Publication Information

{'id': 'https://openalex.org/W2019797192', 'doi': 'https://doi.org/10.1097/wnr.0b013e32833d40c8', 'title': 'Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats', 'display_name': 'Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats', 'publication_year': 2010, 'publication_date': '2010-07-14', 'ids': {'openalex': 'https://openalex.org/W2019797192', 'doi': 'https://doi.org/10.1097/wnr.0b013e32833d40c8', 'mag': '2019797192', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20631586'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/wnr.0b013e32833d40c8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S121278948', 'display_name': 'Neuroreport', 'issn_l': '0959-4965', 'issn': ['0959-4965', '1473-558X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004144742', 'display_name': 'Xinxin Yang', 'orcid': 'https://orcid.org/0000-0002-2024-4307'}, 'institutions': [{'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinxin Yang', 'raw_affiliation_strings': ['Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine', 'institution_ids': ['https://openalex.org/I2801518579', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044837649', 'display_name': 'Weien Yuan', 'orcid': 'https://orcid.org/0000-0003-4177-7812'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weien Yuan', 'raw_affiliation_strings': ['Shanghai Jiao Tong University School of Pharmacy, Shanghai, PR China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Jiao Tong University School of Pharmacy, Shanghai, PR China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060549633', 'display_name': 'Tianan Ren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tianan Ren', 'raw_affiliation_strings': ['Shanghai Jiao Tong University School of Pharmacy, Shanghai, PR China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Jiao Tong University School of Pharmacy, Shanghai, PR China', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100660352', 'display_name': 'Lu Song', 'orcid': 'https://orcid.org/0000-0002-4742-7816'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lu Song', 'raw_affiliation_strings': ['Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I2801518579']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100644979', 'display_name': 'Na Wu', 'orcid': 'https://orcid.org/0000-0003-0082-4969'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Na Wu', 'raw_affiliation_strings': ['Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I2801518579']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100448067', 'display_name': 'Zhenguo Liu', 'orcid': 'https://orcid.org/0000-0003-1743-2937'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}, {'id': 'https://openalex.org/I2801518579', 'display_name': 'XinHua Hospital', 'ror': 'https://ror.org/04dzvks42', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801518579']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenguo Liu', 'raw_affiliation_strings': ['Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine', 'institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I2801518579']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.465836, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 71}, 'biblio': {'volume': '21', 'issue': '12', 'first_page': '837', 'last_page': '840'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10919', 'display_name': 'Neurological disorders and treatments', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/benserazide', 'display_name': 'Benserazide', 'score': 0.9790473}], 'concepts': [{'id': 'https://openalex.org/C2779026782', 'wikidata': 'https://www.wikidata.org/wiki/Q818165', 'display_name': 'Benserazide', 'level': 5, 'score': 0.9790473}, {'id': 'https://openalex.org/C2780304432', 'wikidata': 'https://www.wikidata.org/wiki/Q300989', 'display_name': 'Levodopa', 'level': 4, 'score': 0.9490655}, {'id': 'https://openalex.org/C2780405171', 'wikidata': 'https://www.wikidata.org/wiki/Q629444', 'display_name': 'Dyskinesia', 'level': 4, 'score': 0.7584779}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.6654424}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.62848556}, {'id': 'https://openalex.org/C2776525014', 'wikidata': 'https://www.wikidata.org/wiki/Q1531991', 'display_name': 'Parkinsonism', 'level': 3, 'score': 0.50276303}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.48400018}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.47740713}, {'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.46947157}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.37306067}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.31748933}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28836966}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.2835876}], 'mesh': [{'descriptor_ui': 'D001545', 'descriptor_name': 'Benserazide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004409', 'descriptor_name': 'Dyskinesia, Drug-Induced', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D008863', 'descriptor_name': 'Microspheres', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000978', 'descriptor_name': 'Antiparkinson Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001545', 'descriptor_name': 'Benserazide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004409', 'descriptor_name': 'Dyskinesia, Drug-Induced', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004409', 'descriptor_name': 'Dyskinesia, Drug-Induced', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007794', 'descriptor_name': 'Lameness, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007794', 'descriptor_name': 'Lameness, Animal', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D007794', 'descriptor_name': 'Lameness, Animal', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007980', 'descriptor_name': 'Levodopa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/wnr.0b013e32833d40c8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S121278948', 'display_name': 'Neuroreport', 'issn_l': '0959-4965', 'issn': ['0959-4965', '1473-558X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20631586', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1986694134', 'https://openalex.org/W1986782732', 'https://openalex.org/W1990031349', 'https://openalex.org/W1995188661', 'https://openalex.org/W1996121411', 'https://openalex.org/W2000659633', 'https://openalex.org/W2004875858', 'https://openalex.org/W2006241298', 'https://openalex.org/W2013047529', 'https://openalex.org/W2033092161', 'https://openalex.org/W2034945701', 'https://openalex.org/W2035286056', 'https://openalex.org/W2045866132', 'https://openalex.org/W2067720211', 'https://openalex.org/W2097863680', 'https://openalex.org/W2122472164', 'https://openalex.org/W2140463558', 'https://openalex.org/W2154011816', 'https://openalex.org/W2158527339', 'https://openalex.org/W2166381457', 'https://openalex.org/W2403708588', 'https://openalex.org/W3185454048', 'https://openalex.org/W4253345114'], 'related_works': ['https://openalex.org/W3208193611', 'https://openalex.org/W2415165756', 'https://openalex.org/W2360165200', 'https://openalex.org/W2120518070', 'https://openalex.org/W2064864365', 'https://openalex.org/W2039380466', 'https://openalex.org/W2026700942', 'https://openalex.org/W2019797192', 'https://openalex.org/W2008485195', 'https://openalex.org/W1986916753'], 'abstract_inverted_index': {"Parkinson's": [0, 27, 80, 97, 113], 'disease': [1, 31, 114], 'is': [2], 'a': [3], 'neurodegenerative': [4], 'disorder': [5], 'characterized': [6], 'by': [7, 67], 'progressive': [8], 'loss': [9], 'of': [10, 26, 39, 61, 69, 73, 90, 112, 119], 'dopaminergic': [11], 'neurons': [12], 'in': [13, 23, 77, 94, 109, 121], 'the': [14, 19, 24, 37, 59, 70, 88, 91, 110, 117], 'substantia': [15], 'niara.': [16], 'Levodopa': [17], 'remains': [18], 'most': [20], 'effective': [21], 'drug': [22], 'treatment': [25, 111], 'disease.': [28, 81, 98], 'Unfortunately,': [29], 'with': [30, 79, 96], 'progression,': [32], 'levodopa': [33], 'reduces': [34], 'Parkinsonism': [35], 'at': [36], 'cost': [38], 'evoking': [40], 'abnormal': [41], 'involuntary': [42], 'movements': [43], 'known': [44], 'as': [45], 'levodopa-induced': [46], 'dyskinesia': [47], '(LID).': [48], 'In': [49], 'this': [50], 'study,': [51], 'we': [52], 'found': [53], 'that': [54, 102], 'levodopa/benserazide-loaded': [55, 83, 103], 'biodegradable': [56, 84, 104], 'microspheres': [57, 85, 105], 'reduce': [58], 'expression': [60, 118], 'LID,': [62], 'which': [63], 'was': [64], 'easily': [65], 'evoked': [66], 'administrating': [68], 'same': [71], 'dose': [72], 'levodapa': [74], 'and': [75, 115], 'benserazide': [76], 'rats': [78, 95], 'Moreover,': [82], 'can': [86], 'improve': [87], 'stepping': [89], 'lesioned': [92], 'forepaw': [93], 'These': [99], 'data': [100], 'showed': [101], 'might': [106], 'be': [107], 'useful': [108], 'reducing': [116], 'LID': [120], 'rats.': [122]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019797192', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-19T12:53:35.976379', 'created_date': '2016-06-24'}