Title: Membrane Stabilization and Inhibition of Lipid Peroxidation by Anti-Inflammatory Indoles
Abstract: Nine 2-aryl-3-[4-(substituted phenyl)-3-thiosemicarbazone] indoles were evaluated for their ability to protect the human erythrocyte membrane against hypo-osmotic hemolysis and inhibit lipid peroxidation in rat liver homogenate in vitro. All compounds caused membrane stabilization and inhibition of lipid peroxidation when tested at final concentrations of 5 × 10–4 and 2.5 × 10–5 mol/l, respectively. These biochemical effects were not related to the anti-inflammatory property exhibited by the compounds.
Publication Year: 1982
Publication Date: 1982-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 14
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