Title: <i>Pneumocystis jirovecii</i> Dihydropteroate Synthase Gene Mutations and Human Immunodeficiency Virus‐Associated <i>Pneumocystis</i> Pneumonia
Abstract: Journal of Eukaryotic MicrobiologyVolume 53, Issue s1 p. S114-S116 Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations and Human Immunodeficiency Virus-Associated Pneumocystis Pneumonia LAURENCE HUANG, LAURENCE HUANG HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorDAVID A. WELSH, DAVID A. WELSH Pulmonary and Critical Care Medicine, Medical Center of Louisiana at New Orleans, Louisiana State University Health Sciences Center, New Orleans, Los Angeles, andSearch for more papers by this authorROBERT F. MILLER, ROBERT F. MILLER Department of Population Sciences and Primary Care, Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, London, United Kingdom, andSearch for more papers by this authorC. BEN BEARD, C. BEN BEARD Division of Vector-Borne Infectious Diseases, Bacterial Diseases Branch, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado, andSearch for more papers by this authorGENA G. LAWRENCE, GENA G. LAWRENCE Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this authorMELISSA FOX, MELISSA FOX Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this authorALEXANDRA SWARTZMAN, ALEXANDRA SWARTZMAN HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorMATTHEW R. BENSLEY, MATTHEW R. BENSLEY HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorDENISE CARBONNET, DENISE CARBONNET Pulmonary and Critical Care Medicine, Medical Center of Louisiana at New Orleans, Louisiana State University Health Sciences Center, New Orleans, Los Angeles, andSearch for more papers by this authorJ. LUCIAN DAVIS, J. LUCIAN DAVIS Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorAMY CHI, AMY CHI HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorBECKY J. YOO, BECKY J. YOO HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorJEFFREY L. JONES, JEFFREY L. JONES Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this author LAURENCE HUANG, LAURENCE HUANG HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorDAVID A. WELSH, DAVID A. WELSH Pulmonary and Critical Care Medicine, Medical Center of Louisiana at New Orleans, Louisiana State University Health Sciences Center, New Orleans, Los Angeles, andSearch for more papers by this authorROBERT F. MILLER, ROBERT F. MILLER Department of Population Sciences and Primary Care, Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, London, United Kingdom, andSearch for more papers by this authorC. BEN BEARD, C. BEN BEARD Division of Vector-Borne Infectious Diseases, Bacterial Diseases Branch, U.S. Centers for Disease Control and Prevention, Fort Collins, Colorado, andSearch for more papers by this authorGENA G. LAWRENCE, GENA G. LAWRENCE Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this authorMELISSA FOX, MELISSA FOX Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this authorALEXANDRA SWARTZMAN, ALEXANDRA SWARTZMAN HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorMATTHEW R. BENSLEY, MATTHEW R. BENSLEY HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorDENISE CARBONNET, DENISE CARBONNET Pulmonary and Critical Care Medicine, Medical Center of Louisiana at New Orleans, Louisiana State University Health Sciences Center, New Orleans, Los Angeles, andSearch for more papers by this authorJ. LUCIAN DAVIS, J. LUCIAN DAVIS Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorAMY CHI, AMY CHI HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorBECKY J. YOO, BECKY J. YOO HIV/AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, andSearch for more papers by this authorJEFFREY L. JONES, JEFFREY L. JONES Division of Parasitic Diseases, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, GeorgiaSearch for more papers by this author First published: 27 November 2006 https://doi.org/10.1111/j.1550-7408.2006.00195.xCitations: 10 Corresponding Author: L. Huang, HIV/AIDS Division and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA—Telephone number: +1-415-476-4082, extension 406; FAX number: +1-415-476-6953; e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat LITERATURE CITED Beard, C. B., Carter, J. L., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N., Roberts, J. M., Hightower, A. W., Bens, M. S., Freeman, A. R., Lee, S., Stringer, J. R., Duchin, J. S., Del Rio, C., Rimland, D., Baughman, R. P., Levy, D. A., Dietz, V. J., Simon, P. & Navin, T. R. 2000. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg. Infect. Dis., 6: 265–272. Beard, C. B., Roux, P., Nevez, G., Hauser, P. M., Kovacs, J. A., Unnasch, T. R. & Lundgren, B. 2004. Strain typing methods and molecular epidemiology of Pneumocystis pneumonia. Emerg. Infect. Dis., 10: 1729–1735. Benson, C. A., Kaplan, J. E., Masur, H., Pau, A. & Holmes, K. K. 2004. Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. MMWR Recomm. Rep., 53: 1–112. Costa, M. C., Helweg-Larsen, J., Lundgren, B., Antunes, F. & Matos, O. 2003. Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia. Int. J. Antimicrob. Agents, 22: 516–520. Crothers, K., Beard, C. B., Turner, J., Groner, G., Fox, M., Morris, A., Eiser, S. & Huang, L. 2005. Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. AIDS, 19: 801–805. Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D. & Lundgren, B. 1999. Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia. Lancet, 354: 1347–1351. Huang, L., Hecht, F. M., Stansell, J. D., Montanti, R., Hadley, W. K. & Hopewell, P. C. 1995. Suspected Pneumocystis carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful? Am. J. Respir. Crit. Care Med., 151: 1866–1871. Huang, L., Beard, C. B., Creasman, J., Levy, D., Duchin, J. S., Lee, S., Pieniazek, N., Carter, J. L., Del Rio, C., Rimland, D. & Navin, T. R. 2000. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. J. Infect. Dis., 182: 1192–1198. Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M. & Helweg-Larsen, J. 2004. Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. Emerg. Infect. Dis., 10: 1721–1728. Iliades, P., Meshnick, S. R. & Macreadie, I. G. 2004a. Dihydropteroate synthase mutations in Pneumocystis jiroveci can affect sulfamethoxazole resistance in a Saccharomyces cerevisiae model. Antimicrob. Agents Chemother., 48: 2617–2623. Iliades, P., Meshnick, S. R. & Macreadie, I. G. 2005b. Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs. Antimicrob. Agents Chemother., 49: 741–748. Kazanjian, P., Locke, A. B., Hossler, P. A., Lane, B. R., Bartlett, M. S., Smith, J. W., Cannon, M. & Meshnick, S. R. 1998. Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients. AIDS, 12: 873–878. Kazanjian, P., Armstrong, W., Hossler, P. A., Burman, W., Richardson, J., Lee, C. H., Crane, L., Katz, J. & Meshnick, S. R. 2000. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J. Infect. Dis., 182: 551–557. Lane, B. R., Ast, J. C., Hossler, P. A., Mindell, D. P., Bartlett, M. S., Smith, J. W. & Meshnick, S. R. 1997. Dihydropteroate synthase polymorphisms in Pneumocystis carinii. J. Infect. Dis., 175: 482–485. Ma, L., Borio, L., Masur, H. & Kovacs, J. A. 1999. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. J. Infect. Dis., 180: 1969–1978. Ma, L., Kovacs, J. A., Cargnel, A., Valerio, A., Fantoni, G. & Atzori, C. 2002. Mutations in the dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxis. J. Infect. Dis., 185: 1530–1532. Meneau, I., Sanglard, D., Bille, J. & Hauser, P. M. 2004. Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob. Agents Chemother., 48: 2610–2616. Morris, A., Lundgren, J. D., Masur, H., Walzer, P. D., Hanson, D. L., Frederick, T., Huang, L., Beard, C. B. & Kaplan, J. E. 2004. Current epidemiology of Pneumocystis pneumonia. Emerg. Infect. Dis., 10: 1713–1720. Navin, T. R., Beard, C. B., Huang, L., Del Rio, C., Lee, S., Pieniazek, N. J., Carter, J. L., Le, T., Hightower, A. & Rimland, D. 2001. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study. Lancet, 358: 545–549. Stein, C. R., Poole, C., Kazanjian, P. & Meshnick, S. R. 2004. Sulfa use, dihydropteroate synthase mutations, and Pneumocystis jirovecii pneumonia. Emerg. Infect. Dis., 10: 1760–1765. Citing Literature Volume53, Issues1November 2006Pages S114-S116 ReferencesRelatedInformation
Publication Year: 2006
Publication Date: 2006-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 13
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