Inhibition of p66ShcA Longevity Gene Rescues Podocytes from HIV-1-induced Oxidative Stress and Apoptosis

Name: Work Video:
Duration: 3 min 30 s
Mohammad Husain; Leonard G. Meggs; Himanshu Vashistha; Sónia Simões; Kevin O. Griffiths; Dileep Kumar; Joanna Mikulak; Peter W. Mathieson; Moin A. Saleem; Luis Del Valle; Sergio Piña‐Oviedo; Jin Ying Wang; Surya V. Seshan; Ashwani Malhotra; Krzysztof Reiss; Pravin C. Singhal
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'exhibit': [77, 267, 1312, 3944, 4106], 'increased': [78, 140, 268, 330], 'metabolism,': [82, 272, 3754], 'DNA': [83, 273, 2184, 2872, 3557, 3567, 3574, 4231], 'strand': [84, 274, 3566, 3573], 'breaks,': [85, 275], '5-fold': [88, 278, 3525], 'increase': [89, 154, 279, 344, 785, 3526, 3737, 3795, 4023], 'apoptosis,': [91, 157, 281, 347, 3509], 'whereas': [92, 282, 1022, 4018, 4089, 4128], 'opposite': [94, 284], 'was': [95, 135, 285, 325, 1861, 1877, 1947, 2017, 2156, 2228, 2235, 2246, 2278, 2293, 2302, 2328, 2371, 2591, 2613, 2725, 2823, 2873, 2879, 2919, 2946, 3053, 3082, 3179, 3352, 3373, 3530, 3781, 3799, 3841, 3994, 4064, 4077, 4095], 'true': [96, 286], 'NL4-3/CIDHP': [98, 288, 1334, 3480, 3528, 3698, 3725, 3789, 3809, 4005, 4019, 4117, 4130], 'co-transfected': [99, 289], 'mu-36p66ShcA': [101, 291], '(mu-36)': [102, 292, 1298], 'dominant': [103, 293, 910, 3837], 'negative': [104, 294, 1944, 3838], 'expression': [105, 295, 1377, 1761, 1961, 2014, 4069, 4094], 'vector': [106, 296, 837, 883, 2208, 2363, 2503, 3112], 'or': [107, 297, 384, 760, 775, 1299, 1344, 1445, 2207, 2604, 2664, 2772, 2994, 2997, 3004, 3116, 3338, 3445, 3670, 3812], 'isoform-specific': [108, 298, 1300, 4042], 'p66-small': [109, 299], 'interfering': [110, 149, 300, 339, 424, 458, 818, 864], 'RNA.': [111, 301], 'Phosphorylation': [112, 302], 'at': [113, 303, 1165, 1214, 1713, 2052, 2066, 2073, 2083, 2142, 2222, 2254, 2297, 2312, 2353, 2405, 2491, 2670, 2817, 2963, 3023, 3359, 3488, 3783, 3848, 3996], 'Ser-36': [114, 304, 1168], 'wild': [117, 307, 3901], 'type': [118, 308, 2088, 3902], 'protein,': [120, 310, 4088], 'required': [121, 311, 3826], 'redox': [124, 175, 314, 365, 1111, 1172, 1248, 1330, 4039, 4177], 'function': [125, 315, 3920, 4178], 'inhibition': [127, 172, 317, 362, 1245, 3916, 3956], 'potent': [130, 320, 1100, 3545], 'stress': [131, 181, 321, 371, 923, 1101, 1257, 1335, 3612], 'response': [132, 322, 1102], 'regulator': [133, 323, 1103], 'Foxo3a,': [134, 324], 'unchanged': [136, 326], 'mu-36/NL4-3/CIDHP': [138, 156, 328, 346], 'but': [139, 329], 'NL4-3/CIDHP.': [142, 332, 3966], 'Acute': [143, 333], 'knockdown': [144, 334, 4067], 'Foxo3a': [146, 336], 'small': [148, 338, 817, 863], 'RNA': [150, 340, 819, 865], 'induced': [151, 341], '50%': [153, 343], 'indicating': [158, 348], 'that': [159, 171, 349, 361, 390, 732, 749, 784, 920, 1086, 1113, 1226, 1259, 1308, 1337, 1490, 2830, 3798], 'Foxo3a-dependent': [160, 350], 'responses': [161, 351, 1092], 'promote': [162, 352, 1353, 1760], 'survival': [164, 354, 1355, 2072, 4186], 'mu-36': [167, 357, 1343, 2653, 2662, 2773, 3891, 3922, 3961, 4007], 'cells.': [168, 358], 'We': [169, 359, 1238, 3820, 4101], 'conclude': [170, 360], 'activity': [176, 366, 1173, 1249, 1331], 'prevents': [177, 367], 'signals': [182, 372, 796, 1112, 1225], 'activation': [184, 374, 1233, 1253], 'apoptosis': [188, 378, 761, 925, 1236, 1270, 1320, 2155, 2301, 2528, 3529, 3548, 3617], 'program.': [189, 379, 1237], 'are': [386, 1010, 2190, 3552, 4189], 'specialized': [388], 'focal': [399], 'segmental': [400], 'glomerular': [401, 490, 499, 742, 780, 809], 'sclerosis': [402], '(FSGS)': [403], 'collapsing': [406], 'variant': [407], 'this': [409, 789, 1215, 1484, 4025, 4150], 'entity,': [410], 'frequently': [411], 'encountered': [412], 'HIVAN.': [414, 751], '3The': [415], 'abbreviations': [416, 450], 'used': [417, 451, 1573, 1771, 1780, 1878, 2592, 2614, 4032, 4065, 4078], 'are:': [418, 452], 'HIVANhuman': [419, 453], 'nephropathysiRNAsmall': [423, 457], 'RNACIDHPconditionally': [425, 459], 'podocyte(s)GFPgreen': [429, 463], 'fluorescence': [430, 464, 826, 872, 1850, 2706, 2887, 3052, 3702], 'proteinDPIdiphenyleneiodoniumγH2AXphospho-histone': [431, 465], 'H2AXDCFDA2′,7′-dichlorofluorescein': [432, 466], '(DCF)': [433, 467, 832, 878], 'diacetateSFMserum-free': [434, 468], 'mediaEVempty': [435, 469], 'vectorPBMCperipheral': [436, 470], 'blood': [437, 471, 839, 885, 3321], 'mononuclear': [438, 472, 840, 886, 3322], 'cellsROSreactive': [439, 473], 'speciesELISAenzyme-linked': [441, 475], 'immunosorbent': [442, 476, 846, 892], 'assayTUNELterminal': [443, 477], 'dUTP': [444, 478, 849, 895], 'nick-end': [445, 479, 850, 896], 'labelingPBSphosphate-buffered': [446, 480], 'salinePKBprotein': [447, 481], 'kinase': [448, 482, 855, 901], 'BHAhemagglutinin.3The': [449], 'BHAhemagglutinin.': [483], 'The': [484, 752, 982, 1099, 1672, 1735, 1914, 1963, 2007, 2045, 2112, 2129, 2151, 2174, 2225, 2260, 2288, 2395, 2419, 2433, 2458, 2469, 2534, 2597, 2723, 2913, 2938, 3076, 3261, 3887, 4230], 'podocyte,': [485], 'strategically': [486], 'positioned': [487], 'along': [488, 3899], 'basement': [491], 'membrane,': [492], 'is': [493, 762, 1024, 1105, 1338, 1420, 1485, 2176, 2628, 2968, 2978, 3453, 3543, 3767, 3825, 3894, 3973, 4137, 4179, 4234], 'component': [496], 'filtration': [500, 743, 810], 'barrier,': [501], 'functioning': [502], 'tandem': [504], 'its': [506, 1475], 'associated': [507], 'slit': [508], 'diaphragm': [509], 'to': [510, 518, 734, 766, 773, 794, 801, 924, 1093, 1288, 1304, 1318, 1352, 1422, 1506, 1575, 1729, 1759, 1781, 1879, 1886, 1910, 2030, 2081, 2092, 2098, 2104, 2170, 2593, 2615, 2907, 2973, 2982, 3273, 3473, 3554, 3564, 3616, 3704, 3769, 4035, 4066, 4108, 4171], 'limit': [511], 'passage': [512], 'albumin': [514, 2813], 'plasma': [516], 'proteins': [517], 'urinary': [520], 'space': [521], '(1Kriz': [522], 'W.': [523, 590], 'Gretz': [524], 'N.': [525, 662, 1594, 1799, 3577, 3867], 'Lemley': [526], 'K.V.': [527], 'Kidney': [528, 569, 640, 705], 'Int.': [529, 570, 641, 706], '1998;': [530, 4222], '54:': [531], '687-697Abstract': [532], 'Full': [533, 535, 575, 577, 645, 647, 710, 712], 'Text': [534, 536, 576, 578, 646, 648, 711, 713], 'PDF': [537, 579, 649, 714], 'PubMed': [538, 580, 602, 625, 650, 686, 715, 952, 977, 1081, 1131, 1158, 1208, 1416, 1536, 1561, 1601, 1669, 1705, 1806, 1842, 2002, 3106, 3586, 3605, 3634, 3652, 3882, 4059, 4210, 4225], 'Scopus': [539, 581, 603, 626, 651, 687, 716, 953, 978, 1082, 1132, 1159, 1209, 1562, 1602, 1706, 1807, 1843, 2003, 3107, 3587, 3606, 3635, 3653, 3883, 4060, 4211, 4226], '(511)': [540], 'Google': [541, 583, 605, 628, 653, 689, 718, 955, 980, 1084, 1134, 1161, 1211, 1417, 1537, 1564, 1604, 1670, 1708, 1809, 1845, 2005, 3109, 3589, 3608, 3637, 3655, 3885, 4062, 4213, 4228], 'Scholar,': [542, 606, 629, 654, 690, 956, 1135, 1538, 3590, 3638, 4214], '2Li': [543], 'J.J.': [544, 550], 'Kwak': [545], 'S.J.': [546, 562], 'Jung': [547], 'D.S.': [548, 566], 'Kim': [549, 563], 'Yoo': [551], 'T.H.': [552, 3579], 'Ryu': [553], 'D.R.': [554], 'Han': [555, 565], 'S.H.': [556], 'Choi': [557], 'H.Y.': [558], 'Lee': [559], 'J.E.': [560], 'Moon': [561], 'D.K.': [564], 'Kang': [567], 'S.W.': [568], 'Suppl.': [571], '2007;': [572, 1205, 1558, 1702, 3879, 4207], '106:': [573], '36-42Abstract': [574], '(175)': [582], 'Scholar).': [584, 981, 1162, 1565, 1605, 1671, 1709, 1810, 1846, 2006, 3110, 3609, 3656, 3886, 4229], 'Compelling': [585], 'evidence': [586, 907], '(3Barisoni': [587], 'L.': [588, 631, 929, 970, 1141, 1404, 1524, 1550, 1657, 1694], 'Kriz': [589], 'Mundel': [591, 634, 1407, 1527, 1660], 'P.': [592, 635, 700, 943, 966, 1061, 1070, 1179, 1189, 1193, 1408, 1528, 1584, 1661, 1789], "D'Agati": [593, 636, 673], 'V.': [594], 'J.': [595, 619, 692, 696, 1394, 1409, 1514, 1529, 1586, 1590, 1592, 1647, 1662, 1791, 1795, 1797, 1835, 1995, 3646, 3647, 3859, 3875, 4055], 'Am.': [596, 1410, 1530, 1663, 1836, 1996, 3874], 'Soc.': [597, 1411, 1531, 1664, 1837, 1997, 4218], 'Nephrol.': [598, 1412, 1532, 1665, 1838, 1998], '1999;': [599, 974], '10:': [600], '51-61Crossref': [601], '(6)': [604], '4Bruggeman': [607], 'L.A.': [608, 633, 658], 'Dikman': [609], 'S.': [610, 927, 962, 1076, 1203, 1546, 1690, 3861, 4047], 'Meng': [611], 'C.': [612, 933, 935, 945, 1050], 'Quaggin': [613], 'S.E.': [614, 4203], 'Coffman': [615], 'T.M.': [616], 'Klotman': [617, 638, 677, 679, 1823, 1833, 1983, 1993], 'P.E.': [618, 639, 680, 1834, 1994], 'Clin.': [620], 'Invest.': [621], '1997;': [622], '100:': [623, 1079], '84-92Crossref': [624], '(229)': [627], '5Barisoni': [630], 'Bruggeman': [632, 657], 'V.D.': [637, 674], '2000;': [642], '58:': [643], '173-181Abstract': [644], '(170)': [652], '6Marras': [655], 'D.': [656, 3863], 'Gao': [659], 'F.': [660, 937, 1055, 1197], 'Tanji': [661], 'Mansukhani': [663], 'M.M.': [664], 'Cara': [665, 1831, 1991], 'A.': [666, 1077, 1204, 1544, 1613, 1688, 1832, 1992, 3099, 3627, 3869, 4051], 'Ross': [667, 1827, 1987], 'M.D.': [668, 1828, 1988], 'Gusella': [669, 1821, 1981], 'G.L.': [670, 1822, 1982], 'Benson': [671], 'G.': [672, 931, 947, 964, 1059, 1065, 1068], 'Hahn': [675], 'B.H.': [676], 'M.E.': [678, 1824, 1984], 'Nat.': [681], 'Med.': [682, 4221], '2002;': [683, 1413, 1533, 1666, 1839, 1999, 4056], '8:': [684, 3584], '522-526Crossref': [685], '(257)': [688], '7Zhong': [691], 'Zuo': [693], 'Y.': [694, 1137, 3642, 3644, 4053], 'Ma': [695], 'Fogo': [697], 'A.B.': [698], 'Jolicoeur': [699], 'Ichikawa': [701], 'I.': [702, 1052, 1183], 'Matsusaka': [703], 'T.': [704, 1400, 1520, 1653], '2005;': [707, 1155, 3103, 3631], '68:': [708], '1048-1060Abstract': [709], '(112)': [717], 'Scholar)': [719, 1085, 4063], 'supports': [720], 'gene': [726, 1123, 1376, 1854], 'products': [727, 1124], 'podocyte': [730, 755, 1364], 'injury': [731, 759], 'leads': [733], 'breach': [736], 'integrity': [739, 804], 'barrier': [744], 'massive': [747], 'proteinuria': [748], 'characterizes': [750], 'absence': [753, 2571], 'regeneration': [756], 'after': [757, 1727, 2136], 'cell': [758, 792, 1273, 1471, 2071, 2152, 2226, 2325, 3486], 'major': [764], 'limitation': [765], 'development': [768, 2290], 'innovative': [770], 'therapeutic': [771], 'strategies': [772], 'arrest': [774, 1725], 'prevent': [776], 'HIVAN': [777, 1582, 1787], 'other': [779], 'diseases.': [781], 'Accordingly,': [782], 'interventions': [783], 'resistance': [787, 1317, 4107], 'population': [793], 'death': [795, 2153, 2326, 3506], 'offer': [797], 'novel': [799], 'approach': [800, 4030], 'preserve': [802], 'permselectivity': [806], 'barrier.': [811], 'nephropathy': [816, 862], 'podocyte(s)': [824, 870], 'green': [825, 871, 1849], 'diphenyleneiodonium': [828, 874, 2343], 'phospho-histone': [829, 875], 'H2AX': [830, 876, 2821], '2′,7′-dichlorofluorescein': [831, 877, 2960], 'diacetate': [833, 879, 2961], 'serum-free': [834, 880, 3037], 'media': [835, 881, 2479, 3038, 3121, 3334, 3675], 'empty': [836, 882, 1960, 2651, 2770, 2995, 3005], 'peripheral': [838, 884, 3320], 'enzyme-linked': [845, 891], 'assay': [847, 893, 2175, 2370, 3139, 3521], 'terminal': [848, 894], 'labeling': [851, 897], 'phosphate-buffered': [852, 898], 'saline': [853, 899], 'B': [856, 902], 'hemagglutinin.': [857, 903], 'Several': [904], 'lines': [905], 'support': [908], 'intracellular': [918, 2971, 3662, 3952], 'pathways': [919], 'convert': [921], 'oxidative': [922, 1094, 2322, 3611], '(8Menini': [926], 'Amadio': [928], 'Oddi': [930], 'Ricci': [932], 'Pesce': [934], 'Pugliese': [936, 946], 'Giorgio': [938, 959, 1056], 'M.': [939, 960, 1057, 1063, 1177, 1181, 1185, 1191, 1588, 1793, 1820, 1980, 3640, 4045, 4049], 'Migliaccio': [940], 'E.': [941, 958], 'Pelicci': [942, 963, 971, 1069, 1188], 'Iacobini': [944], 'Diabetes.': [948, 1557, 1701], '2006;': [949, 3602], '55:': [950], '1642-1650Crossref': [951], '(161)': [954], '9Migliaccio': [957], 'Mele': [961], 'Reboldi': [965], 'Pandolfi': [967], 'P.P.': [968], 'Lanfrancone': [969], 'P.G.': [972], 'Nature.': [973], '402:': [975], '309-313Crossref': [976], '(1472)': [979], 'three': [983], 'overlapping': [984], 'Shc': [985], 'proteins,': [986], 'p66ShcA,': [987, 3835], 'p52ShcA,': [988], 'p46ShcA,': [990], 'share': [991], 'C-terminal': [993], 'Src': [994], 'homology': [995, 1000, 1032], '2': [996, 2127, 2252], 'domain,': [997], 'central': [998], 'collagen': [999], 'region,': [1001], 'N-terminal': [1003, 1029], 'phosphotyrosine': [1004], 'binding': [1005, 3516, 3536], 'domain.': [1006], 'p46ShcA': [1007], 'p52ShcA': [1009], 'product': [1012], 'alternative': [1014, 1036], 'translation': [1015], 'initiation': [1016], 'sites': [1017], 'within': [1018, 2834], 'same': [1020, 1568, 1773, 3305], 'transcript,': [1021], 'distinguished': [1025], 'unique': [1028], 'region': [1030], '(collagen': [1031], '2),': [1033], 'generated': [1034], 'splicing.': [1037], 'has': [1039, 1777, 3613], 'emerged': [1040], 'as': [1041, 1477, 1776, 1816, 1976, 2019, 2521, 3403, 3494, 4079], 'genetic': [1043], 'determinant': [1044], 'longevity': [1046, 4188], 'mammals': [1048], '(10Napoli': [1049], 'Martin-Padura': [1051, 1182], 'de': [1053], 'Nigris': [1054], 'Mansueto': [1058], 'Somma': [1060], 'Condorelli': [1062], 'Sica': [1064], 'De': [1066], 'Rosa': [1067], 'Proc.': [1071, 1198, 4217], 'Natl.': [1072, 1199], 'Acad.': [1073, 1200], 'Sci.': [1074, 1201], 'U.': [1075, 1202], '2003;': [1078], '2112-2116Crossref': [1080], '(330)': [1083], 'controls': [1087, 2854], 'mitochondrial': [1088], 'metabolism': [1089, 2942], 'cellular': [1091, 1428], 'stress,': [1095, 2323], 'aging,': [1096], 'Foxo3A': [1104, 1121, 1228], 'downstream': [1107], 'target': [1108, 1227, 4236], 'phosphorylate': [1114], 'regulatory': [1116], 'sites,': [1117], 'inhibiting': [1118], 'transcription': [1119], 'stress-related': [1122], '(11Ravichandran': [1125], 'K.S.': [1126], 'Oncogene.': [1127], '2001;': [1128, 3583], '20:': [1129], '6322-6330Crossref': [1130], '(333)': [1133], '12Hu': [1136], 'Wang': [1138], 'X.': [1139], 'Zeng': [1140], 'Cai': [1142], 'D.Y.': [1143], 'Sabapathy': [1144], 'K.': [1145, 3596, 3871], 'Goff': [1146], 'S.P.': [1147], 'Firpo': [1148], 'E.J.': [1149, 1830, 1990], 'Li': [1150], 'B.': [1151], 'Mol.': [1152], 'Biol.': [1153, 4220], 'Cell.': [1154], '16:': [1156], '3705-3718Crossref': [1157], '(69)': [1160], 'Because': [1163], 'phosphorylation': [1164], 'residue': [1169], 'activates': [1170, 3504], '(13Camici': [1174], 'G.G.': [1175], 'Schiavoni': [1176], 'Francia': [1178], 'Bachschmid': [1180], 'Hersberger': [1184], 'Tanner': [1186], 'F.C.': [1187], 'Volpe': [1190], 'Anversa': [1192], 'Lüscher': [1194], 'T.F.': [1195], 'Cosentino': [1196], '104:': [1206], '5217-5222Crossref': [1207], '(201)': [1210], 'Scholar),': [1212, 1418], 'mutation': [1213], 'site': [1216], 'should': [1217], 'inhibit': [1218, 4036], 'transmission': [1219], '(ROS)-dependent': [1224], 'genomic': [1230, 4196], 'DNA,': [1231], 'triggering': [1232], 'have': [1239, 1674, 1770], 'proposed': [1240], 'model': [1242, 1580, 1785], 'results': [1250, 1323], 'Foxo3A-dependent': [1256], 'program': [1258, 3507], 'shifts': [1260, 3749], 'expressing': [1265, 2124, 2622, 3977, 4006], 'genes': [1267, 1425, 1476, 1492, 1867, 1920, 3412], 'away': [1268], 'from': [1269, 1610, 1950, 2028, 2921, 2956, 3327, 3388, 3471, 3560], 'toward': [1272], 'survival.': [1274], 'In': [1275, 1435, 1460, 1765, 1847, 2204, 2383, 2637, 2869, 3460], 'present': [1277, 1437, 1767], 'study': [1278, 1423, 1438, 1768, 2070], '(CIDHPs)': [1284, 2494], 'were': [1285, 1441, 1608, 1632, 1814, 1897, 1921, 1966, 2033, 2040, 2047, 2078, 2114, 2131, 2211, 2262, 2348, 2387, 2397, 2421, 2435, 2460, 2471, 2486, 2511, 2536, 2550, 2560, 2580, 2668, 2696, 2736, 2741, 2775, 2783, 2801, 2855, 2902, 3007, 3028, 3048, 3118, 3133, 3193, 3214, 3263, 3285, 3325, 3331, 3386, 3395, 3422, 3443, 3512, 3666, 3680, 3756, 3928, 3980], 'genetically': [1286], 'engineered': [1287], 'co-express': [1289], '(NL4-3-GFP)': [1294], 'together': [1295], 'mutant-36p66ShcA': [1297], 'siRNA': [1302, 4033, 4076], '(p66-siRNA)': [1303], 'test': [1305, 3501, 3658, 3914], 'hypothesis': [1307], 'p66ShcA-deficient': [1309], 'will': [1311], 'oxidant-resistant': [1314], 'NL4-3-induced': [1319, 3828, 3924, 3970, 4109], 'signals.': [1321], 'Our': [1322], 'abrogated': [1339], 'co-transfection': [1341], 'p66Shc-siRNA,': [1345], 'turn': [1348, 2977, 3766], 'increases': [1349, 3661], 'FOXO3a': [1350], 'ability': [1351], 'phenotype.': [1356], 'Previously,': [1357], 'lack': [1359], 'culture': [1365, 2780], 'prevented': [1367], 'detailed': [1369], 'analysis': [1370, 3723, 3807, 4151], 'effects': [1373], 'on': [1378, 2086, 2178, 2237, 2331, 2350, 2473, 2488, 2777, 3195, 3303], 'However,': [1380], 'establishment': [1383], '(14Saleem': [1389, 1509, 1642], 'M.A.': [1390, 1510, 1556, 1643, 1700], "O'Hare": [1391, 1511, 1644], 'M.J.': [1392, 1512, 1645], 'Reiser': [1393, 1513, 1646], 'Coward': [1395, 1515, 1648], 'R.J.': [1396, 1516, 1540, 1649, 1684], 'Inward': [1397, 1517, 1650], 'C.D.': [1398, 1518, 1651], 'Farren': [1399, 1519, 1652], 'Xing': [1401, 1521, 1654], 'C.Y.': [1402, 1522, 1655], 'Ni': [1403, 1523, 1549, 1656, 1693], 'Mathieson': [1405, 1525, 1553, 1658, 1697], 'P.W.': [1406, 1526, 1554, 1659, 1698], '13:': [1414, 1534, 1667, 1840, 2000], '630-638Crossref': [1415, 1535, 1668], 'it': [1419, 1478], 'possible': [1421, 1488], 'responsible': [1426], 'changes': [1430], 'studies.': [1434], '(CIDHP)': [1440, 1726, 2762], 'either': [1442, 2991, 3336], 'transduced': [1444, 2209, 2357, 2496, 2989, 3444], 'under': [1449, 1480, 2257, 2282, 2482], 'natural': [1451, 1481, 3437], 'long': [1452, 1955, 3438], 'term': [1453, 1956, 3439], 'repeat': [1454, 3440], 'promoter': [1455], 'gag/pol-deleted': [1457], 'NL4-3:EGFP': [1458, 3448], 'construct.': [1459, 3450], 'both': [1461, 2305, 3533], 'cases': [1463], 'integrates': [1467], 'into': [1468, 2185], 'host': [1470], 'expresses': [1474], 'does': [1479], 'conditions.': [1482], 'Therefore,': [1483], 'best': [1487], 'way': [1489], 'HIV': [1491, 2647, 3003], 'can': [1493], 'be': [1494], 'expressed': [1495, 3416], 'system,': [1501], 'imitates': [1503], 'maximum': [1504], 'closeness': [1505], 'physiological': [1507], 'conditions': [1508], '15Coward': [1539], 'Welsh': [1541, 1685], 'G.I.': [1542, 1686], 'Koziell': [1543, 1687], 'Hussain': [1545, 1689], 'Lennon': [1547, 1691], 'R.': [1548, 1692, 3594], 'Tavaré': [1551, 1695], 'J.M.': [1552, 1696], 'Saleem': [1555, 1614, 1699], '56:': [1559, 1703], '1127-1135Crossref': [1560, 1704], '(128)': [1563, 1707], 'Furthermore,': [1566], 'plasmid': [1569, 2643, 2765, 3000, 3449], 'had': [1571], 'been': [1572, 1676, 1778, 3614], 'earlier': [1574], 'generate': [1576, 1782], 'Tg': [1578], 'mouse': [1579, 1784, 2827, 3231], '(16Dickie': [1583, 1788], 'Felser': [1585, 1790], 'Eckhaus': [1587, 1792], 'Bryant': [1589, 1794], 'Silver': [1591, 1796], 'Marinos': [1593, 1798], 'Notkins': [1595, 1800], 'A.L.': [1596, 1801], 'Virology.': [1597, 1802], '1991;': [1598, 1803], '185:': [1599, 1804], '109-119Crossref': [1600, 1805], '(239)': [1603, 1808], 'Human': [1606, 1630], 'obtained': [1609], 'Dr.': [1611, 1934], 'Moin': [1612], "(Children's": [1615], 'Renal': [1616, 1620, 3877], 'Unit': [1617], 'Academic': [1619], 'Unit,': [1621], 'University': [1622], 'Bristol,': [1624, 1628], 'South': [1625], 'Mead': [1626], 'Hospital,': [1627], 'UK).': [1629], 'introducing': [1636], 'temperature-sensitive': [1637, 2106], 'SV40-T': [1638], 'antigen': [1639, 2108], 'transfection': [1641, 1901], 'additionally': [1675], 'telomerase': [1681], '(15Coward': [1683], 'These': [1710], 'proliferate': [1712], 'permissive': [1714, 2067, 2084], 'temperature': [1715, 1732, 2085, 2256, 2355, 2407, 2493], '(33': [1716], '°C,': [1717], 'podocytes)': [1721], 'enter': [1723], 'growth': [1724, 1736, 2064], 'transfer': [1728, 3284], 'nonpermissive': [1731, 2354], '(37': [1733], '°C).': [1734], 'medium': [1737, 2065, 3018], 'contains': [1738], 'RPMI': [1739], '1640': [1740], 'supplemented': [1741], '10%': [1743], 'fetal': [1744], 'bovine': [1745, 2811], 'serum,': [1746], '1×': [1747, 1752, 2393, 3160], 'penicillin-streptomycin,': [1748], '1': [1749, 2089, 2102, 3150, 3168], 'mml-glutamine,': [1750], 'insulin,': [1753], 'transferrin,': [1754], 'selenium': [1756], '(ITS)': [1757], '(Invitrogen)': [1758], 'T': [1763, 2107], 'antigen.': [1764], 'proviral': [1774, 1870], 'previously': [1779, 1818, 1978], 'Tg26': [1783], 'Replication-defective': [1811], 'viral': [1812, 1895, 1964, 2038], 'supernatants': [1813, 1896], 'prepared': [1815, 2903, 3374, 3396], 'published': [1817], '(17Husain': [1819, 1979], 'Gelman': [1825, 1985], 'I.H.': [1826, 1986], 'Schwartz': [1829, 1989], '1806-1815Crossref': [1841, 2001], '(132)': [1844, 2004], 'brief,': [1848, 2205, 2384, 2638], '(GFP)': [1852], 'reporter': [1853], '(from': [1855], 'pEGFP-C1;': [1856], 'Clontech,': [1857], 'Palo': [1858], 'Alto,': [1859], 'CA)': [1860, 3302], 'substituted': [1862], 'place': [1864, 2865], 'gag/pol': [1866, 1916], 'pNL4-3.': [1872], 'This': [1873], 'parental': [1874], '(pNL4-3:ΔG/P-GFP)': [1876], 'produce': [1880], 'vesicular': [1881], 'stomatitis': [1882], 'G-pseudotyped': [1884], 'viruses': [1885, 2365, 2505], 'provide': [1887], 'pleiotropism': [1888], 'high': [1890], 'titer': [1891, 2037], 'stocks.': [1893], 'Infectious': [1894], 'produced': [1898, 1949], 'transient': [1900], '293T': [1903, 1970], 'Effectene': [1906], '(Qiagen': [1907], 'Inc.)': [1908], 'according': [1909, 2169], "manufacturer's": [1912, 2172], 'instructions.': [1913, 2173], 'VSV.G': [1918], 'envelope': [1919], 'provided': [1922], 'trans': [1924], 'pCMV': [1926], 'R8.91': [1927], 'pMD.G': [1929], 'plasmids,': [1930], 'respectively': [1931], '(gifts': [1932], 'Didier': [1935], 'Trono,': [1936], 'Salk': [1937], 'Institute,': [1938], 'La': [1939], 'Jolla,': [1940], 'CA).': [1941], 'As': [1942, 3475, 3693, 3937, 4000, 4027, 4112, 4158], 'control,': [1945], 'also': [1948, 2329, 3313], 'pHR-CMV-IRES2-GFP-ΔB,': [1951], 'contained': [1953], 'repeats': [1957], 'GFP': [1959, 2016, 2123, 2556], 'vector.': [1962], 'stocks': [1965, 2026, 2039], 'titrated': [1967], 'infecting': [1969], '10-fold': [1973], 'serial': [1974], 'dilution': [1975, 2012], 'reported': [1977], 'reciprocal': [2008], 'lowest': [2011], 'showing': [2013, 3457], 'defined': [2018], 'GFP-expressing': [2020], 'units': [2021, 2125], '(GEU)': [2022], 'per': [2023, 2058, 4146], 'ml.': [2024], 'Viral': [2025, 3369], 'ranging': [2027, 3559], '105': [2029], '106': [2031], 'GEU/ml': [2032], 'obtained.': [2034], 'Some': [2035], 'low': [2036], 'further': [2041, 3217], 'concentrated': [2042], 'ultracentrifugation.': [2044], 'plated': [2048, 2776, 3008], '24-well': [2050, 3010], 'plates': [2051, 3011], 'density': [2054], '10,000': [2056], 'well': [2059], '1.0': [2061], 'ml': [2062], 'temperature.': [2068, 2224], 'To': [2069, 2317, 3308, 3406, 3500, 3657, 3745, 3831, 3913, 3967, 4139], 'non-permissive': [2074, 2492], 'temperature,': [2075], 'first': [2079], 'allowed': [2080], 'grow': [2082], 'collagen-coated': [2090, 2351, 2489], 'surface': [2091], '90%': [2093], 'confluence': [2094], 'then': [2096, 2271, 2409, 3215, 3681], 'transferred': [2097, 2236, 3203], '37': [2099, 2671, 2818, 3024, 3360], '°C': [2100, 2672, 3361], 'week': [2103], 'inactivate': [2105], '(differentiated': [2109], 'CIDHP).': [2111], 'infected': [2115], 'multiplicity': [2118], 'infection': [2120, 3312], '0.5': [2122], 'h.': [2128, 2368, 2508, 3124, 3678], 'counted': [2132], 'hemocytometer': [2135], 'staining': [2137, 2568, 2724, 2878], 'trypan': [2139, 3497], 'blue': [2140, 3498], 'dye': [2141, 3689], '48,': [2143, 3489], '72,': [2144, 3490], '96': [2146], 'h': [2147, 2253, 3022], 'triplicate': [2149], 'wells.': [2150, 2240], 'performed': [2157, 2330, 2372, 2726, 2856], 'Cell': [2160, 3100, 3229, 3580, 3628, 4185], 'Death': [2161, 3101, 3581, 3629], 'Detection': [2162, 2375], 'ELISA': [2163, 2202, 2327], 'Plus': [2164], 'kit': [2165, 2378, 2525, 3186, 3269], '(Roche': [2166], 'Applied': [2167], 'Science)': [2168], 'based': [2177], 'endogenous': [2179, 3834, 3918, 3958, 4037], 'endonuclease': [2180], 'cleavage': [2181], 'chromosomal': [2183], 'mono-': [2186], 'oligonucleosomes,': [2188], 'detected': [2191, 2824, 3054, 3531], 'cytoplasmic': [2193], 'fraction': [2194], 'biotin-labeled': [2196], 'anti-histone': [2197], 'antibody': [2198, 2829, 2850, 2863, 3298], '96-well': [2201], 'format.': [2203], 'lysed': [2212, 3135], '200': [2214], 'μl': [2215, 2232, 2243, 2273], 'lysis': [2217], 'buffer': [2218, 2427, 2789, 3140, 3337], '30': [2220, 2815, 3045], 'min': [2221, 2404, 2443, 2675, 2816, 3364], 'room': [2223, 2255, 2406], 'lysate': [2227], 'centrifuged,': [2229], '20': [2231, 2674], 'supernatant': [2234], 'streptavidin-coated': [2238], 'microplate': [2239], 'Subsequently,': [2241, 2509, 3026], '80': [2242], 'immuno-reagent': [2245], 'added': [2247, 2279], 'followed': [2248, 2428, 2444, 3365], 'incubation': [2250, 2450, 3130, 3355], 'gentle': [2258, 2283], 'shaking.': [2259], 'wells': [2261], 'washed': [2263, 2422, 2697, 2802, 3029], 'thoroughly': [2264], '4': [2265, 2931], 'times': [2266, 2804], 'washing': [2268, 2431, 2446], 'buffer,': [2269], '100': [2272], 'ABTS': [2275], 'substrate': [2276, 2453], 'solution': [2277, 2401, 2440, 2454], 'incubated': [2281, 2436, 3035, 3119, 3332], 'shaking': [2284], '10–20': [2286], 'min.': [2287, 2418, 2457, 3046], 'color': [2289], 'peroxidase': [2292, 2439], 'measured': [2294, 2303, 3180, 3782], 'absorbance': [2296], 'A405-490': [2298], 'nm.': [2299, 3075], 'Podocyte': [2300], 'CIDHPs': [2311, 2335, 2621, 2988], 'indicated': [2314], 'time': [2315, 2965, 3785, 3998], 'periods.': [2316], 'determine': [2318, 3746, 3968], 'HIV-': [2332], 'vector-transduced': [2334], 'presence': [2338, 2554, 2564, 2584, 2632, 2859, 3382, 3728], 'NADPH': [2340], 'oxidase': [2341], 'inhibitor': [2342, 3162], '(DPI,': [2344], '5': [2345, 2417], 'μm).': [2346], 'Podocytes': [2347, 2485], 'grown': [2349, 2487], 'coverslips': [2352, 2470], 'pseudotyped': [2359, 2498], 'replication-deficient': [2360], 'control': [2364, 2504, 3389, 4091, 4172], '48': [2367, 3021, 3123, 3677], 'TUNEL': [2369, 3520, 3538], 'Apoptosis': [2374], 'Tacs': [2376], 'TdT': [2377], '(R&D': [2379], 'System,': [2380], 'Minneapolis,': [2381], 'MN).': [2382], 'fixed': [2388, 2784], '3.7%': [2390], 'formaldehyde': [2391, 2796], 'PBS.': [2394, 2798], 'permeabilized': [2398, 2786], 'Cytonin': [2400], '15': [2403], 'quenched': [2410], '3%': [2412], 'H2O2': [2413, 2981], 'methanol': [2415], 'treated': [2424], 'TdT-labeling': [2426], 'PBS': [2430, 2448, 2701, 2806], 'again.': [2432], 'streptavidin-horseradish': [2438], '10': [2442, 2456, 2733, 3363], 'diaminobenzidine': [2452], 'rinsed': [2461], 'H2O': [2463], 'counterstained': [2465, 2874], 'methyl': [2467], 'green.': [2468], 'mounted': [2472, 2699], 'slide': [2475], 'aqueous': [2477], 'mounting': [2478], 'observed': [2481], 'light': [2483], 'microscope.': [2484], 'flasks': [2490], 'replication': [2499], 'deficient': [2500], '24': [2507, 3347], 'harvested': [2512], 'stained': [2514], 'annexin': [2516, 2566, 3514, 3534], 'V-phosphatidylethanolamine': [2517], '7-aminoactinomycin': [2519, 2573], 'D': [2520, 2574], 'described': [2522], '(Annexin': [2526], 'V-PE': [2527], 'detection': [2529, 3268], 'kit,': [2530], 'BD': [2531], 'Biosciences': [2532], 'Pharmingen).': [2533], 'Cells': [2535, 2782, 3047, 3679], 'analyzed': [2537], 'flow': [2539, 2544], 'cytometry': [2540], 'FACS-Vantage': [2543], 'cytometer': [2545], '(BD': [2546], 'Biosciences).': [2547], 'Transduced': [2548], 'identified': [2551, 2561, 2581], 'fluorescence.': [2557], 'Apoptotic': [2558], 'V': [2567, 3515, 3535], '(7-AAD)': [2575], 'staining,': [2576], 'necrotic': [2578], '7-AAD': [2586], 'staining.': [2587], 'p': [2588], '<': [2589], '0.05': [2590], 'define': [2594], 'statistical': [2595], 'significance.': [2596], 'trafficking': [2598], '2,3,4-': [2600], '5,6-pentafluorodihydrotetramethyllrosamine': [2602], '(PF-HTMRos': [2603], 'Redox': [2605, 2624, 2677], 'Sensor': [2606, 2625, 2678], 'Red': [2607, 2626, 2679, 3684, 3708, 3931, 4153], 'CC-1,': [2608], 'Molecular': [2609, 2692], 'Probes,': [2610], 'Eugene,': [2611], 'OR)': [2612], 'detect': [2616], 'intermediates': [2619], 'HIV-1.': [2623], 'CC-1': [2627, 2680, 3685, 3709, 3932, 4154], 'oxidized': [2629, 2979, 3707, 3768], 'O2⨪': [2634], 'H2O2.': [2636], 'constructs,': [2644], 'including': [2645, 2767], 'NL4-3': [2646, 2660, 2665, 2768, 3429, 3503, 3542, 3660, 3671, 3748, 4182], '(pNL4-3:': [2648], 'ΔG/P-EGFP,': [2649], 'NL4-3/DCIHP),': [2650], 'vector,': [2652, 2771], 'p66shc': [2654], '(dominant': [2655], 'negative,': [2656], 'DN,': [2657], 'mu-36p66ShcA)': [2658], '+': [2659, 2666, 3810], 'HIV,': [2661, 2769], 'p66shcA,': [2663], 'DPI,': [2667], 'loaded': [2669, 3682, 3757, 3929, 3981], '(1': [2681], 'μm)': [2682], 'mitochondria-specific': [2685, 3688], 'dye,': [2686], 'MitoTracker': [2687, 3690, 3711, 3934], 'Green': [2688, 3691, 3712, 3935], 'FM': [2689, 3713], '(50': [2690], 'nm;': [2691], 'Probes).': [2693, 2852], 'Culture': [2694], 'slides': [2695], 'visualized': [2703, 2880], 'Nikon': [2705, 2744], 'microscope': [2707, 2888], '(Nikon': [2708, 2721], 'Eclipse': [2709], 'E800)': [2710], 'equipped': [2711, 2889], 'triple': [2713], 'filter': [2714], 'cube': [2715], 'charge-coupled': [2717], 'device': [2718], '(CCD)': [2719], 'camera': [2720, 2895], 'DXM1200).': [2722], 'quadruplicate': [2728], 'each': [2730], 'group,': [2731], 'random': [2734], 'fields': [2735], 'studied': [2737], 'replicate.': [2739], 'Images': [2740], 'captured': [2742], 'ACT-1': [2745], '(Version': [2746], '1.12)': [2747], 'software': [2748, 2932], 'combined': [2750], 'publishing': [2752], 'format': [2753], 'Adobe': [2755, 2905], 'Photoshop': [2756, 2906], '6.0': [2757], 'software.': [2758], 'Differentiated': [2759], 'constructs': [2766, 3001], 'poly-d-lysine-coated': [2778], 'Lab-Tek': [2779], 'slides.': [2781], 'containing': [2790, 3040, 3141, 3335], '0.02%': [2791], 'Triton': [2792], 'X-100': [2793], '4%': [2795], 'Fixed': [2799], '3': [2803], 'blocked': [2808], '1%': [2810, 3153], 'serum': [2812], '°C.': [2819, 3025], 'Phospho-histone': [2820], '(γH2AX)': [2822], 'monoclonal': [2828, 3232], 'recognizes': [2831], 'phosphorylated': [2832], 'serine': [2833], 'amino': [2836], 'acid': [2837], 'sequence': [2838], '134–142': [2839], 'histone': [2842], 'H2A.X': [2843], '(UBI)': [2844], 'rhodamine-conjugated': [2846], 'goat': [2847], 'anti-mouse': [2848], 'secondary': [2849, 3259], '(Molecular': [2851], 'Negative': [2853], 'nonspecific': [2861], 'isotype': [2862], 'primary': [2867, 3221, 3317, 3377], 'antibody.': [2868], 'all': [2870, 3226], 'variables': [2871], '4′6′-diamidino-2-phenylindole.': [2876], 'Specific': [2877], 'inverted': [2883], 'Olympus': [2884], '1X': [2885], '70': [2886], 'Cook': [2892], 'Sensicom': [2893], 'ER': [2894], '(Olympus': [2896], 'America,': [2897], 'Melville,': [2898], 'NY).': [2899], 'Final': [2900], 'images': [2901], 'demonstrate': [2908], 'subcellular': [2909], 'localization': [2910, 2916], 'γH2AX.': [2912], 'percentage': [2914], 'γH2AX': [2918], 'calculated': [2920, 3083], 'entire': [2923], 'volume': [2924], 'nucleus': [2926], 'utilizing': [2928], 'Slide': [2929], 'Book': [2930], '(Intelligent': [2933], 'Imaging': [2934], 'Innovations,': [2935], 'Denver,': [2936], 'CO).': [2937], 'kinetics': [2939, 3751], 'ROS': [2941, 3551, 3663, 3719, 3753, 3818, 3829, 3925, 3953, 3963, 3971, 4015, 4110, 4126, 4183], 'HIV-1-expressing': [2944], 'determined': [2947, 3995], 'measuring': [2949], 'intensity': [2951, 3077, 3740, 3776, 3989, 4142, 4166], 'fluorescent': [2954, 2984, 3080, 3743, 3772, 3779, 3947, 4135, 4144, 4169], 'signal': [2955, 3081, 3780, 3993, 4136, 4145, 4170], 'redox-sensitive': [2958, 3760, 3984], 'fluoroprobe': [2959, 3761, 3985], '(DCFDA)': [2962], 'multiple': [2964, 3556, 3784, 3997], 'points.': [2966, 3999], 'DCFDA': [2967, 3041], 'converted': [2969], 'esterases': [2972], '2′,7′-dichlorodihydrofluorescein,': [2974], '2′7′-dichlorohydrofluorescein': [2985], '(DCF).': [2986], 'Briefly,': [2987], 'pseudo-virus': [2992], '(NL4-3HIV': [2993], 'vector)': [2996, 3006], '(pNL4-3': [3002], 'phenol': [3013, 3031], 'red-free': [3014, 3032], "Dulbecco's": [3015], 'modified': [3016], "Eagle's": [3017], '(DMEM)': [3019], 'DMEM': [3033], '(SFM)': [3039], '(10': [3042], 'mm)': [3043], 'washed,': [3049], 'DCF': [3051], 'Fluorescence': [3057], 'Multi-Well': [3058], 'Plate': [3059], 'Reader': [3060], 'CytoFluor': [3061], '4000': [3062], '(PerSeptive': [3063], 'Biosystems)': [3064], 'set': [3065], 'excitation': [3067], '485': [3069], 'nm': [3070], 'emission': [3072], '530': [3074], 'Microsoft': [3085], 'excel': [3086], 'equation': [3088], '((Ft': [3089], '−': [3090], 'F0)/F0': [3091], '×': [3092], '100)': [3093], '(20Mattson': [3094, 3622], 'M.P.': [3095, 3623], 'Haughey': [3096, 3624], 'N.J.': [3097, 3625], 'Nath': [3098, 3626], 'Differ.': [3102, 3582, 3630], '12:': [3104, 3632], '893-904Crossref': [3105, 3633], '(252)': [3108, 3636], 'Empty': [3111], '(EV)/CIDHPs,': [3113], 'EV/mu36-p66Shc/CIDHPs,': [3114], 'NL4-3/CIDHPs,': [3115], 'mu36-p66Shc/NL4-3/CIDHPs': [3117], 'At': [3125], 'end': [3127], 'period,': [3131], 'harvested,': [3134], 'radioimmune': [3137], 'precipitation': [3138], '50': [3142], 'mm': [3143, 3148, 3151, 3169, 3174], 'Tris-Cl': [3144], '(pH': [3145], '7.5),': [3146], '150': [3147], 'NaCl,': [3149], 'EDTA,': [3152], 'Nonidet': [3154], 'P-40,': [3155], '0.25%': [3156], 'deoxycholate,': [3157], '0.1%': [3158], 'SDS,': [3159], 'protease': [3161], 'mixture': [3163], '(Calbiochem,': [3164], 'Mixture': [3165], 'Set': [3166], 'I),': [3167], 'phenylmethylsulfonyl': [3170], 'fluoride,': [3171], '0.2': [3173], 'sodium': [3175], 'orthovanadate.': [3176], 'Protein': [3177, 3184], 'concentration': [3178], 'BCA': [3183], 'Assay': [3185], '(Pierce).': [3187], 'Total': [3188], 'extracts': [3190], '(20': [3191], 'μg/lane)': [3192], 'separated': [3194], '15%': [3197], 'PAGE': [3198], 'pre-made': [3199], 'gel': [3200], '(Bio-Rad)': [3201], 'onto': [3204], 'nitrocellulose': [3206], 'membrane': [3207], 'Bio-Rad': [3209], 'miniblot': [3210], 'apparatus.': [3211], 'Nitrocellulose': [3212], 'membranes': [3213], 'processed': [3216], 'immunostaining': [3219], 'antibodies': [3222], 'against,': [3223], 'p66(ShcA)': [3224], '(recognizes': [3225], 'ShcA': [3227], 'isoforms,': [3228], 'Signaling),': [3230], 'anti-phospho-ShcA-Ser-36': [3233], '(Calbiochem),': [3234], 'anti-phospho-Foxo3a': [3235], '(Th-32),': [3236], 'rabbit': [3237], 'polyclonal': [3238, 3296], 'antibody/pS9138/321Foxo3a/ps253/Foxo3a': [3239], '(Cell': [3240, 3246], 'Signaling': [3241, 3247], 'Technology,': [3242], 'Beverly,': [3243], 'MA),': [3244], 'anti-phospho-S473/Akt': [3245], 'Technology),': [3248], 'anti-AKT': [3250], 'anti-Foxo3A': [3252], 'subsequently': [3254], 'horseradish': [3256], 'peroxidase-labeled': [3257], 'appropriate': [3258], 'antibodies.': [3260], 'blots': [3262, 3394], 'developed': [3264], 'chemiluminescence': [3267], '(Pierce)': [3270], 'exposed': [3272], 'x-ray': [3274], 'film': [3275], '(Eastman': [3276], 'Kodak': [3277], 'Co.).': [3278], 'Equal': [3279], 'loading': [3281], 'confirmed': [3286, 3854], 'immunoblotting': [3288], 'determination': [3290], 'actin': [3292, 3402], 'α-Actin': [3297], '(I-19,': [3299], 'Santa': [3300], 'Cruz,': [3301], 'Western': [3306, 3393], 'blots.': [3307], 'explore': [3309, 3407], 'whether': [3310, 3747, 3969], 'enhances': [3314], 'phospho-p66Shca': [3315], 'cells,': [3319], '(PBMC)': [3324], 'isolated': [3326, 3387], 'fresh': [3328], 'blood.': [3329], 'PBMC': [3330], 'X4': [3339], 'strain,': [3340], 'HIV-1HT/92/599': [3341, 3372], 'variable': [3343], 'periods': [3344], '(6': [3345], 'h).': [3348], 'Afterward,': [3349], 'non-internalized': [3350], 'removed': [3353], '0.05%': [3357], 'trypsin': [3358], 'extensive': [3367], 'washing.': [3368], 'stock': [3370], 'phytohemagglutinin-activated': [3376], 'lymphocytes': [3378], 'cultivated': [3379], 'interleukin-2.': [3384], 'Proteins': [3385], 'HIV-1-infected': [3391], 'PBMC.': [3392], 'probed': [3398], 'phospho-p66ShcA': [3400], 'mentioned': [3404], 'above.': [3405], 'HIVAN,': [3420], '(lacking': [3430], 'gag': [3431], 'pol': [3433], 'genes)': [3434], 'promoter.': [3441], 'Fig.': [3451, 3478, 3696, 3897, 3940, 4003, 4115], '1A': [3452], 'representative': [3455], 'microphotograph': [3456], 'GFP(+)': [3458, 3468], 'CIDHP.': [3459, 3550, 4073], 'various': [3462], 'experimental': [3463], 'protocols': [3464], '%': [3466], 'ranged': [3470], '60': [3472], '80%.': [3474], 'shown': [3476, 3694, 3895, 3938, 4001, 4113, 4159], '1B,': [3479], 'show': [3481, 3699, 3792, 4008, 4020, 4083, 4118], 'progressive': [3483], 'decline': [3484], 'viability': [3487], '96-h': [3492], 'post-transduction,': [3493], 'judged': [3495], 'exclusion.': [3499], 'if': [3502, 3659, 3823, 3915, 4104], 'two': [3510], 'approaches': [3511], 'employed;': [3513], '(Fig.': [3517, 3522, 3787, 4070, 4156], '1C)': [3518], '1D).': [3523], 'assay.': [3539], 'Taken': [3540, 4174], 'together,': [3541, 4175], 'stimulus': [3546], 'known': [3553], 'induce': [3555], 'lesions': [3558], 'single': [3561, 3565], 'base': [3562], 'modifications': [3563], 'breaks': [3568, 3575], 'potentially': [3570], 'lethal': [3571], 'double': [3572, 4232], '(18Selliah': [3576], 'Finkel': [3578], '127-136Crossref': [3585], '(72)': [3588], '19Monks': [3591], 'T.J.': [3592], 'Xie': [3593], 'Tikoo': [3595], 'Lau': [3597], 'S.S.': [3598], 'Drug': [3599], 'Metab.': [3600], 'Rev.': [3601], '38:': [3603], '755-767Crossref': [3604], '(42)': [3607, 3654], 'linked': [3615, 4191], 'macrophages': [3619], 'neurons': [3621], '21Cui': [3639], 'Huang': [3641], 'Zhao': [3643], 'Zheng': [3645], 'Immunol.': [3648], '2008;': [3649], '180:': [3650], '898-906Crossref': [3651], 'production,': [3664, 3926, 4127], 'EV': [3669], 'maintained': [3673], 'FM.': [3692, 3936], '2A,': [3697], 'bright': [3700, 3945, 4119], 'yellow/orange': [3701, 3946], 'due': [3703], 'co-localization': [3705], 'mitochondria,': [3715], 'indicative': [3716, 3949, 4123], 'augmented': [3718, 3951, 4125], 'production.': [3720, 3830, 3954], 'An': [3721, 3805, 4041], 'identical': [3722, 3806], 'free': [3731], 'radical': [3732], 'scavenger': [3733], 'DPI': [3734, 3811], 'shows': [3735, 3814], 'no': [3736], 'signal.': [3744], 'dichlorofluorescein': [3762], '(DCFDA),': [3763], 'DCF,': [3773], 'points': [3786], '2B).': [3788], 'kinetic': [3790, 4016], 'curves': [3791], 'marked': [3794, 4009], 'amplitude': [3797, 4013], 'sustained': [3800, 4022], 'over': [3801], '3-h': [3803], 'interval.': [3804], 'EV/CIDHP': [3813], 'suppressed': [3815], 'rates': [3816], 'metabolism.': [3819], 'next': [3821, 4102], 'asked': [3822, 4103], 'compete': [3832], 'mutant': [3839], 'constructed': [3842], 'standard': [3844], 'methods,': [3845], 'replacing': [3846], 'Ser': [3847], 'position': [3849, 3888], '36': [3850], 'alanine,': [3852], 'direct': [3856], 'sequencing': [3857], '(22Chintapalli': [3858], 'Yang': [3860], 'Opawumi': [3862], 'Goyal': [3864], 'S.R.': [3865], 'Shamsuddin': [3866], 'Malhotra': [3868], 'Reiss': [3870], 'Meggs': [3872], 'L.G.': [3873], 'Physiol.': [3876, 3878], '292:': [3880], 'F523-F530Crossref': [3881], '(22)': [3884], '(arrow)': [3893], '3A': [3898], '(immediately': [3905], 'below)': [3906], 'p52': [3909], 'p46': [3911], 'isoforms.': [3912], 'attenuates': [3923], '3B,': [3941], 'NL4-3/': [3942], 'signal,': [3948], 'Conversely,': [3955], 'attenuated': [3962, 3974], 'production': [3964, 3972], 'mu-36,': [3978], 'DCFDA,': [3986], '2′,7′-dichlorohydrofluorescein': [3992], '3C,': [4004], 'attenuation': [4010], 'curves,': [4017], 'parameter.': [4026], 'second': [4029], 'strategy': [4034], 'function.': [4040], 'p66-siRNA': [4043, 4081, 4163], '(23Kisielow': [4044], 'Kleiner': [4046], 'Nagasawa': [4048], 'Faisal': [4050], 'Nagamine': [4052], 'Biochem.': [4054], '363:': [4057], '1-5Crossref': [4058], '(75)': [4061], '4A)': [4071], 'Nuclear': [4074], 'lamin': [4075, 4099], 'control.': [4080], 'minimal': [4084], 'levels': [4085], 'not': [4096], 'affected': [4097], 'siRNA.': [4100], 'p66-siRNA/CIDHP': [4105], 'generation.': [4111, 4184], '4B,': [4116], 'yellow': [4120], 'orange': [4121], 'fluorescence,': [4122], 'p66-siRNA,': [4133], 'attenuated.': [4138], 'quantify': [4140], 'cell,': [4147], 'repeated': [4149], 'alone': [4155], '4C).': [4157], 'panel': [4161], 'D,': [4162], 'reduced': [4164], 'values.': [4173], 'indispensable': [4180], 'closely': [4190], 'maintenance': [4194], 'stability': [4197], '(24Chen': [4198], 'J.H.': [4199], 'Hales': [4200], 'C.N.': [4201], 'Ozanne': [4202], 'Nucleic': [4204], 'Acids': [4205], 'Res.': [4206], '35:': [4208], '7417-7428Crossref': [4209], '(310)': [4212], '25Wei': [4215], 'Y.H.': [4216], 'Exp.': [4219], '217:': [4223], '53-63Crossref': [4224], '(293)': [4227], 'helix': [4233], 'f': [4237]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019169759', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-20T19:39:46.807647', 'created_date': '2016-06-24'}
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