat. in preparation. Google Scholar 89 Guth, L. 1968. Trophic influences of nerve on muscle. Ann. Rev. Physiol. 48: 645–687. PubMedWeb of Science®Google Scholar Citing Literature Volume183, Issue1Myasthenia GravisSeptember 1971Pages 5-20 ReferencesRelatedInformation
Publication Year: 1971
Publication Date: 1971-09-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 36
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