Publication Information

{'id': 'https://openalex.org/W2020212296', 'doi': 'https://doi.org/10.1074/jbc.c000449200', 'title': 'Kinase Signaling Initiates Coat Complex II (COPII) Recruitment and Export from the Mammalian Endoplasmic Reticulum', 'display_name': 'Kinase Signaling Initiates Coat Complex II (COPII) Recruitment and Export from the Mammalian Endoplasmic Reticulum', 'publication_year': 2000, 'publication_date': '2000-11-01', 'ids': {'openalex': 'https://openalex.org/W2020212296', 'doi': 'https://doi.org/10.1074/jbc.c000449200', 'mag': '2020212296', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11001944'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c000449200', 'pdf_url': 'http://www.jbc.org/article/S0021925820886554/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820886554/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001216483', 'display_name': 'Meir Aridor', 'orcid': 'https://orcid.org/0000-0003-4119-6233'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Meir Aridor', 'raw_affiliation_strings': ['Departments of Cell and Molecular Biology and the Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037, USA.'], 'affiliations': [{'raw_affiliation_string': 'Departments of Cell and Molecular Biology and the Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037, USA.', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079375370', 'display_name': 'William E. Balch', 'orcid': 'https://orcid.org/0000-0003-0899-8381'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William E. Balch', 'raw_affiliation_strings': ['Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.2, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 116, 'citation_normalized_percentile': {'value': 0.944536, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '275', 'issue': '46', 'first_page': '35673', 'last_page': '35676'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/copii', 'display_name': 'COPII', 'score': 0.9947159}, {'id': 'https://openalex.org/keywords/copi', 'display_name': 'COPI', 'score': 0.71805084}], 'concepts': [{'id': 'https://openalex.org/C46617944', 'wikidata': 'https://www.wikidata.org/wiki/Q410907', 'display_name': 'COPII', 'level': 5, 'score': 0.9947159}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.8330096}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.76020026}, {'id': 'https://openalex.org/C206912223', 'wikidata': 'https://www.wikidata.org/wiki/Q21111963', 'display_name': 'COPI', 'level': 5, 'score': 0.71805084}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43591702}, {'id': 'https://openalex.org/C6492254', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretory pathway', 'level': 4, 'score': 0.24479014}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.24401557}], 'mesh': [{'descriptor_ui': 'D022181', 'descriptor_name': 'COP-Coated Vesicles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020559', 'descriptor_name': 'Monomeric GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022181', 'descriptor_name': 'COP-Coated Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020690', 'descriptor_name': 'GTPase-Activating Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020559', 'descriptor_name': 'Monomeric GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c000449200', 'pdf_url': 'http://www.jbc.org/article/S0021925820886554/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11001944', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.c000449200', 'pdf_url': 'http://www.jbc.org/article/S0021925820886554/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1491410831', 'https://openalex.org/W1540423321', 'https://openalex.org/W1566771367', 'https://openalex.org/W1578056497', 'https://openalex.org/W1823067696', 'https://openalex.org/W1884442241', 'https://openalex.org/W1971476311', 'https://openalex.org/W1998749044', 'https://openalex.org/W2002426370', 'https://openalex.org/W2003123776', 'https://openalex.org/W2004422661', 'https://openalex.org/W2005777386', 'https://openalex.org/W2009572502', 'https://openalex.org/W2029152767', 'https://openalex.org/W2035124140', 'https://openalex.org/W2045893780', 'https://openalex.org/W2053279473', 'https://openalex.org/W2063180744', 'https://openalex.org/W2079869381', 'https://openalex.org/W2092356580', 'https://openalex.org/W2097020042', 'https://openalex.org/W2100837269', 'https://openalex.org/W2104360518', 'https://openalex.org/W2106735529', 'https://openalex.org/W2137755719', 'https://openalex.org/W2162194520', 'https://openalex.org/W2169112189', 'https://openalex.org/W2179777589', 'https://openalex.org/W2329844962'], 'related_works': ['https://openalex.org/W2908322185', 'https://openalex.org/W2146422967', 'https://openalex.org/W2143219870', 'https://openalex.org/W2125366654', 'https://openalex.org/W2029387709', 'https://openalex.org/W2012749282', 'https://openalex.org/W2003993233', 'https://openalex.org/W1971476311', 'https://openalex.org/W1943315667', 'https://openalex.org/W1914535079'], 'abstract_inverted_index': {'The': [0, 130, 662, 707, 1202, 1216, 1336, 1814, 2003, 2056, 2205, 2442], 'events': [1, 131, 3660], 'regulating': [2, 132, 795, 2349], 'coat': [3, 98, 133, 228, 260, 295, 545, 839, 951, 1352, 1398, 1547, 2370, 3663, 3864], 'complex': [4, 134, 261, 296, 416, 470, 546, 681, 1353, 1358, 1399, 3228, 3465, 3526], 'II': [5, 135, 297], '(COPII)': [6, 136], 'vesicle': [7, 121, 137, 251, 838, 889, 914, 2466, 2507, 2702, 2895, 3166, 3191], 'formation': [8, 122, 138, 252, 1280, 1337, 2703, 3192, 3636], 'involved': [9, 139, 304, 533, 831, 2827, 2833, 2932, 3072, 3661], 'in': [10, 42, 58, 123, 140, 172, 188, 253, 305, 529, 534, 714, 794, 832, 866, 912, 1100, 1119, 1126, 1153, 1558, 1563, 1630, 1633, 1697, 1705, 1722, 1765, 1799, 1871, 1906, 1943, 1955, 2071, 2166, 2348, 2358, 2479, 2618, 2834, 2933, 3093, 3164, 3176, 3189, 3216, 3239, 3286, 3300, 3411, 3419, 3592, 3619, 3662, 3675, 3760, 3767, 3772, 3950, 4073, 4083, 4087], 'the': [11, 16, 29, 32, 52, 74, 91, 94, 109, 141, 146, 159, 162, 182, 204, 221, 224, 239, 293, 311, 367, 372, 375, 386, 399, 402, 407, 410, 468, 472, 479, 488, 526, 530, 535, 541, 544, 575, 579, 670, 679, 685, 715, 798, 864, 881, 909, 1101, 1154, 1183, 1342, 1346, 1350, 1356, 1393, 1396, 1484, 1507, 1536, 1564, 1574, 1612, 1623, 1634, 1656, 1659, 1661, 1706, 1723, 1730, 1736, 1766, 1774, 1795, 1800, 1811, 1835, 1872, 1885, 1944, 1956, 1975, 1978, 1980, 1995, 2000, 2012, 2035, 2042, 2063, 2072, 2083, 2150, 2154, 2160, 2167, 2179, 2188, 2193, 2298, 2310, 2342, 2345, 2353, 2367, 2380, 2385, 2431, 2440, 2445, 2475, 2480, 2494, 2506, 2524, 2573, 2580, 2608, 2619, 2630, 2669, 2714, 2780, 2816, 2819, 2835, 2840, 2843, 2875, 2902, 2926, 2929, 2947, 3030, 3039, 3087, 3094, 3108, 3161, 3226, 3235, 3240, 3254, 3275, 3290, 3301, 3404, 3412, 3420, 3427, 3430, 3437, 3441, 3447, 3460, 3490, 3495, 3499, 3520, 3523, 3589, 3635, 3677, 3729, 3748, 3751, 3773, 3806, 3845, 3861, 3924, 3935, 4054, 4057, 4074, 4084], 'export': [12, 48, 105, 116, 142, 178, 235, 246, 309, 428, 868, 2351, 2382, 2578, 2935, 3031, 3453, 3679, 3925, 3956, 3983, 4031, 4036, 4059], 'of': [13, 31, 55, 82, 93, 101, 106, 119, 143, 161, 185, 212, 223, 231, 236, 249, 285, 374, 381, 401, 467, 537, 578, 664, 836, 884, 1103, 1123, 1158, 1338, 1345, 1395, 1486, 1506, 1566, 1577, 1638, 1658, 1702, 1708, 1725, 1797, 1837, 1876, 1902, 1948, 1958, 1977, 1986, 2005, 2014, 2031, 2037, 2058, 2066, 2074, 2095, 2169, 2178, 2199, 2207, 2215, 2301, 2313, 2325, 2344, 2447, 2484, 2487, 2496, 2503, 2526, 2564, 2569, 2576, 2602, 2610, 2638, 2671, 2685, 2716, 2776, 2779, 2822, 2837, 2928, 2949, 2987, 3032, 3089, 3096, 3111, 3117, 3225, 3237, 3258, 3282, 3294, 3303, 3397, 3422, 3429, 3440, 3462, 3507, 3517, 3522, 3563, 3586, 3629, 3637, 3750, 3762, 3805, 3844, 3947, 4017, 4029, 4034, 4056, 4077], 'cargo': [14, 47, 107, 144, 177, 237, 306, 420, 422, 474, 573, 673, 892, 2350, 2450, 2577, 3037, 3674, 3712, 3727, 3738, 3771, 3855, 4078], 'from': [15, 108, 145, 238, 310, 366, 406, 478, 487, 574, 955, 1020, 1032, 1810, 1999, 2352, 2439, 2456, 2579, 3038, 3172], 'endoplasmic': [17, 147, 263, 312], 'reticulum': [18, 148, 264, 313], '(ER)': [19, 149, 314], 'are': [20, 150, 299, 493, 525, 719, 2535, 2711, 3068, 3104, 3272, 3643], 'unknown.': [21, 151, 722], 'COPII': [22, 40, 86, 97, 102, 120, 152, 170, 216, 227, 232, 250, 403, 491, 580, 837, 877, 885, 913, 950, 1286, 1339, 1526, 1712, 1850, 1997, 2024, 2052, 2369, 2477, 2498, 2615, 2701, 2894, 3091, 3165, 3190, 3283, 3638, 3678, 3863, 4081], 'recruitment': [23, 45, 66, 81, 92, 103, 153, 175, 196, 211, 222, 233, 400, 466, 883, 898, 1035, 1037, 1344, 1394, 1485, 1545, 1673, 1713, 1825, 1836, 2004, 2044, 2209, 2230, 2307, 2329, 2592, 2616, 2697, 2919, 3255, 3281, 3428, 3439, 3503, 3521, 3560, 3585], 'to': [24, 50, 67, 154, 180, 197, 302, 398, 409, 412, 427, 475, 495, 497, 540, 674, 678, 684, 879, 886, 899, 904, 984, 1400, 1516, 1522, 1535, 1617, 1651, 1653, 1711, 1734, 1773, 1842, 1993, 2159, 2211, 2304, 2317, 2376, 2500, 2505, 2523, 2531, 2572, 2589, 2613, 2687, 2692, 2720, 2885, 2891, 2914, 2920, 2942, 3010, 3070, 3078, 3106, 3123, 3181, 3221, 3229, 3284, 3450, 3558, 3625, 3645, 3708, 3740, 3769, 3801, 3857, 3927, 3929, 4027, 4061], 'membranes': [25, 68, 155, 198, 901, 1402, 1514, 1555, 1613, 1662, 1704, 1775, 1780, 1843, 2165, 2194, 2459, 2921, 3080, 3128, 3285], 'is': [26, 126, 156, 256, 369, 818, 902, 918, 1480, 1540, 1904, 2231, 2454, 2529, 2598, 2623, 3007, 3262, 3399, 3481, 3498, 3513, 3527, 3579, 3588, 3745, 3984], 'initiated': [27, 157, 370, 1533, 3528], 'by': [28, 88, 158, 218, 371, 385, 481, 709, 871, 1239, 1355, 1621, 1666, 1716, 1794, 1844, 3081, 3260, 3268, 3425, 3494, 3511, 3529, 3573, 3986, 4080], 'activation': [30, 160, 373, 395, 843, 1405, 1524, 1530, 1806, 1901, 2046, 2236, 3257, 3424, 3510, 3562, 3761, 3946], 'small': [33, 163, 376, 3508], 'GTPase': [34, 164, 377, 1348, 3509], 'Sar1.': [35, 165], 'We': [36, 61, 71, 166, 191, 201, 723, 859, 894, 1387, 1880, 2339, 2355, 3941, 4051, 4104], 'have': [37, 167, 788, 860, 1388, 1881, 2080, 2491, 2667, 3018, 3416, 3623, 3669, 3942], 'utilized': [38, 168, 1858, 2336, 2356, 2771], 'purified': [39, 169, 876, 929, 954, 1285, 1846, 2023, 2172, 2368, 2476, 2497, 3090], 'components': [41, 171, 539, 549, 577, 878, 1287, 1998, 2025, 2371, 2478], 'both': [43, 173, 1726, 1838, 2034, 2185], 'membrane': [44, 80, 174, 210, 411, 2029], 'and': [46, 117, 176, 247, 308, 421, 582, 757, 792, 800, 825, 891, 928, 948, 987, 1026, 1109, 1149, 1198, 1237, 1243, 1297, 1349, 1406, 1476, 1525, 1546, 1669, 1728, 1826, 1840, 1848, 1863, 1954, 1965, 1991, 2016, 2039, 2045, 2175, 2187, 2327, 2374, 2695, 2842, 2917, 3256, 3266, 3288, 3402, 3433, 3504, 3561, 3719, 3848, 3980, 4032, 4113], 'assays': [49, 179], 'analyze': [51, 181, 1829], 'possible': [53, 183, 1504, 2064], 'role': [54, 184, 2343, 3110, 3650, 3672, 3749, 4023], 'kinase': [56, 76, 128, 186, 206, 258, 276, 279, 287, 827, 905, 920, 2069, 2084, 2097, 2152, 2180, 2347, 2386, 2627, 2675, 2824, 3157, 3497, 3718, 3838, 3920, 4018, 4064], 'regulation': [57, 187], 'ER': [59, 115, 189, 245, 368, 480, 542, 799, 867, 900, 1401, 1513, 1554, 1703, 2075, 2363, 2381, 2458, 2581, 2841, 2934, 3040, 3127, 3452, 3722, 3741, 3752, 3763, 3774, 3846, 3917, 3955, 3982, 4030, 4035, 4058], 'export.': [60, 190, 893, 2076, 3100, 3742], 'now': [62, 192, 300, 861, 3251], 'demonstrate': [63, 113, 193, 243, 3153, 3252, 3488], 'that': [64, 73, 114, 194, 203, 244, 417, 813, 817, 896, 908, 1392, 1512, 1818, 1884, 1898, 2082, 2433, 2528, 2596, 2625, 2818, 2899, 2951, 3021, 3074, 3154, 3208, 3234, 3253, 3418, 3487, 3489, 3584, 3799, 3851, 3945, 3981, 4015, 4053], 'Sar1': [65, 195, 378, 842, 897, 916, 1067, 1106, 1291, 1347, 1404, 1523, 1529, 1739, 1790, 1805, 1824, 1839, 1847, 1855, 1862, 1887, 1903, 1964, 2008, 2032, 2043, 2059, 2157, 2186, 2208, 2235, 2314, 2328, 2591, 2694, 2916, 3159, 3246, 3259, 3295, 3305, 3395, 3423, 3502, 3564, 3587, 3631, 3652, 3720], 'requires': [69, 199, 1341, 1403, 2054, 3403], 'ATP.': [70, 200, 2055, 3085], 'find': [72, 202], 'serine/threonine': [75, 205, 824, 2777], 'inhibitor': [77, 207, 282, 1028, 2085, 2181, 2601, 2775], 'H89': [78, 208, 872, 2086, 2183, 2223, 2302, 2570, 2597, 2611, 2633, 2768, 3178, 3218], 'abolishes': [79, 209], 'Sar1,': [83, 213, 2173, 2372], 'thereby': [84, 214, 2429, 3736], 'preventing': [85, 215], 'polymerization': [87, 217], 'interfering': [89, 219], 'with': [90, 220, 419, 1039, 1221, 1275, 1284, 1333, 1473, 1519, 1569, 1783, 1867, 1950, 2192, 2366, 2474, 2518, 2537, 2566, 2586, 2713, 2893, 2898, 3084, 3274, 3289, 3408, 3484, 3581, 3726, 3747, 3854, 3860, 3938, 4063], 'cytosolic': [95, 225, 294, 1738, 1789, 2007], 'Sec23/24': [96, 226, 405, 947, 1110, 1294, 1351, 1397, 1544, 1672, 1771, 1841, 1849, 1966, 2190, 2216, 2229, 2306, 2320, 2326, 2696, 2918, 3431], 'complex.': [99, 229], 'Inhibition': [100, 230], 'prevents': [104, 234], 'ER.': [110, 240, 2354], 'These': [111, 241, 2709, 3270], 'results': [112, 242, 1816, 2710, 3152, 3215, 3271, 3486], 'initiation': [118, 248, 2073], 'mammalian': [124, 254, 1886, 4088], 'cells': [125, 255, 4089], 'under': [127, 257, 919, 3919], 'regulation.': [129, 259, 921], 'I/II': [262], 'guanine': [265, 389, 3297], 'nucleotide': [266, 390], 'exchange': [267, 380, 391, 3307], 'factor': [268, 392], 'vesicular': [269, 988], 'stomatitis': [270, 989], 'virus': [271, 990], 'glycoprotein': [272, 991], 'guanosine': [273], '5′-3-O-(thio)triphosphate': [274], 'protein': [275, 278, 286, 826, 2068, 2626, 2674, 2823, 3530, 3758, 3991], 'A': [277, 280, 828, 2322, 2628, 2676], 'peptide': [281, 2677, 2877, 2883, 2905, 4111], 'μ': [283, 2820], 'isozyme': [284, 2821], 'C': [288, 2825], 'phosphatidylinositol': [289, 3012], '3': [290, 2705, 3013], 'Components': [291], 'comprising': [292], '(COPII)1': [298], 'recognized': [301], 'be': [303, 476, 675, 1517, 1532, 1808, 1821, 2832, 2943, 3071, 3124, 3571, 3709], 'selection': [307, 425, 3849, 4079], '(1Barlowe': [315], 'C.': [316, 436, 507, 760, 969, 1003, 1311, 1415, 1912, 2104, 2244, 2394, 2549, 2725, 2846, 2956, 3316, 3603, 3776], 'Orci': [317, 1361, 1913], 'L.': [318, 1362, 1914, 3814, 3866], 'Yeung': [319, 1371], 'T.': [320, 505, 607, 622, 693, 934, 1052, 1076, 1247, 1372, 1434, 1453, 1594, 1681, 1745, 1916, 2263, 2278, 2409, 3335, 3350, 3375, 3686, 3964], 'Hosobuchi': [321], 'M.': [322, 330, 332, 348, 430, 453, 553, 586, 603, 624, 689, 963, 997, 1048, 1078, 1249, 1305, 1364, 1409, 1430, 1449, 1590, 1677, 1741, 1918, 1922, 2238, 2259, 2280, 2388, 2411, 2543, 3310, 3331, 3352, 3371, 3542, 3597, 3682, 3868, 3903, 3960, 3993, 4091], 'Hamamoto': [323, 1367], 'S.': [324, 434, 509, 967, 1001, 1309, 1368, 1413, 2242, 2392, 2547, 3314, 3601, 3958, 3995], 'Salama': [325], 'N.': [326, 762, 2106, 2727, 2848, 2958], 'Rexach': [327], 'M.F.': [328], 'Ravazzola': [329, 1921], 'Amherdt': [331, 1363, 1917], 'Schekman': [333, 454, 1369, 3884], 'R.': [334, 455, 555, 645, 1370, 3132, 3778, 3885], 'Cell.': [335, 648, 774, 850, 1373, 1494, 2118, 2138, 2656, 2739, 2759, 2802, 2860, 2970, 2997, 3199, 3472, 3821], '1994;': [336, 1932, 4001], '77:': [337], '895-907Abstract': [338], 'Full': [339, 357, 595, 652, 654, 751, 778, 780, 1175, 1377, 1379, 1462, 1464, 2122, 2124, 2743, 2745, 2864, 2866, 2974, 2976, 3141, 3143, 3384, 3386, 3695, 3697, 3787, 3789, 3825, 3827, 3892, 3894, 4004], 'Text': [340, 358, 596, 653, 655, 752, 779, 781, 1176, 1378, 1380, 1463, 1465, 2123, 2125, 2744, 2746, 2865, 2867, 2975, 2977, 3142, 3144, 3385, 3387, 3696, 3698, 3788, 3790, 3826, 3828, 3893, 3895, 4005], 'PDF': [341, 359, 597, 656, 753, 782, 1177, 1381, 1466, 2126, 2747, 2868, 2978, 3145, 3388, 3699, 3791, 3829, 3896, 4006], 'PubMed': [342, 360, 445, 460, 518, 564, 598, 616, 637, 657, 702, 736, 754, 783, 854, 942, 978, 1012, 1061, 1091, 1178, 1232, 1262, 1320, 1382, 1424, 1443, 1467, 1498, 1603, 1690, 1754, 1935, 2127, 2142, 2253, 2272, 2293, 2403, 2424, 2558, 2660, 2748, 2763, 2806, 2869, 2979, 3001, 3057, 3146, 3203, 3325, 3344, 3365, 3389, 3476, 3553, 3612, 3700, 3792, 3830, 3875, 3897, 3911, 4007, 4046, 4099], 'Scopus': [343, 361, 446, 461, 519, 565, 599, 617, 638, 658, 703, 737, 784, 855, 943, 979, 1013, 1062, 1092, 1233, 1263, 1321, 1383, 1425, 1444, 1468, 1499, 1604, 1691, 1755, 1936, 2128, 2143, 2254, 2273, 2294, 2404, 2425, 2559, 2661, 2749, 2764, 2807, 2870, 2980, 3002, 3058, 3147, 3204, 3326, 3345, 3366, 3390, 3477, 3613, 3701, 3793, 3831, 3876, 3898, 3912, 3976, 4047, 4100], '(1048)': [344], 'Google': [345, 363, 448, 463, 521, 567, 601, 619, 640, 660, 705, 739, 755, 786, 857, 945, 981, 1015, 1064, 1094, 1179, 1235, 1265, 1323, 1385, 1427, 1446, 1470, 1501, 1606, 1693, 1757, 1938, 2130, 2145, 2256, 2275, 2296, 2406, 2427, 2561, 2663, 2751, 2766, 2809, 2872, 2982, 3004, 3060, 3149, 3206, 3328, 3347, 3368, 3392, 3479, 3554, 3615, 3703, 3795, 3833, 3878, 3900, 3914, 3978, 4008, 4049, 4102], 'Scholar,': [346, 449, 620, 641, 740, 1428, 1447, 2131, 2257, 2276, 2407, 2752, 3329, 3348, 3369, 3879, 3901], '2Aridor': [347], 'Balch': [349, 437, 512, 587, 608, 629, 694, 728, 743, 935, 970, 1004, 1053, 1083, 1167, 1254, 1312, 1416, 1435, 1454, 1595, 1682, 1746, 1927, 2245, 2264, 2285, 2395, 2416, 2550, 3049, 3317, 3336, 3357, 3376, 3604, 3687, 3904, 3965, 3996, 4092], 'W.E.': [350, 438, 513, 588, 609, 630, 695, 729, 744, 936, 971, 1005, 1054, 1084, 1168, 1255, 1313, 1417, 1436, 1455, 1596, 1683, 1747, 1928, 2246, 2265, 2286, 2396, 2417, 2551, 3050, 3318, 3337, 3358, 3377, 3605, 3688, 3905, 3966, 3997, 4093], 'Trends': [351, 589, 3781, 3886], 'Cell': [352, 440, 558, 590, 611, 632, 697, 731, 973, 1007, 1056, 1086, 1257, 1315, 1419, 1438, 1598, 1685, 1749, 1930, 2248, 2267, 2288, 2398, 2419, 2553, 3052, 3320, 3339, 3360, 3607, 3782, 3887, 4041], 'Biol.': [353, 441, 560, 591, 612, 633, 698, 732, 746, 849, 974, 1008, 1057, 1087, 1170, 1258, 1316, 1420, 1439, 1457, 1493, 1599, 1686, 1750, 1931, 2137, 2249, 2268, 2289, 2399, 2420, 2554, 2655, 2758, 2801, 2996, 3053, 3136, 3198, 3321, 3340, 3361, 3379, 3471, 3608, 3690, 3783, 3888, 3972, 3999, 4042], '1996;': [354, 592, 634, 1088, 1259, 2290, 2421, 3362], '6:': [355, 593], '315-320Abstract': [356, 594], '(80)': [362, 600], 'Scholar).': [364, 464, 522, 661, 706, 858, 946, 982, 1016, 1065, 1180, 1266, 1324, 1386, 1471, 1502, 1694, 1758, 1939, 2146, 2562, 2664, 2767, 2810, 2873, 3005, 3061, 3150, 3393, 3555, 3616, 3704, 3834, 3915, 4009, 4050, 4103], 'Export': [365], 'through': [379, 3519, 3565], 'GDP': [382, 1152, 1868, 1894], 'for': [383, 682, 1206, 1483, 1509, 1543, 1580, 1627, 1642, 1671, 1823, 1893, 1968, 2632, 2901, 3244, 3277, 3280, 3296, 3651, 3673, 3837, 4109], 'GTP': [384], 'membrane-associated': [387, 3575], 'Sec12': [388, 3405, 3633, 3654], '(GEF).': [393], 'This': [394, 3577, 3743], 'step': [396, 528, 835, 865, 911, 2047, 2383, 3163, 3188, 3492, 4072], 'leads': [397, 3800], 'subunits': [404, 952, 1967], 'cytosol': [408, 958, 1116, 1568, 1709, 1960, 2334, 2539], 'form': [413, 498, 1576], 'a': [414, 805, 822, 833, 1120, 1127, 1188, 1559, 1760, 1889, 1987, 2067, 2093, 2196, 2212, 2220, 2448, 2461, 2583, 2599, 2672, 2880, 2985, 3023, 3115, 3173, 3183, 3304, 3435, 3567, 3574, 3649, 3671, 3802, 3987, 4021], 'tertiary': [415], 'interacts': [418], 'receptors,': [423], 'initiating': [424], 'prior': [426, 1521, 1534, 1650, 3856], '(3Aridor': [429, 962, 996, 1304, 1408, 2237, 2387, 2542, 3309, 3596], 'Weissman': [431, 964, 998, 1306, 1410, 2239, 2389, 2544, 3311, 3598, 3817], 'J.': [432, 439, 610, 631, 696, 730, 745, 765, 767, 965, 972, 999, 1006, 1055, 1085, 1169, 1256, 1307, 1314, 1411, 1418, 1437, 1456, 1597, 1684, 1748, 1929, 2109, 2111, 2240, 2247, 2266, 2287, 2390, 2397, 2418, 2545, 2552, 2730, 2732, 2851, 2853, 2961, 2963, 3051, 3135, 3312, 3319, 3338, 3359, 3378, 3549, 3599, 3606, 3689, 3998, 4040], 'Bannykh': [433, 508, 604, 690, 966, 1000, 1049, 1308, 1412, 1431, 1450, 1591, 1678, 1742, 2241, 2260, 2391, 2546, 3313, 3332, 3372, 3600, 3683, 3994], 'Nouffer': [435, 968, 1002, 1310, 1414, 2243, 2393, 2548, 3315, 3602], '1998;': [442, 457, 515, 975, 1009, 1317, 1374, 1421, 2250, 2400, 2555, 3322, 3609, 3784], '141:': [443, 976, 1010, 1318, 1422, 2251, 2401, 2556, 3323, 3610], '61-70Crossref': [444, 977, 1011, 1319, 1423, 2252, 2402, 2557, 3324, 3611], '(247)': [447, 980, 1014, 1322, 1426, 2255, 2405, 2560, 3327, 3614], '4Kuehn': [450], 'M.J.': [451], 'Herrmann': [452], 'Nature.': [456], '391:': [458], '187-190Crossref': [459], '(326)': [462], 'Subsequent': [465], 'Sec13/31': [469, 949, 1298, 1357, 1487, 2375, 3227, 3442, 3464], 'allows': [471], 'selected': [473], 'exported': [477], 'budding': [482, 581, 2360, 2896, 3594, 3918], 'vesicles.': [483, 3639], 'Following': [484, 1181, 1610], 'COPII-mediated': [485, 888], 'sorting': [486, 667, 712], 'ER,': [489], 'cargo-containing': [490], 'vesicles': [492, 1340, 2532], 'believed': [494], 'fuse': [496], 'pre-Golgi': [499], 'intermediates': [500, 524], 'containing': [501, 1130, 1194, 2362], 'tubular': [502], 'elements': [503], '(5Rowe': [504], 'Dascher': [506, 1911], 'Plutner': [510, 627, 1081, 1252, 1919, 2283, 2414, 3047, 3355, 3961], 'H.': [511, 628, 1082, 1253, 1920, 2284, 2415, 3048, 3356, 3962], 'Science.': [514, 3871], '279:': [516], '696-700Crossref': [517], '(98)': [520], 'Pre-Golgi': [523], 'first': [527, 910, 1792, 2155, 3162, 3500, 4071], 'exocytic': [531, 3807, 4085], 'pathway': [532, 718, 3808, 3937, 4086], 'retrieval': [536], 'recycling': [538, 2437], 'using': [543, 809, 1674, 1845, 2468, 2879, 3455], 'I': [547], '(COPI)': [548], '(6Kreis': [550], 'T.E.': [551, 647], 'Lowe': [552], 'Pepperkok': [554, 644], 'Annu.': [556], 'Rev.': [557], 'Dev.': [559], '1995;': [561, 613, 699, 939, 1058, 1440, 1600, 1687, 1751, 2269, 3054, 3341, 3973], '11:': [562, 852, 1496, 2140, 2658, 2761, 2804, 2999, 3201, 3474], '677-706Crossref': [563], '(101)': [566], 'Scholar),': [568, 2297, 2428, 3480, 3796], 'thus': [569, 3933], 'separating': [570], 'forward': [571, 671], 'moving': [572, 672], 'membrane-bound': [576, 2001], 'fusion': [583], 'machinery': [584, 3680, 3850, 3926, 4060, 4082], '(2Aridor': [585], 'Scholar,7Aridor': [602], 'S.I.': [605, 691, 1050, 1432, 1451, 1592, 1679, 1743, 2261, 3333, 3373, 3684], 'Rowe': [606, 692, 1051, 1433, 1452, 1593, 1680, 1744, 1915, 2262, 3334, 3374, 3685, 3963], '131:': [614, 700, 1059, 1441, 1601, 1688, 1752, 2270, 3342], '875-893Crossref': [615, 701, 1060, 1442, 1602, 1689, 1753, 2271, 3343], '(343)': [618, 704, 1063, 1445, 1605, 1692, 1756, 2274, 3346], '8Rowe': [621, 2277, 2408, 3349], 'Aridor': [623, 1077, 1248, 2279, 2410, 3351, 3959], 'McCaffery': [625, 1079, 1250, 2281, 2412, 3353], 'J.M.': [626, 1080, 1251, 2282, 2413, 3354, 3881], '135:': [635, 1089, 1260, 2291, 2422, 3363], '895-911Crossref': [636, 1090, 1261, 2292, 2423, 3364], '(151)': [639, 1093, 1264, 2295, 2426, 3367], '9Scales': [642], 'S.J.': [643], 'Kreis': [646], '1997;': [649, 3138], '90:': [650], '1137-1148Abstract': [651], '(417)': [659], 'integration': [663], 'these': [665, 1474, 1551, 3657, 3734], 'two': [666, 1552], 'steps': [668, 713, 2438], 'enables': [669], 'selectively': [676], 'delivered': [677], 'Golgi': [680, 801, 2828, 2844, 2953], 'transport': [683, 796, 2649, 2723, 2795, 2836], 'cell': [686, 3952], 'surface': [687], '(7Aridor': [688, 1047, 1589, 1676, 1740], 'mechanisms': [708], 'which': [710, 1539, 2050, 2453, 3177, 3217, 3724], 'different': [711], 'early': [716], 'secretory': [717, 3936], 'regulated': [720, 870, 3572, 3985], 'remain': [721], '(10Davidson': [724], 'H.W.': [725, 742, 1166], 'McGowan': [726], 'C.H.': [727], '1992;': [733], '116:': [734], '1343-1355Crossref': [735], '(103)': [738], '11Davidson': [741], 'Chem.': [747, 1171, 1458, 3137, 3380, 3691, 4000], '1993;': [748, 1172], '268:': [749, 1173], '4216-4226Abstract': [750, 1174], 'Scholar)': [756, 787, 1095, 1236, 1607, 2983, 3979], 'others': [758], '(12Jamora': [759, 2103, 2724, 2845, 2955], 'Yamanouye': [761, 2105, 2726, 2847, 2957], 'Van': [763, 2107, 2728, 2849, 2959], 'Lint': [764, 2108, 2729, 2850, 2960], 'Laudenslager': [766, 2110, 2731, 2852, 2962], 'Vandenheede': [768, 2112, 2733, 2854, 2964], 'J.R.': [769, 2113, 2734, 2855, 2965], 'Faulkner': [770, 2114, 2735, 2856, 2966], 'D.J.': [771, 2115, 2736, 2857, 2967, 3816], 'Malhotra': [772, 2116, 2737, 2858, 2968, 4108], 'V.': [773, 2117, 2738, 2859, 2969], '1999;': [775, 1459, 2119, 2740, 2861, 2971, 3381, 3692, 3872, 3889, 3908, 4096], '98:': [776, 2120, 2741, 2862, 2972], '59-68Abstract': [777, 2121, 2742, 2863, 2973], '(244)': [785, 2129, 2750, 2871, 2981], 'previously': [789, 932, 961, 995, 1046, 1074, 1164, 1303, 1389, 1588, 1882, 2492, 2772, 3019, 3943], 'implicated': [790], 'kinases': [791, 2778, 2990, 3015, 3512, 3532, 3766], 'phosphatases': [793], 'between': [797, 2839], 'compartments.': [802], 'More': [803], 'recently,': [804], 'qualitative': [806], 'morphological': [807, 2813], 'study': [808], 'indirect': [810, 3456], 'immunoflourescence': [811], 'suggested': [812, 1817, 2081, 3670], 'H89,': [814, 1024], 'an': [815, 1159, 1643, 2357, 2774, 3155, 3797, 4069], 'isoquinolinesulfonamide': [816], 'frequently': [819], 'used': [820], 'as': [821, 930, 959, 1044, 1072, 1162, 1301, 1477, 1586, 1770, 2641, 2773, 2787, 3016, 3114, 3434], 'selective': [823], 'inhibitor,': [829, 2678, 3025], 'was': [830, 926, 1018, 1042, 1219, 1282, 1511, 1763, 1776, 1791, 2009, 2330, 2335, 2617, 2629, 2769, 3179, 3219, 3232, 3242], 'late': [834], 'assembly': [840], 'following': [841], '(13Lee': [844, 1488, 2650, 2796, 2991, 3193, 3466], 'T.H.': [845, 1489, 2133, 2651, 2754, 2797, 2992, 3194, 3467], 'Linstedt': [846, 1490, 2134, 2652, 2755, 2798, 2993, 3195, 3468], 'A.D.': [847, 1491, 2135, 2653, 2756, 2799, 2994, 3196, 3469], 'Mol.': [848, 1492, 2136, 2654, 2757, 2800, 2995, 3197, 3470], '2000;': [851, 1495, 2139, 2657, 2760, 2803, 2998, 3200, 3473, 3550, 3822, 4043], '2577-2590Crossref': [853, 1497, 2141, 2659, 2762, 2805, 3000, 3202, 3475], '(77)': [856, 1500, 2144, 2662, 2765, 2808, 3003, 3205, 3478], 'examined': [862], 'quantitatively': [863], 'directly': [869, 2378], 'sensitive': [873, 903], 'kinase(s)': [874, 2931], 'utilizing': [875, 1288], 'follow': [880], 'ordered': [882], 'membranes,': [887, 1070, 2161], 'formation,': [890, 915], 'show': [895], 'activation,': [906, 917, 1856, 3721], 'demonstrating': [907], 'Recombinant': [922], 'wild': [923, 1104, 1289, 1860, 1962], 'type': [924, 1105, 1290, 1861, 1963], 'Sar1a': [925], 'expressed': [927], 'described': [931, 960, 994, 1045, 1073, 1163, 1302, 1587], '(14Rowe': [933], 'Methods': [937], 'Enzymol.': [938], '257:': [940], 'C49-C53Crossref': [941], '(33)': [944], 'were': [953, 993, 1030, 1098, 1185, 1204, 1270, 1328, 1556, 1614, 1663, 1781, 1941, 1982, 2026, 2472, 3076], 'rat': [956, 1114], 'liver': [957, 1115], 'Antibodies': [983], 'Sec23,': [985], 'Sar1a,': [986], '(VSV-G)': [992], 'GTPγS': [1017, 1641, 1798, 1877, 2015, 3223, 3238, 3261, 3398], 'purchased': [1019, 1031], 'Roche': [1021], 'Molecular': [1022], 'Biochemicals.': [1023], 'PKI,': [1025], 'PKD': [1027, 2882, 2887, 2910, 2950, 4110], 'peptides': [1029, 2911], 'Calbiochem.': [1033], 'Sec23': [1034, 1717], '(two-stage': [1036], 'assay': [1038, 1281, 1908, 2361, 2443, 3241], 'salt': [1040], 'wash)': [1041], 'performed': [1043, 1271, 1283, 1329], 'For': [1066], 'binding,': [1068], 'microsome': [1069], 'prepared': [1071], '(8Rowe': [1075, 1246], '(20–40': [1096], 'μg),': [1097, 1293, 1296], 'incubated': [1099, 1557, 1942, 2163, 2365, 2473, 2536], 'presence': [1102, 1155, 1565, 1635, 1707, 1724, 1873, 1945, 1957, 2168, 2483], '(0.1': [1107], 'μg)': [1108, 1112, 1118, 1300], '(0.7': [1111], 'or': [1113, 1156, 1570, 1619, 1636, 1640, 1874, 1946, 1951, 1961, 2482, 2643, 2700, 2789, 2946, 3035, 3632, 3647, 3653], '(200': [1117], 'final': [1121], 'volume': [1122], '60': [1124], 'μl': [1125], 'reaction': [1128, 1562, 3595], 'mix': [1129], '36': [1131, 2682], 'mm': [1132, 1137, 1142, 1147, 1196, 1200], 'Hepes': [1133], 'pH': [1134], '7.2,': [1135], '70': [1136], 'KOAc,': [1138], '2.5': [1139], 'mmMgOAc,': [1140], '250': [1141, 2688], 'sorbitol,': [1143], '1.8': [1144], 'mmCaCl2+,': [1145], '5': [1146], 'EGTA,': [1148], '100': [1150], 'μm': [1151, 2201, 2620], 'absence': [1157, 1637, 1875, 1947, 2481, 3095, 3302, 3421], 'ATP-regenerating': [1160], 'system': [1161], '(11Davidson': [1165], 'incubation,': [1182, 1611, 1660, 1769, 1979], 'reactions': [1184, 1203, 1981], 'layered': [1186, 1983], 'on': [1187, 1984, 2011, 2060, 2234, 2379, 3029, 3126, 3213, 3264, 3459], '15%': [1189, 1988], 'sucrose': [1190, 1989], 'cushion': [1191, 1990], '(180': [1192], 'μl)': [1193], '75': [1195], 'KOAc': [1197], '2': [1199, 1768, 2203, 2226], 'MgOAc.': [1201], 'centrifuged': [1205, 1992], '15': [1207, 1969], 'min': [1208, 1582, 1646, 1970], 'at': [1209, 1213, 1272, 1330, 1583, 1647, 1971, 2195, 2219, 2582, 2604], '16,000': [1210], '×': [1211], 'g': [1212], '4': [1214], '°C.': [1215, 1973], 'membrane-containing': [1217], 'pellet': [1218], 'solubilized': [1220], 'Laemmli': [1222], 'SDS-sample': [1223], 'buffer': [1224], '(15Laemmli': [1225], 'U.K.': [1226], 'Nature': [1227], '(Lond.).': [1228], '1970;': [1229], '227:': [1230], '680-685Crossref': [1231], '(207233)': [1234], 'analyzed': [1238, 1670, 1715, 2341, 2668], 'SDS-polyacrylamide': [1240], 'gel': [1241], 'electrophoresis': [1242], 'quantitative': [1244], 'immunoblotting': [1245, 1675], 'All': [1267, 1325], 'experiments': [1268, 1326, 3103, 3414, 3621], 'presented': [1269, 1327], 'least': [1273, 1331], 'twice': [1274, 1332], 'identical': [1276, 1334], 'results.': [1277, 1335], 'In': [1278, 3248, 3617], 'vitrovesicle': [1279], '(2': [1292], '(1': [1295], '(12': [1299], 'sequential': [1343], 'followed': [1354], '(16Matsuoka': [1359], 'K.': [1360, 3130], 'Bednarek': [1365], 'S.Y.': [1366], '93:': [1375], '263-275Abstract': [1376], '(501)': [1384], 'demonstrated': [1390, 1883, 3122, 3944], 'biochemically': [1391], 'ATP': [1407, 1479, 1510, 1520, 1572, 1639, 1727, 1784, 1819, 2017, 2038, 2061, 3265], '7Aridor': [1429, 2258, 3330], '17Aridor': [1448, 3370], '274:': [1460, 3382, 3693], '4389-4399Abstract': [1461, 3383, 3694], '(91)': [1469, 3391, 3702], 'Consistent': [1472, 3407], 'results,': [1475], 'expected,': [1478], 'also': [1481, 2770, 2831, 2912, 3008], 'required': [1482, 1542, 1822, 2033, 2303, 2612, 3644], 'One': [1503], 'explanation': [1505], 'need': [1508, 1515], 'primed': [1518, 1782], 'recruitment.': [1527, 2321], 'Alternatively,': [1528, 3665], 'may': [1531, 1820, 2308, 2830, 3570, 3732, 3840, 4067], 'ATP-dependent': [1537, 1812], 'step,': [1538, 2156, 3501], 'then': [1541, 1664], 'assembly.': [1548, 3664], 'To': [1549, 1828, 1852, 2147], 'test': [1550], 'possibilities,': [1553], '“stage': [1560, 1631], '1”': [1561], 'crude': [1567, 1959], 'without': [1571, 1952], 'and/or': [1573], 'nonhydrolyzable': [1575], 'GTP,': [1578, 1896, 2049], 'GTPγS,': [1579, 1729, 1953, 2171], '10': [1581, 1645], '32': [1584, 1648, 1972], '°C': [1585, 1649], '(Fig.1': [1608], 'A).': [1609, 2204], 'either': [1615, 2944, 3033, 3630], 'transferred': [1616], 'ice': [1618], 'collected': [1620, 1665], 'centrifugation,': [1622, 1667], 'latter': [1624, 1731], 'being': [1625, 1732], 'resuspended': [1626], 'further': [1628, 3102, 3641], 'incubation': [1629], '2”': [1632], 'additional': [1644], 'transfer': [1652], 'ice.': [1654], 'At': [1655, 1974], 'end': [1657, 1976], 'solubilized,': [1668], 'As': [1695, 2228, 2489], 'shown': [1696, 3020, 4014], 'Fig.': [1698], '1': [1699, 1802, 2019], 'A,': [1700, 2511], 'preincubation': [1701], 'led': [1710, 2210, 2499, 2571], '(as': [1714], 'binding);': [1718], 'this': [1719, 1830, 3409], 'occurred': [1720], 'only': [1721, 1899], 'necessary': [1733, 3105], 'activate': [1735], 'endogenous': [1737, 1788, 2006], 'Moreover,': [1759, 2665, 2811, 4010], 'similar': [1761, 2323, 2522], 'pattern': [1762], 'observed': [1764, 2331, 2900, 3220, 3417], 'stage': [1767, 1801], 'binding': [1772, 2030, 2158, 3396], 'not': [1777, 2646, 2792, 2940, 3186, 3400, 3514], 'detected': [1778], 'when': [1779, 1787, 2022, 2332, 2533], 'alone': [1785], 'nor': [1786, 2984], 'activated': [1793], 'addition': [1796, 2013, 2036, 2495, 3088], 'incubation.': [1803], 'Therefore,': [1804, 2041], 'cannot': [1807, 3444], 'separated': [1809], 'step.': [1813], 'above': [1815], 'activation.': [1827, 3247, 3505], 'possibility': [1831, 2432, 2817], 'directly,': [1832], 'we': [1833, 1857, 2162, 2490, 2666, 2889, 3017, 3075, 3250, 3415, 3622], 'measured': [1834, 1905], 'subunits.': [1851], 'assure': [1853], 'membrane-dependent': [1854], 'recombinant': [1859], 'supplemented': [1864], 'all': [1865], 'incubations': [1866], '(100': [1869, 1878], 'μm)': [1870], 'μm).': [1879], 'has': [1888, 3026, 3120, 4012], '10-fold': [1890], 'higher': [1891, 2222], 'affinity': [1892, 3293], 'over': [1895], 'assuring': [1897], 'GEF-driven': [1900], 'our': [1907, 3485, 3582, 3593, 3666], '(18Kuge': [1909], 'O.': [1910], 'Tanigawa': [1923], 'G.': [1924, 3534, 3544], 'Rothman': [1925], 'J.E.': [1926], '125:': [1933], '51-65Crossref': [1934], '(254)': [1937], 'Membranes': [1940], 'ATP,': [1949, 2170], 'top': [1985], 'remove': [1994], 'unbound': [1996], 'forms.': [2002], 'dependent': [2010, 2233, 3263], '(Fig.': [2018, 2202, 2225, 2593, 2704], 'B).': [2020, 2227], 'Similarly,': [2021], 'utilized,': [2027], 'efficient': [2028, 2501, 3099], 'GTPγS.': [2040], 'involving': [2048, 2384], 'initiates': [2051, 3158], 'assembly,': [2053], 'dependence': [2057], 'suggests': [2062], 'involvement': [2065], 'activity': [2070, 2315, 3308, 3839, 4019], 'Two': [2077], 'recent': [2078, 2812, 3174], 'reports': [2079], 'could': [2087], 'block': [2088, 2305, 2590, 2721], 'general': [2089, 4075], 'ER-to-Golgi': [2090, 2648, 2722, 2794], 'traffic,': [2091], 'whereas': [2092, 2607], 'variety': [2094], 'other': [2096, 2717, 2988], 'inhibitors': [2098, 2637, 2719, 2785, 4112], 'had': [2099], 'no': [2100, 3027], 'detectable': [2101], 'affect': [2102, 2693, 2793, 3182], '13Lee': [2132, 2753], 'determine': [2148], 'whether': [2149, 3711], 'H89-sensitive': [2151, 2346, 2930, 3156, 3496], 'affected': [2153, 3493], 'microsomal': [2164], 'Sec23/24,': [2174, 2373], 'increasing': [2176, 2485, 2567], 'concentrations': [2177, 2486, 2568], 'H89.': [2182, 2488, 3269], 'abolished': [2184], 'subsequent': [2189, 3438], 'interaction': [2191], 'K': [2197], 'i': [2198], '25': [2200], 'inhibition': [2206, 2214, 2324, 2434, 2575], 'parallel': [2213], 'recruitment,': [2217, 3160], 'albeit': [2218], 'slightly': [2221], 'concentration': [2224, 2300, 2584, 2609], 'absolutely': [2232], 'increased': [2299], 'reflect': [2309], 'minimal': [2311], 'levels': [2312], 'sufficient': [2316, 3243], 'support': [2318], 'maximal': [2319], 'whole': [2333, 2538], '(not': [2337, 2540], 'shown).': [2338], 'next': [2340], 'vitro': [2359, 3287, 3620], 'microsomes': [2364, 2534, 2565], 'focus': [2377], 'eliminating': [2430], 'reflects': [2435], 'COPI-dependent': [2436], 'Golgi.': [2441], 'follows': [2444], 'mobilization': [2446, 2502], 'reporter': [2449], 'molecule,': [2451], 'VSV-G,': [2452], 'released': [2455], 'dense': [2457], 'into': [2460], 'more': [2462], 'slowly': [2463], 'sedimenting': [2464], 'COPII-containing': [2465], 'fraction,': [2467], 'differential': [2469], 'centrifugation.': [2470], 'Microsomes': [2471], 'reported,': [2493], 'VSV-G': [2504, 2527, 2838], 'fraction': [2508], '(∼15–30%)': [2509], '(Fig.3': [2510, 2906], 'lane': [2512], '2,': [2513], 'compare': [2514], 'medium': [2515], 'speed': [2516, 2520], '(M)': [2517], 'high': [2519], '(H)),': [2521], 'amount': [2525], 'mobilized': [2530], 'shown)': [2541], 'Incubation': [2563], 'complete': [2574], 'consistent': [2585, 2712, 3273, 3483, 3580, 3746], 'its': [2587, 3211, 3858], 'ability': [2588, 4055], '2).': [2594], 'Given': [2595], 'specific': [2600, 2673, 2881, 3306], 'PKA': [2603, 2639, 2718, 2945], 'nanomolar': [2605], 'concentration,': [2606], 'inhibit': [2614, 2647, 2915, 3222], 'range,': [2621], 'it': [2622, 2938, 3706, 4011], 'unlikely': [2624, 3009, 3069], 'target': [2631], 'inhibition.': [2634], 'Indeed,': [2635, 3446], 'related': [2636, 2784], 'such': [2640, 2786], 'H8': [2642], 'KT5720': [2644], 'do': [2645, 2791], 'effects': [2670], 'PKI': [2679, 2690, 2876], '(K': [2680], 'i,': [2681], 'nm).': [2683], 'Concentrations': [2684], 'up': [2686], 'nm': [2689], 'failed': [2691, 2890, 2913, 3624], '(Fig.2': [2698, 2922], 'C)': [2699], 'B,': [2706, 2907], 'see': [2707], 'below).': [2708], 'inability': [2715, 3448], 'PKC': [2781], 'family.': [2782], 'However,': [2783, 3101, 3640], 'H7': [2788], 'chelerythrine': [2790], 'observations': [2814, 3583], 'raised': [2815], '(PKD)': [2826], 'disassembly': [2829, 2954], 'Like': [2874], 'substrate,': [2878], 'substrate': [2884], 'antagonize': [2886], 'function,': [2888], 'interfere': [2892], 'compared': [2897], 'control,': [2903], 'scrambled': [2904], 'lanes': [2908], '3–5).': [2909], 'C).': [2923], 'Thus,': [2924, 3394], 'although': [2925], 'identity': [2927], 'remains': [2936, 3707], 'unknown,': [2937], 'does': [2939], 'appear': [2941], 'isoform': [2948], 'mediates': [2952], 'host': [2986], 'known': [2989], 'It': [3006, 3231], 'involve': [3011], '(PI3)-lipid': [3014], 'wortmannin,': [3022], 'PI3-specific': [3024], 'effect': [3028], 'soluble': [3034, 3063], 'transmembrane': [3036, 3568], '(19Brown': [3041], 'W.J.': [3042, 4039], 'DeWald': [3043], 'D.B.': [3044], 'Emr': [3045], 'S.D.': [3046], '130:': [3055], '781-796Crossref': [3056], '(251)': [3059], 'Other': [3062], 'lipid': [3064, 3112], 'kinases,': [3065, 3113], 'including': [3066], 'PI4-kinases,': [3067], 'given': [3073], 'unable': [3077], 'prime': [3079], 'preincubating': [3082], 'them': [3083], 'Furthermore,': [3086], 'components,': [3092], 'cytosol,': [3097], 'supports': [3098], 'address': [3107], 'potential': [3109], 'PI4-kinase': [3116], 'unknown': [3118], 'function': [3119, 4076], 'been': [3121, 4013], 'enriched': [3125], '(20Wong': [3129], 'Meyers': [3131], 'Cantley': [3133], 'L.C.': [3134], '272:': [3139], '13236-13241Abstract': [3140], '(160)': [3148], 'Our': [3151, 3168], 'formation.': [3167], 'conclusions': [3169], 'differ': [3170], 'significantly': [3171], 'report': [3175, 3209], 'proposed': [3180], 'late,': [3184], 'but': [3185], 'early,': [3187], 'Scholar);': [3207], 'based': [3210, 3458], 'conclusion': [3212, 3578], 'experimental': [3214], 'stabilization': [3224], 'membranes.': [3230], 'assumed': [3233], 'inclusion': [3236], 'passive': [3245, 3401], 'contrast,': [3249], 'inhibited': [3267], 'requirement': [3276], 'physiological': [3278], 'temperatures': [3279], 'relatively': [3291], 'low': [3292], 'triphosphate': [3298], 'nucleotides': [3299], 'GEF.': [3406], 'observation,': [3410], 'present': [3413], 'Sec12,': [3426, 3566], 'complex,': [3432, 3443], 'consequence,': [3436], 'occur.': [3445], 'morphologically': [3449], 'detect': [3451, 3626], 'sites': [3454, 4037], 'immunofluorescence': [3457], 'detection': [3461], 'recruited': [3463, 3862], 'entirely': [3482], 'primary': [3491], 'Control': [3506], 'unprecedented.': [3515], 'Activation': [3516], 'Ras': [3518], 'Grb2·SOS': [3524], 'GEF': [3525], 'tyrosine': [3531], '(21Scita': [3533], 'Tenca': [3535], 'P.': [3536, 3780, 3820, 3883], 'Frittoli': [3537], 'E.': [3538], 'Tocchetti': [3539], 'A.': [3540, 3870], 'Innocenti': [3541], 'Giardina': [3543], 'Di': [3545], 'Fiore': [3546], 'P.P.': [3547], 'EMBO': [3548], '19:': [3551], '2393-2398Crossref': [3552], 'By': [3556], 'analogy': [3557], 'Ras,': [3559], 'GEF,': [3569], 'kinase.': [3576], 'limiting': [3590], 'component': [3591], 'preliminary': [3618], 'direct': [3627], 'phosphorylation': [3628, 3655], 'during': [3634, 3656, 3728, 4024], 'studies': [3642, 3668], 'establish': [3646], 'preclude': [3648], 'potentially': [3658], 'transient': [3659], 'previous': [3667], 'modulating': [3676], '(17Aridor': [3681], 'Although': [3705], 'seen': [3710], 'availability': [3713, 3739], 'per': [3714], 'se': [3715], 'can': [3716, 3852], 'regulate': [3717], 'chaperones,': [3723], 'interact': [3725, 3853], 'folding': [3730, 3847], 'cascade,': [3731], 'mediate': [3733], 'events,': [3735], 'linking': [3737], 'interpretation': [3744], 'resident': [3753], 'chaperone': [3754], 'Ig': [3755], 'heavy': [3756], 'chain-binding': [3757], '(BIP)': [3759], 'stress': [3764], 'receptor': [3765], 'response': [3768], 'misfolded': [3770], '(22Sidrauski': [3775], 'Chapman': [3777], 'Walter': [3779, 3819], '8:': [3785], '245-250Abstract': [3786], '(255)': [3794], 'event': [3798], 'global': [3803], 'up-regulation': [3804], '(23Travers': [3809], 'K.J.': [3810], 'Patil': [3811], 'C.K.': [3812], 'Wodicka': [3813], 'Lockhart': [3815], 'J.S.': [3818], '101:': [3823], '249-258Abstract': [3824], '(1594)': [3832], 'Additional': [3835], 'targets': [3836], 'therefore': [3841], 'include': [3842], 'proteins': [3843], 'association': [3859], '(24Ellgaard': [3865], 'Molinari': [3867], 'Helenius': [3869], '286:': [3873], '1882-1888Crossref': [3874], '(1064)': [3877], '25Herrmann': [3880], 'Malkus': [3882], '9:': [3890], '5-7Abstract': [3891], '(107)': [3899], '26Aridor': [3902], 'Nat.': [3906, 4094], 'Med.': [3907, 4095], '5:': [3909, 4097], '745-751Crossref': [3910, 4098], '(256)': [3913, 4101], 'Placing': [3916], 'control': [3921], 'would': [3922], 'allow': [3923], 'respond': [3928], 'extracellular': [3930], 'signaling': [3931, 4065], 'pathways,': [3932], 'integrating': [3934], 'cellular': [3939], 'physiology.': [3940], 'IgE': [3948], 'receptors': [3949], 'mast': [3951], 'lines': [3953], 'enhances': [3954], '(27Bannykh': [3957], 'Cold': [3967], 'Spring': [3968], 'Harbor': [3969], 'Symp.': [3970], 'Quant.': [3971], 'LX:': [3974], '127-137Crossref': [3975], '(13)': [3977], 'calphostin': [3988], 'C-sensitive,': [3989], 'diacylglycerol-binding': [3990], '(28Fabbri': [3992], '269:': [4002], '26848-26857Abstract': [4003], 'modulation': [4016], 'plays': [4020], 'major': [4022], 'mitosis,': [4025], 'leading': [4026], 'cessation': [4028], 'dispersal': [4033], '(29Nelson': [4038], '149:': [4044], '243-248Crossref': [4045], '(41)': [4048], 'propose': [4052], 'integrate': [4062], 'cascades': [4066], 'represent': [4068], 'important': [4070], '(26Aridor': [4090], 'thank': [4105], 'Dr.': [4106], 'Vivek': [4107], 'valuable': [4114], 'discussions.': [4115]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2020212296', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-04T17:20:43.141749', 'created_date': '2016-06-24'}