Publication Information

{'id': 'https://openalex.org/W2020753350', 'doi': 'https://doi.org/10.1074/jbc.m112.366807', 'title': 'The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation', 'display_name': 'The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation', 'publication_year': 2012, 'publication_date': '2012-07-10', 'ids': {'openalex': 'https://openalex.org/W2020753350', 'doi': 'https://doi.org/10.1074/jbc.m112.366807', 'mag': '2020753350', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22778262', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3436160'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.366807', 'pdf_url': 'http://www.jbc.org/article/S0021925820632094/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820632094/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058165673', 'display_name': 'Julien Moretti', 'orcid': 'https://orcid.org/0000-0002-3415-9058'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Julien Moretti', 'raw_affiliation_strings': ['Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'University Pierre et Marie Curie, Cellule Pasteur UPMC, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'University Pierre et Marie Curie, Cellule Pasteur UPMC, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I39804081']}, {'raw_affiliation_string': 'Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035249300', 'display_name': 'Patricia Chastagner', 'orcid': 'https://orcid.org/0000-0001-5751-9645'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Patricia Chastagner', 'raw_affiliation_strings': ['Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022376007', 'display_name': 'Chih‐Chao Liang', 'orcid': 'https://orcid.org/0000-0001-5039-7008'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chih-Chao Liang', 'raw_affiliation_strings': ['Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024570139', 'display_name': 'Martin A. Cohn', 'orcid': 'https://orcid.org/0000-0002-2988-3009'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin A. Cohn', 'raw_affiliation_strings': ['Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104101336', 'display_name': 'Alain Israël', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alain Israël', 'raw_affiliation_strings': ['Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029854536', 'display_name': 'Christel Brou', 'orcid': 'https://orcid.org/0000-0003-0229-8202'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Christel Brou', 'raw_affiliation_strings': ['Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Pasteur and CNRS Unité de Recherche Associée (URA) 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5029854536'], 'corresponding_institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I1294671590'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.55, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '287', 'issue': '35', 'first_page': '29429', 'last_page': '29441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9926, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/degradation', 'display_name': 'Degradation', 'score': 0.51320505}, {'id': 'https://openalex.org/keywords/negative-regulator', 'display_name': 'Negative regulator', 'score': 0.46467835}, {'id': 'https://openalex.org/keywords/deubiquitinating-enzyme', 'display_name': 'Deubiquitinating enzyme', 'score': 0.4557812}], 'concepts': [{'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.8524053}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7532696}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.7231531}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.6816479}, {'id': 'https://openalex.org/C2779679103', 'wikidata': 'https://www.wikidata.org/wiki/Q5251805', 'display_name': 'Degradation (telecommunications)', 'level': 2, 'score': 0.51320505}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5052441}, {'id': 'https://openalex.org/C3017707949', 'wikidata': 'https://www.wikidata.org/wiki/Q2138797', 'display_name': 'Negative regulator', 'level': 3, 'score': 0.46467835}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46308902}, {'id': 'https://openalex.org/C102658986', 'wikidata': 'https://www.wikidata.org/wiki/Q5266092', 'display_name': 'Deubiquitinating enzyme', 'level': 4, 'score': 0.4557812}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.40410596}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.35512775}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2394492}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06329098}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.051796377}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D051880', 'descriptor_name': 'Receptors, Notch', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051880', 'descriptor_name': 'Receptors, Notch', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051880', 'descriptor_name': 'Receptors, Notch', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.366807', 'pdf_url': 'http://www.jbc.org/article/S0021925820632094/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3436160', 'pdf_url': 'https://europepmc.org/articles/pmc3436160?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22778262', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.366807', 'pdf_url': 'http://www.jbc.org/article/S0021925820632094/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1526207627', 'https://openalex.org/W1660631781', 'https://openalex.org/W1972682144', 'https://openalex.org/W1993775542', 'https://openalex.org/W1995068520', 'https://openalex.org/W1997801717', 'https://openalex.org/W2006548753', 'https://openalex.org/W2008207745', 'https://openalex.org/W2012325184', 'https://openalex.org/W2016099927', 'https://openalex.org/W2019007505', 'https://openalex.org/W2020036904', 'https://openalex.org/W2020536597', 'https://openalex.org/W2022278464', 'https://openalex.org/W2031009502', 'https://openalex.org/W2037475776', 'https://openalex.org/W2040611862', 'https://openalex.org/W2051459755', 'https://openalex.org/W2051894580', 'https://openalex.org/W2064585727', 'https://openalex.org/W2082195162', 'https://openalex.org/W2106969933', 'https://openalex.org/W2109755778', 'https://openalex.org/W2118225942', 'https://openalex.org/W2118642448', 'https://openalex.org/W2118810801', 'https://openalex.org/W2131004933', 'https://openalex.org/W2134805829', 'https://openalex.org/W2145319683', 'https://openalex.org/W2158588008'], 'related_works': ['https://openalex.org/W2888617581', 'https://openalex.org/W2784005223', 'https://openalex.org/W2770653741', 'https://openalex.org/W2611649496', 'https://openalex.org/W2159751912', 'https://openalex.org/W2067364318', 'https://openalex.org/W2056210416', 'https://openalex.org/W2034032029', 'https://openalex.org/W2020053069', 'https://openalex.org/W1954801073'], 'abstract_inverted_index': {'Notch': [0, 22, 30, 38, 44, 57, 69, 92, 98, 122, 138, 155], 'signaling': [1, 45, 156], 'is': [2, 46], 'critical': [3], 'for': [4], 'development': [5], 'and': [6, 50, 71, 82, 118, 142], 'adult': [7], 'tissue': [8], 'physiology,': [9], 'controlling': [10], 'cell': [11, 61, 116, 140], 'fate': [12], 'in': [13, 73, 139, 143], 'a': [14, 105, 120, 148], 'context-dependent': [15], 'manner.': [16], 'Upon': [17], 'ligand': [18], 'binding,': [19], 'the': [20, 35, 54, 60, 74, 101, 115, 125, 134, 158], 'transmembrane': [21], 'receptor': [23, 58, 113], 'undergoes': [24], 'two': [25], 'ordered': [26], 'proteolytic': [27], 'cleavages': [28], 'releasing': [29], 'intracellular': [31], 'domain,': [32], 'which': [33], 'regulates': [34], 'transcription': [36], 'of': [37, 43, 47, 56, 76, 91, 112, 137, 151, 154], 'target': [39], 'genes.': [40], 'The': [41], 'strength': [42], 'crucial': [48], 'importance': [49], 'depends': [51], 'notably': [52], 'on': [53], 'quantity': [55], 'at': [59, 114], 'surface.': [62], 'Using': [63], 'an': [64, 109], 'shRNA': [65], 'library': [66], 'screen': [67], 'monitoring': [68], 'trafficking': [70, 99], 'degradation': [72], 'absence': [75], 'ligand,': [77], 'we': [78], 'identified': [79], 'mammalian': [80], 'USP12': [81, 94, 128], 'its': [83, 130], 'Drosophila': [84], 'melanogaster': [85], 'homolog': [86], 'as': [87, 104], 'novel': [88], 'negative': [89], 'regulators': [90], 'signaling.': [93], 'silencing': [95], 'specifically': [96], 'interrupts': [97], 'to': [100, 108, 119], 'lysosomes': [102], 'and,': [103], 'consequence,': [106], 'leads': [107], 'increased': [110], 'amount': [111], 'surface': [117], 'higher': [121], 'activity.': [123], 'At': [124], 'biochemical': [126], 'level,': [127], 'with': [129], 'activator': [131], 'UAF1': [132], 'deubiquitinate': [133], 'nonactivated': [135], 'form': [136], 'culture': [141], 'vitro.': [144], 'These': [145], 'results': [146], 'characterize': [147], 'new': [149], 'level': [150], 'conserved': [152], 'regulation': [153], 'by': [157], 'ubiquitin': [159], 'system.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2020753350', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-08T17:31:55.520860', 'created_date': '2016-06-24'}