Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2021860689', 'doi': 'https://doi.org/10.1016/0028-3908(83)90163-6', 'title': 'Age-related differences in the effect of chronic administration of naloxone on opiate binding in rat brain', 'display_name': 'Age-related differences in the effect of chronic administration of naloxone on opiate binding in rat brain', 'publication_year': 1983, 'publication_date': '1983-04-01', 'ids': {'openalex': 'https://openalex.org/W2021860689', 'doi': 'https://doi.org/10.1016/0028-3908(83)90163-6', 'mag': '2021860689', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6304564'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0028-3908(83)90163-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160566677', 'display_name': 'Neuropharmacology', 'issn_l': '0028-3908', 'issn': ['0028-3908', '1873-7064'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009450662', 'display_name': 'Michael T. Bardo', 'orcid': 'https://orcid.org/0000-0002-8632-3032'}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M.T. Bardo', 'raw_affiliation_strings': ['Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.', 'institution_ids': ['https://openalex.org/I126307644']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061110223', 'display_name': 'Rahul Bhatnagar', 'orcid': 'https://orcid.org/0000-0003-3906-1997'}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R.K. Bhatnagar', 'raw_affiliation_strings': ['Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.', 'institution_ids': ['https://openalex.org/I126307644']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105939304', 'display_name': 'Gerald F. Gebhart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126307644', 'display_name': 'University of Iowa', 'ror': 'https://ror.org/036jqmy94', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126307644']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G.F. Gebhart', 'raw_affiliation_strings': ['Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Iowa, Iowa City, IA 52242 U.S.A.', 'institution_ids': ['https://openalex.org/I126307644']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4050, 'currency': 'USD', 'value_usd': 4050, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.701, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.656261, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '22', 'issue': '4', 'first_page': '453', 'last_page': '461'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/opiate', 'display_name': 'Opiate', 'score': 0.90164435}, {'id': 'https://openalex.org/keywords/opiate-receptors', 'display_name': 'Opiate receptors', 'score': 0.47159585}], 'concepts': [{'id': 'https://openalex.org/C2778140631', 'wikidata': 'https://www.wikidata.org/wiki/Q2026938', 'display_name': 'Opiate', 'level': 3, 'score': 0.90164435}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.8741768}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.62392527}, {'id': 'https://openalex.org/C2777389121', 'wikidata': 'https://www.wikidata.org/wiki/Q81225', 'display_name': 'Morphine', 'level': 2, 'score': 0.6020097}, {'id': 'https://openalex.org/C2910977262', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opiate receptors', 'level': 5, 'score': 0.47159585}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46617058}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.46451938}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4175832}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.3871037}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.35720572}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.21686032}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009020', 'descriptor_name': 'Morphine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009020', 'descriptor_name': 'Morphine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0028-3908(83)90163-6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160566677', 'display_name': 'Neuropharmacology', 'issn_l': '0028-3908', 'issn': ['0028-3908', '1873-7064'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6304564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1580340214', 'https://openalex.org/W1684853394', 'https://openalex.org/W1775749144', 'https://openalex.org/W1965632205', 'https://openalex.org/W1975676031', 'https://openalex.org/W1979569718', 'https://openalex.org/W1981440196', 'https://openalex.org/W1982773167', 'https://openalex.org/W1984627990', 'https://openalex.org/W1986130864', 'https://openalex.org/W1989334851', 'https://openalex.org/W2001827664', 'https://openalex.org/W2006316005', 'https://openalex.org/W2010083256', 'https://openalex.org/W2011187641', 'https://openalex.org/W2016877284', 'https://openalex.org/W2017036944', 'https://openalex.org/W2017920564', 'https://openalex.org/W2018324268', 'https://openalex.org/W2018505526', 'https://openalex.org/W2022846075', 'https://openalex.org/W2027472434', 'https://openalex.org/W2027730590', 'https://openalex.org/W2033011574', 'https://openalex.org/W2034491899', 'https://openalex.org/W2039724528', 'https://openalex.org/W2042004313', 'https://openalex.org/W2043175555', 'https://openalex.org/W2046791061', 'https://openalex.org/W2051922537', 'https://openalex.org/W2055831702', 'https://openalex.org/W2060581684', 'https://openalex.org/W2067130328', 'https://openalex.org/W2076531996', 'https://openalex.org/W2078916825', 'https://openalex.org/W2086485861', 'https://openalex.org/W2135865946', 'https://openalex.org/W2171187460', 'https://openalex.org/W2288830012', 'https://openalex.org/W2341035495', 'https://openalex.org/W2398107255', 'https://openalex.org/W2408954827', 'https://openalex.org/W2409281043', 'https://openalex.org/W2419067909', 'https://openalex.org/W2462048728', 'https://openalex.org/W2484022162', 'https://openalex.org/W2522758279', 'https://openalex.org/W614106044', 'https://openalex.org/W643339628'], 'related_works': ['https://openalex.org/W2478916312', 'https://openalex.org/W2414996128', 'https://openalex.org/W2048277806', 'https://openalex.org/W2040753312', 'https://openalex.org/W2039496949', 'https://openalex.org/W2021860689', 'https://openalex.org/W1998735443', 'https://openalex.org/W1977870305', 'https://openalex.org/W1873301473', 'https://openalex.org/W1597211607'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2021860689', 'counts_by_year': [{'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T23:44:03.947895', 'created_date': '2016-06-24'}