Publication Information

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'https://openalex.org/W2121325716', 'https://openalex.org/W2124536446', 'https://openalex.org/W2140813472', 'https://openalex.org/W2142416302', 'https://openalex.org/W2143013308', 'https://openalex.org/W2146252849', 'https://openalex.org/W2155158959', 'https://openalex.org/W2161234475', 'https://openalex.org/W2161803468', 'https://openalex.org/W2164998112', 'https://openalex.org/W2165906913'], 'related_works': ['https://openalex.org/W4319062967', 'https://openalex.org/W4211180001', 'https://openalex.org/W2903290256', 'https://openalex.org/W2390710048', 'https://openalex.org/W2360066506', 'https://openalex.org/W214686084', 'https://openalex.org/W2009037891', 'https://openalex.org/W2001675597', 'https://openalex.org/W185499726', 'https://openalex.org/W1521411817'], 'abstract_inverted_index': {'Autophagy-essential': [0, 186, 752, 4001], 'proteins': [1, 22, 187, 208, 753, 851, 1965, 3201, 3428, 4002, 4100], 'are': [2, 188, 841, 1004, 1162, 1977, 2650, 3058, 4090], 'the': [3, 17, 24, 169, 189, 203, 210, 355, 379, 519, 717, 731, 743, 842, 863, 882, 976, 1165, 1174, 1179, 1266, 1310, 1313, 1324, 1368, 1392, 1569, 1585, 1667, 1756, 1767, 1801, 1806, 1881, 1899, 1914, 1922, 1955, 1967, 1971, 2187, 2197, 2240, 2255, 2299, 2337, 2369, 2391, 2405, 2472, 2484, 2512, 2516, 2555, 2562, 2613, 2700, 2771, 2780, 2795, 2815, 2892, 2923, 2938, 2950, 2963, 2986, 3002, 3022, 3048, 3152, 3158, 3188, 3196, 3203, 3229, 3273, 3553, 3563, 3616, 3627, 3767, 3966, 3980, 3992, 4091, 4112, 4131], 'molecular': [4, 190, 843, 2556, 3189, 4092], 'basis': [5, 191, 844, 2563, 4093], 'of': [6, 27, 43, 50, 62, 92, 95, 103, 122, 125, 146, 173, 192, 213, 229, 236, 248, 278, 281, 289, 308, 311, 332, 359, 383, 518, 547, 575, 719, 730, 735, 766, 809, 845, 867, 881, 1176, 1181, 1307, 1312, 1326, 1398, 1530, 1538, 1587, 1669, 1728, 1770, 1786, 1790, 1818, 1840, 1924, 1933, 1949, 1970, 1982, 2006, 2021, 2189, 2200, 2244, 2257, 2280, 2301, 2306, 2336, 2371, 2393, 2409, 2432, 2474, 2509, 2519, 2564, 2575, 2580, 2631, 2704, 2721, 2730, 2759, 2800, 2810, 2862, 2866, 2925, 2932, 2941, 2965, 3037, 3060, 3072, 3079, 3083, 3125, 3145, 3154, 3160, 3198, 3206, 3234, 3349, 3374, 3430, 3565, 3612, 3618, 3631, 3766, 3795, 3823, 3968, 3979, 3984, 4015, 4058, 4094, 4116, 4130, 4197], 'protective': [7, 182, 193, 368, 1829, 3584], 'or': [8, 127, 131, 183, 194, 313, 317, 369, 748, 1815, 1837, 2326, 2991, 3076, 3085, 3101, 3217, 3221, 3315, 3353, 3997], 'destructive': [9, 184, 195, 370, 1851, 3596], 'autophagy': [10, 28, 56, 108, 196, 214, 242, 294, 736, 780, 823, 846, 871, 1374, 1389, 1524, 1534, 1577, 1588, 1633, 1664, 1771, 1798, 1874, 1908, 1932, 2032, 2192, 2201, 2232, 2302, 2310, 2394, 2475, 2533, 2565, 2598, 2871, 2879, 2897, 2926, 3135, 3161, 3210, 3219, 3244, 3314, 3316, 3341, 3422, 3585, 3597, 3985, 4029, 4072, 4095, 4120], 'machinery.': [11, 197, 847, 4096], 'However,': [12, 198, 1755, 2186], 'little': [13, 199], 'is': [14, 40, 200, 226, 373, 972, 1187, 1246, 1255, 1403, 1510, 1724, 2222, 2296, 2403, 2481, 2612, 2626, 2711, 2935, 2947, 3245, 3251, 3256, 3277, 3311, 3331, 3603, 3621], 'known': [15, 201, 974, 2242, 2712], 'about': [16, 202], 'signaling': [18, 204, 1579, 1757, 1883, 1961, 2833], 'mechanisms': [19, 205, 1758], 'governing': [20, 206], 'these': [21, 207], 'and': [23, 48, 100, 115, 149, 209, 234, 286, 301, 335, 381, 545, 579, 582, 692, 854, 957, 1002, 1160, 1170, 1172, 1260, 1367, 1432, 1442, 1525, 1535, 1638, 1766, 1779, 1788, 1792, 1820, 1825, 1848, 1963, 1996, 2008, 2016, 2259, 2271, 2287, 2314, 2342, 2355, 2381, 2398, 2411, 2471, 2515, 2525, 2561, 2583, 2586, 2633, 2653, 2702, 2770, 2777, 2791, 2840, 2864, 2884, 2943, 2957, 3041, 3052, 3094, 3109, 3118, 3157, 3178, 3193, 3202, 3231, 3253, 3376, 3442, 3592, 3629, 3793, 3827, 3830, 3940, 4103], 'opposing': [25, 211, 1768, 1934, 3204], 'consequences': [26, 212, 1769, 3205], 'in': [29, 141, 215, 327, 386, 392, 777, 820, 852, 856, 980, 988, 1009, 1164, 1173, 1183, 1279, 1371, 1513, 1584, 1589, 1663, 1726, 1732, 1762, 1861, 1921, 1945, 1966, 1987, 2030, 2191, 2230, 2247, 2298, 2368, 2390, 2421, 2429, 2487, 2521, 2595, 2637, 2642, 2646, 2706, 2727, 2788, 2838, 2846, 2868, 2901, 2922, 2954, 2977, 2985, 3088, 3112, 3167, 3195, 3237, 3269, 3346, 3360, 3380, 3539, 3552, 3562, 3615, 3634, 3640, 4026, 4069, 4101, 4105], 'mammals.': [30, 216], 'Here': [31, 217], 'we': [32, 218, 2292, 2960, 3338], 'report': [33, 219, 2893], 'that': [34, 168, 220, 354, 727, 1386, 1722, 1868, 1894, 1937, 2025, 2225, 2250, 2294, 2361, 2401, 2412, 2529, 2573, 2630, 2649, 2756, 2797, 2876, 2887, 2894, 2962, 2997, 3021, 3243, 3308, 3340, 3368, 3976], 'a': [35, 181, 221, 367, 390, 573, 724, 949, 982, 1190, 1241, 1250, 1273, 1575, 1660, 1781, 1869, 1942, 1960, 1978, 2003, 2028, 2274, 2384, 2415, 2605, 2618, 2811, 2850, 2918, 2974, 2982, 2989, 3089, 3113, 3165, 3175, 3260, 3334, 3343, 3536, 3583, 3595, 3638, 3821, 3973], 'non-canonical': [36, 222, 1782, 1870, 2365, 2517, 2831, 3023], 'MEK/ERK': [37, 83, 104, 134, 153, 223, 269, 290, 320, 339, 1783, 1795, 1819, 1841, 1871, 1888, 1902, 1973, 2252, 2520, 2576, 2587, 2694, 2705, 2832, 2859, 2942, 2952, 2969, 3024, 3038, 3063, 3080, 3103, 3132, 3192], 'module,': [38, 224], 'which': [39, 225, 947, 1254, 1655, 2510, 3057], 'positioned': [41, 227, 1780], 'downstream': [42, 228, 1785, 1948, 2366, 2385, 2407, 2861], 'AMP-activated': [44, 230, 4189], 'protein': [45, 231, 761, 781, 783, 804, 824, 826, 864, 994, 1375, 1984, 2804, 4010, 4030, 4032, 4053, 4073, 4075, 4113, 4188, 4190], 'kinase': [46, 232, 786, 829, 865, 874, 1314, 1395, 1653, 2479, 2805, 2807, 4035, 4078, 4114, 4123, 4191], '(AMPK)': [47, 233], 'upstream': [49, 235, 1789, 2218, 2865], 'tuberous': [51, 237, 4192], 'sclerosis': [52, 238, 763, 806, 4012, 4055, 4193], 'complex': [53, 97, 239, 283, 1315, 2480, 4194], '(TSC),': [54, 240], 'regulates': [55, 241, 1873, 2426, 2878, 2896, 3026], 'by': [57, 89, 105, 129, 151, 243, 275, 291, 315, 337, 952, 1265, 1390, 1406, 1435, 1665, 1813, 1835, 1843, 1875, 1904, 1912, 2002, 2202, 2261, 2321, 2344, 2476, 2534, 2590, 2652, 2696, 2716, 2723, 2882, 3030, 3065, 3131, 3426, 3542], 'regulating': [58, 244, 989, 1391, 1800, 1862, 1876, 2231, 2422, 2522, 2707, 2978, 3031], 'Beclin': [59, 87, 138, 158, 174, 245, 273, 324, 344, 360, 778, 821, 991, 1316, 1372, 1383, 1393, 1399, 1508, 1519, 1531, 1572, 1657, 1764, 1802, 1811, 1833, 1858, 1877, 1892, 1925, 1938, 2276, 2477, 2523, 2581, 2933, 2945, 2966, 3003, 3032, 3054, 3068, 3091, 3116, 3128, 3147, 3235, 3249, 3262, 3329, 3355, 3370, 3432, 3532, 3546, 3566, 3572, 3579, 3589, 3601, 3613, 4027, 4070], '1.': [60, 246], 'Depletion': [61, 247], 'ERK': [63, 78, 249, 264, 1998, 2026, 2190, 2213, 2226, 2234, 2295, 2308, 2320, 2329, 2362, 2378, 2389, 2402, 2420, 2530, 2781], 'partially': [64, 250, 2332], 'inhibited': [65, 73, 251, 259, 2333, 3106], 'autophagy,': [66, 143, 252, 329, 2334, 3098], 'whereas': [67, 144, 253, 330, 1649, 2316], 'specific': [68, 254, 2317], 'inhibition': [69, 145, 255, 331, 1822, 1845, 2318, 3082], 'on': [70, 256, 1571, 1823, 1846, 2319, 2762, 2814, 2968, 3001, 3545], 'MEK': [71, 75, 257, 261, 2375, 2410, 2413, 2425, 2766, 2776, 2790], 'completely': [72, 258, 3105], 'autophagy.': [74, 81, 163, 185, 260, 267, 349, 371, 990, 1830, 1852, 2423, 3062, 3122, 3619], 'could': [76, 262, 2376], 'bypass': [77, 263, 2377], 'to': [79, 114, 161, 265, 300, 347, 585, 740, 944, 1249, 1258, 1628, 1773, 1897, 1927, 1931, 2238, 2597, 2713, 2802, 2870, 2937, 2949, 3138, 3214, 3560, 3833, 3989], 'promote': [80, 266], 'Basal': [82, 268, 1887, 3035], 'activity': [84, 270, 1889, 2253, 2256, 2940, 2999, 3036, 3051, 3255, 3276], 'conferred': [85, 271, 1890], 'basal': [86, 272, 2251, 2275, 2939, 3049, 3053, 3335, 3354], '1': [88, 98, 139, 159, 175, 274, 284, 325, 345, 361, 995, 1268, 1376, 1400, 1444, 1509, 1520, 1532, 1573, 1803, 1812, 1834, 1859, 1878, 1893, 1926, 1939, 2277, 2524, 2582, 2934, 2946, 2967, 2980, 3004, 3033, 3055, 3069, 3092, 3117, 3129, 3148, 3236, 3250, 3263, 3330, 3356, 3371, 3444, 3533, 3547, 3573, 3580, 3590, 3602, 3614], 'preventing': [90, 276], 'disassembly': [91, 277], 'mammalian': [93, 279, 938, 1010, 1184, 1280, 1590, 1630, 1733, 1968, 2488, 3199, 3238, 3350, 3554, 3557, 4195], 'target': [94, 280, 765, 808, 866, 4014, 4057, 4115, 4196], 'rapamycin': [96, 282, 868, 4117, 4198], '(mTORC1)': [99, 285], 'mTORC2.': [101, 287], 'Activation': [102, 288, 2720], 'AMPK': [106, 292, 1787, 1905, 2591, 2600, 2655, 2697, 2722, 2757, 2863, 2895, 3066], 'upon': [107, 293, 1906], 'stimuli': [109, 295, 1909, 2010, 2395, 2886, 3220], 'disassembled': [110, 119, 296, 305, 2266], 'mTORC1': [111, 126, 148, 297, 312, 334, 1824, 1847, 1917, 2258, 3040, 3084, 3108], 'via': [112, 298, 872, 1189, 1634, 1799, 2214, 4121], 'binding': [113, 299, 2799, 3431], 'activating': [116, 302, 1369, 4210], 'TSC': [117, 303, 1791, 2710, 2731, 2760, 2778, 2867], 'but': [118, 304, 1528, 2554, 2592, 2844, 3099], 'mTORC2': [120, 128, 150, 306, 314, 336, 1826, 1849, 2260, 3042], 'independently': [121, 307, 2431], 'TSC.': [123, 309], 'Inhibition': [124, 310], 'transiently': [130, 316], 'moderately': [132, 136, 318, 322, 3587], 'activated': [133, 319, 2001, 2589, 2765, 2775], 'caused': [135, 155, 321, 341, 1828, 1850, 2309, 2880, 3081], 'enhanced': [137, 323, 1810, 2944, 2951, 3127, 3146, 3588], 'resulting': [140, 326, 1920, 3087, 3111, 3211], 'cytoprotective': [142, 328, 3097], 'both': [147, 333, 1635, 2508, 2789, 2881, 2955, 3107], 'sustained': [152, 338, 1836, 3100], 'activation': [154, 340, 1817, 1839, 1903, 2574, 2695, 2758, 2953, 3064, 3078, 3104, 3133, 3373], 'strongly': [156, 342, 3114], 'pronounced': [157, 343, 1832, 3115], 'leading': [160, 346, 1930], 'cytodestructive': [162, 348, 3121], 'Our': [164, 350, 1853, 1951, 2753, 2853, 3184, 3364], 'findings': [165, 351, 2854, 3185], 'thus': [166, 352, 1855, 1953, 2272, 2698, 2855, 3046, 3136, 3186], 'propose': [167, 353], 'AMPK-MEK/ERK-TSC-mTOR': [170, 356, 1807, 1882], 'pathway': [171, 357, 1784, 1884, 1962, 2560, 2834], 'regulation': [172, 358, 546, 1586, 1727, 2300, 2924, 3197, 3617, 3794], 'represents': [176, 362], 'different': [177, 363, 983, 1928], 'thresholds': [178, 364, 1860, 1929], 'responsible': [179, 365], 'for': [180, 366, 746, 1006, 1323, 1574, 2617, 3134, 3995], 'Autophagy': [372, 388, 569, 3620, 3636, 3817, 3963], 'an': [374, 720, 1646, 2205, 2634, 2643, 3095, 3119, 3126, 3622, 3969], 'evolutionally': [375, 3623], 'conserved': [376, 1980, 3624], 'machinery': [377, 884, 2566, 3625, 4133], 'involving': [378, 3626], 'degradation': [380, 3628], 'turnover': [382, 3630], 'cytoplasmic': [384, 3632], 'material': [385, 3633], 'lysosomes.': [387, 3635], 'plays': [389, 1645, 1659, 2027, 2414, 3342, 3637], 'role': [391, 1662, 1944, 2029, 2188, 2418, 2514, 3166, 3177, 3345, 3538, 3639], 'cellular': [393, 1989, 2607, 2619, 2623, 2717, 3362, 3641], 'homeostasis': [394, 3642], '(1Levine': [395, 471, 3643, 3719], 'B.': [396, 439, 472, 553, 613, 1095, 1099, 1295, 1297, 1345, 1421, 1423, 1488, 1552, 1556, 2115, 3458, 3460, 3512, 3644, 3687, 3720, 3801, 3861], 'Klionsky': [397, 473, 627, 921, 3645, 3721, 3875, 4170], 'D.J.': [398, 474, 628, 922, 3646, 3722, 3876, 4171], 'Dev.': [399, 475, 536, 923, 3647, 3723, 3784, 4172], 'Cell.': [400, 476, 924, 1048, 1150, 1346, 3296, 3648, 3724, 4173], '2004;': [401, 477, 509, 630, 925, 1031, 1151, 1232, 1601, 3297, 3649, 3725, 3757, 3878, 4174], '6:': [402, 478, 926, 3650, 3726, 4175], '463-477Abstract': [403, 479, 3651, 3727], 'Full': [404, 406, 480, 482, 705, 707, 928, 930, 1350, 1352, 1707, 1709, 2090, 2092, 2141, 2143, 2163, 2165, 3400, 3402, 3652, 3654, 3728, 3730, 3953, 3955, 4177, 4179], 'Text': [405, 407, 481, 483, 706, 708, 929, 931, 1351, 1353, 1708, 1710, 2091, 2093, 2142, 2144, 2164, 2166, 3401, 3403, 3653, 3655, 3729, 3731, 3954, 3956, 4178, 4180], 'PDF': [408, 484, 709, 932, 1354, 1711, 2094, 2145, 2167, 3404, 3656, 3732, 3957, 4181], 'PubMed': [409, 423, 444, 465, 485, 512, 540, 564, 620, 633, 656, 687, 710, 910, 933, 965, 1034, 1053, 1081, 1104, 1133, 1154, 1216, 1235, 1303, 1355, 1429, 1478, 1503, 1561, 1604, 1621, 1686, 1712, 1750, 2045, 2067, 2095, 2121, 2146, 2168, 2181, 2448, 2466, 2503, 2549, 2689, 2748, 2825, 2912, 3012, 3300, 3405, 3416, 3466, 3502, 3527, 3657, 3671, 3692, 3713, 3733, 3760, 3788, 3812, 3868, 3881, 3904, 3935, 3958, 4159, 4182], 'Scopus': [410, 424, 445, 466, 486, 513, 541, 565, 621, 634, 657, 688, 711, 911, 934, 966, 1035, 1054, 1082, 1105, 1134, 1155, 1217, 1236, 1356, 1479, 1504, 1562, 1605, 1622, 1687, 1713, 1751, 2046, 2068, 2096, 2122, 2147, 2169, 2182, 2449, 2467, 2504, 2550, 2690, 2749, 2826, 2913, 3013, 3301, 3406, 3417, 3503, 3528, 3658, 3672, 3693, 3714, 3734, 3761, 3789, 3813, 3869, 3882, 3905, 3936, 3959, 4160, 4183], '(3140)': [411, 487, 3659, 3735], 'Google': [412, 426, 447, 468, 488, 515, 543, 567, 623, 636, 659, 690, 713, 913, 936, 968, 1037, 1056, 1084, 1107, 1136, 1157, 1219, 1238, 1304, 1358, 1430, 1481, 1506, 1564, 1607, 1624, 1689, 1715, 1753, 2048, 2070, 2098, 2124, 2149, 2171, 2184, 2451, 2469, 2506, 2552, 2692, 2751, 2828, 2915, 3015, 3303, 3408, 3419, 3467, 3505, 3530, 3660, 3674, 3695, 3716, 3736, 3763, 3791, 3815, 3871, 3884, 3907, 3938, 3961, 4162, 4185], 'Scholar),': [413, 469, 516, 544, 660, 691, 1239, 2470, 2507, 2553, 2916, 3531, 3661, 3717, 3764, 3792, 3908, 3939], 'antiaging': [414, 3662], '(2Longo': [415, 2817, 3663], 'V.D.': [416, 2818, 3664], 'Finch': [417, 2819, 3665], 'C.E.': [418, 2820, 3666], 'Science.': [419, 440, 629, 2821, 3667, 3688, 3877], '2003;': [420, 441, 462, 617, 653, 702, 2160, 2463, 2822, 3668, 3689, 3710, 3865, 3901, 3950], '299:': [421, 2823, 3669], '1342-1346Crossref': [422, 2824, 3670], '(489)': [425, 2827, 3673], 'Scholar,': [427, 448, 489, 624, 637, 914, 1038, 1057, 1085, 1108, 1137, 1220, 1482, 1608, 1690, 2049, 2071, 2099, 2125, 2150, 2172, 2452, 3409, 3468, 3506, 3675, 3696, 3737, 3872, 3885, 4163], '3Meléndez': [428, 3676], 'A.': [429, 456, 491, 497, 601, 667, 700, 1013, 1019, 1042, 1065, 1112, 1141, 1200, 1331, 1448, 1450, 1463, 1673, 1692, 2435, 2454, 2491, 2659, 2661, 2674, 3287, 3472, 3474, 3487, 3677, 3704, 3739, 3745, 3849, 3915, 3948], 'Tallóczy': [430, 3678], 'Z.': [431, 639, 3679, 3887], 'Seaman': [432, 1090, 1547, 3680], 'M.': [433, 493, 495, 698, 901, 1015, 1017, 1091, 1114, 1143, 1341, 1459, 1469, 1548, 2103, 2670, 2680, 2905, 2907, 3289, 3483, 3493, 3681, 3741, 3743, 3946, 4150], 'Eskelinen': [434, 604, 668, 3682, 3852, 3916], 'E.L.': [435, 605, 669, 960, 3683, 3853, 3917], 'Hall': [436, 3684], 'D.H.': [437, 3685], 'Levine': [438, 612, 644, 1098, 1296, 1344, 1422, 1555, 3459, 3686, 3860, 3892], '301:': [442, 3690], '1387-1391Crossref': [443, 3691], '(1009)': [446, 3694], '4Vellai': [449, 3697], 'T.': [450, 501, 505, 551, 626, 895, 897, 1023, 1027, 1063, 1067, 1069, 1075, 1122, 1126, 1145, 1198, 1202, 1204, 1210, 1224, 1612, 1675, 2036, 2497, 2540, 2737, 3291, 3698, 3749, 3753, 3799, 3874, 4144, 4146], 'Takacs-Vellai': [451, 3699], 'K.': [452, 557, 680, 899, 1093, 1120, 1471, 1550, 2176, 2682, 2733, 3495, 3700, 3805, 3928, 4148], 'Zhang': [453, 3701], 'Y.': [454, 503, 609, 663, 893, 903, 1025, 1059, 1073, 1116, 1118, 1124, 1147, 1194, 1208, 1614, 1679, 1736, 2038, 2053, 2061, 2081, 2493, 2495, 2542, 2735, 3293, 3389, 3702, 3751, 3857, 3911, 4142, 4152], 'Kovacs': [455, 3703], 'Orosz': [457, 3705], 'L.': [458, 1452, 2663, 3476, 3706], 'Müller': [459, 3707], 'F.': [460, 916, 1473, 2077, 2684, 3497, 3708, 4165], 'Nature.': [461, 508, 683, 1030, 1100, 1474, 1557, 2685, 3498, 3709, 3756, 3931], '426:': [463, 3711], '620Crossref': [464, 3712], '(814)': [467, 3715], 'development': [470, 3718], '5Kuma': [490, 3738], 'Hatano': [492, 1014, 1113, 3740], 'Matsui': [494, 1016, 1142, 3288, 3742], 'Yamamoto': [496, 1018, 1064, 1111, 1140, 1199, 3286, 3744], 'Nakaya': [498, 1020, 3746], 'H.': [499, 599, 1021, 1097, 1554, 1740, 2051, 3387, 3747, 3847], 'Yoshimori': [500, 1022, 1074, 1125, 1144, 1209, 2496, 3290, 3748], 'Ohsumi': [502, 608, 900, 902, 1024, 1072, 1123, 1146, 1207, 1678, 2494, 3292, 3750, 3856, 4149, 4151], 'Tokuhisa': [504, 1026, 1121, 3752], 'Mizushima': [506, 606, 1028, 1060, 1195, 1338, 3754, 3854], 'N.': [507, 597, 607, 647, 1029, 1061, 1110, 1139, 1196, 1339, 1610, 1677, 2034, 2107, 2538, 3285, 3755, 3845, 3855, 3895], '432:': [510, 1032, 3758], '1032-1036Crossref': [511, 1033, 3759], '(2362)': [514, 1036, 3762], 'protection': [517, 3765], 'genome': [520, 3768], '(6Karantza-Wadsworth': [521, 3769], 'V.': [522, 2441, 2458, 3770], 'Patel': [523, 3771], 'S.': [524, 532, 641, 1089, 1329, 1455, 1546, 1616, 2040, 2055, 2079, 2105, 2129, 2152, 2174, 2544, 2666, 3393, 3479, 3772, 3780, 3889], 'Kravchuk': [525, 3773], 'O.': [526, 3774], 'Chen': [527, 3775], 'G.': [528, 595, 611, 665, 1289, 1293, 1415, 1419, 3452, 3456, 3776, 3843, 3859, 3913], 'Mathew': [529, 3777], 'R.': [530, 673, 1335, 1457, 2057, 2668, 3481, 3778, 3921], 'Jin': [531, 640, 3779, 3888], 'White': [533, 3781], 'E.': [534, 1071, 1206, 1226, 1694, 2101, 2127, 3782], 'Genes': [535, 3783], '2007;': [537, 1475, 1618, 2042, 2064, 2087, 2546, 2686, 2909, 3499, 3785], '21:': [538, 3786], '1621-1635Crossref': [539, 3787], '(670)': [542, 3790], 'cell': [548, 750, 1993, 2842, 3168, 3182, 3796, 3999], 'size': [549, 3797], '(7Vellai': [550, 3798], 'Bicsák': [552, 3800], 'Tóth': [554, 3802], 'M.L.': [555, 3803], 'Takács-Vellai': [556, 3804], 'Kovács': [558, 3806], 'A.L.': [559, 3807], 'Autophagy.': [560, 961, 1617, 2041, 2545, 2908, 3008, 3412, 3808], '2008;': [561, 3009, 3397, 3413, 3809], '4:': [562, 2746, 3010, 3414, 3810], '507-509Crossref': [563, 3811], '(33)': [566, 3814], 'Scholar).': [568, 969, 1158, 1305, 1359, 1507, 1565, 1625, 1716, 1754, 2185, 2693, 2752, 2829, 3016, 3304, 3420, 3816, 3962, 4186], 'may': [570, 985, 1940, 2363, 2971, 3150, 3163, 3357, 3534, 3818], 'act': [571, 3819], 'as': [572, 1272, 1381, 1992, 2604, 3226, 3820], 'means': [574, 3822], 'defense': [576, 3824], 'against': [577, 3825], 'bacterium': [578, 3826], 'virus': [580, 3828], 'invasion': [581, 3829], 'be': [583, 986, 1774, 2000, 2239, 2714, 2973, 3358, 3424, 3831], 'linked': [584, 3832], 'various': [586, 1907, 3543, 3834], 'diseases': [587, 3835], 'including': [588, 2011, 3434, 3836], 'cancer': [589, 1541, 3270, 3837], '(8Qu': [590, 3838], 'X.': [591, 1333, 3839], 'Yu': [592, 3840], 'J.': [593, 603, 614, 677, 696, 904, 1077, 1127, 1212, 1228, 1298, 1424, 1597, 1680, 1701, 1746, 2085, 2132, 2135, 2157, 2442, 2739, 3007, 3385, 3394, 3411, 3461, 3841, 3851, 3862, 3925, 3944, 4153], 'Bhagat': [594, 3842], 'Furuya': [596, 3844], 'Hibshoosh': [598, 1096, 1553, 3846], 'Troxel': [600, 3848], 'Rosen': [602, 3850], 'Cattoretti': [610, 3858], 'Clin.': [615, 3863], 'Investig.': [616, 3864], '112:': [618, 3866], '1809-1820Crossref': [619, 3867], '(1837)': [622, 3870], '9Shintani': [625, 3873], '306:': [631, 3879], '990-995Crossref': [632, 3880], '(2134)': [635, 3883], '10Yue': [638, 3886], 'Yang': [642, 3890], 'C.': [643, 1461, 1484, 2075, 2154, 2456, 2672, 3485, 3508, 3891], 'A.J.': [645, 1593, 1698, 3893], 'Heintz': [646, 3894], 'Proc.': [648, 3896], 'Natl.': [649, 3897], 'Acad.': [650, 3898], 'Sci.': [651, 3899], 'U.S.A.': [652, 3900], '100:': [654, 3902], '15077-15082Crossref': [655, 3903], '(1746)': [658, 3906], 'cardiomyopathy': [661, 3909], '(11Tanaka': [662, 3910], 'Guhde': [664, 3912], 'Suter': [666, 3914], 'Hartmann': [670, 3918], 'D.': [671, 1492, 3516, 3919], 'Lüllmann-Rauch': [672, 3920], 'Janssen': [674, 3922], 'P.M.': [675, 3923], 'Blanz': [676, 3924], 'von': [678, 3926], 'Figura': [679, 3927], 'Saftig': [681, 3929], 'P.': [682, 1465, 1467, 1486, 1595, 1700, 2109, 2111, 2113, 2134, 2156, 2676, 2678, 3489, 3491, 3510, 3930], '2000;': [684, 907, 1078, 1213, 1704, 2138, 2445, 3932, 4156], '406:': [685, 3933], '902-906Crossref': [686, 3934], '(716)': [689, 3937], 'neurodegenerative': [693, 3941], 'disorders': [694, 3942], '(12Yuan': [695, 3943], 'Lipinski': [697, 3945], 'Degterev': [699, 3947], 'Neuron.': [701, 3949], '40:': [703, 3951], '401-413Abstract': [704, 3952], '(402)': [712, 3960], 'Scholar).Autophagy': [714], 'starts': [715, 3964], 'with': [716, 878, 942, 954, 1401, 2383, 2578, 2768, 2794, 2891, 3171, 3570, 3577, 3965, 4127], 'formation': [718, 1008, 1180, 1311, 1325, 3967], 'autophagosome,': [721, 3970], 'enclosed': [722, 3971], 'within': [723, 3972], 'double': [725, 3974], 'membrane': [726, 3975], 'engulfs': [728, 3977], 'part': [729, 3978], 'cytoplasm.': [732, 3981], 'During': [733, 1178, 3982], 'periods': [734, 3983], 'stimuli,': [737, 3986], 'cells': [738, 1281, 1542, 1591, 1631, 1734, 2489, 3208, 3383, 3987], 'respond': [739, 3988], 'either': [741, 3309, 3990], 'maintain': [742, 3991], 'metabolism': [744, 3993], 'essential': [745, 1005, 1322, 3994], 'survival': [747, 3996], 'execute': [749, 3998], 'death.': [751, 3183, 4000], '(Atg)': [754, 4003], '2The': [755, 798, 4004, 4047], 'abbreviations': [756, 799, 4005, 4048], 'used': [757, 800, 4006, 4049], 'are:': [758, 801, 4007, 4050], 'Atgautophagy-essential': [759, 802, 4008, 4051], 'proteinAMPKAMP-activated': [760, 803, 4009, 4052], 'kinaseTSCtuberous': [762, 805, 4011, 4054], 'complexmTORmammalian': [764, 807, 4013, 4056], 'rapamycinLC3light': [767, 810, 4016, 4059], 'chain': [768, 811, 997, 4017, 4060, 4200], '3Bcl2B-cell': [769, 812, 4018, 4061], 'lymphoma-2PI3Kphosphatidylinositol': [770, 813, 4019, 4062], '3-kinasePI3KC3class': [771, 814, 4020, 4063], 'III': [772, 815, 1318, 1640, 1651, 1730, 4021, 4064, 4207], 'phosphatidylinositol': [773, 816, 1319, 4022, 4065, 4204, 4208], '3-kinaseAmbra': [774, 817, 4023, 4066], '1activating': [775, 818, 4024, 4067], 'molecule': [776, 819, 1370, 4025, 4068], '1-regulated': [779, 822, 1373, 4028, 4071], '1MEKmitogen-activated': [782, 825, 4031, 4074], 'kinase/extracellular': [784, 827, 4033, 4076], 'signal-regulated': [785, 788, 828, 831, 4034, 4037, 4077, 4080], 'kinaseERKextracellular': [787, 830, 4036, 4079], 'kinasemTORCmTOR': [789, 832, 4038, 4081], 'complexGΒLG-protein': [790, 833, 4039, 4082], 'Β-subunit-likeAICAR5-aminoimidazole-4-carboxamide': [791, 834, 4040, 4083], 'ribosideGFPgreen': [792, 835, 4041, 4084], 'fluorescent': [793, 836, 4042, 4085], 'proteinsiRNAshort': [794, 837, 4043, 4086], 'interfering': [795, 838, 4044, 4087], 'RNAGSTglutathione': [796, 839, 4045, 4088], 'S-transferase.': [797, 840, 4046, 4089], 'About': [848, 4097], '30': [849, 4098], 'Atg': [850, 4099], 'yeast': [853, 4102], '10': [855, 4104], 'mammals': [857, 4106], 'have': [858, 1581, 2023, 4107], 'been': [859, 1582, 2236, 2602, 4108], 'identified.': [860, 4109], 'In': [861, 1626, 3272, 4110], 'yeast,': [862, 1629, 4111], '(TOR)': [869, 4118], 'mediates': [870, 4119], 'Atg1-Atg13': [873, 4122], 'complex.': [875, 1396, 4124], 'Atg1': [876, 977, 4125], 'interacts': [877, 4126], 'multiple': [879, 4128], 'components': [880, 4129], 'autophagic': [883, 1670, 1900, 2282, 2350, 2372, 2584, 2708, 2998, 3155, 3254, 3275, 4132], 'through': [885, 1805, 1880, 2898, 2927, 3070, 4134], 'direct': [886, 2728, 4135], 'association,': [887, 4136], 'phosphorylation,': [888, 4137], 'and/or': [889, 1918, 4138], 'intracellular': [890, 4139], 'localization': [891, 4140], '(13Kamada': [892, 4141], 'Funakoshi': [894, 4143], 'Shintani': [896, 4145], 'Nagano': [898, 4147], 'Cell': [905, 1128, 1230, 1498, 1599, 1681, 2443, 2461, 2743, 3522, 4154], 'Biol.': [906, 1049, 1129, 1149, 1231, 1499, 1600, 1682, 1702, 2136, 2158, 2444, 2462, 2744, 3295, 3395, 3523, 4155], '150:': [908, 4157], '1507-1513Crossref': [909, 4158], '(898)': [912, 4161], '14Reggiori': [915, 4164], 'Tucker': [917, 4166], 'K.A.': [918, 4167], 'Stromhaug': [919, 4168], 'P.E.': [920, 4169], '79-90Abstract': [927, 4176], '(369)': [935, 4184], 'Scholar).In': [937], 'systems,': [939], 'autophagosomes': [940, 1182, 1259, 1327], 'fuse': [941], 'lysosomes': [943, 958], 'generate': [945], 'autophagolysosomes,': [946], 'undergo': [948, 3209], 'maturation': [950], 'process': [951], 'fusing': [953], 'endocytic': [955], 'compartments': [956], '(15Eskelinen': [959], '2005;': [962, 1347], '1:': [963], '1-10Crossref': [964], '(497)': [967], 'Because': [970, 2208, 2929, 3421], 'it': [971, 2221], 'not': [973, 2223, 2348, 2404, 2593, 2836, 3246, 3257], 'how': [975], 'homolog': [978], 'acts': [979], 'mammals,': [981], 'mechanism': [984, 2921, 2976], 'involved': [987, 2297], '1/Atg6,': [992], 'microtubule-associated': [993], 'light': [996, 4199], '3': [998, 4201], '(LC3)/Atg8,': [999], 'Atg5,': [1000], 'Atg12,': [1001], 'Atg13': [1003], 'autophagosome': [1007], 'species': [1011, 3558], '(5Kuma': [1012], '16Chan': [1039], 'E.Y.': [1040], 'Longatti': [1041], 'McKnight': [1043], 'N.C.': [1044], 'Tooze': [1045], 'S.A.': [1046], 'Mol.': [1047, 1148, 2062, 3294], '2009;': [1050, 1747], '29:': [1051], '157-171Crossref': [1052], '(341)': [1055], '17Kabeya': [1058], 'Ueno': [1062, 1197, 1223], 'Kirisako': [1066, 1201], 'Noda': [1068, 1203, 1674], 'Kominami': [1070, 1205, 1225], 'EMBO': [1076, 1211, 2498], '19:': [1079, 1214], '5720-5728Crossref': [1080, 1215], '(5363)': [1083, 1218], '18Liang': [1086], 'X.H.': [1087, 1283, 1337, 1409, 1544, 3446], 'Jackson': [1088, 1545], 'Brown': [1092, 1549], 'Kempkes': [1094, 1551], '1999;': [1101, 1558], '402:': [1102, 1559], '672-676Crossref': [1103, 1560], '(2700)': [1106, 1563], '19Mizushima': [1109], 'Kobayashi': [1115], 'Kabeya': [1117, 2492], 'Suzuki': [1119], '2001;': [1130, 1683, 2500], '152:': [1131, 1684], '657-668Crossref': [1132], '(1146)': [1135], '20Mizushima': [1138], '15:': [1152, 2464, 3298], '1101-1111Crossref': [1153, 3299], '(1892)': [1156, 3302], 'Atg7': [1159], 'Atg3': [1161], 'required': [1163, 1725, 2779], 'conjugation': [1166], 'reaction': [1167], 'between': [1168, 1959, 2558, 2774, 3191], 'Atg12': [1169], 'Atg5': [1171], 'lipidation': [1175], 'LC3.': [1177], 'cells,': [1185, 2959, 3239], 'LC3': [1186], 'lipidated': [1188], 'ubiquitylation-like': [1191], 'system': [1192, 3555], '(17Kabeya': [1193], '21Tanida': [1221], 'I.': [1222, 1490, 3514], 'Int.': [1227, 1596], 'Biochem.': [1229, 1598, 1745], '36:': [1233, 1602], '2503-2518Crossref': [1234], '(1043)': [1237], 'generating': [1240], 'soluble': [1242], 'form,': [1243, 1252], 'LC3-I.': [1244], 'LC3-I': [1245], 'further': [1247], 'modified': [1248], 'membrane-bound': [1251], 'LC3-II,': [1253], 'subsequently': [1256], 'localized': [1257], 'autolysosomes': [1261], 'until': [1262, 3248], 'being': [1263, 2265, 3044], 'degraded': [1264], 'lysosome.Beclin': [1267], 'was': [1269, 1895, 2193, 2227, 2588], 'initially': [1270], 'isolated': [1271], 'B-cell': [1274, 4202], 'lymphoma-2': [1275, 4203], '(Bcl2)-interacting': [1276], 'tumor': [1277, 1365, 1440, 3440], 'suppressor': [1278, 1366, 1441], '(22Liang': [1282, 1408, 3445], 'Kleeman': [1284, 1410, 3447], 'L.K.': [1285, 1411, 3448], 'Jiang': [1286, 1412, 3449], 'H.H.': [1287, 1413, 3450], 'Gordon': [1288, 1414, 3451], 'Goldman': [1290, 1416, 3453], 'J.E.': [1291, 1417, 3454], 'Berry': [1292, 1418, 3455], 'Herman': [1294, 1420, 3457], 'Virol.': [1299, 1425, 3462], '1998;': [1300, 1426, 3463], '72:': [1301, 1427, 2065, 3464], '8586-8596Crossref': [1302, 1428, 3465], 'Overexpression': [1306], 'Bcl2': [1308, 1407], 'attenuates': [1309], '1-class': [1317], '3-kinase': [1320, 4205, 4209], '(PI3KC3)': [1321], '(23Pattingre': [1328], 'Tassa': [1330], 'Qu': [1332], 'Garuti': [1334], 'Liang': [1336], 'Packer': [1340], 'Schneider': [1342], 'M.D.': [1343], '122:': [1348], '927-939Abstract': [1349], '(2896)': [1357], 'The': [1360, 2622, 3017, 3123, 3143], 'UV': [1361, 1436, 3436], 'radiation': [1362, 1437, 3437], 'resistance-associated': [1363, 1438, 3438], 'gene': [1364, 1439, 3439], '(Ambra': [1377], '1)': [1378], 'were': [1379], 'identified': [1380, 1778], 'new': [1382, 3610], '1-binding': [1384], 'partners': [1385], 'also': [1387, 1720, 2845, 2900, 2972], 'regulate': [1388, 1632], '1-PI3KC3': [1394, 2478], 'Association': [1397], 'PI3KC3': [1402], 'negatively': [1404], 'regulated': [1405, 1434, 1797, 2715, 3425], 'Scholar)': [1431], 'positively': [1433], 'Ambra': [1443, 3443], '(24Fimia': [1445, 2656], 'G.M.': [1446, 2657, 3470], 'Stoykova': [1447, 2658, 3471], 'Romagnoli': [1449, 2660, 3473], 'Giunta': [1451, 2662, 3475], 'Di': [1453, 2664, 3477], 'Bartolomeo': [1454, 2665, 3478], 'Nardacci': [1456, 2667, 3480], 'Corazzari': [1458, 2669, 3482], 'Fuoco': [1460, 2671, 3484], 'Ucar': [1462, 2673, 3486], 'Schwartz': [1464, 2675, 3488], 'Gruss': [1466, 2677, 3490], 'Piacentini': [1468, 2679, 3492], 'Chowdhury': [1470, 2681, 3494], 'Cecconi': [1472, 2683, 3496], '447:': [1476, 2687, 3500], '1121-1125Crossref': [1477, 2688, 3501], '(773)': [1480, 2691, 3504], '25Liang': [1483, 3507], 'Feng': [1485, 3509], 'Ku': [1487, 3511], 'Dotan': [1489, 3513], 'Canaani': [1491, 3515], 'Oh': [1493, 3517], 'B.H.': [1494, 3518], 'Jung': [1495, 3519], 'J.U.': [1496, 3520], 'Nat.': [1497, 2742, 3521], '2006;': [1500, 2118, 2178, 3524], '8:': [1501, 3525], '688-699Crossref': [1502, 3526], '(828)': [1505, 3529], 'homoallelically': [1511], 'deleted': [1512], 'many': [1514, 1988], 'human': [1515, 1539, 2839, 2956], 'tumors.': [1516], 'A': [1517, 1717, 2354], 'decreased': [1518], 'level': [1521, 1804, 1879, 2278, 3005, 3130, 3149, 3153, 3264], 'causes': [1522], 'defective': [1523], 'breast': [1526, 1540], 'cancer,': [1527], 'restoration': [1529], 'induces': [1533], 'inhibits': [1536, 3372], 'tumorigenicity': [1537], '(18Liang': [1543], 'These': [1566, 3305], 'reports': [1567], 'evidence': [1568], 'dependence': [1570, 2964], 'functional': [1576, 1915], 'mechanism.Diverse': [1578], 'pathways': [1580], 'reported': [1583], '(26Meijer': [1592], 'Codogno': [1594, 1699, 2133, 2155], '2445-2462Crossref': [1603], '(538)': [1606], '27Shinojima': [1609], 'Yokoyama': [1611, 2035, 2539], 'Kondo': [1613, 1615, 2037, 2039, 2054, 2060, 2541, 2543], '3:': [1619, 2043, 2547, 2910], '635-637Crossref': [1620, 2044, 2548], '(280)': [1623, 2047, 2551], 'contrast': [1627], 'class': [1636, 1639, 1650, 1729, 4206], 'I': [1637, 1643], 'PI3K.': [1641], 'Class': [1642], 'PI3K': [1644, 1652, 1731], 'inhibitory': [1647], 'role,': [1648], 'complex,': [1654], 'includes': [1656], '1,': [1658, 1765, 3433, 3567], 'stimulatory': [1661], 'promoting': [1666, 3181], 'nucleation': [1668, 2473], 'vesicles': [1671], '(28Kihara': [1672], 'Ishihara': [1676], '519-530Crossref': [1685], '(797)': [1688], '29Petiot': [1691], 'Ogier-Denis': [1693], 'Blommaart': [1695], 'E.F.': [1696], 'Meijer': [1697], 'Chem.': [1703, 2137, 2159, 3396], '275:': [1705, 2139], '992-998Abstract': [1706], '(1029)': [1714], 'recent': [1718, 3365], 'study': [1719, 2249, 2754, 2874, 2995, 3019, 3608], 'indicates': [1721], 'hVps15': [1723], '(30Yan': [1735], 'Flinn': [1737], 'R.J.': [1738], 'Wu': [1739, 2738], 'Schnur': [1741], 'R.S.': [1742], 'Backer': [1743], 'J.M.': [1744], '417:': [1748], '747-755Crossref': [1749], '(75)': [1752], 'controlling': [1759], 'autophagy-essential': [1760, 1964, 3200, 4187], 'proteins,': [1761], 'particular': [1763], 'remain': [1772], 'resolved.Our': [1775], 'present': [1776, 2873, 3018, 3607], 'studies': [1777, 1952, 2022, 2527, 3366], 'mTOR.': [1793, 1950, 2928], 'This': [1794, 2357, 2830], 'module': [1796, 1872, 2518, 2860, 3025], 'pathway.': [1808], 'Moderately': [1809], 'transient': [1814], 'moderate': [1816, 3077, 3090], 'subsequent': [1821], 'individually': [1827], 'Strongly': [1831], 'strong': [1838, 3102], 'followed': [1842], 'dual': [1844], 'results': [1854, 1864, 2726], 'reveal': [1856], 'interesting': [1857, 3140], 'autophagy.DISCUSSIONThe': [1863], 'presented': [1865], 'here': [1866, 2572], 'demonstrate': [1867, 3242, 3548], '(Fig.': [1885, 2267, 2324, 2330, 2352, 2379], '9).': [1886], 'constitutive': [1891, 2304, 2930, 3232, 3261, 3313, 3369], 'insufficient': [1896], 'trigger': [1898], 'response.': [1901], 'inactivated': [1910], 'mTOR': [1911, 2877, 2899, 3050, 3073, 3194], 'disassembling': [1913], 'complexes': [1916], 'mTORC2,': [1919, 3086, 3110], 'up-regulation': [1923, 2579], 'consequences,': [1935], 'suggesting': [1936, 2917], 'play': [1941, 3164, 3535], 'central': [1943, 3537], 'integrating': [1946, 3540], 'signals': [1947, 2970, 3541], 'provide': [1954], 'first': [1956], 'mechanistic': [1957], 'link': [1958, 2557], 'system.Mechanism': [1969], 'Non-canonical': [1972], 'Module': [1974], 'Regulating': [1975], 'AutophagyERKs': [1976], 'widely': [1979], 'family': [1981], 'serine/threonine': [1983], 'kinases': [1985], 'implicated': [1986, 3359], 'programs': [1990], 'such': [1991, 3225], 'proliferation,': [1994], 'differentiation,': [1995], 'apoptosis.': [1997], 'can': [1999, 2640, 3317, 3423], 'wide': [2004], 'variety': [2005], 'oncogenes': [2007], 'extracellular': [2009], 'mitogens,': [2012], 'growth': [2013, 3267, 3326], 'factors,': [2014], 'cytokines,': [2015], 'chemokines.': [2017], 'An': [2018], 'increasing': [2019, 3550], 'number': [2020], 'suggested': [2024], 'modulating': [2031], '(27Shinojima': [2033, 2537], '43Aoki': [2050], 'Takada': [2052], 'Sawaya': [2056], 'Aggarwal': [2058], 'B.B.': [2059], 'Pharmacol.': [2063], '29-39Crossref': [2066], '(464)': [2069], '44Zhu': [2072], 'J.H.': [2073], 'Horbinski': [2074], 'Guo': [2076], 'Watkins': [2078], 'Uchiyama': [2080], 'Chu': [2082], 'C.T.': [2083], 'Am.': [2084], 'Pathol.': [2086], '170:': [2088], '75-86Abstract': [2089], '(388)': [2097], '54Corcelle': [2100], 'Nebout': [2102], 'Bekri': [2104], 'Gauthier': [2106], 'Hofman': [2108], 'Poujeol': [2110], 'Fénichel': [2112], 'Mograbi': [2114], 'Cancer': [2116], 'Res.': [2117], '66:': [2119], '6861-6870Crossref': [2120], '(152)': [2123], '55Ogier-Denis': [2126], 'Pattingre': [2128], 'El': [2130], 'Benna': [2131], '39090-39095Abstract': [2140], '(255)': [2148], '56Pattingre': [2151], 'Bauvy': [2153], '278:': [2161], '16667-16674Abstract': [2162], '(244)': [2170], '57Subramaniam': [2173], 'Unsicker': [2175], 'Neuroscience.': [2177], '138:': [2179], '1055-1065Crossref': [2180], '(76)': [2183], 'primarily': [2194], 'concluded': [2195], 'from': [2196, 2264, 3043, 3212, 3594], 'pharmacological': [2198], 'blockage': [2199], 'compound': [2203], 'PD98059,': [2204], 'MEK-specific': [2206], 'inhibitor.': [2207], 'this': [2209, 2248, 2559, 2857], 'chemical': [2210], 'indirectly': [2211], 'blocks': [2212], 'inhibiting': [2215], 'its': [2216, 3549], 'canonical': [2217, 2338], 'regulator,': [2219], 'MEK,': [2220], 'surprising': [2224], 'exclusively': [2228], 'credited': [2229], 'because': [2233, 2303, 2610, 3556], 'has': [2235, 2601], 'believed': [2237], 'only': [2241, 2837, 3318], 'substrate': [2243, 2816], 'MEK.We': [2245], 'demonstrated': [2246], 'maintains': [2254, 2273], 'protecting': [2262], 'them': [2263], '6E,': [2268, 2288], 'lower': [2269], 'panel)': [2270], 'incapable': [2279, 3059], 'triggering': [2281, 3061], 'response': [2283, 2311, 2351, 2596, 2869], '(Figs.': [2284, 2312, 2396], '1E,': [2285], '3C,': [2286], 'upper': [2289], 'panel).': [2290], 'Although': [2291], 'found': [2293, 3020], 'expression': [2305, 2931, 3233], 'active': [2307], '1C': [2313], '7A)': [2315], 'RNA': [2322, 2345], 'interference': [2323, 2346], '2C)': [2325], 'dominant': [2327], 'negative': [2328], '2D)': [2331, 2380], 'knockdown': [2335], 'effectors': [2339, 2367], 'ERK,': [2340], 'p90RSK,': [2341], 'Elk': [2343], 'did': [2347], 'cripple': [2349], '2,': [2353], 'B).': [2356], 'unusual': [2358, 2513, 2858], 'observation': [2359], 'suggests': [2360], 'use': [2364], 'context': [2370, 2392], 'signaling.': [2373], 'Coincidentally': [2374], 'interact': [2382], 'effector': [2386, 2408], 'other': [2387, 3361], 'than': [2388, 2419, 2629], '4D': [2397], '5B),': [2399], 'indicating': [2400, 2849], 'sole': [2406], 'more': [2416], 'important': [2417], 'Interestingly': [2424], 'Golgi': [2427], 'fragmentation': [2428], 'mitosis': [2430], 'ERK1/2': [2433], '(58Colanzi': [2434], 'Deerinck': [2436], 'T.J.': [2437], 'Ellisman': [2438], 'M.H.': [2439], 'Malhotra': [2440, 2457], '149:': [2446], '331-339Crossref': [2447], '(85)': [2450], '59Colanzi': [2453], 'Suetterlin': [2455], 'Curr.': [2459], 'Opin.': [2460], '462-467Crossref': [2465], '(103)': [2468], 'executed': [2482], 'at': [2483, 3259, 3320, 3333, 3586], 'trans-Golgi': [2485], 'network': [2486], '(60Kihara': [2490], 'Rep.': [2499], '2:': [2501], '330-335Crossref': [2502], '(721)': [2505], 'support': [2511], 'autophagy.Recent': [2526], 'show': [2528, 3367], 'up-regulates': [2531], 'starvation-caused': [2532], 'down-regulating': [2535], 'Akt/mTOR/S6K': [2536], 'remains': [2567], 'largely': [2568], 'unclear.': [2569], 'We': [2570], 'observed': [2571], 'coincided': [2577], 'responses,': [2585], 'Raf1': [2594], 'stimuli.': [2599], 'proposed': [2603], 'physiological': [2606, 2851, 3223], 'energy': [2608, 2620, 2718, 2724], 'sensor': [2609], 'AMP': [2611, 2647], 'most': [2614], 'sensitive': [2615], 'indicator': [2616], 'status.': [2621], 'ATP': [2624, 2638], 'concentration': [2625], 'much': [2627, 3600], 'higher': [2628], 'AMP,': [2632], 'insignificant': [2635], 'decrease': [2636], 'levels': [2639, 2648, 3173, 3180, 3323], 'result': [2641], 'extraordinary': [2644], 'increase': [2645, 3093], 'sensed': [2651], 'stimulate': [2654], 'confers': [2699, 3377], 'sensitivity': [2701], 'accuracy': [2703], 'activity.': [2709, 3074], 'levels.': [2719, 3034], 'starvation': [2725, 2883, 3282], 'phosphorylation': [2729], '(49Inoki': [2732], 'Li': [2734], 'Zhu': [2736], 'Guan': [2740], 'K.L.': [2741], '2002;': [2745], '648-657Crossref': [2747], '(2365)': [2750], 'showed': [2755, 2875], 'depends': [2761, 3000], 'MEK/ERK.': [2763], 'Furthermore,': [2764], 'interacted': [2767], 'TSC,': [2769, 2792], 'physical': [2772, 3218], 'interaction': [2773], 'D': [2782], 'docking': [2783, 2812], 'site': [2784, 2813], 'sequence': [2785], 'motif': [2786], 'contained': [2787], 'consistent': [2793, 2890], 'notion': [2796], 'stable': [2798], 'substrates': [2801], 'mitogen-activated': [2803], '(MAPK)': [2806], 'involves': [2808], 'recognition': [2809], 'functions': [2835], 'rat': [2841, 2958], 'lines': [2843], 'neonatal': [2847], 'mice,': [2848], 'significance.': [2852], 'position': [2856], 'stimuli.Our': [2872], 'non-starvation': [2885], 'activate': [2888], 'MEK/ERK,': [2889], 'non-starved': [2902], 'conditions': [2903, 3224, 3268, 3283, 3327], '(61Høyer-Hansen': [2904], 'Jäättelä': [2906], '381-383Crossref': [2911], '(202)': [2914], 'possible': [2919], 'universal': [2920, 2975], 'due': [2936], 'attributed': [2948], 'postulate': [2961], 'autophagy.Beclin': [2979], 'Plays': [2981], 'Central': [2983], 'Role': [2984], 'Mechanisms': [2987], 'Determining': [2988], 'Protective': [2990], 'Destructive': [2992], 'AutophagyOur': [2993], 'previous': [2994], 'shows': [2996], '(41Wang': [3006], '947-948Crossref': [3011, 3415], '(123)': [3014, 3418], 'mutually': [3027], 'antagonistic': [3028], 'processes': [3029], 'protected': [3039], 'disassembled,': [3045], 'conferring': [3047], 'level,': [3056], 'up-regulated': [3067], 'down-regulation': [3071], 'Transient': [3075], 'ultimate': [3096, 3120], 'requirement': [3124], 'appears': [3137], 'represent': [3139], 'threshold': [3141], 'effects.': [3142], 'degree': [3144, 3159], 'determine': [3151], 'activity,': [3156], 'elicited': [3162], 'fate': [3169], 'decisions': [3170], 'low': [3172, 3279, 3322, 3571], 'serving': [3174], 'homeostatic': [3176], 'high': [3179], 'establish': [3187], 'connection': [3190], 'autophagy.Mammalian': [3207], 'exposure': [3213], 'nutritional,': [3215], 'chemical,': [3216], 'extreme': [3222], 'birth.': [3227], 'Despite': [3228], 'ubiquitous': [3230], 'our': [3240, 3606], 'data': [3241, 3306], 'evident': [3247], 'elevated,': [3252], 'detectable': [3258], 'under': [3265, 3281, 3324], 'normal': [3266, 3325, 3578], 'cells.': [3271, 3351], 'brain,': [3274], 'very': [3278], 'even': [3280], '(20Mizushima': [3284], 'suggest': [3307], 'there': [3310], 'no': [3312], 'occur': [3319], 'extremely': [3321], 'when': [3328, 3598], 'maintained': [3332], 'level.': [3336], 'Therefore,': [3337], 'doubt': [3339], 'housekeeping': [3344], 'all': [3347], 'types': [3348], 'Constitutive': [3352], 'processes.': [3363], 'apoptosis': [3375], 'differentiation': [3378], 'capability': [3379], 'leukemia': [3381], 'HL-60': [3382], '(37Wang': [3384], 'Lian': [3386], 'Zhao': [3388], 'Kauss': [3390], 'M.A.': [3391], 'Spindel': [3392], '283:': [3398], '25596-25605Abstract': [3399], '(117)': [3407], '41Wang': [3410], 'several': [3427], 'capable': [3429], 'Bcl2,': [3435], 'suppressor,': [3441], '24Fimia': [3469], 'stimuli.Studies': [3544], 'importance': [3551], 'fail': [3559], 'survive': [3561], 'absence': [3564], 'develop': [3568], 'cancers': [3569], 'levels,': [3574, 3581, 3591], 'suppress': [3575], 'tumorigenesis': [3576], 'secure': [3582], 'suffer': [3593], 'too': [3599], 'induced.': [3604], 'Thus,': [3605], 'adds': [3609], 'understanding': [3611], 'molecu': [4211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019576484', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 32}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 21}], 'updated_date': '2024-12-22T02:11:54.328003', 'created_date': '2016-06-24'}