Title: Excessive right ventricular hypertrophic response in adults with the mustard procedure for transposition of the great arteries
Abstract: Patients with a morphologic right ventricle supplying the systemic circulation are common in the adult congenital cardiac clinic. 1 Paul MH, Wernovsky G. Transposition of the great arteries. In: Emmanouilides GC, Riemenschneider TA, Allen HD, Gutgesell HP, eds. Moss and Adams Heart Disease in Infants, Children and Adolescents. 5th Ed. Baltimore: Williams and Wilkins, 1995:1154–1224 Google Scholar , 2 Mustard W.T. Succesful two-stage correction of transposition of the great vessels. Surgery. 1964; 55: 469-472 PubMed Google Scholar , 3 Senning A. Surgical correction of transposition of the great vessels. Surgery. 1959; 45: 966-980 PubMed Google Scholar , 4 Presbitero P. Somerville J. Rabajoli F. Stone S. Conte M.R. Corrected transposition of the great arteries without associated defects in adult patients clinical profile and follow up. Br Heart J. 1995; 74: 57-59 Crossref PubMed Scopus (170) Google Scholar Such patients are at risk of right ventricular (RV) dysfunction, 5 Hornung T.S. Bernard E.J. Celermajer D.S. Jaeggi E.T. Howman-Giles R.B. Chard R.B. Hawker R.E. Right ventricular dysfunction in congenitally corrected transposition of the great arteries. Am J Cardiol. 1999; 84: 1116-1119 Abstract Full Text Full Text PDF PubMed Scopus (76) Google Scholar , 6 Millane T. Bernard E.J. Jaeggi E. Howman-Giles R.B. Uren R.F. Cartmill T.B. Hawker R.E. Celermajer D.S. Role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposition of the great arteries. J Am Coll Cardiol. 2000; 35: 1661-1668 Abstract Full Text Full Text PDF PubMed Scopus (121) Google Scholar , 7 Lubiszewska B. Gosiewska E. Hoffman P. Teresinska A. Rozanski J. Piotrowski W. Rydlewska-Sadowska W. Kubicka K. Ruzyllo W. Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition long-term follow-up. J Am Coll Cardiol. 2000; 36: 1365-1370 Abstract Full Text Full Text PDF PubMed Scopus (129) Google Scholar , 8 Lorenz C.H. Walker E.S. Graham Jr, T.P. Powers T.A. Right ventricular performance and mass by use of cine MRI late after atrial repair of transposition of the great arteries. Circulation. 1995; 92: 233-239 Crossref Google Scholar the mechanism of which remains unclear. We and others have shown previously that RV myocardial ischemia is common in these subjects, but the reason for this ischemia is not known. 5 Hornung T.S. Bernard E.J. Celermajer D.S. Jaeggi E.T. Howman-Giles R.B. Chard R.B. Hawker R.E. Right ventricular dysfunction in congenitally corrected transposition of the great arteries. Am J Cardiol. 1999; 84: 1116-1119 Abstract Full Text Full Text PDF PubMed Scopus (76) Google Scholar , 6 Millane T. Bernard E.J. Jaeggi E. Howman-Giles R.B. Uren R.F. Cartmill T.B. Hawker R.E. Celermajer D.S. Role of ischemia and infarction in late right ventricular dysfunction after atrial repair of transposition of the great arteries. J Am Coll Cardiol. 2000; 35: 1661-1668 Abstract Full Text Full Text PDF PubMed Scopus (121) Google Scholar , 7 Lubiszewska B. Gosiewska E. Hoffman P. Teresinska A. Rozanski J. Piotrowski W. Rydlewska-Sadowska W. Kubicka K. Ruzyllo W. Myocardial perfusion and function of the systemic right ventricle in patients after atrial switch procedure for complete transposition long-term follow-up. J Am Coll Cardiol. 2000; 36: 1365-1370 Abstract Full Text Full Text PDF PubMed Scopus (129) Google Scholar We speculated that the reduced efficiency of the right ventricle as a systemic pressure pump would necessitate a greater muscle mass than a systemic left ventricle, increasing myocardial oxygen demands and potentially contributing to ischemia. We hypothesized that increased RV myocardial mass is related to impaired RV systolic function and we used cardiovascular magnetic resonance imaging to test this hypothesis. Systemic right ventricle: possible cause of ventricular dysfunction?American Journal of CardiologyVol. 90Issue 7Preview Full-Text PDF
Publication Year: 2002
Publication Date: 2002-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 74
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