Title: Lymphocyte α-mannosidase — A supplementary test for determining mannosidosis genotype in cattle
Abstract: Abstract Extract Mannosidosis is an inherited neurological disease of Angus calves associated with a deficiency of lysosomal α-mannosidase (Hocking et al., 1972 Boyum, A. 1968. Isolation of leucocytes from human blood. Further observations. Scand. J. clin, lab. Invest., 21(Suppl. 97) [Google Scholar]). The disease can now be controlled through the ability to recognize heterozygous individuals that have less than half the normal levels of plasma α-mannosidase activity (Jolly et al., 1973 de Duve, C. 1963. “The lysosome concept”. In Lysosomes, Edited by: de Reuck, A. V. S. and Cameron, M. P. 1–31. London: Churchill. In [Google Scholar]; 1974a Hocking, J. D., Jolly, R. D. and Batt, R. D. 1972. Deficiency of α-mannosidase in Angus cattle. Biochem. J., 128: 69–78. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). As a consequence a test and control program, has been developed within the Angus bult-breeding herds of New Zealand, to be run by the Ministry of Agriculture and Fisheries in conjunction with the New Zealand Angus Association (Jolly et al., 1974b Jolly, R. D., Tse, C. A. and Greenway, R. M. 1973. Plasma α-mannosidase activity as a means of detecting mannosidosis heterozygotes. N.Z. vet. J., 21: 64–69. [Taylor & Francis Online] , [Google Scholar],c Jolly, R. D., Thompson, K. G., Tse, C. A., Munford, R. D. and Merrall, M. 1974a. Identification of mannosidosis heterozygotes — factors affecting normal plasma α-mannosidase levels. N.Z. vet. J., 22: 155–162. [Taylor & Francis Online] , [Google Scholar]). Because various factors may influence plasma α-mannosidase activity, it is necessary to analyse results within relatively homogeneous age, sex and mob groups on the one property (Jolly et al., 1974a Jolly, R. D., Thompson, K. D. and Tse, C. A. 1974b. Evaluation of a screening programme for identification of mannosidosis heterozygotes in Angus cattle. N.Z. vet. J., 22: 185–190. [Taylor & Francis Online] , [Google Scholar] and unpublished data). In most groups there will be a small overlap area which, includes animals with high heterozygous and low normal values. Designation of the genotype of individuals in this area may be facilitated by reference to the genotype of parents when known, but there will remain a small percentage where a diagnosis cannot be made with an acceptable degree of probability. This applies especially where; groups are small, or when single animals are tested. For this reason the need for a supplementary test has been recognized (Jolly et al., 1974c Jolly, R. D., Digby, J. G. and Rammell, C. G. 1974c. A mass screening programme of Angus cattle for the mannosidosis genotype — a prototype programme for control of inherited diseases in animals. N.Z. vet. J., 22: 218–222. [Taylor & Francis Online] , [Google Scholar]). This paper presents an evaluation of the supplementary test currently used for animals whose plasma test was equivocal.
Publication Year: 1976
Publication Date: 1976-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 6
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