Title: Ruthenium-Catalyzed Asymmetric Hydrogenation of <i>N</i>-Boc-Indoles
Abstract: Highly enantioselective hydrogenation of various N-Boc-indoles proceeded successfully in the presence of the ruthenium complex generated from an appropriate ruthenium precursor and a trans-chelate chiral bisphosphine PhTRAP. Various 2- or 3-substituted indoles were converted into chiral indolines with high enantiomeric excesses (up to 95% ee). The PhTRAP-ruthenium catalyst was able to promote the hydrogenation of 2,3-dimethylindoles, giving cis-2,3-dimethylindolines with 72% ee.
Publication Year: 2006
Publication Date: 2006-05-18
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 185
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot