Title: A mechanism for effects of nitric oxide donors on LPS-induced pulmonary oedema
Abstract: I am writing to you regarding the Letter to the Editor submitted by Dr. Michael Eisenhut about our recent article. 2 Xia Z.Y. Wang X.Y. Chen X. Xia Z. Effect of NO donor sodium nitroprusside on lipopolysaccharide induced acute lung injury in rats. Injury. 2007; 38: 53-59 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar A mechanism for effects of nitric oxide donors on LPS-induced pulmonary oedemaInjuryVol. 38Issue 10PreviewThe authors of a recent article7 demonstrated that sodium nitroprusside (SNP) is able to reduce lung oedema formation induced by LPS in the rat model. It was suggested that NO may down-regulate inducible nitric oxide synthase expression by an inhibitory action on NF-kB activation, due to its direct blockade of phosphorylation and subsequent degradation of IkB-alpha via the cGMP-independent pathway. Previous studies showed contradictory results regarding effects of nitric oxide on pulmonary oedema associated with a systemic inflammatory response. Full-Text PDF
Publication Year: 2007
Publication Date: 2007-10-01
Language: en
Type: article
Indexed In: ['crossref']
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