Title: Contributions of PK/PD Modeling to Intravenous Anesthesia
Abstract: Clinical Pharmacology & TherapeuticsVolume 84, Issue 1 p. 27-38 State of the Art Contributions of PK/PD Modeling to Intravenous Anesthesia CF Minto, CF Minto Department of Anaesthesia and Pain Management, Royal North Shore Hospital, St. Leonards, New South Wales, AustraliaSearch for more papers by this authorTW Schnider, TW Schnider [email protected] Institut für Anästhesiologie, Kantonsspital St. Gallen, St. Gallen, Switzerland University of Bern, Bern, SwitzerlandSearch for more papers by this author CF Minto, CF Minto Department of Anaesthesia and Pain Management, Royal North Shore Hospital, St. Leonards, New South Wales, AustraliaSearch for more papers by this authorTW Schnider, TW Schnider [email protected] Institut für Anästhesiologie, Kantonsspital St. Gallen, St. Gallen, Switzerland University of Bern, Bern, SwitzerlandSearch for more papers by this author First published: 07 May 2008 https://doi.org/10.1038/clpt.2008.100Citations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Pharmacokinetic (PK)/pharmacodynamic (PD) modeling has made an enormous contribution to intravenous anesthesia. PK/PD models have provided us with insight into the factors affecting the onset and offset of drug effect. For example, we are now able to describe the influence of cardiac output on the disposition of intravenous drugs within the first few minutes after administration of the drug. We are able to calculate intravenous loading doses that allow for the delay between the concentration of the drug in the plasma and the rising concentration at the site of drug effect. We are able to achieve and maintain a stable level of anesthetic effect using computerized infusion pumps that target the site of drug effect rather than the plasma. 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Publication Year: 2008
Publication Date: 2008-05-07
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 72
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