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3329, 3342, 3442, 3580, 3591, 3705, 3749, 4093, 4101, 4119, 4849, 4912, 4942, 5089, 5140, 5203, 5248, 5334, 5411], 'more': [46, 121, 147, 222, 511, 1837, 2984, 3379, 3750, 3836], 'papers': [47, 122, 148, 223], 'by': [48, 123, 149, 224, 403, 614, 1126, 1149, 1565, 1764, 2009, 2130, 2404, 3444, 3454, 3607, 3851, 3995, 4188, 4249, 4302, 4316, 4366, 4424], 'this': [49, 124, 150, 225, 315, 366, 371, 555, 566, 647, 760, 776, 836, 980, 1429, 1440, 1507, 2437, 2916, 3168, 3175, 3243, 3512, 3574, 3799, 4458], 'authorR.': [50, 151], 'James': [51, 56, 75, 152, 157, 176, 235], 'White,': [52, 153], 'Corresponding': [53, 154], 'Author': [54, 155], 'R.': [55, 74, 156, 175, 234], 'White': [57, 76, 158, 177, 236, 5214, 5240], '[email': [58, 159], 'protected]': [59, 160], 'NY': [73, 118, 174, 219], 'a': [78, 179, 238, 311, 326, 380, 457, 468, 483, 502, 682, 738, 749, 765, 811, 908, 1062, 1098, 1140, 1255, 1273, 1405, 1416, 1769, 1919, 2032, 2099, 2135, 2359, 2490, 2687, 2694, 2701, 2725, 2796, 2834, 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256], '123;': [97, 198, 257], 'FAX:': [98, 199, 258], '585-486-0947Division': [99, 200], '400': [111, 212, 2261], 'Red': [112, 213], 'Creek': [113, 214], 'Drive,': [114, 215], 'Suite': [115, 216], '110,': [116, 217], '14623Search': [119, 220], 'author': [125, 226], 'First': [227, 2204, 2218, 2223, 2227], 'published:': [228], '24': [229, 5213], 'December': [230], '2008': [231, 580], 'https://doi.org/10.1002/lt.21533Citations:': [232], '73': [233], '585-486-0947': [259], 'AboutSectionsPDF': [260], 'ToolsRequest': [261], 'permissionExport': [262], 'citationAdd': [263], 'to': [264, 286, 309, 351, 361, 374, 475, 524, 536, 639, 656, 659, 673, 790, 833, 903, 928, 965, 1313, 1415, 1445, 1458, 1467, 1526, 1562, 1814, 1829, 1864, 1918, 1959, 2053, 2093, 2504, 2535, 2556, 2587, 2593, 2626, 2666, 2693, 2709, 2737, 2820, 2828, 2861, 2920, 3041, 3072, 3141, 3351, 3434, 3522, 3545, 3553, 3560, 3572, 3598, 3665, 3734, 3772, 3803, 3982, 4044, 4072, 4139, 4261, 4289, 4299, 4338, 4362, 4397, 4405, 4442, 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3162, 4439], '5%': [340, 672, 4430], 'patients': [342, 384, 396, 446, 481, 509, 827, 860, 900, 957, 1068, 1123, 1138, 1232, 1250, 1271, 1299, 1308, 1326, 1334, 1392, 1403, 1447, 1504, 1548, 1557, 1775, 1807, 1860, 1899, 1932, 2030, 2079, 2121, 2141, 2150, 2345, 2451, 2581, 2608, 2680, 2720, 2739, 2902, 3065, 3082, 3098, 3116, 3178, 3190, 3207, 3271, 3308, 3317, 3347, 3377, 3416, 3495, 3582, 3715, 3746, 3790, 3807, 3835, 3876, 4012, 4030, 4052, 4102, 4196, 4271, 4291, 4305, 4336, 4357, 4372, 4388, 4403, 4441, 4463, 4469, 4643, 4732, 5253, 5441, 5476], 'being': [343, 3073], 'evaluated': [344, 364, 1125], 'transplantation.': [347, 545, 691, 976, 3021, 3078, 3491, 4220, 4646, 4738, 5148], 'Treatment': [348], 'required': [350, 3069], 'facilitate': [352], 'safe': [353, 544, 3490, 4475, 5002], 'transplantation,': [354], 'oral': [356, 847, 866, 4969, 5056], 'vasodilators': [358], 'yet': [360], 'be': [362, 657, 1413, 2710, 3924, 3993, 4504], 'prospectively': [363, 664], 'disease.': [367, 1318], 'The': [368, 429, 644, 1348, 1425, 2056, 2355, 2390, 2900, 3245, 3275, 3422, 3549, 3621, 3944, 4278, 4342, 4420, 5300, 5575], 'objective': [369], 'study': [372, 740, 1110, 1430, 2772, 3155, 3204, 3431, 3568, 4245, 4290, 4460, 5473], 'was': [373, 441, 530, 549, 761, 1134, 1185, 1194, 1253, 1290, 1355, 1422, 1505, 1540, 1762, 1891, 2006, 2017, 2066, 2091, 2111, 2128, 2398, 2432, 2527, 2533, 2570, 2654, 2662, 2750, 2777, 2831, 2854, 2864, 2945, 2958, 2981, 2990, 3004, 3030, 3039, 3047, 3058, 3092, 3106, 3227, 3278, 3309, 3363, 3404, 3432, 3484, 3528, 3569, 3700, 3716, 3896, 4383, 4451], 'determine': [375, 3523, 3573, 4406], 'hemodynamic': [377, 518, 617, 953, 2731, 2979, 3119, 3265, 3423, 3636, 4471, 4501], 'outcome': [378, 954], 'consecutive': [381, 395, 956, 1067, 1773, 2139, 3064, 3391, 3745, 4304, 4331, 4462], 'cohort': [382, 2439, 3802, 3833, 4408], 'offered': [385, 1394, 1911, 4377], 'sildenafil': [386, 548, 844, 927, 946, 960, 1435, 1454, 1479, 1890, 1914, 1945, 2000, 2152, 2445, 2505, 2661, 3056, 3110, 3166, 3217, 3230, 3239, 3273, 3352, 4450, 5171, 5369, 5654], 'as': [387, 467, 712, 962, 1342, 1357, 1915, 4113, 4115, 4123, 4880, 5370], 'first-line': [388], 'treatment': [389, 801, 874, 969, 1973, 1983, 2154, 2163, 2397, 2486, 3070, 3627, 3689, 4094, 4851, 4975, 5024, 5174, 5202, 5336], 'portopulmonary': [391, 607, 1031, 2348, 4734, 4763, 4802, 4853, 4888, 4977, 4999, 5026, 5059, 5090, 5121, 5141, 5176, 5204, 5222, 5255, 5309, 5407, 5443, 5481], 'hypertension.': [392, 643, 1782, 2148, 4552, 4584, 4854, 4889, 4915, 4945, 4978, 5027, 5091, 5122, 5177, 5205, 5342, 5381, 5444, 5482], 'We': [393, 949, 1060, 1167, 1319, 2999, 3133, 3369, 3387, 3463, 3847, 3912, 4015, 4297], 'identified': [394, 3339, 3382], 'at': [397, 435, 492, 1934, 1963, 2039, 2122, 2203, 2217, 2222, 2910, 2961, 3471, 3899, 4417], 'referred': [402, 1080, 1122, 1776, 2142, 4337], 'transplant': [406, 651, 668, 702, 742, 793, 830, 933, 1346, 1868, 2591, 3046, 3619, 4340, 4351, 4614, 4679, 4771, 5693], 'team.': [407], 'All': [408, 1078, 1121, 1307, 1333, 4371], 'had': [409, 451, 516, 720, 729, 1272, 1309, 1327, 1335, 1491, 1900, 1933, 1952, 1979, 1984, 2031, 2476, 2489, 2582, 2611, 2620, 2786, 2810, 2896, 2903, 3086, 3100, 3356, 3378, 3503, 3877, 4173, 4224, 4346, 4470, 4488], 'catheter-confirmed': [410], 'disease': [411, 539, 611, 1223, 2909], 'were': [413, 418, 982, 1079, 1091, 1124, 1214, 1300, 1393, 1448, 1544, 1808, 1842, 1910, 2350, 2367, 2383, 2456, 2803, 3256, 3282, 3297, 3318, 3334, 3338, 3497, 3791, 3848, 4286, 4307, 4376, 4413, 4484], 'treated': [414, 1069, 3808, 3909, 4308], 'sildenafil.': [416, 1399, 1824, 2604, 2766, 2899, 2972, 3143, 3892], 'Patients': [417, 1588, 2472], 'excluded': [419, 569, 859, 3193], 'from': [420, 473, 570, 1081, 1115, 1474, 2051, 2624, 2664, 3158, 3194, 3284, 3519, 3543, 3695, 3768, 3838, 4149, 4702, 5052], 'analysis': [421, 5538], 'if': [422, 1251, 1418, 3360], 'they': [423, 808, 1411, 2802, 3281, 3756, 3797, 4061, 4070], 'did': [424, 1247, 1320, 1956, 3134, 3595, 3780, 4016], 'not': [425, 1017, 1248, 1291, 1321, 1423, 1877, 1957, 2413, 3135, 3301, 3570, 3596, 3781, 4017, 4287, 4414], 'follow-up': [427, 440, 452, 514, 1420, 1840, 1937, 2044, 2064, 2124, 2158, 2353, 2431, 2496, 2632, 2756, 3084, 4382, 4390], 'catheterizations.': [428, 1834, 4391], 'change': [430, 1881], 'vascular': [433, 461, 677, 1035, 2116, 2577, 5245, 5285], 'resistance': [434, 462, 678, 2117, 2578, 5246], 'time': [437, 494, 1441, 2041, 2058, 2672, 2912, 2963, 4210, 4315], 'first': [439, 496, 1464, 2043, 2063, 2123, 2495, 2631, 2674, 4178, 4479], 'primary': [443, 3481, 4639], 'outcome.': [444], 'Eleven': [445, 1586, 1898], 'began': [447], 'sildenafil,': [448, 1408, 2782, 2862, 3025, 4231], '9': [450, 480, 1622, 1663, 1724, 1830, 2029, 2267, 2284, 2679, 3081, 3115, 4029, 4468, 4779], 'right': [453, 734, 1038, 1041, 1099, 1153, 1156, 1765, 2131, 2364, 2423, 2426, 2584, 3916], 'heart': [454, 735, 1042, 1766, 2132, 2365, 2427, 2585], 'catheterizations': [455, 1841, 1854, 1901, 2366, 2455, 2586, 3085, 3505], 'during': [456, 1304, 1439, 3340, 3429, 3685, 3719, 5468], '3-year': [458, 3811], 'period.': [459, 1442], 'dropped': [463, 472, 1995, 2050, 2076, 3439], 'each': [465, 1401, 1997], 'patient;': [466], 'group,': [469], 'mean': [471, 484, 1012, 1180, 1885, 2049, 2393, 2691, 3028], '575': [474, 2052], '375': [476, 2054], 'dynes/second/cm5.': [477, 2055], 'Four': [478, 506, 2605], 'achieved': [482, 2686, 2724, 3118], 'artery': [486, 709, 1014, 1164, 1182, 1275, 4675], 'pressure': [487, 710, 1102, 1183, 1246, 1277, 2395, 3918, 4068], '≤': [488, 2696], '35': [489, 2296, 2697, 5560], 'mm': [490, 1106, 1189, 1281, 1286, 2698, 3034], 'Hg': [491, 1190, 1282, 2211, 2231, 2699], 'recatheterization,': [497], 'patient': [500, 521, 812, 1512, 1940, 1969, 1998, 2461, 2500, 2635, 2858, 3002, 3105, 3276, 3392, 3531, 3593, 3650, 3676, 3683, 3730, 3902, 4164, 4223, 4487, 5145], 'received': [501, 1111, 4358], 'successful': [503, 3228, 3625, 3645, 3737, 4490], 'cadaveric': [504], 'transplant.': [505, 3343, 3738, 4491], '6': [508, 1828, 2245, 2450, 2607, 3097, 3113, 3253, 3706, 4688], 'than': [512, 1187, 1196, 1279, 2985, 3184, 3312, 3751], 'catheterization': [515, 1142, 1296, 1421, 1767, 2065, 2133, 2159, 2428, 2516, 2757, 3016, 4482], 'sustained': [517, 2612], 'benefit.': [519], 'One': [520, 692, 1939, 1968, 2634, 3104], 'initially': [522, 1813, 2502], 'responded': [523, 2503, 3350], 'favorable': [527, 942, 2978, 3935, 4064], 'but': [529, 852, 2026, 2506, 3530, 3566, 3788, 3931], 'found': [531, 671, 2991, 4062], 'operating': [534, 3008, 4242], 'room': [535, 3009], 'recrudescent': [538, 4166], '(on': [540], 'therapy)': [541], 'that': [542, 748, 800, 891, 1324, 1410, 1904, 2706, 2733, 3001, 3055, 3147, 3174, 3389, 3430, 3487, 3508, 3732, 3854, 3914, 3971, 4003, 4069, 4329, 4435], 'precluded': [543], 'In': [546, 737, 1400, 1805, 2460, 2498, 2791, 3314, 3691, 4448], 'conclusion,': [547], 'small,': [556, 3513], 'uncontrolled': [557, 3149, 3514, 4459], 'cohort.': [558], 'A': [559, 1617, 2244, 2514, 2841, 2929, 3202, 3893, 4492], 'multicenter,': [560, 3800], 'prospective': [561, 4493, 5415], 'evaluation': [562], 'warranted': [564], 'group': [567, 597, 940, 1770, 2048, 2136, 2189, 3176, 3452, 4027, 4050], 'uniformly': [568], 'phase': [571, 3196], 'III': [572, 1625, 1656, 1679, 1689, 1727, 1740, 1754, 3197, 3293], 'clinical': [573, 1924, 3198, 3881, 4670], 'trials.': [574], 'Transpl': [576, 4617, 4740, 4774, 5150, 5446, 5696], '15:30–36,': [577], '2009.': [578], '©': [579], 'AASLD.': [581], '(PAH)': [585], 'one': [591, 1127, 3956, 4000], 'diseases': [594, 1210], 'included': [595], 'World': [601, 1052, 1802], 'Health': [602, 1053, 1803, 3289], "Organization's": [603], 'classification.1': [604], 'Also': [605], 'called': [606], '(PoPH),': [609], 'defined': [613], 'standard': [616, 1849, 2192], 'profile': [618], 'PAH2;': [620], 'presence': [623], 'cirrhosis': [625, 640, 1234, 1744, 1758, 1774, 1965, 2140, 2799, 3862, 3870, 3884, 3929, 4054, 5547], 'absence': [629, 4251], 'other': [631, 1209, 1489, 2901], 'factors': [632, 698], 'PAH,': [635, 1022, 1137, 4226], 'PAH': [636, 771, 786, 850, 1213, 1438, 1481, 1819, 2746, 2806, 2926, 3186, 3286, 3381, 3581, 3840, 4207], 'ascribed': [638, 4071], 'prevalence': [645], 'condition': [648], 'reported': [655, 941, 1427, 1492, 3235, 3644, 3742, 4179, 4428], '3.5%': [658], '8.5%.3-5': [660], 'Krowka': [661, 744, 4367, 4425, 4571, 4656, 4689, 4713, 4746, 5268, 5296, 5452, 5669], 'et': [662, 745, 3171, 3740, 4368, 4426, 4546, 4575, 4607, 4636, 4666, 4758, 4792, 4873, 4908, 4937, 5048, 5085, 5112, 5199, 5331, 5366, 5403, 5435, 5573, 5611, 5679], 'al.6': [663, 4427], 'screened': [665, 4404, 4438], '1235': [666], 'elevated': [675, 1244], '(PVR).': [679, 2579], 'PoPH': [680, 876, 930, 971, 1071, 1176, 1903, 1977, 3067, 3349, 3626, 3806, 3856, 4032, 4104, 4163, 4167, 4375], 'significant': [683, 2008, 2400], 'risk': [684, 697, 757, 3125], 'factor': [685], 'perioperative': [687, 804, 3127, 4728], 'mortality': [688, 3129, 3183, 3711, 4730], 'large': [693, 882, 1258, 3693, 3905], 'retrospective': [694, 739, 1063, 1109, 2438, 3051, 3400, 3801, 4279, 4322], 'examined': [696], 'poor': [701], 'outcome.3': [703], 'These': [704, 3641], 'investigators': [705, 798, 3642, 4038, 4138, 4201], 'recorded': [706], 'systolic': [707, 1101], '(PAP)': [711], 'indication': [714], 'PAH;': [716], '7': [717, 3270, 4712], '1205': [719], 'severe': [721, 904, 4887, 5378, 5480], 'elevations': [722], 'PAP,': [724], '5': [726, 911, 2027, 2322, 3268, 4653], 'those': [728, 3867, 3908, 4200, 4514], 'unfavorable': [730], 'outcomes': [731, 944], 'progressive': [733, 2477, 2614], 'failure.': [736, 2546], 'recipients,': [743], 'al.7': [746], 'demonstrated': [747, 3634], 'PVR': [750, 1193, 1883, 1994, 2038, 2090, 2168, 2464, 2481, 2599, 2703, 2726, 3038, 3062, 3305, 3438, 3538, 3662, 3704, 3763, 4456], '≥': [751], '250': [752, 1497, 3478], 'dynes/second/cm5': [753, 3446, 3456, 3470], 'significantly': [754], 'increased': [755, 1523, 2095, 2623, 2663, 3364, 4673], "candidates'": [756], 'mortality;': [759], 'subsequently': [762, 809, 3643], 'confirmed': [763, 4225, 4374], 'multicenter': [766, 4769], 'registry.8': [767], 'Routine': [768], 'screening': [769, 1096, 1778, 2144, 3341, 3385, 4189, 4214, 4359, 4411, 4705], 'Doppler': [773, 1094, 4796, 5683], 'echocardiography': [774, 4797, 5684], 'population': [777, 3277, 3393], 'now': [779, 950], 'mandatory.6,': [780], '9,': [781], '10': [782, 1366, 1712, 2247, 2262, 2269, 2286, 3708, 3714, 4813], 'Treatments': [783], 'idiopathic': [785, 3185], 'used': [789, 872, 1293, 3628, 4039], 'treat': [791, 929], 'PoPH.': [796, 4465], 'Early': [797], 'postulated': [799], 'would': [802, 1412, 1905, 3488, 3583, 3992, 4006, 4136], 'reduce': [803], 'cardiopulmonary': [805, 3128], 'mortality,11': [806], 'transplanted': [810, 1742, 1756, 2751, 3108], 'after': [813, 1549, 1777, 1889, 1943, 1975, 2143, 2160, 2369, 2493, 2550, 2630, 2754, 2943, 2969, 3013, 3130, 3229, 4055, 4171, 4195, 4477, 5653], 'months': [814, 1812, 1831, 1947, 2753, 2774, 2883, 2968, 3012, 3753, 4170, 4237], 'epoprostenol.12': [816], 'Although': [817, 2429, 4320], 'quite': [818], 'effective,': [819], 'epoprostenol': [820, 3629, 3652, 3699, 4848, 4879, 5470], 'cumbersome': [822], 'intravenous': [823, 4845, 5469], 'therapy.': [824, 2747, 2807, 2927, 4277], 'Particularly': [825], 'because': [826, 3280, 3375, 4199], 'awaiting': [828], 'are': [831, 845, 1926, 3191, 3212, 4197, 4258, 4294], 'prone': [832], 'septic': [834, 2542], 'shock,': [835], 'nidus': [837], 'infection': [839], 'troublesome.': [841], 'Bosentan': [842, 4910, 5087], 'approved': [846, 1564], 'therapies': [848, 1961], 'patients,': [851, 1839, 2793, 3187, 3251], 'pivotal': [854, 1476], 'trials': [855, 3199], 'both': [857, 2094], 'drugs': [858], 'PoPH.13,': [862], '14': [863, 2308, 2335, 2339, 3255, 4924], 'Bosentan,': [864], 'endothelin': [867, 4995, 5581], 'receptor': [868, 4996, 5583], 'antagonist,': [869], 'case': [878, 883, 921, 3214, 4078], 'reports15-18': [879], 'series.19,': [884], '20': [885, 2297, 2317, 2625, 3366, 3544, 3601, 5099], 'However,': [886, 3144, 4076, 4221], 'package': [888], 'insert': [889], 'states': [890], 'drug': [893, 2830, 3501], '"not': [895], 'recommended': [896], 'use': [898, 925, 3612, 4876, 5169], 'moderate': [902, 5478], 'hepatic': [905, 4143], 'impairment."': [906], 'Sildenafil,': [907], 'phosphodiesterase': [909], 'type': [910], 'inhibitor': [912, 4092, 4498, 5617], '(PDE-5),': [913], 'no': [915, 4395], 'hepatotoxicity.': [916], 'There': [917, 2016, 3211], '2': [920, 1946, 2719, 2792, 3213, 4077, 4562], 'reports': [922, 3215, 4079], 'detailing': [923], 'candidates.21,': [934], '22': [935, 1285, 1737, 2274, 2313, 5155], 'Very': [936], 'recently,': [937], 'Giesen': [939], 'short-term': [943], 'PoPH.23': [948], 'report': [951, 1551, 3623, 4766, 5656], 'who': [958, 1522, 3068, 3099, 3496, 3594, 3868, 4292, 4306], 'started': [959, 1449, 2971, 3498], 'alternative': [964, 1917], 'prostanoid': [966, 1396, 1417], 'infusion': [967, 3673, 4846], 'preparation': [973], 'Preliminary': [977], 'presentations': [978, 1470], 'data': [981, 1473, 3263, 3521, 4260, 4512], 'made': [983, 1981, 2917], '200424': [985], 'again': [987], '2006.25': [989], 'Abbreviations': [990], 'CO,': [991, 2409], 'cardiac': [992, 1141, 1146, 1241, 1853, 2096, 2410, 3921], 'output;': [993, 2411], 'EtOH,': [994, 1784], 'alcoholic': [995, 1785], 'cirrhosis;': [996, 1786], 'F,': [997, 1787, 5188, 5324, 5357, 5400], 'female;': [998, 1788], 'Hep': [999, 1620, 1649, 1672, 1708, 1722, 1733, 1789], 'C,': [1000, 1790, 2682, 3325, 4604, 4757, 4791, 4986, 5037, 5047, 5078, 5459], 'hepatitis': [1001, 1791], 'C;': [1002, 1792], 'M,': [1003, 1793, 4566, 4633, 4655, 4781, 4956, 4964, 5076, 5161, 5490, 5610], 'male;': [1004, 1794], 'MELD,': [1005, 1795], 'Model': [1006, 1349, 1359, 1796, 3328], 'End-Stage': [1008, 1351, 1361, 1798, 3330], 'Disease;': [1010, 1800], 'mPAP,': [1011], 'pressure;': [1015], 'N/A,': [1016, 2412], 'available;': [1018, 2414], 'PA,': [1019, 2415], 'artery;': [1021, 2417], 'hypertension;': [1025, 1032], 'PCW,': [1026, 2418], 'capillary': [1028, 2420], 'wedge;': [1029, 2421], 'PoPH,': [1030, 4266, 4433], 'PVR,': [1033, 2879, 3565], 'resistance;': [1036], 'RA,': [1037, 2422], 'atrium;': [1039, 2424], 'RHC,': [1040, 2425], 'catheterization;': [1043], 'SUPER-1,': [1044], 'Hypertension': [1049, 1486, 1593], '1;': [1050], 'WHO,': [1051, 1801], 'Organization.': [1054, 1804], 'PATIENTS': [1055], 'AND': [1056], 'METHODS': [1057], 'Study': [1058], 'Design': [1059], 'conducted': [1061], 'chart': [1064, 3052, 3401], 'between': [1072, 1494, 2059, 2844, 3321, 3475, 3961, 4208], 'July': [1073], '2003': [1074, 1444], 'October': [1076], '2006.': [1077], 'Solid': [1086], 'Organ': [1087], 'Transplantation': [1088, 4808, 4855, 4890, 4979], 'Program.': [1089], 'Referrals': [1090], 'initiated': [1092], 'when': [1093, 1177, 1204, 1537], 'echocardiographic': [1095], 'revealed': [1097, 2517], 'ventricular': [1100, 1157], 'estimate': [1103, 4398], '>': [1104, 1519], '40': [1105, 2627, 3449, 3546, 3585], 'Hg.': [1107], 'Our': [1108, 3050, 3480, 4244], 'exempt': [1113], 'approval': [1114], 'local': [1117], 'institutional': [1118], 'board.': [1120], 'authors': [1130, 1490, 3246], '(R.J.W.).': [1131], 'When': [1132, 2886], 'there': [1133, 1252, 4257], 'suspicion': [1135], 'underwent': [1139], 'laboratory': [1143], 'assessment': [1144, 4118, 4580, 4800, 5687], 'including': [1145], 'output': [1147, 2097, 3922], '(measured': [1148], 'Fick': [1151], 'equation),': [1152], 'atrial': [1154, 3917], 'pressure,': [1155, 1158, 1161], 'occlusion': [1165, 1245, 1276], 'pressure.': [1166], 'followed': [1168], 'European': [1170, 1573], 'Respiratory': [1171], 'Society': [1172], 'consensus26': [1173], 'diagnosed': [1175], '(1)': [1178], '(mPAP)': [1184], 'greater': [1186, 1195, 1278, 2035, 3311], '25': [1188, 1451, 5237], '3': [1197, 1811, 2273, 2385, 2470, 2551, 4594], 'woods': [1198], 'units': [1199], '(240': [1200], 'dynes/second/cm5)': [1201, 2705], '(2)': [1203], 'signs': [1205], 'or': [1206, 1398, 1966, 2034, 2212, 2232, 2386, 2592, 2613, 3586, 3784, 3818, 4009, 4023, 4480], 'symptoms': [1207, 1817], 'absent': [1215], '(for': [1216], 'example,': [1217], 'scleroderma,': [1218], 'advanced': [1219, 1414, 1457, 3845], 'chronic': [1220, 1316, 4878, 5339], 'obstructive': [1221], 'hypoxemia,': [1225], 'history': [1227], 'anorexigen': [1229], 'use).': [1230], 'Because': [1231, 1870], 'often': [1235], 'element': [1238], 'high-output': [1240], 'failure,': [1242], 'exclude': [1249], 'also': [1254, 2075, 2855, 3717, 3942, 4295], 'simultaneous': [1256], 'elevation': [1259], 'transpulmonary': [1262], 'gradient': [1263], 'PVR.6,': [1265], '8,': [1266], '27': [1267, 5295], 'Two': [1268, 3873], '11': [1270, 1772, 2138, 2256, 2295, 2333, 3744, 4831], '15': [1280, 1636, 2258, 2264, 2300, 4954, 5475], '(16': [1283], 'Hg).': [1287], 'Supplemental': [1288], 'oxygen': [1289, 1302], 'ordinarily': [1292], 'lab': [1297], 'unless': [1298], 'already': [1301, 3257], 'requiring': [1303], 'day.': [1306], 'ventilation': [1310], 'perfusion': [1311], 'scans': [1312], 'rule': [1314], 'out': [1315], 'thromboembolic': [1317, 5340], 'routinely': [1322], 'establish': [1323], 'invasive': [1331, 4040, 4108, 4129], 'measurements.': [1332], 'abdominal': [1336], 'ultrasounds': [1337], 'consistent': [1338], 'part': [1343], 'evaluation.': [1347], 'Disease': [1353, 1363, 3332], 'score': [1354, 1364], 'calculated': [1356], 'follows:': [1358], '=': [1365, 3816, 3821], '×': [1367, 1369, 1375, 1381, 3777], '{[0.957': [1368], 'ln(serum': [1370], 'creatinine,': [1371], 'mg/dL)]': [1372, 1378], '+': [1373, 1379, 1386], '[0.378': [1374], 'ln(total': [1376], 'bilirubin,': [1377], '[1.12': [1380], 'ln(international': [1382], 'normalized': [1383], 'ratio,': [1384], 'seconds)]': [1385], '0.643}.': [1387], 'After': [1388], 'their': [1389, 3236, 3307, 3832, 3880], 'catheterization,': [1390, 2676], 'all': [1391, 1503, 1909, 2120, 3337, 3792, 4356], 'continuous': [1395], 'case,': [1402], 'chose': [1404, 2151], 'trial': [1406, 1477, 4100, 4494, 4524], 'knowing': [1409], 'improved.': [1424], 'doses': [1426, 1543, 1563, 2382, 2602, 3474], 'reflect': [1431], 'evolution': [1433], 'dosing': [1436, 1493, 3590], 'From': [1443], '2004,': [1446], 'on': [1450, 1594, 1866, 2375, 2600, 2745, 2765, 2781, 2804, 2871, 2898, 2924, 2938, 2997, 3109, 3258, 3272, 3499, 3743, 3937, 3949, 4066, 4142, 4152, 4230, 4276, 5620], 'mg': [1452, 1460, 1498, 1528, 1577, 2628, 2668, 3367, 3450, 3460, 3547, 3588, 3602], 'TID': [1453, 1461, 2629, 3451, 3461, 3589, 3603], 'generally': [1456, 1843, 3335], '50': [1459, 2665], 'week.': [1465], 'Prior': [1466, 2860], 'initial': [1469, 3600, 3622], '[Sildenafil': [1482], '(SUPER-1)],14': [1488], '150': [1495, 2272, 2294, 2305], 'daily.28,': [1499], '29': [1500, 5353], 'Dosing': [1501], 'range,': [1508], 'except': [1509], '(patient': [1513, 2487], 'B': [1514, 1632, 1637, 1654, 1664, 1699, 1713, 1725, 1752, 2255, 2809, 2974, 3323], 'Table': [1516, 1555, 1579, 1929, 2072, 2194], '1,': [1517, 1556], 'weight': [1518], '300': [1520, 2728], 'lbs)': [1521], 'his': [1524, 1976, 1990, 2553, 2825, 2893, 3037, 3045], 'dose': [1525, 1539, 2379, 2491, 2622, 2659, 3362, 3541, 3604, 4058, 4088], '100': [1527], 'QID;': [1529], 'he': [1530, 1987, 2532, 2561, 2863, 2880, 2887, 2989], 'consistently': [1531], 'complained': [1532], 'reduced': [1534, 1545, 2114, 3061, 3088, 3124, 3915, 4455], 'exertional': [1535], 'tolerance': [1536], 'reduced.': [1541], 'Initial': [1542], 'subsequent': [1547, 2454, 4481], 'SUPER-1': [1553, 3420, 3550], '(see': [1554, 2071, 2649], 'G,': [1558, 4535, 4545, 4960, 5080, 5105, 5604], 'H,': [1559, 4574, 5039, 5107, 5132, 5198, 5361], 'I)': [1561, 2723], 'US': [1567, 4350], 'Food': [1568], 'Drug': [1570], 'Administration': [1571], 'Medicines': [1574], 'Agency': [1575], '(20': [1576], 'TID).': [1578], '1.': [1580, 1930], 'Clinical': [1581, 4548], 'Demographic': [1583], 'Data': [1584], 'Cirrhosis': [1587], 'Found': [1589], 'To': [1590, 4156], 'Have': [1591], 'Portopulmonary': [1592, 1760, 2126, 4699, 4818], 'Right': [1595], 'Catheterization': [1597, 2206], 'Patient': [1598, 2207, 2618, 2652, 2748, 2808, 2928, 2973], 'Age': [1599], 'Gender': [1600], 'Mechanism': [1601], 'Hepatic': [1603], 'Failure': [1604], 'MELD': [1605], 'Score': [1606], 'Child-Pugh': [1607, 3322, 3793], 'Class': [1608, 1612], '(Score)': [1609], 'WHO': [1610], 'Functional': [1611], 'Transplant': [1613, 1690, 5181], 'Status': [1614, 1616], 'Vital': [1615], '56': [1618], 'F': [1619, 1648, 1661, 1671, 1682, 1707, 1721, 1747, 2299, 2501, 3003], 'C': [1621, 1623, 1646, 1650, 1673, 1677, 1687, 1709, 1723, 1734, 1738, 2266], '(11)': [1624, 1688, 1739], 'Listed': [1626, 1640, 1657, 1667, 1728], 'before': [1627, 1641, 1832, 1887, 1989, 2988], 'death': [1628, 1642], 'Dead,': [1629, 1643, 1692, 1743, 1757], 'breast': [1630, 2932], 'cancer': [1631, 2933], '54': [1633, 2279], 'M': [1634, 1684, 1696, 1732], 'EtOH': [1635, 1652, 1662, 1675, 1685, 1697, 1711, 1736, 1748], '(9)': [1638, 1655, 1753], 'II': [1639, 1701, 1715], 'cause': [1644], 'unknown': [1645], '49': [1647, 1670], '13': [1653, 1686, 1751, 2341, 4895], 'Alive': [1658, 1668, 1681, 1704, 1718, 1729], 'D': [1659, 2277, 2653], '52': [1660, 1695, 1731, 1746, 2318], '(8)': [1665, 1700], 'I': [1666, 1719, 2332, 2473], 'E': [1669, 2288, 2749], '17': [1676, 5011], '(12)': [1678], 'Transplanted': [1680], '46': [1683], 'cancelled': [1691], 'sepsis': [1693, 2642], 'G': [1694, 2310, 2475, 2488, 2619, 3532], '21': [1698, 2311, 5130], 'Not': [1702, 1716, 1741, 1755], 'listed': [1703, 1717, 2712, 2946, 2982, 3074], 'H': [1705, 2321], '51': [1706], '(7)': [1714, 1726], '41': [1720, 2329, 2340], 'J': [1730, 4553, 4585, 4918, 4948, 5094, 5125, 5178, 5208, 5229, 5290, 5344, 5382, 5513, 5551], 'K': [1745], 'steatohepatitis': [1750], 'NOTE:': [1759, 2343], 'established': [1763, 2129, 2347], 'echocardiogram': [1779, 2145, 4190, 4215], 'suggested': [1780, 2146, 4193], 'Abbreviations:': [1783, 2408], 'general,': [1806], 'seen': [1809, 2856, 3425, 3897], 'every': [1810, 2171], 'assess': [1815, 2921], 'adverse': [1821, 3138], 'effects': [1822, 4141, 4151], 'Initially,': [1825], 'we': [1826, 2762, 2794, 3145, 3436, 3611, 4327, 4393, 4436], 'waited': [1827], 'repeating': [1833], 'For': [1835], 'recent': [1838], 'performed': [1844, 1857, 2368, 2457], 'within': [1845, 3010], '4': [1846, 2251, 2387, 2448, 2677, 2967, 3011, 3095, 3639, 4169, 4236, 4623], 'months.': [1847], 'As': [1848, 3722], 'care,': [1851, 2559], 'repeat': [1852, 2515, 2583, 2675, 3504, 3608], 'annually': [1858], 'alive': [1861, 2778], 'wishing': [1863], 'remain': [1865], 'list.30': [1869], 'variability': [1872], 'probably': [1876, 3370, 4437], 'normally': [1878], 'distributed,': [1879], 'PAP': [1886, 2692, 3029], 'analyzed': [1892], 'Wilcoxon': [1894, 2011, 2176, 2405], 'signed': [1895, 2177, 2406], 'rank.': [1896, 2407], 'RESULTS': [1897], 'confirming': [1902], 'preclude': [1906], 'transplantation;': [1908], 'parenteral': [1920], 'prostanoid.': [1921, 3261], 'Their': [1922, 3262], 'baseline': [1923, 2061, 2356, 3304], 'characteristics': [1925], 'presented': [1927, 2156], 'Nine': [1931, 2149, 2344], 'least': [1935, 3900], 'catheterization.': [1938, 2045, 2125, 2354, 2633], '(K)': [1941], 'died': [1942, 1988, 2640, 2930], 'stopping': [1944], 'into': [1948], 'her': [1949, 1964, 2494, 2621, 2658, 2755, 2764, 2788, 2954, 3661], 'treatment;': [1950, 3300], 'she': [1951, 2776, 2944, 2970], 'refractory': [1953], 'ascites': [1954, 2511, 2868], 'wish': [1958], 'continue': [1960], 'directed': [1962], 'PAH.': [1967, 3201, 3872], '(J)': [1970], 'elected': [1971], 'hospice': [1972], 'immediately': [1974], 'diagnosis': [1978, 2936], 'started;': [1986], '3-month': [1991], 'follow-up.': [1992, 3103, 3721], 'Calculated': [1993], '(Fig.': [2001, 2458, 2521], '1),': [2002], 'difference': [2005], 'statistically': [2007, 2399], 'paired': [2010], 'rank': [2012], '(P': [2013, 2173, 2401], '<': [2014, 2084, 2174, 2402, 2727], '0.004)': [2015], 'considerable': [2018], 'variation': [2019], 'size': [2022], 'effect,': [2025], '40%': [2033], 'drop': [2036, 2688, 2952, 3467], 'Overall,': [2046], 'average': [2057, 2162, 3466, 3766], '170': [2067, 2166], '±': [2068, 2191, 3770, 3774], '74': [2069], 'days': [2070, 2374], '2).': [2073, 2459], 'mPAP': [2074], 'most': [2078], '(Table': [2080, 2440], '2,': [2081], 'paired-effect': [2082], 'P': [2083], '0.01),': [2085], 'so': [2086], 'reduction': [2088, 2100, 2391, 2797, 2877, 3536, 3659, 3761, 3927], 'attributable': [2092, 3140], 'mPAP.': [2103], 'Figure': [2104, 2563], '1Open': [2105], 'figure': [2107, 2566], 'viewerPowerPoint': [2108, 2567], '(PVR)': [2118], 'duration': [2164, 2435], 'days.': [2167], 'decreased': [2169, 4073], 'subject': [2172, 4529], '0.004,': [2175], 'rank);': [2178], 'boxes': [2180], 'illustrate': [2181, 2358], 'overall': [2183], 'decrease': [2184], '35%': [2186], '(mean': [2190], 'deviation).': [2193], '2.': [2195], 'Baseline': [2196, 2208], 'Hemodynamics,': [2197], 'Duration,': [2198], 'Dose': [2200, 2221], 'Follow-Up': [2205, 2219, 2224, 2228], 'RHC': [2209, 2220, 2225, 2229], '(mm': [2210, 2230], 'L/minute)': [2213, 2233], 'Days': [2214], 'Therapy': [2216], '(mg/day)': [2226], 'RA': [2234, 2239], 'Mean': [2235, 2240], 'PA': [2236, 2241, 2394], 'PCW': [2237, 2242], 'CO': [2238, 2243], '38': [2246, 4370, 5666], '6.5': [2248, 2276], '197': [2249], '200': [2250, 2283], '30': [2252, 5390], '12': [2253, 2280, 2291, 2306, 2319, 2752, 3427, 3752, 4860], '7.8': [2254], '53': [2257, 2301], '5.8': [2259], '280': [2260], '42': [2263], '6.4': [2265], '36': [2268, 5598], '3.1': [2270], '95': [2271, 2326], '8': [2275, 2278, 2289, 2324, 4745], '4.3': [2281], '282': [2282], '39': [2285], '5.4': [2287, 2331, 2342], '37': [2290, 5639], '4.1': [2292], '195': [2293], '5.2': [2298], '16': [2302, 4984], '6.0': [2303], '97': [2304], '34': [2307, 5520], '6.8': [2309, 2325], '66': [2312], '3.8': [2314], '129': [2315], '60': [2316, 2327, 2338, 3476], '4.7': [2320], '44': [2323], 'N/A': [2328], '19': [2330, 5072], '47': [2334], '6.1': [2336], '168': [2337], 'available': [2351], 'moderately': [2360], 'symptomatic': [2361, 3283, 3837], 'population.': [2362, 3169, 3244, 3620], 'Follow-up': [2363], 'stated': [2371, 2377], 'number': [2372], 'daily': [2378, 3473], 'sildenafil;': [2381, 2824], 'divided': [2384], 'times': [2388], 'daily.': [2389], 'following': [2396, 3651, 3888], '0.01)': [2403], 'total': [2430, 3472], 'variable': [2434], '2),': [2441, 2522], 'effect': [2443, 3091, 3527, 3895, 3945, 4065], 'persisted': [2446], 'whom': [2453], 'B,': [2462, 5194, 5492, 5522, 5566, 5643], 'declined': [2465], 'then': [2467, 4233], 'stabilized': [2468], 'over': [2469, 2482, 3809, 4309], 'years.': [2471], 'drops': [2478], 'year': [2484, 2942, 2987], 'increase': [2492, 3542], 'catheterization).': [2497], 'contrast,': [2499, 3315], 'represented': [2507, 2888], 'later': [2508, 4238, 4272], 'recurrent': [2510], 'encephalopathy.': [2513], 'worsening': [2518, 3785], 'subcutaneous': [2524, 2647], 'treprostinil': [2525, 2648], 'added.': [2528], 'Six': [2529, 2580, 4466], 'weeks': [2530, 3428], 'later,': [2531], 'admitted': [2534], 'surgical': [2537], 'intensive': [2538], 'care': [2539], 'unit': [2540], 'shock': [2543], 'respiratory': [2545], 'With': [2547], 'little': [2548], 'improvement': [2549, 2923, 3266, 3424, 4175, 4228], 'weeks,': [2552], 'family': [2554], 'agreed': [2555], 'stop': [2557], 'aggressive': [2558], 'died.': [2562], '2Open': [2564], 'durable': [2573, 2826, 3093, 3357], 'reductions': [2574, 2597, 2615], 'maintain': [2588], 'eligibility': [2589], 'test': [2594], 'further': [2596, 3535], 'higher': [2601, 3181], '(dotted': [2609], 'lines)': [2610], 'PVR.': [2617, 2955], '(F)': [2636], 'deteriorated': [2637], 'clinically': [2638, 2655], 'despite': [2643], 'addition': [2645], 'text).': [2651], 'well,': [2656], '80': [2667, 3459, 3587], 'TID.': [2669, 3368, 3548], 'At': [2670, 2767], '(A,': [2681], 'E,': [2683, 4631, 5109, 5192, 5396], 'F)': [2685], 'value': [2695], 'corresponding': [2702], '(≤260': [2704], 'allowed': [2707, 3728], 'them': [2708], 'safely': [2711], 'transplantation.8': [2715], 'Ultimately,': [2716], 'additional': [2718], '(B': [2721], 'dynes/second/cm5,': [2729], 'criterion': [2732], 'center': [2735], 'uses': [2736], 'consider': [2738, 3584], 'eligible': [2740], 'while': [2744, 2801, 2937, 2996, 4229, 4239, 4274], 'showed': [2758, 3017, 3173, 3264], 'acceptable': [2759, 3018], 'hemodynamics,': [2760], 'continued': [2763], 'end': [2769], '(10': [2773], 'post-transplant),': [2775], 'still': [2780, 4275], 'although': [2783, 3327, 3955], 'renal': [2784], 'insufficiency': [2785], 'complicated': [2787], 'postoperative': [2789], 'recovery.': [2790], 'observed': [2795, 3371, 3824, 4202], 'manifestations': [2800, 2849, 2905, 3859, 3882], 'effective': [2805, 2872, 2925, 3405, 3701, 5004], 'frequent': [2811], 'admissions': [2812], 'ascites,': [2814], 'gastrointestinal': [2815], 'bleeding,': [2816], 'encephalopathy': [2818], 'prior': [2819, 3071], 'initiation': [2822], 'response': [2827, 3374], 'complete': [2835], 'remission': [2836, 4264], 'manifestations.': [2840], 'similar': [2842, 3433, 3894], 'correlation': [2843], 'decompensated': [2851, 2890, 2907, 3861], 'failure': [2853], 'F.': [2859, 4817], 'frequently': [2865], 'hospitalized': [2866, 3684], 'encephalopathy;': [2870], 'therapy,': [2873, 4378], 'measured': [2876, 3464], 'spent': [2881], 'several': [2882, 4268], 'without': [2884, 2993], 'hospitalization.': [2885], 'disease,': [2892], 'recrudesced': [2897], 'fewer': [2904], 'presentation,': [2914], 'it': [2918], 'difficult': [2919], '(a': [2934, 4033], 'new': [2935], 'sildenafil)': [2939], 'substantial': [2951, 4206], 'Her': [2956], 'tumor': [2957], '5.5': [2959], 'cm': [2960], 'diagnosis,': [2965], 'only': [2966], '(with': [2975], 'persistently': [2977], 'response)': [2980], 'dead': [2992], 'prodromal': [2994], 'illness': [2995], 'vacation.': [2998], 'note': [3000], 'catheterized': [3005], 'outpatient': [3015], 'Despite': [3022], 'compliance': [3023], "patient's": [3027], 'unacceptably': [3031], 'high': [3032], '(50': [3033], 'Hg),': [3035], 'unresponsive': [3040], 'acute': [3042, 4082], 'nitric': [3043, 3973, 3989, 5503], 'oxide;': [3044], 'cancelled.': [3048], 'DISCUSSION': [3049], 'demonstrates': [3054], 'orthotopic': [3076, 5249], 'Each': [3079, 3344], 'PVR;': [3089], 'longer': [3101], 'term': [3102], 'successfully': [3107], 'monotherapy,': [3111], 'ultimately': [3117, 3506], 'parameters': [3120], 'transplantation.7': [3132], 'identify': [3136, 4443], 'obvious': [3137], 'events': [3139], 'administering': [3142], 'acknowledge': [3146], 'small': [3151], 'nature': [3152], 'precludes': [3156], 'us': [3157], 'making': [3159], 'any': [3160], 'conclusions': [3161], 'safety': [3164, 4125], 'Kawut': [3170, 4752, 5423], 'al.31': [3172], 'adjusted': [3182], 'these': [3189, 3206, 4444], 'universally': [3192], 'detailed': [3203], 'clearly': [3209, 4106], 'warranted.': [3210], 'describing': [3216], 'monotherapy': [3218], 'PoPH21,': [3220], '22;': [3221], 'patient,': [3224], 'therapy.21': [3231], 'German': [3232], 'investigators23': [3233], 'recently': [3234], 'experience': [3237, 4422], 'iloprost': [3241, 3819, 5054, 5117, 5376], 'described': [3247], 'selected': [3248], '(not': [3249], 'consecutive)': [3250], 'inhaled': [3260, 5116, 5375], 'monotherapy.': [3274], 'different': [3279, 3649, 4035], 'perspective': [3287, 3841], '(World': [3288], 'Organization': [3290], 'functional': [3291], 'classes': [3292], 'IV)': [3295], 'presenting': [3298], 'surprisingly,': [3302], 'among': [3306, 3712], 'substantially': [3310], 'ours.': [3313], 'equally': [3319], 'split': [3320], 'scores': [3333], 'low,': [3336], 'initially,': [3353], 'some': [3355], 'responses,': [3358], 'especially': [3359], 'above': [3365], 'superior': [3373, 3827], 'modest': [3380], 'process.': [3386], 'think': [3388], 'important': [3396, 4822], 'strength': [3397], 'review.': [3402], 'improving': [3407], 'formal': [3409], 'measure': [3410, 4045], 'submaximal': [3412], 'exercise': [3413], '278': [3415], 'enrolled': [3417], 'trial.14': [3421], 'what': [3435], 'observed.': [3437], '(when': [3440], 'corrected': [3441], 'placebo)': [3443], '192': [3445], '310': [3455], 'group.': [3462], '287': [3469], 'mg.': [3479], 'therapeutic': [3482, 3509], 'goal': [3483, 3510], 'allow': [3489, 4137], 'Two-thirds': [3492], 'met': [3507], 'study.': [3515, 5416, 5631], 'It': [3516], 'impossible': [3518], 'whether': [3524, 4517], 'dose-response': [3526, 3556], 'present,': [3529], 'experienced': [3533], 'data14': [3551], 'appeared': [3552], 'show': [3554], 'relationship': [3557], 'respect': [3559], 'secondary': [3562], 'endpoint': [3563, 4502], 'powered': [3571], 'effect.': [3575], 'Many': [3576], 'expert': [3577], 'clinicians': [3578], 'caring': [3579], 'respond': [3597], '(as': [3605], 'assessed': [3606], 'catheterization),': [3609], 'such': [3613, 4522], 'approach': [3615], '(range,': [3630], '8-28': [3631], 'ng/kg/minute)': [3632], 'impressive': [3635, 3760], 'benefit': [3637, 3828], 'patients.11': [3640], 'transplantation12': [3646], '(23': [3653], 'ng/kg/minute).': [3654], 'She': [3655], 'enjoyed': [3656], '60%': [3658, 3718], '(from': [3663], '550': [3664], '240': [3666], 'dynes/second/cm5);': [3667], 'underscoring': [3668], 'difficulty': [3670], 'prostacyclin': [3672], 'cirrhosis,': [3678, 3787], 'physicians': [3680], 'kept': [3681], 'entire': [3687], 'preoperative': [3688], 'phase.12': [3690], 'series': [3694, 3733, 3906], 'Mayo': [3697, 4681], 'Clinic,': [3698], 'reducing': [3703], 'patients32;': [3709], 'however,': [3710, 4256], 'study,': [3725, 4326], 'PAH-specific': [3726], 'Hoeper': [3739, 5073, 5100], 'al.19': [3741], 'receiving': [3747], 'bosentan': [3748, 3814, 3830, 4972, 5057, 5119], 'follow-up;': [3755], 'too': [3757], 'saw': [3758], 'fall': [3767], '944': [3769], '519': [3771], '635': [3773], '321': [3775], 'dynes': [3776], 'second/L.': [3778], 'They': [3779, 3823], 'observe': [3782, 4018], 'hepatotoxicity': [3783], 'class': [3794], 'A.': [3795, 5219], 'Recently,': [3796], 'updated': [3798], 'include': [3804], '31': [3805, 5422], 'period20': [3812], '(n': [3815, 3820], '18)': [3817], '13).': [3822], 'apparently': [3826], '(but': [3842], 'less': [3844], 'cirrhosis).': [3846], 'particularly': [3849], 'intrigued': [3850], 'possibility': [3853, 3970], 'untreated': [3855], 'may': [3857, 3923], 'drive': [3858], 'attenuation': [3878], '(ascites': [3885], 'bleeding)': [3887], 'introduction': [3890], 'epoprostenol.32': [3911], 'postulate': [3913, 4002], 'driving': [3925], 'manifestations,': [3930], 'direct': [3933, 4150], 'impact': [3936], 'circulation': [3940, 3952, 3979], 'possible.': [3943], 'PDE-5': [3947, 3997, 4004, 4091], 'inhibitors': [3948], 'unknown,': [3954], 'team': [3957], 'investigating': [3958], 'interaction': [3960], 'circulations': [3966], 'raised': [3968], 'excess': [3972], 'oxide': [3974, 3990, 5504], 'activity': [3975], 'might': [3980, 4001], 'contribute': [3981], 'development': [3984, 4020, 4204], 'hepatopulmonary': [3986, 5306, 5510, 5588], 'syndrome.33-35': [3987], 'Excess': [3988], 'signaling': [3991], 'magnified': [3994], 'inhibitor,': [3998], 'inhibition': [4005], 'promote': [4007], 'shunt': [4008, 4022], 'hypoxemia': [4010, 4024], 'cirrhosis.': [4014, 4825, 5064], 'very': [4034], 'disease).': [4036], 'Different': [4037], 'noninvasive': [4042], 'techniques': [4043], 'pressures': [4047, 4112, 4135, 4676], 'single': [4057, 4087], 'vardenafil;': [4060], 'sinusoidal': [4074], 'resistance.36': [4075], 'variceal': [4083, 4120, 5651], 'bleeding': [4084, 4121], 'erectile': [4096], 'dysfunction.37': [4097], 'Any': [4098], 'large-scale': [4099], 'will': [4105], 'require': [4107], 'measurements': [4109, 4130], 'well': [4114], 'careful': [4117], 'episodes': [4122], 'endpoint.': [4126], 'Serial,': [4127], 'simultaneous,': [4128], 'distinguish': [4140], 'congestion': [4144], '(elevated': [4145], 'central': [4146], 'venous': [4147], 'pressure)': [4148], 'circulation.': [4155], 'knowledge,': [4158], 'observation': [4160], 'developing': [4165], 'having': [4172, 4389], 'documented': [4174, 4227], 'literature.': [4182], 'Annual': [4183], 're-evaluation': [4184], 'even': [4194], 'listed30': [4198], 'normal': [4213, 5624], 'day': [4218], 'unacceptable': [4234], 'room.': [4243], 'mainly': [4247], 'limited': [4248], 'control': [4254, 4520], 'group;': [4255], 'few': [4259], 'suggest': [4262], 'spontaneous': [4263], 'progressed': [4273], 'design': [4280, 4323], 'selection': [4283, 4301], 'bias': [4284], '(we': [4285], 'able': [4288], 'died)': [4293], 'problematic.': [4296], 'attempted': [4298], 'avoid': [4300], 'studying': [4303], 'relatively': [4311], 'short': [4312], 'period': [4313], 'same': [4318], 'clinician.': [4319], 'limits': [4324], 'believe': [4328], 'sample': [4332], 'representative': [4334], 'centers.': [4341], 'second': [4348], 'largest': [4349], 'volume': [4352], '2006,': [4354], 'echocardiograms': [4360, 4412], 'according': [4361], 'algorithm': [4364], 'advocated': [4365], 'al.6,': [4369], 'disposition': [4381], '100%,': [4384], '>80%': [4386], 'Unfortunately,': [4392], 'way': [4396], 'accurately': [4399], 'denominator': [4401], '11:': [4410, 5448], 'always': [4415], 'done': [4416], 'university.': [4419], '10-year': [4421, 4704], 'published': [4423], 'incidence': [4431], 'suggesting': [4434], '220': [4440], 'consecutively': [4445], 'studied': [4446], 'patients.': [4447, 4680], 'summary,': [4449], 'profiles': [4472], 'compatible': [4473], 'listed;': [4485], 'PDE': [4497], 'using': [4499], 'should': [4503], 'undertaken': [4505], 'evaluate': [4507], 'formally': [4508], 'intriguing': [4510], 'preliminary': [4511, 5225], 'others23;': [4516], 'placebo': [4519], 'ethical': [4526], 'remains': [4527], 'controversy.': [4531], 'REFERENCES': [4532], 'Simonneau': [4534], 'Galie': [4536, 4902, 4925], 'N,': [4537, 4903, 4926], 'Rubin': [4538, 4842, 4865, 4896, 4933], 'LJ,': [4539, 4866, 4897, 4934], 'Langleben': [4540], 'D,': [4541, 4936, 5041, 5568], 'Seeger': [4542], 'W,': [4543, 5019, 5043, 5647], 'Domenighetti': [4544], 'al.': [4547, 4576, 4608, 4637, 4667, 4759, 4793, 4874, 4909, 4938, 5049, 5086, 5113, 5200, 5332, 5367, 5404, 5436, 5574, 5612, 5680], 'classification': [4549], 'Am': [4554, 4586, 5228, 5343, 5383, 5512, 5550], 'Coll': [4555, 4587, 5384], 'Cardiol': [4556, 4588, 5385], '2004;': [4557, 4589, 4775, 4980, 5031, 5068, 5151, 5234, 5291, 5556, 5594], '43(': [4558, 4590], 'suppl):': [4559, 4591], 'S5–': [4560], 'S12.': [4561], 'Barst': [4563, 4900, 4931], 'RJ,': [4564, 4901, 4932, 5215], 'McGoon': [4565, 4695, 5456], 'Torbicki': [4567, 4929], 'A,': [4568, 4785, 4787, 4789, 4907, 4930, 4962, 5134, 5136, 5159, 5165, 5196, 5330, 5365, 5402], 'Sitbon': [4569], 'O,': [4570], 'MJ,': [4572, 4657, 4690, 4714, 4747, 5269, 5297, 5453, 5670], 'Olschewski': [4573, 5197, 5360], 'Diagnosis': [4577, 5405], 'differential': [4579], 'S40–': [4592], 'S47.': [4593], 'Ramsay': [4595, 4601, 4750], 'MA,': [4596, 4751], 'Simpson': [4597], 'BR,': [4598], 'Nguyen': [4599], 'AT,': [4600], 'KJ,': [4602], 'East': [4603], 'Klintmalm': [4605], 'GB,': [4606], 'Severe': [4609], 'candidates.': [4615, 4807, 5694], 'Surg': [4618, 5661], '1997;': [4619, 4856], '3:': [4620], '494–': [4621], '500.': [4622, 5185], 'Taura': [4624], 'P,': [4625, 5271, 5600], 'Garcia-Valdecasas': [4626], 'JC,': [4627], 'Beltran': [4628], 'J,': [4629, 4635, 4783, 4872, 5084, 5398, 5528, 5564, 5645, 5674], 'Izquierdo': [4630], 'Navasa': [4632], 'Sala-Blanch': [4634], 'Moderate': [4638], 'undergoing': [4644, 4736, 5146], 'Anesth': [4647], 'Analg': [4648], '1996;': [4649, 4684], '83:': [4650], '675–': [4651], '680.': [4652], 'Castro': [4654], 'Schroeder': [4658], 'DR,': [4659], 'Beck': [4660], 'KC,': [4661], 'Plevak': [4662, 4715, 5298, 5460, 5671], 'DJ,': [4663, 4716, 5461, 5672], 'Rettke': [4664, 5675], 'SR,': [4665, 5676], 'Frequency': [4668], 'implications': [4671, 5304], 'Clin': [4682, 5028], 'Proc': [4683], '71:': [4685, 4810], '543–': [4686], '551.': [4687], 'Swanson': [4691], 'KL,': [4692], 'Frantz': [4693, 5454, 5677], 'RP,': [4694, 5455, 5678], 'MD,': [4696, 5457], 'Wiesner': [4697, 4721, 5462], 'RH.': [4698, 4966, 5463], 'hypertension:': [4700, 4764, 4819, 5000, 5223, 5256], 'results': [4701], 'algorithm.': [4706], 'Hepatology': [4707, 5417, 5483, 5593], '2006;': [4708, 5209, 5262, 5635], '44:': [4709], '1502–': [4710], '1510.': [4711], 'Findlay': [4717], 'JY,': [4718], 'Rosen': [4719], 'CB,': [4720], 'RH,': [4722], 'Krom': [4723], 'RA.': [4724], 'cardiopulmonary-related': [4729], '2000;': [4741, 5697], '6:': [4742, 5698], '443–': [4743], '450.': [4744], 'Mandell': [4748], 'MS,': [4749, 5239], 'SM,': [4753, 5424], 'Fallon': [4754, 5272, 5497, 5531], 'MB,': [4755, 5273], 'Manzarbeitia': [4756], 'Hepatopulmonary': [4760], 'syndrome': [4761, 5307, 5589], 'database.': [4772], '10:': [4776, 5152], '174–': [4777], '182.': [4778], 'Torregrosa': [4780], 'Genesca': [4782], 'Gonzalez': [4784], 'Evangelista': [4786], 'Mora': [4788], 'Margarit': [4790], 'Role': [4794], '2001;': [4809], '572–': [4811], '574.': [4812], 'Blendis': [4814], 'L,': [4815, 5013, 5524, 5526, 5570, 5572], 'Wong': [4816], 'increasingly': [4821], 'complication': [4823], 'Gastroenterology': [4826, 5006], '2003;': [4827, 5349, 5386, 5418], '125:': [4828], '622–': [4829], '624.': [4830], 'Kuo': [4832, 4863], 'PC,': [4833, 4864], 'Johnson': [4834], 'LB,': [4835], 'Plotkin': [4836, 4861], 'JS,': [4837, 4862], 'Howell': [4838, 4869], 'CD,': [4839, 4870], 'Bartlett': [4840], 'ST,': [4841], 'LJ.': [4843], 'Continuous': [4844], '63:': [4857], '604–': [4858], '606.': [4859], 'Gaine': [4867], 'S,': [4868, 4958, 5430], 'Laurin': [4871], 'Successful': [4875, 5050], 'bridge': [4882], '1998;': [4891], '65:': [4892], '457–': [4893], '459.': [4894], 'Badesch': [4898, 4935], 'DB,': [4899, 5426], 'Black': [4904], 'CM,': [4905, 5017, 5045], 'Keogh': [4906, 5158, 5164], 'N': [4916, 4946], 'Engl': [4917, 4947], 'Med': [4919, 4949, 5233, 5314, 5348], '2002;': [4920], '346:': [4921], '896–': [4922], '903.': [4923], 'Ghofrani': [4927, 5319, 5354], 'HA,': [4928, 5320, 5355], 'citrate': [4940], '2005;': [4950, 5007, 5095, 5182, 5315, 5447, 5662], '353:': [4951], '2148–': [4952], '2157.': [4953], 'Halank': [4955, 5075], 'Miehlke': [4957], 'Hoeffken': [4959, 5079, 5104], 'Schmeisser': [4961], 'Schulze': [4963], 'Strasser': [4965], 'endothelin-receptor': [4970], 'antagonist': [4971, 4997, 5023], '77:': [4981], '1775–': [4982], '1776.': [4983], 'Kuntzen': [4985], 'Gulberg': [4987], 'V,': [4988], 'Gerbes': [4989], 'AL.': [4990], 'mixed': [4994], 'therapy?': [5005], '128:': [5008], '164–': [5009], '168.': [5010], 'Hinterhuber': [5012], 'Graziadei': [5014], 'IW,': [5015], 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5267, 5326, 5363, 5394], 'Miyashita': [5160, 5166], 'M.': [5167], 'Novel': [5168], 'Lung': [5180], '24:': [5183, 5292], '498–': [5184], '23': [5186], 'Reichenberger': [5187], 'Voswinckel': [5189], 'Steveling': [5191], 'Enke': [5193], 'Kreckel': [5195, 5329, 5364], '28:': [5210], '563–': [5211], '567.': [5212], 'Lansing': [5216], 'K,': [5217], 'Bozorgzadeh': [5218], 'single-center': [5226, 5259], 'report.': [5227, 5260], 'Crit': [5231, 5312, 5346], '169:': [5235], 'A177.': [5236], 'RJ.': [5241], 'reduces': [5243], 'allowing': [5247], 'open-label': [5258], 'Chest': [5261], '130:': [5263], '250S.': [5264], '26': [5265], 'Rodriguez-Roisin': [5266], 'Herve': [5270], 'ERS': [5275], 'Task': [5276], 'Force': [5277], 'Pulmonary-Hepatic': [5278], 'Vascular': [5279], 'Disorders': [5280], '(PHD)': [5281], 'Scientific': [5282], 'Committee.': [5283], 'Pulmonary-hepatic': [5284], 'disorders': [5286], '(PHD).': [5287], '861–': [5293], '880.': [5294], 'D.': [5299], 'distinct': [5301], 'concepts': 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