Publication Information

{'id': 'https://openalex.org/W2021314556', 'doi': 'https://doi.org/10.1074/jbc.m109.058396', 'title': 'TRAMP Complex Enhances RNA Degradation by the Nuclear Exosome Component Rrp6', 'display_name': 'TRAMP Complex Enhances RNA Degradation by the Nuclear Exosome Component Rrp6', 'publication_year': 2009, 'publication_date': '2009-12-03', 'ids': {'openalex': 'https://openalex.org/W2021314556', 'doi': 'https://doi.org/10.1074/jbc.m109.058396', 'mag': '2021314556', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19955569', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2823493'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.058396', 'pdf_url': 'http://www.jbc.org/article/S0021925820810217/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820810217/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109034192', 'display_name': 'Kevin P. Callahan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin P. Callahan', 'raw_affiliation_strings': ['From the Departments of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I28792581']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014087589', 'display_name': 'J. Scott Butler', 'orcid': 'https://orcid.org/0000-0001-7428-2897'}, 'institutions': [{'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'J. Scott Butler', 'raw_affiliation_strings': ['Departments of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642', 'From the Departments of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642', 'the Center for RNA Biology: From Genome to Medicine, University of Rochester Medical Center, Rochester, New York 14642'], 'affiliations': [{'raw_affiliation_string': 'the Center for RNA Biology: From Genome to Medicine, University of Rochester Medical Center, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I28792581']}, {'raw_affiliation_string': 'Departments of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I28792581']}, {'raw_affiliation_string': 'From the Departments of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642', 'institution_ids': ['https://openalex.org/I28792581']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5014087589'], 'corresponding_institution_ids': ['https://openalex.org/I28792581'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 5.979, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 108, 'citation_normalized_percentile': {'value': 0.918299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '285', 'issue': '6', 'first_page': '3540', 'last_page': '3547'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exosome-complex', 'display_name': 'Exosome complex', 'score': 0.75183594}, {'id': 'https://openalex.org/keywords/tramp', 'display_name': 'Tramp', 'score': 0.7389484}, {'id': 'https://openalex.org/keywords/component', 'display_name': 'Component (thermodynamics)', 'score': 0.62356114}, {'id': 'https://openalex.org/keywords/degradation', 'display_name': 'Degradation', 'score': 0.5845519}, {'id': 'https://openalex.org/keywords/exosome', 'display_name': 'Exosome', 'score': 0.51650494}], 'concepts': [{'id': 'https://openalex.org/C75449159', 'wikidata': 'https://www.wikidata.org/wiki/Q418869', 'display_name': 'Exosome complex', 'level': 5, 'score': 0.75183594}, {'id': 'https://openalex.org/C2780940892', 'wikidata': 'https://www.wikidata.org/wiki/Q1965933', 'display_name': 'Tramp', 'level': 4, 'score': 0.7389484}, {'id': 'https://openalex.org/C168167062', 'wikidata': 'https://www.wikidata.org/wiki/Q1117970', 'display_name': 'Component (thermodynamics)', 'level': 2, 'score': 0.62356114}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.6032181}, {'id': 'https://openalex.org/C2779679103', 'wikidata': 'https://www.wikidata.org/wiki/Q5251805', 'display_name': 'Degradation (telecommunications)', 'level': 2, 'score': 0.5845519}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5406894}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52660596}, {'id': 'https://openalex.org/C2781261824', 'wikidata': 'https://www.wikidata.org/wiki/Q903634', 'display_name': 'Exosome', 'level': 5, 'score': 0.51650494}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34615785}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32327205}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.2654546}, {'id': 'https://openalex.org/C194993378', 'wikidata': 'https://www.wikidata.org/wiki/Q427087', 'display_name': 'Non-coding RNA', 'level': 4, 'score': 0.23186144}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.19578505}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.18256399}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.18088013}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11177692}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.0674524}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005095', 'descriptor_name': 'Exoribonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012331', 'descriptor_name': 'RNA, Fungal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053487', 'descriptor_name': 'DEAD-box RNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004259', 'descriptor_name': 'DNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004259', 'descriptor_name': 'DNA-Directed DNA Polymerase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004259', 'descriptor_name': 'DNA-Directed DNA Polymerase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005095', 'descriptor_name': 'Exoribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005095', 'descriptor_name': 'Exoribonucleases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D063326', 'descriptor_name': 'Exosome Multienzyme Ribonuclease Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011061', 'descriptor_name': 'Poly A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011061', 'descriptor_name': 'Poly A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026723', 'descriptor_name': 'Polyadenylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012331', 'descriptor_name': 'RNA, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.058396', 'pdf_url': 'http://www.jbc.org/article/S0021925820810217/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2823493', 'pdf_url': 'https://europepmc.org/articles/pmc2823493?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823493', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19955569', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m109.058396', 'pdf_url': 'http://www.jbc.org/article/S0021925820810217/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1575542444', 'https://openalex.org/W1902501542', 'https://openalex.org/W1968043375', 'https://openalex.org/W1979277911', 'https://openalex.org/W1987777159', 'https://openalex.org/W1988309554', 'https://openalex.org/W2003260938', 'https://openalex.org/W2016015573', 'https://openalex.org/W2032501207', 'https://openalex.org/W2039089865', 'https://openalex.org/W2040010148', 'https://openalex.org/W2048557198', 'https://openalex.org/W2048870226', 'https://openalex.org/W2050338283', 'https://openalex.org/W2052357841', 'https://openalex.org/W2057777173', 'https://openalex.org/W2074405508', 'https://openalex.org/W2084619201', 'https://openalex.org/W2089004878', 'https://openalex.org/W2101559095', 'https://openalex.org/W2102884156', 'https://openalex.org/W2103724315', 'https://openalex.org/W2104030280', 'https://openalex.org/W2104940829', 'https://openalex.org/W2106311348', 'https://openalex.org/W2106601322', 'https://openalex.org/W2129258942', 'https://openalex.org/W2135392625', 'https://openalex.org/W2144414956', 'https://openalex.org/W2146558686', 'https://openalex.org/W2148399348', 'https://openalex.org/W2150014428', 'https://openalex.org/W2154570701', 'https://openalex.org/W2155495457'], 'related_works': ['https://openalex.org/W2948732021', 'https://openalex.org/W2524166092', 'https://openalex.org/W2152432732', 'https://openalex.org/W2091141707', 'https://openalex.org/W2062012140', 'https://openalex.org/W2033773344', 'https://openalex.org/W2018981840', 'https://openalex.org/W2016247874', 'https://openalex.org/W1577230857', 'https://openalex.org/W1505600359'], 'abstract_inverted_index': {'The': [0], 'RNA-processing': [1], 'exosome': [2, 25, 41, 59, 69, 99], 'contains': [3], 'ribonucleases': [4], 'that': [5, 50, 77, 93, 115, 183], 'degrade': [6], 'aberrant': [7, 45], 'RNAs': [8], 'in': [9, 60, 90, 102, 124, 163, 200], 'archael': [10], 'and': [11], 'eukaryotic': [12], 'cells.': [13], 'In': [14, 30], 'Saccharomyces': [15], 'cerevisiae,': [16], 'the': [17, 23, 27, 32, 36, 39, 57, 63, 67, 106, 129, 141, 150, 175, 185, 192, 201], 'nuclear/nucleolar': [18], "3'-5'": [19], 'exoribonuclease': [20], 'Rrp6': [21, 89, 122, 145, 154, 178, 212], 'distinguishes': [22], 'nuclear': [24, 40, 58, 68, 98], 'from': [26, 138], 'cytoplasmic': [28], 'exosome.': [29], 'vivo,': [31], 'TRAMP': [33, 52, 72, 78, 94, 119, 147, 206], 'complex': [34], 'enhances': [35], 'ability': [37], 'of': [38, 66, 108, 117, 128, 131, 140, 144, 152, 177, 189, 195, 211], 'to': [42], 'destroy': [43], 'some': [44], 'RNAs.': [46], 'Previous': [47], 'reports': [48], 'showed': [49], 'purified': [51, 86, 118], 'enhanced': [53, 70], 'RNA': [54, 83, 132], 'degradation': [55, 84], 'by': [56, 71, 85, 180], 'vitro.': [61], 'However,': [62], 'exoribonucleolytic': [64], 'component(s)': [65], 'remain': [73], 'unidentified.': [74], 'We': [75, 167], 'show': [76, 114], 'does': [79], 'not': [80], 'significantly': [81], 'enhance': [82, 149], 'exosomes': [87], 'lacking': [88, 156], 'vitro,': [91], 'suggesting': [92, 182], 'activation': [95], 'experiments': [96], 'with': [97, 111, 120], 'preparations': [100], 'reflect,': [101], 'part,': [103], 'effects': [104], 'on': [105], 'activity': [107, 136, 143, 151, 179, 188, 194], 'Rrp6.': [109], 'Consistent': [110], 'this,': [112], 'we': [113], 'incubation': [116], 'recombinant': [121], 'results': [123, 137], 'a': [125, 157, 198], '10-fold': [126], 'enhancement': [127, 139, 176], 'rate': [130], 'degradation.': [133], 'This': [134], 'increased': [135], 'hydrolytic': [142], 'because': [146], 'cannot': [148], 'an': [153, 208], 'mutant': [155], 'key': [158], 'amino': [159], 'acid': [160], 'side': [161], 'chain': [162], 'its': [164], 'active': [165], 'site.': [166], 'observed': [168], 'no': [169], 'ATP': [170], 'or': [171], 'polyadenylation': [172], 'dependence': [173], 'for': [174], 'TRAMP,': [181], 'neither': [184], 'poly(A)': [186], 'polymerase': [187], 'Trf4': [190], 'nor': [191], 'helicase': [193], 'Mtr4': [196], 'plays': [197], 'role': [199], 'enhancement.': [202], 'These': [203], 'findings': [204], 'identify': [205], 'as': [207], 'exosome-independent': [209], 'enhancer': [210], 'activity.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2021314556', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-08T09:09:43.577575', 'created_date': '2016-06-24'}