Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2022292087', 'doi': 'https://doi.org/10.1111/j.2042-7158.1992.tb03631.x', 'title': 'Parthenolide Content and Bioactivity of Feverfew (<i>Tanacetum parthenium</i> (L.) Schultz-Bip.). Estimation of Commercial and Authenticated Feverfew Products', 'display_name': 'Parthenolide Content and Bioactivity of Feverfew (<i>Tanacetum parthenium</i> (L.) Schultz-Bip.). Estimation of Commercial and Authenticated Feverfew Products', 'publication_year': 1992, 'publication_date': '1992-05-01', 'ids': {'openalex': 'https://openalex.org/W2022292087', 'doi': 'https://doi.org/10.1111/j.2042-7158.1992.tb03631.x', 'mag': '2022292087', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1359053'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.1992.tb03631.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089627879', 'display_name': 'Stan Heptinstall', 'orcid': 'https://orcid.org/0000-0003-1843-2269'}, 'institutions': [{'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S Heptinstall', 'raw_affiliation_strings': ["Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK."], 'affiliations': [{'raw_affiliation_string': "Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK.", 'institution_ids': ['https://openalex.org/I4210137227']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011725950', 'display_name': 'Dennis V. C. Awang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1288894424', 'display_name': 'Health Canada', 'ror': 'https://ror.org/05p8nb362', 'country_code': 'CA', 'type': 'government', 'lineage': ['https://openalex.org/I1288894424']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'D V C Awang', 'raw_affiliation_strings': ["Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada"], 'affiliations': [{'raw_affiliation_string': "Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada", 'institution_ids': ['https://openalex.org/I1288894424']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111858128', 'display_name': 'Brian A. Dawson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1288894424', 'display_name': 'Health Canada', 'ror': 'https://ror.org/05p8nb362', 'country_code': 'CA', 'type': 'government', 'lineage': ['https://openalex.org/I1288894424']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'B A Dawson', 'raw_affiliation_strings': ["Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada"], 'affiliations': [{'raw_affiliation_string': "Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada", 'institution_ids': ['https://openalex.org/I1288894424']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046782749', 'display_name': 'Daryl Kindack', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1288894424', 'display_name': 'Health Canada', 'ror': 'https://ror.org/05p8nb362', 'country_code': 'CA', 'type': 'government', 'lineage': ['https://openalex.org/I1288894424']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'D Kindack', 'raw_affiliation_strings': ["Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada"], 'affiliations': [{'raw_affiliation_string': "Bureau of Drug Research, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario K1A OL2, Canada", 'institution_ids': ['https://openalex.org/I1288894424']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111979003', 'display_name': 'D. W. KNIGHT', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142263535', 'display_name': 'University of Nottingham', 'ror': 'https://ror.org/01ee9ar58', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I142263535']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D W Knight', 'raw_affiliation_strings': ['Department of Chemistry, University of Nottingham, UniversIty Park, Nottingham, NG7 2RD, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Nottingham, UniversIty Park, Nottingham, NG7 2RD, UK', 'institution_ids': ['https://openalex.org/I142263535']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109228974', 'display_name': 'Jane May', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J May', 'raw_affiliation_strings': ["Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK."], 'affiliations': [{'raw_affiliation_string': "Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK.", 'institution_ids': ['https://openalex.org/I4210137227']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2665, 'currency': 'GBP', 'value_usd': 3268, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.387, 'has_fulltext': False, 'cited_by_count': 98, 'citation_normalized_percentile': {'value': 0.947696, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '44', 'issue': '5', 'first_page': '391', 'last_page': '395'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11547', 'display_name': 'Sesquiterpenes and Asteraceae Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11547', 'display_name': 'Sesquiterpenes and Asteraceae Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Natural product bioactivities and synthesis', 'score': 0.9719, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/parthenolide', 'display_name': 'Parthenolide', 'score': 0.9993886}, {'id': 'https://openalex.org/keywords/parthenium', 'display_name': 'Parthenium', 'score': 0.504315}], 'concepts': [{'id': 'https://openalex.org/C2780321935', 'wikidata': 'https://www.wikidata.org/wiki/Q2662393', 'display_name': 'Parthenolide', 'level': 3, 'score': 0.9993886}, {'id': 'https://openalex.org/C104488531', 'wikidata': 'https://www.wikidata.org/wiki/Q864212', 'display_name': 'Bioassay', 'level': 2, 'score': 0.5477901}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5307712}, {'id': 'https://openalex.org/C2775864690', 'wikidata': 'https://www.wikidata.org/wiki/Q3236767', 'display_name': 'Parthenium', 'level': 3, 'score': 0.504315}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.42390886}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.32736415}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.3223791}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.17591819}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16540515}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.13335302}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.115208}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2775891814', 'wikidata': 'https://www.wikidata.org/wiki/Q101879', 'display_name': 'Weed', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D002214', 'descriptor_name': 'Capsules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055598', 'descriptor_name': 'Chemical Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002627', 'descriptor_name': 'Chemistry, Physical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010946', 'descriptor_name': 'Plants, Medicinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011786', 'descriptor_name': 'Quality Control', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013607', 'descriptor_name': 'Tablets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020903', 'descriptor_name': 'Tanacetum parthenium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.2042-7158.1992.tb03631.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118304455', 'display_name': 'Journal of Pharmacy and Pharmacology', 'issn_l': '0022-3573', 'issn': ['0022-3573', '2042-7158'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1359053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1979955074', 'https://openalex.org/W1985518239', 'https://openalex.org/W2027482944', 'https://openalex.org/W2038967494', 'https://openalex.org/W2054287580', 'https://openalex.org/W2058973529', 'https://openalex.org/W2086757457', 'https://openalex.org/W2129853799', 'https://openalex.org/W2134231557', 'https://openalex.org/W2158030200', 'https://openalex.org/W2508356169', 'https://openalex.org/W79364167'], 'related_works': ['https://openalex.org/W4235850621', 'https://openalex.org/W2921272916', 'https://openalex.org/W2429135618', 'https://openalex.org/W2169567975', 'https://openalex.org/W2137163734', 'https://openalex.org/W2034681231', 'https://openalex.org/W2027482944', 'https://openalex.org/W2024144497', 'https://openalex.org/W1758609564', 'https://openalex.org/W167806727'], 'abstract_inverted_index': {'Three': [0], 'physicochemical': [1, 59], 'methods': [2], '(HPLC,': [3], 'NMR': [4], 'spectroscopy,': [5], 'and': [6, 22, 61, 109, 117, 140, 190], 'HPLC': [7], 'of': [8, 34, 38, 43, 75, 88, 90, 103, 121, 167, 177, 183, 188], 'a': [9, 100, 112, 186], 'derivative)': [10], 'have': [11], 'been': [12, 163], 'used': [13], 'to': [14, 80], 'measure': [15], 'parthenolide': [16, 48, 73, 104, 122, 138, 144, 154, 184], 'in': [17, 23, 45, 96, 105, 115, 123, 136, 141, 153], 'authenticated': [18], 'Tanacetum': [19, 93], 'parthenium': [20, 94], '(feverfew)': [21], 'several': [24], 'commercial': [25], 'purported': [26, 131], 'feverfew': [27, 44, 76, 132, 168, 178], 'products.': [28], 'A': [29], 'bioassay': [30], 'based': [31], 'on': [32], 'inhibition': [33], 'the': [35, 64, 85, 97, 151], 'secretory': [36], 'activity': [37], 'blood': [39], 'platelets': [40], 'by': [41], 'extracts': [42, 89], 'comparison': [46], 'with': [47], 'was': [49, 145], 'also': [50, 62], 'used.': [51], 'Similar': [52], 'results': [53], 'were': [54], 'obtained': [55], 'for': [56, 63, 72, 84, 150, 165], 'all': [57], 'three': [58], 'assays': [60], 'bioassay.': [65], 'Thus': [66], 'different': [67], 'methodologies': [68], 'yield': [69], 'consistent': [70], 'values': [71], 'content': [74, 139, 155], 'preparations.': [77], 'Parthenolide': [78], 'appears': [79], 'be': [81], 'mainly': [82], 'responsible': [83], 'antisecretory': [86], 'effects': [87], 'feverfew.': [91], 'Authenticated': [92], 'grown': [95], 'UK': [98], 'contained': [99], 'high': [101], 'level': [102, 114, 120], 'leaves,': [106], 'flowering': [107], 'tops': [108], 'seeds': [110], 'but': [111], 'low': [113], 'stalks': [116], 'roots.': [118], 'The': [119, 130], 'powdered': [124], 'leaf': [125], 'material': [126], 'fell': [127], 'during': [128], 'storage.': [129], 'products': [133, 143, 179], 'varied': [134], 'widely': [135], 'their': [137], 'some': [142], 'not': [146], 'detected.': [147], 'Possible': [148], 'reasons': [149], 'variation': [152], 'are': [156], 'discussed.': [157], 'Since': [158], 'therapeutic': [159], 'efficacy': [160], 'has': [161], 'only': [162], 'demonstrated': [164], 'preparations': [166], 'that': [169, 175], 'contain': [170], 'parthenolide,': [171], 'it': [172], 'is': [173], 'suggested': [174], 'manufacturers': [176], 'should': [180], 'use': [181], 'measurements': [182], 'as': [185], 'means': [187], 'standardization': [189], 'quality': [191], 'control.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022292087', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T23:13:15.590525', 'created_date': '2016-06-24'}