Publication Information

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[30], 'exclusion': [31], 'from': [32, 90], 'chronic': [33], 'obstructive': [34], 'pulmonary': [35], 'disease': [36], '(COPD)': [37], 'studies.Objectives:': [38], 'To': [39], 'characterize': [40], 'the': [41, 91, 97, 114, 128, 146, 223], 'clinical,': [42], 'functional,': [43], 'and': [44, 59, 64, 73, 85, 111, 118, 130, 137, 156, 168, 181, 188, 204, 208, 235, 247, 257, 269], 'radiographic': [45], 'features': [46], 'Global': [48], 'Initiative': [49], 'for': [50, 162], 'Chronic': [51], 'Obstructive': [52], 'Lung': [53], 'Disease': [54], '(GOLD)-Unclassified': [55], '(FEV1/FVC': [56, 70], '≥': [57, 71], '0.7': [58], '<': [61, 75], '80%': [62], 'predicted)': [63], 'lower': [65], 'limits': [66], 'normal': [68, 82], '(LLN)-unclassified': [69], 'LLN': [72, 217], 'LLN)': [76], 'subjects': [77, 86, 94, 103, 149, 187, 189, 193, 203, 213, 228, 237], 'compared': [78, 199, 211], 'COPD.Methods:': [88], 'Data': [89], 'first': [92], '2,500': [93], 'enrolled': [95], 'in': [96, 145, 166], 'COPDGene': [98, 167], 'study': [99], 'were': [100, 112, 124, 143, 219, 229], 'analyzed.': [101], 'All': [102], 'had': [104], '10': [105], 'or': [106], 'more': [107], 'pack-years': [108], 'smoking': [110, 201], 'between': [113], 'ages': [115], '45': [117], '80': [119], 'years.': [120], 'Multivariate': [121], 'regression': [122], 'models': [123], 'constructed': [125], 'determine': [127], 'clinical': [129], 'radiological': [131], 'variables': [132, 154], 'associated': [133], 'GOLD-Unclassified': [135], '(GOLD-U)': [136], 'LLN-Unclassified': [138, 236], 'status.': [139], 'Separate': [140], 'multivariate': [141], 'regressions': [142], 'performed': [144], 'subgroups': [147], 'complete': [151], 'radiologic': [152], 'measurement': [153], 'available.Measurements': [155], 'Main': [157], 'Results:': [158], 'GOLD-U': [159, 192, 234], 'account': [161], '9%': [163], 'increased': [170, 195, 281], 'body': [171], 'mass': [172], 'index': [173], '(BMI),': [174], 'disproportionately': [176], 'total': [178, 250], 'capacity,': [180], 'higher': [183], 'nonwhite': [186], 'diabetes.': [191], 'exhibit': [194], 'airway': [196], 'wall': [197], 'thickness': [198], 'control': [202], 'decreased': [205], 'gas': [206], 'trapping': [207], 'bronchodilator': [209], 'responsiveness': [210], 'COPD.': [215], 'When': [216], 'criteria': [218], 'used': [220], 'define': [222], '“unclassified”': [224], 'group,': [225], 'African': [226], 'American': [227], 'no': [230], 'longer': [231], 'overrepresented.': [232], 'Both': [233], 'demonstrated': [238], 'wide': [240], 'range': [241], 'impairment,': [245], 'BMI,': [246], 'percentage': [248], 'emphysema.Conclusions:': [252], 'Subjects': [253], 'ratio': [261], 'heterogeneous': [264], 'symptoms': [268], 'functional': [270], 'limitation': [271], 'who': [272], 'likely': [273], 'variety': [276], 'underlying': [278], 'etiologies': [279], 'beyond': [280], 'BMI.Clinical': [282], 'trial': [283], 'registered': [284], 'www.clinicaltrials.gov': [286], '(NCT000608764).': [287]}, 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