A longitudinal HR‐pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover

Name: Work Video:
Duration: 3 min 30 s
Andrew J. Burghardt; Galateia J. Kazakia; Miki Sode; Anne E. de Papp; Thomas M. Link; Sharmila Majumdar
{'id': 'https://openalex.org/W2021542350', 'doi': 'https://doi.org/10.1002/jbmr.157', 'title': 'A longitudinal HR‐pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover', 'display_name': 'A longitudinal HR‐pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover', 'publication_year': 2010, 'publication_date': '2010-06-21', 'ids': {'openalex': 'https://openalex.org/W2021542350', 'doi': 'https://doi.org/10.1002/jbmr.157', 'mag': '2021542350', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20564242', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3179276'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbmr.157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.157', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.157', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069893656', 'display_name': 'Andrew J. Burghardt', 'orcid': 'https://orcid.org/0000-0002-6343-4944'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Andrew J Burghardt', 'raw_affiliation_strings': ['Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046201113', 'display_name': 'Galateia J. Kazakia', 'orcid': 'https://orcid.org/0000-0002-7327-6425'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Galateia J Kazakia', 'raw_affiliation_strings': ['Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045338688', 'display_name': 'Miki Sode', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I19620478', 'display_name': 'Graduate Theological Union', 'ror': 'https://ror.org/00xs48965', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I19620478']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Miki Sode', 'raw_affiliation_strings': ['Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, San Francisco, CA, USA', 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I19620478', 'https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111611951', 'display_name': 'Anne E. de Papp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Anne E de Papp', 'raw_affiliation_strings': ['Merck & Co., Inc., Whitehouse Station, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Merck & Co., Inc., Whitehouse Station, NJ, USA', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109574516', 'display_name': 'Thomas M. Link', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas M Link', 'raw_affiliation_strings': ['Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043462798', 'display_name': 'Sharmila Majumdar', 'orcid': 'https://orcid.org/0000-0002-0201-871X'}, 'institutions': [{'id': 'https://openalex.org/I19620478', 'display_name': 'Graduate Theological Union', 'ror': 'https://ror.org/00xs48965', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I19620478']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sharmila Majumdar', 'raw_affiliation_strings': ['Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, San Francisco, CA, USA', 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I19620478', 'https://openalex.org/I180670191']}, {'raw_affiliation_string': 'Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5069893656'], 'corresponding_institution_ids': ['https://openalex.org/I180670191'], 'apc_list': {'value': 3710, 'currency': 'USD', 'value_usd': 3710, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 16.993, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 230, 'citation_normalized_percentile': {'value': 0.999802, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '25', 'issue': '12', 'first_page': '2558', 'last_page': '2571'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10071', 'display_name': 'Bone health and osteoporosis research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10071', 'display_name': 'Bone health and osteoporosis research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12209', 'display_name': 'Bone and Joint Diseases', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10522', 'display_name': 'Medical Imaging Techniques and Applications', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.73723966}, {'id': 'https://openalex.org/keywords/biomechanics', 'display_name': 'Biomechanics', 'score': 0.6372109}, {'id': 'https://openalex.org/keywords/longitudinal-study', 'display_name': 'Longitudinal Study', 'score': 0.44203076}], 'concepts': [{'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.73723966}, {'id': 'https://openalex.org/C170700871', 'wikidata': 'https://www.wikidata.org/wiki/Q193378', 'display_name': 'Biomechanics', 'level': 2, 'score': 0.6372109}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.602626}, {'id': 'https://openalex.org/C2777425516', 'wikidata': 'https://www.wikidata.org/wiki/Q17083560', 'display_name': 'Quantitative computed tomography', 'level': 4, 'score': 0.5577505}, {'id': 'https://openalex.org/C3018603563', 'wikidata': 'https://www.wikidata.org/wiki/Q177708', 'display_name': 'Postmenopausal women', 'level': 2, 'score': 0.5554927}, {'id': 'https://openalex.org/C2779329777', 'wikidata': 'https://www.wikidata.org/wiki/Q2304401', 'display_name': 'Bone density', 'level': 3, 'score': 0.53875476}, {'id': 'https://openalex.org/C3018268312', 'wikidata': 'https://www.wikidata.org/wiki/Q2671642', 'display_name': 'Trabecular bone', 'level': 3, 'score': 0.47858548}, {'id': 'https://openalex.org/C2781451080', 'wikidata': 'https://www.wikidata.org/wiki/Q265868', 'display_name': 'Cortical bone', 'level': 2, 'score': 0.44339752}, {'id': 'https://openalex.org/C2777895361', 'wikidata': 'https://www.wikidata.org/wiki/Q1758614', 'display_name': 'Longitudinal study', 'level': 2, 'score': 0.44203076}, {'id': 'https://openalex.org/C2776541429', 'wikidata': 'https://www.wikidata.org/wiki/Q165328', 'display_name': 'Osteoporosis', 'level': 2, 'score': 0.3949473}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37707752}, {'id': 'https://openalex.org/C199343813', 'wikidata': 'https://www.wikidata.org/wiki/Q12128', 'display_name': 'Dentistry', 'level': 1, 'score': 0.32797557}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.28951138}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.17275834}], 'mesh': [{'descriptor_ui': 'D019386', 'descriptor_name': 'Alendronate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015519', 'descriptor_name': 'Bone Density', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D016723', 'descriptor_name': 'Bone Remodeling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D017698', 'descriptor_name': 'Postmenopause', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014057', 'descriptor_name': 'Tomography, X-Ray Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015502', 'descriptor_name': 'Absorptiometry, Photon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019386', 'descriptor_name': 'Alendronate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019386', 'descriptor_name': 'Alendronate', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D019386', 'descriptor_name': 'Alendronate', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001696', 'descriptor_name': 'Biomechanical Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015519', 'descriptor_name': 'Bone Density', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050071', 'descriptor_name': 'Bone Density Conservation Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050071', 'descriptor_name': 'Bone Density Conservation Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D050071', 'descriptor_name': 'Bone Density Conservation Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016723', 'descriptor_name': 'Bone Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008137', 'descriptor_name': 'Longitudinal Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017698', 'descriptor_name': 'Postmenopause', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018709', 'descriptor_name': 'Statistics, Nonparametric', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbmr.157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.157', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3179276', 'pdf_url': 'https://europepmc.org/articles/pmc3179276?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179276', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.escholarship.org/uc/item/1w16k9nm', 'pdf_url': 'https://escholarship.org/content/qt1w16k9nm/qt1w16k9nm.pdf?t=oruxcx', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20564242', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbmr.157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.157', 'source': {'id': 'https://openalex.org/S128199769', 'display_name': 'Journal of Bone and Mineral Research', 'issn_l': '0884-0431', 'issn': ['0884-0431', '1523-4681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.69, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1702563725', 'https://openalex.org/W1963864516', 'https://openalex.org/W1964581145', 'https://openalex.org/W1964983194', 'https://openalex.org/W1966877738', 'https://openalex.org/W1971580199', 'https://openalex.org/W1972192940', 'https://openalex.org/W1976387068', 'https://openalex.org/W1978678653', 'https://openalex.org/W1982691273', 'https://openalex.org/W1989783674', 'https://openalex.org/W1998462722', 'https://openalex.org/W2009222457', 'https://openalex.org/W2012074412', 'https://openalex.org/W2012187412', 'https://openalex.org/W2012548026', 'https://openalex.org/W2014480858', 'https://openalex.org/W2017983594', 'https://openalex.org/W2019293043', 'https://openalex.org/W2019554277', 'https://openalex.org/W2021151569', 'https://openalex.org/W2029090208', 'https://openalex.org/W2035405583', 'https://openalex.org/W2049945671', 'https://openalex.org/W2054689187', 'https://openalex.org/W2065916720', 'https://openalex.org/W2066056548', 'https://openalex.org/W2069370255', 'https://openalex.org/W2081070012', 'https://openalex.org/W2085072070', 'https://openalex.org/W2087056005', 'https://openalex.org/W2087378917', 'https://openalex.org/W2087633681', 'https://openalex.org/W2099326137', 'https://openalex.org/W2101235357', 'https://openalex.org/W2104307326', 'https://openalex.org/W2113523811', 'https://openalex.org/W2115028313', 'https://openalex.org/W2128569032', 'https://openalex.org/W2141896252', 'https://openalex.org/W2142908537', 'https://openalex.org/W2153009489', 'https://openalex.org/W2157812230', 'https://openalex.org/W2161555525', 'https://openalex.org/W2162167769', 'https://openalex.org/W2169592466', 'https://openalex.org/W2524061995', 'https://openalex.org/W3203441888', 'https://openalex.org/W4292939704'], 'related_works': ['https://openalex.org/W4206047622', 'https://openalex.org/W2119737749', 'https://openalex.org/W2109038795', 'https://openalex.org/W2072924067', 'https://openalex.org/W2067861699', 'https://openalex.org/W2059797222', 'https://openalex.org/W2035836035', 'https://openalex.org/W2032167677', 'https://openalex.org/W1988960079', 'https://openalex.org/W1977593121'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'goal': [2], 'of': [3, 78, 90, 93, 120, 200, 240, 249], 'this': [4, 25], 'study': [5], 'was': [6, 221, 243], 'to': [7, 65, 101, 214, 232, 259, 292], 'characterize': [8], 'longitudinal': [9], 'changes': [10, 225, 250], 'in': [11, 16, 137, 144, 168, 189, 216, 226, 251, 274, 294, 298], 'bone': [12, 36, 94, 102, 164, 241], 'microarchitecture': [13, 105, 228, 255], 'and': [14, 82, 88, 97, 104, 112, 147, 150, 155, 192, 219, 254, 267, 304, 313], 'function': [15], 'women': [17, 33], 'treated': [18], 'with': [19, 34, 224, 245], 'an': [20], 'established': [21], 'antifracture': [22], 'therapeutic.': [23], 'In': [24, 99], 'double-blind,': [26], 'placebo-controlled': [27], 'pilot': [28], 'study,': [29], '53': [30], 'early': [31], 'postmenopausal': [32], 'low': [35], 'density': [37, 103, 166], '(age': [38], '=': [39, 47, 230, 257], '56': [40], '±': [41, 49], '4': [42], 'years;': [43], 'femoral': [44], 'neck': [45], 'T-score': [46], '−1.5': [48], '0.6)': [50], 'were': [51, 115, 194], 'monitored': [52], 'by': [53, 302], 'high-resolution': [54], 'peripheral': [55], 'quantitative': [56], 'computed': [57], 'tomography': [58], '(HR-pQCT)': [59], 'for': [60, 196, 311], '24': [61, 118, 180], 'months': [62, 119, 181], 'following': [63], 'randomization': [64], 'alendronate': [66], '(ALN)': [67], 'or': [68], 'placebo': [69], '(PBO)': [70], 'treatment': [71, 177], 'groups.': [72], 'Subjects': [73], 'underwent': [74], 'annual': [75], 'HR-pQCT': [76, 130], 'imaging': [77], 'the': [79, 123, 128, 138, 145, 169, 197, 201, 211, 217, 295, 299], 'distal': [80, 124], 'radius': [81, 202, 218], 'tibia,': [83], 'dual-energy': [84], 'X-ray': [85], 'absorptiometry': [86], '(DXA),': [87], 'determination': [89], 'biochemical': [91], 'markers': [92], 'turnover': [95], '(BSAP': [96], 'uNTx).': [98], 'addition': [100], 'assessment,': [106], 'regional': [107], 'analysis,': [108], 'cortical': [109, 146, 265], 'porosity': [110, 268], 'quantification,': [111], 'micro-finite-element': [113], 'analysis': [114, 208], 'performed.': [116], 'After': [117], 'treatment,': [121], 'at': [122, 276], 'tibia': [125, 170, 220, 296], 'but': [126], 'not': [127], 'radius,': [129, 300], 'measures': [131, 143, 269], 'showed': [132, 172], 'significant': [133, 174, 187], 'improvements': [134], 'over': [135], 'baseline': [136], 'ALN': [139, 215, 293], 'group,': [140], 'particularly': [141], 'densitometric': [142], 'trabecular': [148, 227, 303], 'compartments': [149], 'endocortical': [151, 305], 'geometry': [152, 266], '(cortical': [153], 'thickness': [154], 'area,': [156], 'medullary': [157], 'area)': [158], '(p': [159, 182, 203], '&amp;lt;': [160, 183, 204, 235, 262, 283], '.05).': [161, 205, 263, 284], 'Cortical': [162], 'volumetric': [163], 'mineral': [165], '(vBMD)': [167], 'alone': [171], 'a': [173, 246, 288], 'difference': [175], 'between': [176], 'groups': [178], 'after': [179], '.05);': [184], 'however,': [185], 'regionally,': [186], 'differences': [188], 'Tb.vBMD,': [190], 'Tb.N,': [191], 'Ct.Th': [193], 'found': [195], 'lateral': [198], 'quadrant': [199], 'Spearman': [206], 'correlation': [207], 'revealed': [209], 'that': [210], 'biomechanical': [212], 'response': [213, 291], 'specifically': [222], 'associated': [223, 244], '(|ρ|': [229, 256], '0.51': [231], '0.80,': [233], 'p': [234, 261, 282], '.05),': [236], 'whereas': [237], 'PBO': [238], 'progression': [239], 'loss': [242], 'broad': [247], 'range': [248], 'density,': [252], 'geometry,': [253], '0.56': [258], '0.89,': [260], 'Baseline': [264], 'best': [270], 'predicted': [271], 'ALN-induced': [272], 'change': [273], 'biomechanics': [275], 'both': [277], 'sites': [278], '(ρ': [279], '&amp;gt;': [280], '0.48,': [281], 'These': [285], 'findings': [286], 'suggest': [287], 'more': [289], 'pronounced': [290], 'than': [297], 'driven': [301], 'changes.': [306], '©': [307], '2010': [308], 'American': [309], 'Society': [310], 'Bone': [312], 'Mineral': [314], 'Research.': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2021542350', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 31}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-12-23T17:18:28.026288', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
