Title: Development of meningeal leukemia (L1210) during treatment of subcutaneously inoculated mice with methotrexate
Abstract: CancerVolume 17, Issue 3 p. 352-360 ArticleFree Access Development of meningeal leukemia (L1210) during treatment of subcutaneously inoculated mice with methotrexate Louis B. Thomas M.D., Louis B. Thomas M.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorMichael A. Chirigos PH.D., Michael A. Chirigos PH.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorStewart R. Humphreys, Stewart R. Humphreys Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorAbraham Goldin PH.D., Abraham Goldin PH.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this author Louis B. Thomas M.D., Louis B. Thomas M.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorMichael A. Chirigos PH.D., Michael A. Chirigos PH.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorStewart R. Humphreys, Stewart R. Humphreys Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this authorAbraham Goldin PH.D., Abraham Goldin PH.D. Branches of Pathologic Anatomy and Biochemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda 14, Md.Search for more papers by this author First published: March 1964 https://doi.org/10.1002/1097-0142(196403)17:3<352::AID-CNCR2820170311>3.0.CO;2-KCitations: 15AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Chirigos, M. A.: Humphreys, S. R., and Goldin, A.: Effectiveness of Cytoxan against intracerebrally and subcutaneously inoculated mouse lymphoid leukemia L1210. Cancer Res. 22: 187– 195, 1962. 2 Chirigos, M. A.; Thomas, L. B.: Humphreys, S. R., and Goldin, A.: Intracerebral growth and treatment of leukemia L1210. Proc. Soc. Exper. Biol. & Med. 104: 643– 645, 1960. 3 Goldin, A.; Venditti, J. M.; Humphreys, S. R.; Dennis, D., and Mantel, N.: Studies on management of mouse leukemia (L1210) with antagonists of folic acid. Cancer Res. 15: 742– 747, 1955. 4 Goldin, A.; Venditti, J. M.; Humphreys, S. R., and Mantel, N.: Quantitative evaluation of chemother-apeutic agents against advanced leukemia in mice. J. Nat. Cancer. Inst. 21: 495– 511, 1958. 5 Moore, E. W.; Thomas, L. B.; Shaw, R. K., and Freireich, E. J.: Central nervous system in acute leukemia; postmortem study of 117 consecutive cases, with particular reference to hemorrhages, leukemic infiltrations, and syndrome of meningeal leukemia. A. M. A. Arch. Int. Med. 105: 451– 468, 1960. 6 Rall, D. P., and Zubrod, C. G.: Mechanisms of drug absorption and excretion; passage of drugs in and out of central nervous system. Ann. Rev. Pharmacol. 2: 109– 128, 1962. 7 Shaw, R. K.; Moore, E. W.; Freireich, E. J., and Thomas, L. B.: Meningeal leukemia; syndrome resulting from increased intracranial pressure in patients with acute leukemia. Neurology 10: 823– 833, 1960. 8 Thomas, L. B.; Chirigos, M. A.; Humphreys, S. R., and Goldin, A.: Pathology of spread of L1210 leukemia in central nervous system of mice and effect of treatment with Cytoxan. J. Nat. Cancer Inst. 28: 1355– 1389, 1962. 9 Whiteside, J. A.; Philips, F. S.; Dargeon, H. W., and Burchenal, J. H.: Intrathecal amethopterin in neurological manifestations of leukemia. A. M. A. Arch. Int. Med. 101: 279– 285, 1958. Citing Literature Volume17, Issue3March 1964Pages 352-360 ReferencesRelatedInformation