Publication Information

{'id': 'https://openalex.org/W2019439141', 'doi': 'https://doi.org/10.1517/14656566.9.4.509', 'title': 'Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism', 'display_name': 'Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism', 'publication_year': 2008, 'publication_date': '2008-03-01', 'ids': {'openalex': 'https://openalex.org/W2019439141', 'doi': 'https://doi.org/10.1517/14656566.9.4.509', 'mag': '2019439141', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18312153'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14656566.9.4.509', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S52020611', 'display_name': 'Expert Opinion on Pharmacotherapy', 'issn_l': '1465-6566', 'issn': ['1465-6566', '1744-7666'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068639798', 'display_name': 'Asterios Karagiannis', 'orcid': 'https://orcid.org/0000-0003-1517-6984'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Asterios Karagiannis', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076157401', 'display_name': 'Κωνσταντίνος Τζιόμαλος', 'orcid': 'https://orcid.org/0000-0002-3172-1594'}, 'institutions': [{'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB', 'GR'], 'is_corresponding': False, 'raw_author_name': 'Konstantinos Tziomalos', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'University College London (University of London), Royal Free University College Medical School, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital, London NW3 2QG, UK'], 'affiliations': [{'raw_affiliation_string': 'University College London (University of London), Royal Free University College Medical School, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital, London NW3 2QG, UK', 'institution_ids': ['https://openalex.org/I124357947', 'https://openalex.org/I2801138448', 'https://openalex.org/I45129253']}, {'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033289594', 'display_name': 'Theodotis Papageorgiou', 'orcid': 'https://orcid.org/0000-0003-2021-2214'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Athanasios Papageorgiou', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005580657', 'display_name': 'Anna I. Kakafika', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Anna I Kakafika', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004312980', 'display_name': 'Efstathios D. Pagourelias', 'orcid': 'https://orcid.org/0000-0003-0189-8353'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Efstathios D Pagourelias', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061448658', 'display_name': 'Panagiotis Anagnostis', 'orcid': 'https://orcid.org/0000-0002-8949-4312'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Panagiotis Anagnostis', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091008679', 'display_name': 'Vasilios G. Athyros', 'orcid': 'https://orcid.org/0000-0002-0882-8676'}, 'institutions': [{'id': 'https://openalex.org/I21370196', 'display_name': 'Aristotle University of Thessaloniki', 'ror': 'https://ror.org/02j61yw88', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I21370196']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Vasilios G Athyros', 'raw_affiliation_strings': ['Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece'], 'affiliations': [{'raw_affiliation_string': 'Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Medical School, Hippokration Hospital, Thessaloniki, Greece', 'institution_ids': ['https://openalex.org/I21370196']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103273782', 'display_name': 'Dimitri P. Mikhailidis', 'orcid': 'https://orcid.org/0000-0002-9566-2263'}, 'institutions': [{'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I285663978', 'display_name': 'Weatherford College', 'ror': 'https://ror.org/02xwsbr93', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I285663978']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Dimitri P Mikhailidis', 'raw_affiliation_strings': ['+44 0 20 7830 2235', 'University College London (University of London), Royal Free University College Medical School, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital, London NW3 2QG, UK +44 0 20 7830 2258'], 'affiliations': [{'raw_affiliation_string': 'University College London (University of London), Royal Free University College Medical School, Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital, London NW3 2QG, UK +44 0 20 7830 2258', 'institution_ids': ['https://openalex.org/I124357947', 'https://openalex.org/I2801138448', 'https://openalex.org/I45129253']}, {'raw_affiliation_string': '+44 0 20 7830 2235', 'institution_ids': ['https://openalex.org/I285663978']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.018, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 129, 'citation_normalized_percentile': {'value': 0.999897, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '9', 'issue': '4', 'first_page': '509', 'last_page': '515'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11054', 'display_name': 'Adrenal and Paraganglionic Tumors', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/eplerenone', 'display_name': 'Eplerenone', 'score': 0.9801603}, {'id': 'https://openalex.org/keywords/hyperaldosteronism', 'display_name': 'Hyperaldosteronism', 'score': 0.65712875}], 'concepts': [{'id': 'https://openalex.org/C2780072264', 'wikidata': 'https://www.wikidata.org/wiki/Q423804', 'display_name': 'Eplerenone', 'level': 4, 'score': 0.9801603}, {'id': 'https://openalex.org/C2776379505', 'wikidata': 'https://www.wikidata.org/wiki/Q422188', 'display_name': 'Spironolactone', 'level': 3, 'score': 0.9694871}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8490609}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.69856286}, {'id': 'https://openalex.org/C2776292634', 'wikidata': 'https://www.wikidata.org/wiki/Q1640860', 'display_name': 'Hyperaldosteronism', 'level': 3, 'score': 0.65712875}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6169845}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.45579255}, {'id': 'https://openalex.org/C189135053', 'wikidata': 'https://www.wikidata.org/wiki/Q3454531', 'display_name': 'Mineralocorticoid receptor', 'level': 3, 'score': 0.44228595}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38724467}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.36336976}], 'mesh': [{'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006929', 'descriptor_name': 'Hyperaldosteronism', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007008', 'descriptor_name': 'Hypokalemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000451', 'descriptor_name': 'Mineralocorticoid Receptor Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013148', 'descriptor_name': 'Spironolactone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013148', 'descriptor_name': 'Spironolactone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000959', 'descriptor_name': 'Antihypertensive Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077545', 'descriptor_name': 'Eplerenone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006177', 'descriptor_name': 'Gynecomastia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006177', 'descriptor_name': 'Gynecomastia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006929', 'descriptor_name': 'Hyperaldosteronism', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006929', 'descriptor_name': 'Hyperaldosteronism', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006929', 'descriptor_name': 'Hyperaldosteronism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006929', 'descriptor_name': 'Hyperaldosteronism', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D006947', 'descriptor_name': 'Hyperkalemia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006947', 'descriptor_name': 'Hyperkalemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006947', 'descriptor_name': 'Hyperkalemia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D007008', 'descriptor_name': 'Hypokalemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007008', 'descriptor_name': 'Hypokalemia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D007008', 'descriptor_name': 'Hypokalemia', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D007008', 'descriptor_name': 'Hypokalemia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000451', 'descriptor_name': 'Mineralocorticoid Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000451', 'descriptor_name': 'Mineralocorticoid Receptor Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000451', 'descriptor_name': 'Mineralocorticoid Receptor Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013148', 'descriptor_name': 'Spironolactone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013148', 'descriptor_name': 'Spironolactone', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013148', 'descriptor_name': 'Spironolactone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14656566.9.4.509', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S52020611', 'display_name': 'Expert Opinion on Pharmacotherapy', 'issn_l': '1465-6566', 'issn': ['1465-6566', '1744-7666'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18312153', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1558440797', 'https://openalex.org/W1814252166', 'https://openalex.org/W1977117807', 'https://openalex.org/W1980094514', 'https://openalex.org/W1984388924', 'https://openalex.org/W1984717781', 'https://openalex.org/W1990887256', 'https://openalex.org/W1998463406', 'https://openalex.org/W2003989747', 'https://openalex.org/W2012417977', 'https://openalex.org/W2019216135', 'https://openalex.org/W2024885055', 'https://openalex.org/W2034867134', 'https://openalex.org/W2042552892', 'https://openalex.org/W2047458689', 'https://openalex.org/W2047908219', 'https://openalex.org/W2051617480', 'https://openalex.org/W2058801122', 'https://openalex.org/W2059722418', 'https://openalex.org/W2072074888', 'https://openalex.org/W2075460104', 'https://openalex.org/W2078741210', 'https://openalex.org/W2086392932', 'https://openalex.org/W2095527951', 'https://openalex.org/W2097451187', 'https://openalex.org/W2101785330', 'https://openalex.org/W2103340325', 'https://openalex.org/W2116087989', 'https://openalex.org/W2120923907', 'https://openalex.org/W2123778248', 'https://openalex.org/W2125226019', 'https://openalex.org/W2140078175', 'https://openalex.org/W2142803942', 'https://openalex.org/W2143305377', 'https://openalex.org/W2148671035', 'https://openalex.org/W2152094259', 'https://openalex.org/W2158828981', 'https://openalex.org/W2165141146', 'https://openalex.org/W4235206191', 'https://openalex.org/W4242669072'], 'related_works': ['https://openalex.org/W4232964041', 'https://openalex.org/W2801040858', 'https://openalex.org/W2320541894', 'https://openalex.org/W2279875401', 'https://openalex.org/W2271304487', 'https://openalex.org/W2189187458', 'https://openalex.org/W2009328678', 'https://openalex.org/W2007204386', 'https://openalex.org/W1979996291', 'https://openalex.org/W1598280036'], 'abstract_inverted_index': {'The': [0, 105, 126, 292], 'aim': [1], 'of': [2, 17, 96, 111, 134, 140, 185, 194, 206, 213, 220, 226, 236, 272, 294], 'this': [3, 250], 'prospective,': [4], 'randomised,': [5], 'open-label,': [6], 'blinded-end': [7], 'point': [8], 'study': [9], 'was': [10, 66, 100, 108, 129, 177, 276, 280, 297], 'to': [11, 39, 77, 217, 263], 'compare': [12], 'the': [13, 61, 71, 88, 109, 145, 204, 234, 237, 254, 259, 270], 'efficacy': [14], 'and': [15, 82, 137, 147, 187, 228, 244], 'safety': [16], 'eplerenone': [18, 50, 148, 221, 243, 264, 279], 'versus': [19], 'spironolactone': [20, 42, 81, 146, 186, 216, 262, 284], 'in': [21, 131, 144, 169, 179, 188, 224, 285, 288], 'patients': [22, 34, 112, 143, 171, 181, 190, 197, 240, 289], 'with': [23, 35, 113, 122, 159, 199, 290, 299], 'bilateral': [24, 200], 'idiopathic': [25], 'hyperaldosteronism': [26], '(IHA).': [27], 'After': [28], 'a': [29, 93], '2-week': [30], 'washout': [31], 'period,': [32], '34': [33], 'IHA': [36], 'were': [37, 73, 164, 241, 246], 'assigned': [38], 'receive': [40], 'either': [41], '25': [43, 51], 'mg': [44, 52, 79, 84, 99, 184, 193, 212, 219], 'b.i.d.': [45, 53], '(n': [46, 54], '=': [47, 55, 152], '17)': [48, 56], 'or': [49], 'for': [57, 80, 85], '24': [58], 'weeks.': [59, 174], 'If': [60, 87], "patients'": [62, 89, 127], 'blood': [63], 'pressure': [64], '(BP)': [65], 'not': [67, 252], '<': [68, 115], '140/90': [69, 116], 'mmHg,': [70], 'doses': [72], 'gradually': [74], 'increased': [75], 'up': [76], '400': [78, 183, 211], '200': [83], 'eplerenone.': [86, 160, 195], 'BP': [90, 114, 128, 155, 231, 287], 'remained': [91], 'uncontrolled,': [92], 'daily': [94, 222], 'dose': [95], 'hydrochlorothiazide': [97], '12.5': [98], 'added': [101], 'at': [102, 118, 172, 203, 269], 'week': [103, 207, 273], '16.': [104, 274], 'primary': [106, 255], 'outcome': [107], 'percentage': [110], 'mmHg': [117], '16': [119, 208], 'weeks': [120], '(i.e.,': [121], 'aldosterone': [123], 'antagonist': [124], 'monotherapy).': [125], 'normalised': [130, 165], '13': [132], 'out': [133, 139], '17': [135, 141], '(76.5%)': [136], '14': [138], '(82.4%)': [142], 'groups,': [149], 'respectively': [150], '(p': [151], '1.00).': [153], 'Systolic': [154], 'decreased': [156], 'more': [157], 'rapidly': [158], 'Serum': [161], 'potassium': [162], 'levels': [163], '(>': [166], '3.5': [167], 'mmol/l)': [168], 'all': [170], '4': [173], 'Mild': [175], 'hyperkalaemia': [176, 296], 'observed': [178], 'two': [180, 266], 'receiving': [182, 191, 210], 'three': [189], '150': [192, 218], 'Two': [196], 'presented': [198], 'painful': [201], 'gynaecomastia': [202, 227], 'end': [205, 235, 256, 271], 'while': [209], 'spironolactone.': [214, 248], 'Switching': [215], 'resulted': [223], 'resolution': [225], 'also': [229], 'maintained': [230], 'control.': [232], 'At': [233], 'study,': [238], '19': [239], 'on': [242, 247], '15': [245], 'However,': [249], 'did': [251], 'affect': [253], 'point,': [257], 'because': [258], 'switch': [260], 'from': [261], '(in': [265], 'patients)': [267], 'occurred': [268], 'It': [275], 'concluded': [277], 'that': [278], 'as': [281, 283], 'effective': [282], 'reducing': [286], 'IHA.': [291], 'risk': [293], 'mild': [295], 'similar': [298], 'both': [300], 'drugs.': [301]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019439141', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-14T03:31:10.695712', 'created_date': '2016-06-24'}