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3181, 3185, 3303, 3443, 3467, 3470, 3507, 3593, 3628, 3679, 3691, 3696, 3712, 3721, 3841, 4143], 'absorption.': [7, 201, 209, 403, 2934], 'NPC1L1': [8, 210, 1174, 1256, 1285, 1293, 1394, 1460, 1677, 1748, 1790, 1821, 1858, 1897, 1985, 2011, 2040, 2837, 2962, 3653, 4376], 'knockout': [9, 211, 546, 1461, 3517], '(L1-KO)': [10, 212, 1462], 'mice': [11, 60, 110, 181, 196, 213, 262, 312, 383, 398, 1463, 2323, 2334, 2449, 2540, 2621, 2624, 2850, 2902, 2929, 2936, 2989, 2996, 3009, 3025, 3050, 3099, 3167, 3278, 3543, 3619, 3658, 3771, 3816, 3864, 3973, 4000, 4032, 4045, 4095, 4098, 4108, 4150, 4164, 4183, 4193, 4209, 4218, 4236], 'were': [12, 61, 111, 158, 182, 214, 263, 313, 360, 384, 2937, 3013, 3026, 3051, 3073, 3100, 3171, 3193, 3283, 3310, 3410, 3487, 3544, 3552, 3620, 3733, 3865, 3905, 3974, 4001, 4015, 4033, 4046, 4066, 4113, 4151, 4337], 'recently': [13, 215, 2013], 'shown': [14, 216, 507, 2014], 'to': [15, 18, 29, 138, 217, 220, 231, 340, 422, 446, 508, 725, 932, 987, 1395, 1491, 1749, 1833, 1862, 1906, 1990, 2015, 2256, 2337, 2425, 2595, 2612, 2707, 2822, 2914, 2993, 3046, 3439, 3475, 3477, 3742, 3844, 4185, 4263, 4281, 4343], 'be': [16, 218, 979, 1297, 2593], 'resistant': [17, 219, 2336], 'high-fat': [19, 221, 2342, 4373], 'diet': [20, 84, 120, 128, 222, 286, 322, 330, 853, 2343, 2465, 2631, 2742, 2855, 2908, 3058, 3128, 3152, 3176, 3260, 3348, 3368, 3541, 3617, 3862, 3872, 3921, 4105, 4176, 4199, 4206, 4239], '(HFD)-induced': [21, 223], 'obesity': [22, 224, 2258, 2427, 2709], 'in': [23, 38, 48, 174, 195, 198, 225, 240, 250, 376, 397, 400, 444, 448, 517, 544, 581, 589, 624, 651, 680, 682, 773, 813, 845, 864, 934, 949, 1011, 1046, 1092, 1117, 1179, 1257, 1260, 1286, 1299, 1478, 1494, 1789, 1828, 1857, 1859, 1896, 1904, 2080, 2086, 2126, 2216, 2306, 2498, 2538, 2574, 2597, 2619, 2732, 2770, 2805, 2830, 2842, 2885, 2900, 2928, 2931, 3028, 3034, 3150, 3155, 3214, 3224, 3258, 3263, 3329, 3342, 3444, 3515, 3557, 3657, 3714, 3768, 3813, 3846, 3917, 4147, 4157], 'one': [24, 63, 226, 265, 4195], 'study,': [25, 227, 3093], 'which': [26, 228, 438, 1005, 3206, 3876], 'was': [27, 167, 229, 369, 2012, 2616, 3270, 3353, 3358, 3372, 3389, 3462, 3684, 3748, 3894, 3915, 3934, 4125, 4177], 'contrary': [28, 230], 'several': [30, 232], 'other': [31, 233, 1290, 2882, 4360], 'studies.': [32, 234], 'Careful': [33, 235], 'comparison': [34, 236], 'of': [35, 45, 64, 67, 144, 149, 237, 247, 266, 269, 346, 351, 431, 481, 492, 542, 574, 687, 722, 731, 807, 827, 832, 840, 862, 879, 910, 1021, 1063, 1087, 1090, 1119, 1192, 1255, 1361, 1393, 1448, 1485, 1576, 1619, 1629, 1651, 1682, 1747, 1941, 1984, 2010, 2019, 2039, 2077, 2130, 2166, 2250, 2348, 2374, 2419, 2491, 2519, 2524, 2656, 2701, 2798, 2868, 2895, 2918, 2961, 3108, 3125, 3147, 3199, 3204, 3212, 3219, 3255, 3302, 3316, 3321, 3324, 3337, 3367, 3459, 3483, 3513, 3540, 3599, 3614, 3626, 3652, 3677, 3695, 3770, 3815, 3861, 3892, 3928, 3952, 4093, 4107, 4109, 4130, 4138, 4205, 4214, 4223, 4232], 'dietary': [36, 46, 189, 238, 248, 391, 838, 2605, 2825, 2844, 2893, 2921, 3678, 3690], 'compositions': [37, 239], 'these': [39, 241, 2587, 2886, 3220, 3325, 3338], 'studies': [40, 242, 1672, 2591, 2911], 'implies': [41, 243], 'a': [42, 73, 82, 95, 119, 127, 139, 244, 275, 284, 297, 321, 329, 341, 457, 486, 534, 586, 616, 846, 850, 1125, 1352, 1446, 1475, 1573, 1610, 1860, 2325, 2341, 2464, 2542, 2626, 2735, 2843, 2854, 2858, 2863, 2946, 3029, 3040, 3102, 3105, 3173, 3271, 3285, 3290, 3296, 3399, 3505, 3547, 3597, 3870, 3900, 3987, 3991, 4128], 'potential': [43, 245], 'role': [44, 246, 1254, 2518], 'regulating': [49, 251], 'weight': [50, 115, 193, 252, 317, 395, 2338, 2456, 2536, 2614, 2828, 2840, 2879, 2898, 2926, 3352, 4145, 4167, 4189, 4225, 4255, 4273], 'gain.': [51, 253], 'To': [52, 254, 978, 2833, 4134], 'examine': [53, 255], 'this': [54, 256, 454, 1114, 3006, 3151, 3259, 4198], 'potential,': [55, 257], 'wild-type': [56, 258, 2331], '(WT)': [57, 259, 2332], 'and': [58, 154, 169, 260, 356, 371, 407, 426, 451, 513, 685, 720, 952, 960, 999, 1018, 1108, 1185, 1253, 1280, 1288, 1359, 1444, 1472, 1482, 1569, 1572, 1625, 1649, 1669, 1796, 1898, 2025, 2046, 2084, 2123, 2168, 2209, 2254, 2259, 2263, 2304, 2376, 2423, 2428, 2432, 2472, 2567, 2658, 2705, 2710, 2714, 2763, 2851, 2876, 2881, 2906, 2968, 3010, 3055, 3080, 3096, 3138, 3168, 3246, 3279, 3407, 3471, 3555, 3595, 3630, 3693, 3868, 3881, 3910, 3920, 3930, 4022, 4073, 4096, 4159, 4162, 4170, 4229, 4234, 4345, 4355], 'L1-KO': [59, 109, 175, 180, 261, 311, 377, 382, 2322, 2448, 2620, 2849, 2901, 2935, 3008, 3095, 3166, 3277, 4094, 4148, 4161, 4182, 4208, 4235], 'fed': [62, 264, 2541, 2625, 2734, 2848, 3101, 3172, 3284, 3869, 4152, 4237], 'three': [65, 267, 3874, 3908], 'sets': [66, 268], 'diets': [68, 270, 3192, 3221, 3230, 3309, 3326, 3339], 'for': [69, 78, 90, 103, 271, 280, 292, 305, 416, 729, 1113, 1129, 1162, 1224, 1332, 1351, 1526, 1713, 1853, 1988, 2170, 2378, 2530, 2660, 2870, 2997, 3005, 3020, 3118, 3187, 3304, 3361, 3435, 3560, 3623, 3792, 3873, 3907, 3949, 3976, 4035, 4115, 4240, 4339, 4352, 4359], 'various': [70, 272], 'durations:': [71, 273], '(1)': [72, 274], 'HFD': [74, 97, 276, 299, 2543, 2905, 3103, 3273, 3287, 4139], 'without': [75, 87, 100, 121, 277, 289, 302, 323], 'added': [76, 88, 101, 122, 278, 290, 303, 324, 724, 4142], '5': [79, 91, 281, 293, 2871, 3119, 3188, 4221], 'weeks;': [80, 92, 282, 294], '(2)': [81, 283], 'high-carbohydrate': [83, 285, 2907, 3175], 'with': [85, 98, 287, 300, 583, 733, 771, 775, 955, 1609, 1792, 1825, 1900, 2082, 2088, 2308, 3039, 3053, 3772, 3817, 4004, 4049, 4191], 'or': [86, 93, 99, 131, 288, 295, 301, 333, 1052, 2007, 2329, 2622, 2738, 2862, 2873, 3183, 3295, 4103], '(3)': [94, 296], 'synthetic': [96, 298, 3174, 3191, 3286, 3308], '18': [104, 306, 2874, 3305, 3613], 'weeks.': [105, 307, 3189, 3306], 'We': [106, 308], 'found': [107, 309, 2617], 'that': [108, 310, 1101, 1612, 1676, 2610, 2824, 2892, 3890], 'protected': [112, 183, 314, 385], 'against': [113, 315, 2048, 2521, 2970, 3655], 'diet-induced': [114, 192, 316, 394, 649, 2049, 2211, 2257, 2426, 2569, 2613, 2708, 2765, 2925, 2971], 'gain': [116, 194, 318, 396, 2339, 2454, 2537, 2615, 2829, 2841, 2899, 2927, 4146, 4186], 'only': [117, 319, 1296, 2618, 4211], 'on': [118, 126, 320, 328, 2324, 2340, 2450, 2463, 2903, 3015, 3719, 4099, 4144, 4197], 'but': [124, 326, 2730], 'not': [125, 327, 1465, 2534, 2731], 'containing': [129, 331, 1014, 2345, 2466, 2544, 2856, 3104, 3178, 3236, 3288, 4140], '0.16%': [130, 332], '0.2%': [132, 334], '(w/w)': [133, 335], 'cholesterol,': [134, 336, 3235, 3404, 3406], 'an': [135, 337, 412, 1106, 3436], 'amount': [136, 338, 2867, 3107, 3301, 3458], 'similar': [137, 159, 339, 361, 1490, 2455, 4166], 'typical': [140, 342, 851], 'Western': [141, 343, 852], 'diet,': [142, 344, 3888, 4102], 'regardless': [143, 345], 'the': [145, 150, 161, 347, 352, 363, 439, 540, 575, 683, 830, 833, 900, 982, 989, 995, 1000, 1030, 1061, 1072, 1099, 1180, 1189, 1300, 1396, 1469, 1566, 1616, 1627, 1630, 1674, 1679, 1750, 2516, 2522, 2916, 2924, 3003, 3016, 3022, 3076, 3090, 3160, 3196, 3256, 3313, 3347, 3511, 3534, 3538, 3615, 3624, 3682, 3715, 3743, 3878, 3886, 3911, 3950, 3981, 4040, 4090, 4100, 4110, 4119, 4136, 4153, 4172, 4175], 'major': [146, 348, 435], 'energy': [147, 349], 'source': [148, 350], 'diet.': [151, 353], 'Food': [152, 354, 3356], 'intake': [153, 355, 839, 3357], 'fat': [156, 358, 1022, 2208, 2471, 2566, 2606, 2762, 3149, 3257, 3893, 3954], 'absorption': [157, 166, 359, 368, 430, 459, 537, 578, 619, 645, 679, 810, 928, 948, 1028, 1070, 1096, 1104, 1132, 1259, 1599, 1795, 2249, 2418, 2700, 3508, 3629, 3680, 3697, 3713, 3927], 'between': [160, 362, 994, 4089, 4104], 'two': [162, 364, 1854], 'genotypes.': [163, 365], 'Intestinal': [164, 366], 'blocked,': [168, 370], 'fecal': [170, 372, 1479, 3631, 3919], 'excretion': [172, 374, 1481, 3634], 'increased': [173, 375], 'mice.': [176, 378, 2832], 'Under': [177, 379], 'all': [178, 380, 518, 3021], 'diets,': [179, 381], 'from': [184, 386, 903, 930, 1468, 2469, 3043, 3132, 3136, 3141, 3239, 3244, 3249, 3468, 3735, 3986], 'hepatosteatosis.': [185, 387], 'In': [186, 388, 420, 2512, 3611], 'conclusion,': [187, 389], 'increasing': [188, 390, 2920], 'restores': [191, 393, 2923], 'deficient': [197, 399, 2930], 'NPC1L1-dependent': [199, 401], 'Elevated': [404], 'blood': [405, 3983, 4042], 'total': [406, 512, 3148, 3403, 3469, 3929, 4383], 'low-density': [408, 514, 1798, 1830], 'lipoprotein': [409, 515, 1799, 1831], 'is': [411, 433, 842, 897, 1006, 1048, 1105, 1160, 1176, 1222, 1330, 1445, 1524, 1565, 1605, 1678, 1711, 1823, 1943, 1986, 3153, 3261, 3340, 3433, 3596, 3842], 'independent': [413], 'risk': [414], 'factor': [415], 'atherosclerotic': [417], 'cardiovascular': [418], 'disease.': [419], 'addition': [421], 'de': [423, 1486], 'novo': [424, 1487], 'biosynthesis': [425], 'hepatobiliary': [427], 'secretion,': [428], 'another': [434, 2513], 'pathway': [436, 455], 'by': [437, 456, 811, 1008, 1029, 1054, 1071, 2261, 2430, 2712, 3075, 3374, 3392, 3412, 3464, 3473, 3489, 3686, 3896, 3923, 3990, 4118], 'body': [440, 2878, 3351, 3683, 4010, 4061, 4224, 4363], 'regulates': [441, 1440, 3591], 'homeostasis': [443], 'response': [445, 1832, 1905], 'fluctuations': [447], 'availability': [450], 'utilization.': [452], 'Inhibiting': [453], 'inhibitor': [460, 491], 'ezetimibe': [461, 723, 812, 1064, 1091, 1604, 1683, 1907, 1942, 2005, 2167, 2375, 2520, 2528, 2657], '(trade': [462], 'name': [463], 'Zetia)': [464], '(1Rosenblum': [465], 'S.B.': [466], 'Huynh': [467], 'T.': [468, 754, 790, 2286, 2296], 'Afonso': [469], 'A.': [470, 794, 1151, 1213, 1321, 1515, 1646, 1702, 1775, 1971, 2035, 2108, 2957], 'Davis': [471, 613, 641, 672, 1135, 1197, 1305, 1381, 1499, 1686, 1735, 1931, 2197, 2555, 2751], 'Jr,': [472, 525, 560, 857, 944, 1136, 1198, 1306, 1500, 1539, 1687, 1932, 2198, 2476, 2556, 2752, 2783, 3496, 3703], 'H.R.': [473, 526, 561, 614, 642, 673, 1137, 1199, 1307, 1501, 1540, 1688, 1933, 2477, 2784, 3497], 'Yumibe': [474], 'N.': [475, 2067], 'Clader': [476], 'J.W.': [477], 'Burnett': [478, 1925], 'D.A.': [479, 1926], 'Discovery': [480], '1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4': [482], '-hydroxyphenyl)-2-azetidinone': [483], '(SCH': [484], '58235):': [485], 'designed,': [487], 'potent,': [488], 'orally': [489], 'active': [490, 1107], 'absorption.J.': [494], 'Med.': [495], 'Chem.': [496, 1404, 1581, 1758, 2052, 2974], '1998;': [497], '41:': [498], '973-980Crossref': [499], 'PubMed': [500, 554, 597, 631, 658, 696, 746, 784, 818, 871, 888, 919, 975, 1038, 1080, 1169, 1231, 1273, 1339, 1366, 1413, 1455, 1533, 1590, 1640, 1663, 1720, 1767, 1808, 1840, 1868, 1912, 1955, 1999, 2061, 2098, 2137, 2184, 2223, 2274, 2315, 2392, 2443, 2507, 2581, 2674, 2725, 2777, 2814, 2983, 3452, 3525, 3606, 3671, 3726, 3784, 3829, 3853, 3964], 'Scopus': [501, 555, 598, 632, 659, 697, 747, 785, 819, 872, 889, 920, 1039, 1081, 1170, 1232, 1274, 1340, 1367, 1414, 1456, 1534, 1591, 1641, 1721, 1768, 1809, 1841, 1869, 1913, 1956, 2000, 2062, 2099, 2138, 2185, 2224, 2275, 2316, 2393, 2444, 2508, 2582, 2675, 2726, 2778, 2815, 2984, 3453, 3526, 3607, 3672, 3727, 3785, 3830, 3854, 3965], '(368)': [502], 'Google': [503, 557, 600, 634, 661, 699, 749, 787, 821, 874, 891, 922, 976, 1041, 1083, 1172, 1234, 1276, 1342, 1369, 1416, 1458, 1536, 1593, 1643, 1664, 1723, 1770, 1811, 1843, 1871, 1915, 1958, 2002, 2064, 2101, 2140, 2187, 2226, 2277, 2318, 2395, 2446, 2510, 2584, 2677, 2728, 2780, 2817, 2986, 3455, 3528, 3609, 3674, 3729, 3787, 3832, 3856, 3967], 'Scholar)': [504, 2729], 'has': [505, 986, 3207], 'been': [506, 2991, 3795], 'significantly': [509, 4187], 'reduce': [510], 'plasma': [511, 1797, 1829, 3441, 4344], 'mammalian': [519], 'species': [520, 1184], 'tested,': [521], 'including': [522, 2022], 'humans': [523, 1279], '(2Davis': [524, 3495], 'Compton': [527, 639, 668, 3498], 'D.S.': [528, 640, 669, 3499], 'Hoos': [529, 670, 1142, 1204, 1312, 1506, 1543, 1693, 2191, 2478, 2549, 2745, 2785, 3500], 'L.': [530, 671, 758, 1372, 1435, 1726, 2192, 2550, 2746, 3423, 3429, 3501, 3586, 3643, 3649, 3839], 'Tetzloff': [531, 611, 1144, 1206, 1314, 1508, 1545, 1695, 2195, 2480, 2553, 2749, 2787, 3502], 'G.': [532, 855, 1145, 1207, 1315, 1509, 1546, 1696, 2196, 2481, 2554, 2750, 2788, 3503], 'Ezetimibe,': [533, 615, 3504], 'potent': [535, 576, 617, 3506], 'inhibitor,': [538, 579, 620, 646, 3509], 'inhibits': [539, 676, 1613, 3510], 'development': [541, 1650, 2523, 3512], 'atherosclerosis': [543, 2497, 2804, 3514], 'ApoE': [545, 3516], 'mice.Arterioscler.': [547, 2500, 2807, 3445, 3518], 'Thromb.': [548, 2311, 2501, 2808, 3446, 3519], 'Vasc.': [549, 2502, 2809, 3447, 3520], 'Biol.': [550, 1403, 1580, 1757, 2051, 2503, 2810, 2973, 3448, 3521], '2001;': [551, 591, 628, 655, 693, 3522, 3781, 3826], '21:': [552, 3523], '2032-2038Crossref': [553, 3524], '(199)': [556, 3527], 'Scholar,': [558, 601, 635, 662, 700, 750, 788, 875, 1235, 1343, 1370, 1417, 1537, 1644, 1724, 1771, 1812, 1844, 1872, 1916, 1959, 2065, 2102, 2141, 2188, 2227, 2278, 2396, 2678, 2781, 3833], '3Davis': [559], 'Pula': [562], 'K.K.': [563, 3701], 'Alton': [564], 'K.B.': [565], 'Burrier': [566], 'R.E.': [567, 945, 1419, 3570, 3758, 3803], 'Watkins': [568], 'R.W.': [569], 'The': [570, 643, 836, 924, 1085, 1111, 1647, 3049, 3143, 3251, 3267, 3333, 3457, 3746, 4087], 'synergistic': [571], 'hypocholesterolemic': [572], 'activity': [573], 'ezetimibe,': [580, 647, 2083], 'combination': [582, 2081, 2164, 2372, 2654], '3-hydroxy-3-methylglutaryl': [584], 'coenzyme': [585], 'reductase': [587, 1632, 1653], 'inhibitors': [588], 'dogs.Metabolism.': [590], '50:': [592, 629, 3664], '1234-1241Abstract': [593], 'Full': [594, 741, 743, 970, 972, 1268, 1270, 1408, 1410, 1585, 1587, 1660, 1762, 1764, 2056, 2058, 2179, 2181, 2387, 2389, 2669, 2671, 2978, 2980, 3666, 3668, 3959, 3961], 'Text': [595, 742, 744, 971, 973, 1269, 1271, 1409, 1411, 1586, 1588, 1661, 1763, 1765, 2057, 2059, 2180, 2182, 2388, 2390, 2670, 2672, 2979, 2981, 3667, 3669, 3960, 3962], 'PDF': [596, 745, 974, 1272, 1412, 1589, 1662, 1766, 2060, 2183, 2391, 2673, 2982, 3670, 3963], '(83)': [599], '4van': [602], 'Heek': [603, 637, 664, 2201, 2559, 2755], 'M.': [604, 638, 665, 712, 714, 796, 1149, 1153, 1211, 1215, 1243, 1319, 1323, 1513, 1517, 1548, 1700, 1704, 1918, 1963, 2069, 2104, 2106, 2110, 2112, 2114, 2118, 2147, 2157, 2202, 2282, 2355, 2365, 2483, 2560, 2637, 2647, 2756, 2790], 'Austin': [605], 'T.M.': [606], 'Farley': [607, 666], 'C.': [608, 667, 702, 1848, 2031, 2953], 'Cook': [609, 2193, 2551, 2747], 'J.A.': [610, 1623], 'G.G.': [612], 'normalizes': [621], 'combined': [622], 'dyslipidemia': [623], 'obese': [625, 2127], 'hyperinsulinemic': [626], 'hamsters.Diabetes.': [627], '1330-1335Crossref': [630], '(82)': [633], '5van': [636], 'decreases': [648], 'hypercholesterolemia': [650], 'monkeys.Eur.': [652], 'J.': [653, 691, 736, 1550, 1816, 1820, 1846, 1890, 1920, 1967, 2093, 2194, 2218, 2266, 2435, 2552, 2576, 2717, 2748, 2772, 3754, 3799], 'Pharmacol.': [654, 692, 2219, 2577, 2773], '415:': [656], '79-84Crossref': [657], '(132)': [660, 1275], '6van': [663], 'Ezetimibe': [674, 769, 2119, 2205, 2563, 2759], 'selectively': [675], 'rodents': [681], 'presence': [684], 'absence': [686], 'exocrine': [688], 'pancreatic': [689], 'function.Br.': [690], '134:': [694], '409-417Crossref': [695], '(191)': [698], '7Gagne': [701], 'Bays': [703], 'H.E.': [704], 'Weiss': [705], 'S.R.': [706], 'Mata': [707], 'P.': [708, 1384, 1386, 1738, 1740, 1882, 1888, 2243, 2412, 2694, 3944], 'Quinto': [709], 'K.': [710, 805, 2033, 2145, 2149, 2159, 2284, 2288, 2294, 2298, 2353, 2357, 2367, 2635, 2639, 2649, 2955], 'Melino': [711], 'Cho': [713], 'Musliner': [715], 'T.A.': [716], 'Gumbiner': [717], 'B.': [718, 1347, 1975], 'Efficacy': [719], 'safety': [721], 'ongoing': [726], 'statin': [727, 1611, 3845], 'therapy': [728, 2165, 2373, 2655], 'treatment': [730, 2006, 2529], 'patients': [732, 774, 2307], 'primary': [734, 776], 'hypercholesterolemia.Am.': [735], 'Cardiol.': [737, 780], '2002;': [738, 781, 815], '90:': [739], '1084-1091Abstract': [740], '(474)': [748], '8Davidson': [751], 'M.H.': [752, 1556], 'McGarry': [753], 'Bettis': [755], 'R.': [756, 764, 1850], 'Melani': [757], 'Lipka': [759], 'L.J.': [760, 1139, 1201, 1309, 1503, 1542, 1690, 2485, 2792], 'LeBeaut': [761], 'A.P.': [762], 'Suresh': [763], 'Sun': [765], 'S.': [766, 800, 1374, 1728, 1777, 1779, 2073, 2161, 2190, 2280, 2290, 2369, 2548, 2651, 2744], 'Veltri': [767], 'E.P.': [768], 'coadministered': [770], 'simvastatin': [772], 'hypercholesterolemia.J.': [777, 2050, 2309, 2972], 'Am.': [778], 'Coll.': [779], '40:': [782, 968, 3724], '2125-2134Crossref': [783], '(512)': [786], '9Sudhop': [789], 'Lutjohann': [791], 'D.': [792, 1239, 1247], 'Kodal': [793], 'Igel': [795], 'Tribble': [797], 'D.L.': [798], 'Shah': [799], 'Perevozskaya': [801], 'I.': [802, 2071, 3158, 3266, 3345], 'von': [803], 'Bergmann': [804], 'Inhibition': [806], 'humans.Circulation.': [814], '106:': [816], '1943-1948Crossref': [817], '(451)': [820], 'Scholar).': [822, 892, 923, 977, 1042, 1084, 1173, 1277, 1459, 1594, 1665, 2003, 2319, 2447, 2511, 2585, 2818, 2987, 3456, 3610, 3675, 3730, 3788, 3857, 3968], 'Each': [823], 'day,': [824], 'large': [825], 'amounts': [826, 2347], 'enter': [829], 'lumen': [831, 902, 1471], 'small': [834, 1031, 1073, 1181, 1301], 'intestine.': [835], 'daily': [837, 3360], '∼400': [843], 'mg': [844, 895], 'healthy': [847, 935], 'human': [848, 1261, 4051], 'consuming': [849], '(10Salen': [854], 'Ahrens': [856], 'E.H.': [858], 'Grundy': [859, 1782], 'S.M.': [860, 1783], 'Metabolism': [861], 'beta-sitosterol': [863], 'man.J.': [865], 'Clin.': [866, 1450, 3601], 'Invest.': [867, 1451, 3602], '1970;': [868], '49:': [869], '952-967Crossref': [870], '(386)': [873], '11Wang': [876], 'D.Q.': [877, 908], 'Regulation': [878, 909], 'absorption.Annu.': [882, 913], 'Rev.': [883, 914, 1634], 'Physiol.': [884, 915, 2267, 2270, 2436, 2439, 2718, 2721], '2007;': [885, 916, 1452, 2134, 2504, 2811, 3603], '69:': [886, 917], '221-248Crossref': [887, 918], '(231)': [890, 921], 'Additionally,': [893], '∼800': [894], 'secreted': [898], 'into': [899, 3681], 'gut': [901], 'bile': [904, 1015], 'each': [905], 'day': [906], '(11Wang': [907], 'fractional': [925, 3627], 'ranges': [929], '29%': [931], '80%': [933], 'individuals': [936], '(12Bosner': [937], 'M.S.': [938, 3762, 3807], 'Lange': [939], 'L.G.': [940], 'Stenson': [941], 'W.F.': [942], 'Ostlund': [943], 'Percent': [946], 'normal': [950], 'women': [951], 'men': [953], 'quantified': [954], 'dual': [956], 'stable': [957], 'isotopic': [958], 'tracers': [959], 'negative': [961], 'ion': [962], 'mass': [963], 'spectrometry.J.': [964], 'Lipid': [965, 1263, 1655, 3661], 'Res.': [966, 1264, 1656, 3662], '1999;': [967], '302-308Abstract': [969], 'efficiently': [980], 'absorbed,': [981], 'hydrophobic': [983], 'molecule': [985], 'cross': [988], 'unstirred': [990], 'water': [991, 997, 3054], 'layer': [992], 'lying': [993], 'bulk': [996], 'phase': [998], 'mucosal': [1002], 'cell': [1003, 1397, 1670, 1751], 'membrane,': [1004], 'achieved': [1007], 'its': [1009], 'solubilization': [1010], 'mixed': [1012], 'micelles': [1013, 1047], 'acids,': [1016], 'phospholipids,': [1017], 'hydrolytic': [1019], 'products': [1020], '(13Turley': [1023, 1065], 'S.D.': [1024, 1066, 3708], 'Dietschy': [1025, 1067, 3705], 'J.M.': [1026, 1068, 1376, 1730, 3706], 'Sterol': [1027, 1069], 'intestine.Curr.': [1032, 1074], 'Opin.': [1033, 1075], 'Lipidol.': [1034, 1076], '2003;': [1035, 1077, 1637], '14:': [1036, 1078], '233-240Crossref': [1037, 1079], '(117)': [1040, 1082], 'Whether': [1043], 'free': [1044, 1400, 1754, 3405, 3466, 4369], 'taken': [1049], 'up': [1050], 'passively': [1051], 'actively': [1053], 'absorptive': [1055, 1193], 'enterocytes': [1056, 1194], 'had': [1057, 4165], 'remained': [1058], 'elusive': [1059], 'until': [1060], 'discovery': [1062, 1648], 'potency': [1086], 'low': [1088, 2627, 2859, 3291], 'doses': [1089], 'inhibiting': [1093, 1596], 'strongly': [1097], 'supports': [1098], 'notion': [1100, 1675], 'protein-mediated': [1109], 'process.': [1110], 'search': [1112], 'protein': [1115, 1159, 1175, 1221, 1294, 1329, 1523, 1710], 'resulted': [1116], 'identification': [1118, 1358], 'as': [1124, 2457, 3415, 3564, 3635, 3750, 3885, 3899, 3936, 4083, 4155], 'transporter': [1127, 1571], 'essential': [1128], '(14Altmann': [1133, 1195, 1303, 1497, 1684], 'S.W.': [1134, 1196, 1304, 1498, 1685, 2489, 2796], 'Zhu': [1138, 1200, 1308, 1502, 1541, 1689, 2484, 2791], 'Yao': [1140, 1202, 1310, 1504, 1551, 1691], 'X.': [1141, 1203, 1311, 1505, 1552, 1692], 'L.M.': [1143, 1205, 1313, 1433, 1507, 1544, 1694, 2231, 2400, 2479, 2682, 2786, 3584], 'Iyer': [1146, 1208, 1316, 1510, 1553, 1697], 'S.P.': [1147, 1209, 1317, 1511, 1554, 1698], 'Maguire': [1148, 1210, 1318, 1512, 1547, 1699, 2482, 2789], 'Golovko': [1150, 1212, 1320, 1514, 1701], 'Zeng': [1152, 1214, 1322, 1516, 1703], 'et': [1154, 1216, 1324, 1518, 1559, 1705, 1893, 1938, 1980, 2162, 2299, 2370, 2652], 'al.Niemann-Pick': [1155, 1217, 1325, 1519, 1560, 1706], 'C1': [1156, 1218, 1326, 1520, 1561, 1707, 2493, 2800], 'Like': [1157, 1219, 1327, 1521, 1562, 1708, 2494, 2801], 'critical': [1161, 1223, 1331, 1525, 1712], 'absorption.Science.': [1165, 1227, 1335, 1529, 1716], '2004;': [1166, 1228, 1336, 1530, 1582, 1717, 3723, 3956], '303:': [1167, 1229, 1337, 1531, 1718], '1201-1204Crossref': [1168, 1230, 1338, 1532, 1719], '(1429)': [1171, 1233, 1341, 1535, 1722], 'highly': [1177], 'expressed': [1178], 'intestine': [1182, 1302], 'across': [1183], 'localizes': [1186], 'primarily': [1187], 'at': [1188, 2998, 3037, 3083, 3122, 3195, 3312, 4007, 4018, 4058, 4069, 4127, 4168, 4171], 'apical': [1190], 'membrane': [1191], '15Sane': [1236], 'A.T.': [1237], 'Sinnett': [1238], 'Delvin': [1240], 'E.': [1241, 1251], 'Bendayan': [1242], 'Marcil': [1244], 'V.': [1245], 'Menard': [1246], 'Beaulieu': [1248], 'J.F.': [1249], 'Levy': [1250, 1346], 'Localization': [1252], 'intestine.J.': [1262], '2006;': [1265, 1405, 1759, 1805, 2095, 3850], '47:': [1266], '2112-2120Abstract': [1267], 'Although': [1278], 'nonhuman': [1281], 'primates': [1282], 'also': [1283], 'express': [1284], 'liver': [1287, 2091, 2121, 2173, 2214, 2381, 2526, 2572, 2663, 2768, 3561, 4346, 4353], 'perhaps': [1289], 'tissues,': [1291], 'mouse': [1292], 'can': [1295], 'detected': [1298], '16Davies': [1344], 'J.P.': [1345, 1431, 2029, 2239, 2408, 2690, 2951, 3427, 3582, 3647], 'Ioannou': [1348, 1428, 2036, 2240, 2409, 2691, 2958, 3424, 3579, 3644], 'Y.A.': [1349, 1429, 2037, 2241, 2410, 2692, 2959, 3425, 3580, 3645, 3760, 3805], 'Evidence': [1350], 'Niemann-pick': [1353], 'C': [1354, 1983], '(NPC)': [1355], 'gene': [1356], 'family:': [1357], 'characterization': [1360], 'NPC1L1.Genomics.': [1362], '2000;': [1363], '65:': [1364], '137-145Crossref': [1365], '(188)': [1368], '17Yu': [1371, 1725], 'Bharadwaj': [1373, 1727], 'Brown': [1375, 1729, 3761, 3806], 'Ma': [1377, 1422, 1731, 3420, 3573, 3640, 3836], 'Y.': [1378, 1423, 1732, 2143, 2151, 2292, 2351, 2359, 2633, 2641, 3421, 3574, 3641, 3837], 'Du': [1379, 1733], 'W.': [1380, 1421, 1734, 1973, 1977, 3419, 3572, 3639, 3835], 'M.A.': [1382, 1736], 'Michaely': [1383, 1737], 'Liu': [1385, 1549, 1739, 1966], 'Willingham': [1387, 1426, 1741, 3577], 'M.C.': [1388, 1427, 1742, 1876, 3578], 'Rudel': [1389, 1424, 1743, 3575], 'L.L.': [1390, 1425, 1744, 3576], 'Cholesterol-regulated': [1391, 1745], 'translocation': [1392, 1746], 'surface': [1398, 1752], 'facilitates': [1399, 1753], 'uptake.J.': [1402, 1756], '281:': [1406, 1760], '6616-6624Abstract': [1407, 1761], '(169)': [1415, 1769], '18Temel': [1418], 'Tang': [1420, 3571], 'Davies': [1430, 2238, 2407, 2689, 3426, 3581, 3646], 'Nilsson': [1432, 3583], 'Yu': [1434, 3428, 3585, 3648, 3838], 'Hepatic': [1436, 3587], 'C1-like': [1438, 3431, 3589], 'biliary': [1441, 3592], 'concentration': [1443, 3594, 3985], 'target': [1447, 1681, 1940, 3598], 'ezetimibe.J.': [1449, 3600], '117:': [1453, 3604], '1968-1978Crossref': [1454, 3605], '(305)': [1457, 3608], 'do': [1464], 'absorb': [1466], 'thus': [1473, 2944], 'have': [1474, 2990, 3231, 3566, 3794], 'corresponding': [1476], 'increase': [1477], 'compensatory': [1483], 'upregulation': [1484], 'biosynthesis,': [1489], 'phenotypes': [1492], 'observed': [1493], 'ezetimibe-treated': [1495, 2262, 2330, 2431, 2623, 2713], 'animals': [1496], '19Davis': [1538], 'Lam': [1555], 'Lund': [1557], 'E.G.': [1558], 'phytosterol': [1568], 'key': [1574], 'modulator': [1575], 'whole-body': [1577], 'homeostasis.J.': [1579], '279:': [1583], '33586-33592Abstract': [1584], '(593)': [1592], 'Because': [1595], 'increases': [1600], 'endogenous': [1601], 'synthesis,': [1603], 'often': [1606], 'prescribed': [1607], 'together': [1608], '3-hydroxy-3-methyl-glutaryl-CoA': [1614], 'reductase,': [1615], 'rate-limiting': [1617], 'enzyme': [1618], 'synthesis': [1621, 3767, 3812], '(20Tobert': [1622], 'Lovastatin': [1624], 'beyond:': [1626], 'history': [1628], 'HMG-CoA': [1631, 1652], 'inhibitors.Nat.': [1633], 'Drug': [1635], 'Discov.': [1636], '2:': [1638], '517-526Crossref': [1639], '(643)': [1642], '21Endo': [1645], 'inhibitors.J.': [1654], '1992;': [1657], '33:': [1658], '1569-1582Abstract': [1659], 'Subsequent': [1666], 'genetic,': [1667], 'animal,': [1668], 'biology': [1671], 'support': [1673], 'molecular': [1680], '22Cohen': [1772], 'J.C.': [1773, 2233, 2402, 2684], 'Pertsemlidis': [1774], 'Fahmi': [1776], 'Esmail': [1778], 'Vega': [1780], 'G.L.': [1781], 'Hobbs': [1784], 'H.H.': [1785], 'Multiple': [1786], 'rare': [1787], 'variants': [1788], 'associated': [1791, 1824], 'reduced': [1793], 'sterol': [1794, 3633], 'levels.Proc.': [1800], 'Natl.': [1801, 1948, 1992, 3777, 3822], 'Acad.': [1802, 1949, 1993, 3778, 3823], 'Sci.': [1803, 1950, 1994, 3779, 3824], 'USA.': [1804, 1951, 1995, 3780, 3825], '103:': [1806], '1810-1815Crossref': [1807], '(328)': [1810], '23Hegele': [1813], 'R.A.': [1814], 'Guy': [1815], 'Ban': [1817], 'M.R.': [1818], 'Wang': [1819], 'haplotype': [1822], 'inter-individual': [1826], 'variation': [1827, 1895], 'ezetimibe.Lipids': [1834], 'Health': [1835, 3087], 'Dis.': [1836], '2005;': [1837, 1865, 1909, 1952, 2053, 2975], '4:': [1838], '16Crossref': [1839], '(103)': [1842], '24Wang': [1845], 'Williams': [1847, 1974], 'Hegele': [1849], 'Compound': [1851], 'heterozygosity': [1852], 'non-synonymous': [1855], 'polymorphisms': [1856], 'non-responder': [1861], 'ezetimibe.Clin.': [1863], 'Genet.': [1864], '67:': [1866], '175-177Crossref': [1867], '(67)': [1870], '25Simon': [1873], 'J.S.': [1874], 'Karnoub': [1875], 'Devlin': [1877], 'D.J.': [1878], 'Arreaza': [1879], 'M.G.': [1880], 'Qiu': [1881], 'Monks': [1883], 'S.A.': [1884], 'Severino': [1885], 'M.E.': [1886], 'Deutsch': [1887], 'Palmisano': [1889], 'Sachs': [1891], 'A.B.': [1892, 1961], 'al.Sequence': [1894], 'association': [1899], 'improved': [1901], 'LDL-cholesterol': [1902], 'lowering': [1903], 'treatment.Genomics.': [1908], '86:': [1910], '648-656Crossref': [1911], '(108)': [1914], '26Garcia-Calvo': [1917], 'Lisnock': [1919], 'Bull': [1921], 'H.G.': [1922], 'Hawes': [1923], 'B.E.': [1924], 'Braun': [1927], 'M.P.': [1928, 2487, 2794], 'Crona': [1929], 'J.H.': [1930], 'Dean': [1934], 'D.C.': [1935], 'Detmers': [1936], 'P.A.': [1937], 'al.The': [1939], '(NPC1L1).Proc.': [1947], '102:': [1953], '8132-8137Crossref': [1954], '(650)': [1957], '27Weinglass': [1960], 'Kohler': [1962], 'Schulte': [1964], 'U.': [1965], 'Nketiah': [1968], 'E.O.': [1969], 'Thomas': [1970], 'Schmalhofer': [1972], 'Bildl': [1976], 'McMasters': [1978], 'D.R.': [1979], 'al.Extracellular': [1981], 'loop': [1982], 'important': [1987], 'binding': [1989], 'ezetimibe.Proc.': [1991], '2008;': [1996, 2220, 2271, 2440, 2578, 2722, 2774, 3449], '105:': [1997], '11140-11145Crossref': [1998], '(91)': [2001], 'Interestingly,': [2004, 4181], 'genetic': [2008, 2598], 'inactivation': [2009, 3651], 'improve': [2016], 'many': [2017], 'aspects': [2018], 'metabolic': [2020, 2131, 2302, 2883], 'syndrome,': [2021], 'insulin': [2023, 2124, 3371, 4029, 4052, 4077], 'resistance': [2024, 2125, 2255, 2424, 2611, 2706], 'hepatic': [2026, 3720, 4230], 'steatosis': [2027, 2122], '(28Davies': [2028, 2950], 'Scott': [2030, 2952], 'Oishi': [2032, 2954], 'Liapis': [2034, 2956], 'Inactivation': [2038, 2960], 'causes': [2041, 2963], 'multiple': [2042, 2964], 'lipid': [2043, 2965, 3562, 3766, 3811], 'transport': [2044, 2966], 'defects': [2045, 2967], 'protects': [2047, 2969, 3654], '280:': [2054, 2976], '12710-12720Abstract': [2055, 2977], '(246)': [2063, 2985], '29Assy': [2066], 'Grozovski': [2068], 'Bersudsky': [2070], 'Szvalb': [2072], 'Hussein': [2074], 'O.': [2075], 'Effect': [2076], 'insulin-sensitizing': [2078], 'agents': [2079], 'valsartan': [2085], 'rats': [2087], 'non-alcoholic': [2089, 2171, 2212, 2379, 2570, 2661, 2766], 'fatty': [2090, 2172, 2213, 2252, 2380, 2421, 2525, 2571, 2662, 2703, 2767, 3144, 3252, 3334, 3485, 3882, 3912, 3932, 4380], 'disease.World': [2092], 'Gastroenterol.': [2094], '12:': [2096], '4369-4376Crossref': [2097], '(49)': [2100], '30Deushi': [2103], 'Nomura': [2105], 'Kawakami': [2107], 'Haraguchi': [2109], 'Ito': [2111], 'Okazaki': [2113], 'Ishii': [2115], 'H.': [2116, 2153, 2155, 2199, 2361, 2363, 2557, 2643, 2645, 2753], 'Yoshida': [2117, 2289], 'improves': [2120, 2206, 2564, 2760], 'rat': [2128], 'model': [2129], 'syndrome.FEBS': [2132], 'Lett.': [2133], '581:': [2135], '5664-5670Crossref': [2136], '(147)': [2139], '31Nozaki': [2142], 'Fujita': [2144, 2352, 2634], 'Yoneda': [2146, 2354, 2636], 'Wada': [2148, 2356, 2638], 'Shinohara': [2150, 2358, 2640], 'Takahashi': [2152, 2360, 2642], 'Kirikoshi': [2154, 2362, 2644], 'Inamori': [2156, 2364, 2646], 'Kubota': [2158, 2366, 2648], 'Saito': [2160, 2368, 2650], 'al.Long-term': [2163, 2371, 2653], 'acarbose': [2169, 2377, 2659], 'disease.J.': [2174, 2382, 2664], 'Hepatol.': [2175, 2383, 2665], '2009;': [2176, 2384, 2666, 3663], '51:': [2177, 2385, 2667], '548-556Abstract': [2178, 2386, 2668], '(81)': [2186, 2394, 2676], '32Zheng': [2189], 'van': [2200, 2558, 2754], 'Hwa': [2203, 2561, 2757], 'J.J.': [2204, 2562, 2758, 3699], 'high': [2207, 2565, 2736, 2761, 2864, 3297], 'disease': [2215, 2573, 2769], 'mice.Eur.': [2217, 2575, 2771], '584:': [2221, 2579, 2775], '118-124Crossref': [2222, 2580, 2776], '(142)': [2225, 2583, 2779], '33Labonte': [2228, 2397, 2679], 'E.D.': [2229, 2398, 2680], 'Camarota': [2230, 2399, 2681], 'Rojas': [2232, 2401, 2683], 'Jandacek': [2234, 2403, 2685], 'R.J.': [2235, 2404, 2686, 3940], 'Gilham': [2236, 2405, 2687], 'D.E.': [2237, 2406, 2688], 'Tso': [2242, 2411, 2693, 3943], 'Hui': [2244, 2413, 2695], 'D.Y.': [2245, 2414, 2696], 'Howles': [2246, 2415, 2697], 'P.N.': [2247, 2416, 2698], 'Reduced': [2248, 2417, 2699], 'saturated': [2251, 2420, 2702], 'acids': [2253, 2422, 2704, 3486, 3933], 'diabetes': [2260, 2429, 2711], 'Npc1l1−/−': [2264, 2433, 2715], 'mice.Am.': [2265, 2434, 2716], 'Gastrointest.': [2268, 2437, 2719], 'Liver': [2269, 2438, 2720], '295:': [2272, 2441, 2723], 'G776-G783Crossref': [2273, 2442, 2724], '(97)': [2276, 2445, 2727], '34Yagi': [2279], 'Akaike': [2281], 'Aihara': [2283], 'Iwase': [2285], 'Ishikawa': [2287], 'Sumitomo-Ueda': [2291], 'Kusunose': [2293], 'Niki': [2295], 'Yamaguchi': [2297], 'al.Ezetimibe': [2300], 'ameliorates': [2301], 'disorders': [2303], 'microalbuminuria': [2305], 'Atheroscler.': [2310], '2010;': [2312], '17:': [2313], '173-180Crossref': [2314], '(40)': [2317], 'For': [2320, 3089, 3159, 3969, 4028], 'example,': [2321], 'pure': [2326, 2947, 3017], 'C57BL/6': [2327, 2333, 2539, 2940, 2948, 2995, 3018, 3098], 'background': [2328, 2949, 3019], 'are': [2335, 2912, 3222, 3327, 4081], '(HFD)': [2344], 'trace': [2346, 3106], '(31Nozaki': [2350, 2632], '129/OlaHsd': [2451], 'background,': [2452, 2599], 'however,': [2453], 'WT': [2458, 2852, 2994, 3097, 3169, 3281, 4097, 4163, 4192, 4217, 4233], 'controls': [2459, 2853, 3012, 3170, 3282], 'after': [2460, 3364, 3546, 4025, 4076, 4194], '24': [2461], 'weeks': [2462, 2532, 2872, 3124, 3363, 3366, 3860, 4204], '40%': [2467], 'calories': [2468, 3131, 3135, 3140, 3238, 3243, 3248, 3880], 'butter': [2470], '0.15%': [2473], '(35Davis': [2475], 'Graziano': [2486, 2793], 'Altmann': [2488, 2795], 'Deficiency': [2490, 2797], 'prevents': [2496, 2803, 2839], 'ApoE−/−': [2499, 2806], '27:': [2505, 2812], '841-849Crossref': [2506, 2813], '(112)': [2509, 2816], 'study': [2514, 3269], 'examining': [2515], 'protective': [2517], 'disease,': [2527], '4': [2531, 3548, 4340], 'did': [2533], 'prevent': [2535], '0.12%': [2545], '(32Zheng': [2547, 2743], 'While': [2586], 'discrepancies': [2588], 'among': [2589], 'different': [2590], 'may': [2592], 'attributable': [2594], 'differences': [2596, 4088], 'gene-targeting': [2600], 'strategies,': [2601], 'experimental': [2602], 'duration,': [2603], 'and/or': [2604], 'composition,': [2607], 'we': [2608, 2847, 3565], 'noticed': [2609], '(<0.02%,': [2628, 2860, 3292], 'w/w)': [2629, 2740, 2861, 2866, 3111], 'cholesterol-containing': [2630], 'those': [2733], '(0.15%': [2737], '0.12%,': [2739], '35Davis': [2782], 'This': [2819, 3127], 'led': [2820], 'us': [2821], 'hypothesize': [2823], 'modulates': [2827], 'NPC1L1-deficient': [2831], 'systemically': [2834], 'determine': [2835, 4135], 'if': [2836], 'deficiency': [2838, 3710], 'cholesterol-dependent': [2845], 'manner,': [2846], 'either': [2857, 3179, 3289], '(∼0.2%,': [2865], 'weeks,': [2875, 3120], 'monitored': [2877, 3354, 3359], 'changes': [2880], 'parameters': [2884, 4231], 'animals.': [2887], 'Our': [2888], 'findings': [2889], 'clearly': [2890], 'demonstrate': [2891], 'supplementation': [2894], 'rescues': [2897], 'both': [2904, 3918], '(HCD).': [2909], 'Future': [2910], 'needed': [2913], 'solve': [2915], 'conundrum': [2917], 'how': [2919], 'created': [2938], 'using': [2939, 3737], 'embryonic': [2941], 'stem': [2942], 'cells,': [2943], 'having': [2945], 'These': [2988, 3190, 3307], 'crossed': [2992], 'least': [2999], 'four': [3000], 'generations': [3001], 'before': [3002], 'use': [3004], 'study.': [3007, 3274], 'their': [3011, 3280], 'maintained': [3014], 'experiments.': [3023], 'All': [3024, 3070, 3789, 4079], 'housed': [3027, 3622, 3867], 'specific': [3030], 'pathogen-free': [3031], 'animal': [3032, 3071, 3216], 'facility': [3033], 'plastic': [3035], 'cages': [3036], '22°C,': [3038], 'daylight': [3041], 'cycle': [3042], '6': [3044, 3047, 4036], 'AM': [3045], 'PM.': [3048], 'provided': [3052], 'standard': [3056], 'chow': [3057], '(Prolab': [3059], 'RMH': [3060], '3000;': [3061], 'LabDiet,': [3062], 'Brentwood,': [3063], 'MO)': [3064], 'ad': [3065], 'libitum,': [3066], 'unless': [3067], 'stated': [3068], 'otherwise.': [3069], 'procedures': [3072], 'approved': [3074], 'Institutional': [3077], 'Animal': [3078], 'Care': [3079], 'Use': [3081], 'Committee': [3082], 'Wake': [3084, 3200, 3317], 'Forest': [3085, 3201, 3318], 'University': [3086, 3202, 3319], 'Sciences.': [3088], 'first': [3091], 'short-term': [3092, 3162], 'male': [3094, 3165, 3276], '(∼0.007%,': [3110], '(HFD1-C)': [3112], '(TD.93075;': [3113], 'Harlan': [3114], 'Teklad,': [3115], 'Madison,': [3116], 'WI)': [3117], 'starting': [3121], '8': [3123], 'age.': [3126], 'contains': [3129], '54.8%': [3130], 'fat,': [3133], '21.2%': [3134], 'protein,': [3137], '24%': [3139], 'carbohydrates.': [3142], 'acid': [3145, 3253, 3335, 3883, 3913], 'composition': [3146, 3254, 3336, 3884, 3914], 'included': [3154, 3262, 3341], 'supplementary': [3156, 3225, 3264, 3330, 3343], 'Table': [3157, 3226, 3265, 3331, 3344], 'second': [3161], 'experiment,': [3163, 3618], '8-week-old': [3164], '(HCD)': [3177], '<0.02%': [3180], '(HCD-C)': [3182], '∼0.2%': [3184], '(HCD+C)': [3186], 'made': [3194, 3311], 'Diet': [3197, 3314], 'Core': [3198, 3315], 'School': [3203, 3320], 'Medicine,': [3205], 'more': [3208], 'than': [3209], '40': [3210], 'years': [3211], 'experience': [3213], 'preparing': [3215], 'diets.': [3217], 'Ingredients': [3218, 3323], 'presented': [3223, 3328, 4082], 'II.': [3227, 3332], 'Both': [3228], 'carbohydrate': [3229], 'identical': [3232], 'ingredients': [3233], 'except': [3234, 3889], '11%': [3237], 'palm': [3240], 'oil,': [3241], '72%': [3242], 'carbohydrates,': [3245], '17%': [3247], 'protein.': [3250], 'third': [3268], 'long-term': [3272, 3616], 'Six-week-old': [3275], 'w/w,': [3293, 3299], 'HFD-C)': [3294], '(∼0.16%,': [3298], 'HFD+C)': [3300], 'Medicine.': [3322], 'During': [3346], 'feeding': [3349], 'period,': [3350], 'weekly.': [3355], '2': [3362], '16': [3365, 3859], 'feeding.': [3369], 'Plasma': [3370, 3402, 3481, 3840], 'measured': [3373, 3390, 3488, 3916, 4017, 4068], 'Ultra': [3375], 'Sensitive': [3376], 'Mouse': [3377], 'Insulin': [3378], 'Elisa': [3379], 'Kit': [3380], '(Crystal': [3381], 'Chem,': [3382], 'Inc.,': [3383, 4055], 'Downers': [3384], 'Grove,': [3385], 'IL).': [3386], 'Blood': [3387, 4012, 4063], 'glucose': [3388, 3970, 3984, 4006, 4013, 4026, 4043, 4064], 'directly': [3391], 'Glucometer': [3393, 3992], '(Bayer': [3394, 3995], 'Contour,': [3395, 3997], 'Tarrytown,': [3396, 3998], 'NY)': [3397, 4057], 'via': [3398], 'tail': [3400, 3988], 'nick.': [3401], 'triglyceride': [3408], 'concentrations': [3409, 3482, 4014, 4065], 'analyzed': [3411], 'enzymatic': [3413], 'assay': [3414, 3491], 'previously': [3416, 3568, 3637, 3752, 3797, 3937], 'described': [3417, 3567, 3636, 3751, 3938, 4156], '(36Tang': [3418], 'Jia': [3422, 3642], 'required': [3434], 'LXR': [3437], 'agonist': [3438], 'raise': [3440], 'HDL': [3442], '28:': [3450], '448-454Crossref': [3451], '(43)': [3454], 'cholesteryl': [3460, 3478, 4366], 'ester': [3461, 3479], 'calculated': [3463, 3685, 3935], 'subtracting': [3465], 'multiplying': [3472, 3687], '1.67': [3474], 'convert': [3476], 'mass.': [3480], 'nonesterified': [3484, 4379], 'colorimetric': [3490], '[HR': [3492], 'Series': [3493], 'NEFA-HR': [3494], 'Scholar);': [3529], 'Wako,': [3530], 'Richmond,': [3531], 'VA]': [3532], 'following': [3533], "manufacturer's": [3535, 3744], 'instructions.': [3536, 3745], 'At': [3537], 'end': [3539], 'studies,': [3542], 'euthanized': [3545], 'h': [3549, 4341], 'fast.': [3550], 'Livers': [3551], 'removed,': [3553], 'weighed,': [3554], 'snap-frozen': [3556], 'liquid': [3558], 'nitrogen': [3559], 'analyses': [3563], '(18Temel': [3569], 'week': [3612, 4196], 'individually': [3621, 3866], 'determination': [3625], 'neutral': [3632], '(37Tang': [3638], 'Genetic': [3650], 'sitosterolemia': [3656], 'lacking': [3659], 'ABCG5/ABCG8.J.': [3660], '293-300Abstract': [3665], '(45)': [3673], 'Mass': [3676], 'food': [3688], 'intake,': [3689], 'content,': [3692], 'percentage': [3694], '(38Repa': [3698], 'Buhman': [3700], 'Farese': [3702], 'R.V.': [3704], 'Turley': [3707], 'ACAT2': [3709], 'limits': [3711], 'cholesterol-fed': [3716], 'mouse:': [3717], 'impact': [3718], 'homeostasis.Hepatology.': [3722], '1088-1097Crossref': [3725], '(96)': [3728], 'Total': [3731], 'RNAs': [3732], 'extracted': [3734], 'jejuna': [3736], 'TRIzol': [3738], 'reagent': [3739], '(Invitrogen)': [3740], 'according': [3741], 'qPCR': [3747, 3793], 'performed': [3749], '(39Yang': [3753, 3798], 'Goldstein': [3755, 3800], 'J.L.': [3756, 3801], 'Hammer': [3757, 3802], 'Moon': [3759, 3804], 'Horton': [3763, 3808], 'J.D.': [3764, 3809], 'Decreased': [3765, 3810], 'livers': [3769, 3814], 'disrupted': [3773, 3818], 'Site-1': [3774, 3819], 'protease': [3775, 3820], 'gene.Proc.': [3776, 3821], '98:': [3782, 3827], '13607-13612Crossref': [3783, 3828], '(190)': [3786, 3831], 'primers': [3790], 'used': [3791], 'published': [3796], '40Tang': [3834], 'hyperresponsive': [3843], 'ABCG5/ABCG8': [3847], 'transgenic': [3848], 'mice.Hepatology.': [3849], '44:': [3851], '1259-1266Crossref': [3852], '(22)': [3855], 'After': [3858, 3979, 4038, 4202], 'feeding,': [3863, 4207], 'test': [3871, 3993], 'days,': [3875, 3909], 'contained': [3877], 'same': [3879, 4101, 4111], 'previous': [3887], '5%': [3891], 'replaced': [3895], 'sucrose': [3897], 'poly-behenate': [3898], 'nonabsorbable': [3901], 'marker.': [3902], 'Fecal': [3903], 'samples': [3904, 3922], 'collected': [3906], 'gas': [3924], 'chromatography.': [3925], 'Fractional': [3926], 'individual': [3931], '(41Jandacek': [3939], 'Heubi': [3941], 'J.E.': [3942], 'A': [3945], 'novel,': [3946], 'noninvasive': [3947], 'method': [3948], 'measurement': [3951], 'absorption.Gastroenterology.': [3955], '127:': [3957], '139-144Abstract': [3958], '(92)': [3966], 'tolerance': [3971, 4030], 'test,': [3972, 4031], 'fasted': [3975, 4034, 4338], '10': [3977], 'h.': [3978, 4037], 'measuring': [3980, 4039], 'baseline': [3982, 4041], 'cut': [3989], 'strip': [3994], 'Ascensia': [3996], 'NY),': [3999], 'injected': [4002, 4047], 'intraperitoneally': [4003, 4048], '20%': [4005], '1.5': [4008], 'mg/g': [4009], 'weight.': [4011, 4062], 'then': [4016, 4067], '15,': [4019, 4070], '30,': [4020, 4071], '60,': [4021, 4072], '120': [4023, 4074], 'min': [4024, 4075], 'injection.': [4027], 'concentration,': [4044], 'recombinant': [4050], '(Novo': [4053], 'Nordisk,': [4054], 'Princeton,': [4056], '1.2': [4059], 'mU/g': [4060], 'administration.': [4078], 'data': [4080], 'mean': [4084, 4091], '±': [4085, 4249, 4251, 4257, 4259, 4267, 4269, 4275, 4277, 4285, 4287, 4293, 4295, 4299, 4301, 4305, 4307, 4311, 4313, 4317, 4319, 4324, 4326, 4331, 4333], 'SEM.': [4086], 'values': [4092], 'groups': [4106], 'genotype,': [4112], 'tested': [4114], 'statistical': [4116], 'significance': [4117, 4124], 'two-tailed': [4120], "Student's": [4121], 't-test.': [4122], 'Statistical': [4123], 'accepted': [4126], 'value': [4129], 'P': [4131, 4396, 4399], '<': [4132, 4253, 4261, 4271, 4279, 4289, 4335, 4397, 4400], '0.05.': [4133], 'effect': [4137], 'no': [4141], 'mice,': [4149], 'HFD1-C': [4154, 4238], '"Materials': [4158], 'Methods."': [4160], 'birth': [4169], 'time': [4173], 'when': [4174], 'started': [4178], '(Fig.': [4179, 4200], '1A).': [4180], 'began': [4184], 'less': [4188], 'compared': [4190], '1B).': [4201], 'five': [4203, 4241], 'gained': [4210, 4219], '∼2': [4212], 'g': [4213, 4222], 'weight,': [4215], 'whereas': [4216], 'nearly': [4220], '(Table': [4226], '1).TABLE': [4227], '1.Plasma': [4228], 'weeksLow': [4242], 'Cholesterol,': [4243], 'High-Fat': [4244], 'DietParameterWT': [4245], 'MiceL1-KO': [4246], 'MiceBW': [4247], '(g)26.8': [4248], '0.823.8': [4250], '0.2aP': [4252], '0.05.WAT': [4254], '(g)0.99': [4256], '0.040.34': [4258], '0.03bP': [4260], '0.001.WAT': [4262], 'BW': [4264, 4282], 'ratio': [4265, 4283], '(%)3.74': [4266], '0.141.43': [4268], '0.13bP': [4270], '0.001.Liver': [4272], '(g)1.1': [4274], '0.050.9': [4276], '0.03aP': [4278], '0.05.Liver': [4280], '(%)4.2': [4284], '0.133.8': [4286], '0.12aP': [4288], '0.05.Plasma': [4290], 'TC': [4291, 4321], '(mg/dl)129.8': [4292], '9.8115.1': [4294], '8.1Plasma': [4296], 'FC': [4297], '(mg/dl)33.9': [4298], '2.828.7': [4300], '1.5Plasma': [4302], 'CE': [4303], '(mg/dl)160.1': [4304], '12.4144.3': [4306], '11.8Plasma': [4308], 'TG': [4309, 4328], '(mg/dl)49.1': [4310], '8.331.3': [4312], '3.1Plasma': [4314], 'NEFA': [4315], '(mmol/l)0.37': [4316], '0.030.24': [4318], '0.05Hepatic': [4320], '(mg/g': [4322, 4329], 'WW)2.1': [4323], '0.312.0': [4325], '0.08Hepatic': [4327], 'WW)24.9': [4330], '6.595.2': [4332], '0.79aP': [4334], '0.05.Mice': [4336], 'prior': [4342], 'lipids': [4347, 4354], 'analysis;': [4348], 'n': [4349, 4356], '=': [4350, 4357], '4–7': [4351], '6–7': [4358], 'measurements.': [4361], 'BW,': [4362], 'weight;': [4364, 4393], 'CE,': [4365], 'ester;': [4367], 'FC,': [4368], 'cholesterol;': [4370, 4384], 'HFD1-C,': [4371], 'low-cholesterol,': [4372], 'diet;': [4374], 'L1-KO,': [4375], 'knockout;': [4377], 'NEFA,': [4378], 'acid;': [4381], 'TC,': [4382], 'TG,': [4385], 'triglyceride;': [4386], 'WAT,': [4387], 'white': [4388], 'adipose': [4389], 'tissue;': [4390], 'WW,': [4391], 'wet': [4392], 'WT,': [4394], 'wild-type.a': [4395], '0.05.b': [4398], '0.001.': [4401]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019924734', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-08T06:00:03.112223', 'created_date': '2016-06-24'}