Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2019129446', 'doi': 'https://doi.org/10.1158/1538-7445.chtme14-a02', 'title': 'Abstract A02: Effect of curcumin on the tumor growth and angiogenesis of breast cancer', 'display_name': 'Abstract A02: Effect of curcumin on the tumor growth and angiogenesis of breast cancer', 'publication_year': 2015, 'publication_date': '2015-01-01', 'ids': {'openalex': 'https://openalex.org/W2019129446', 'doi': 'https://doi.org/10.1158/1538-7445.chtme14-a02', 'mag': '2019129446'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.chtme14-a02', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111448206', 'display_name': 'Lívia Carvalho Ferreira', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Lívia Carvalho Ferreira', 'raw_affiliation_strings': ['1Universidade Estadual Paulista, Sao Jose Do Rio Preto, Sao Paulo, Brazil,'], 'affiliations': [{'raw_affiliation_string': '1Universidade Estadual Paulista, Sao Jose Do Rio Preto, Sao Paulo, Brazil,', 'institution_ids': ['https://openalex.org/I879563668']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011681716', 'display_name': 'Ali S. Arbab', 'orcid': 'https://orcid.org/0000-0003-2902-3671'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ali Syed Arbab', 'raw_affiliation_strings': ['2Henry Ford Hospital, Detroit, MI,'], 'affiliations': [{'raw_affiliation_string': '2Henry Ford Hospital, Detroit, MI,', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085076471', 'display_name': 'Bruna V. Jardim‐Perassi', 'orcid': 'https://orcid.org/0000-0001-5908-4470'}, 'institutions': [{'id': 'https://openalex.org/I879563668', 'display_name': 'Universidade Estadual Paulista (Unesp)', 'ror': 'https://ror.org/00987cb86', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I879563668']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Bruna Victorasso Jardim-Perassi', 'raw_affiliation_strings': ['1Universidade Estadual Paulista, Sao Jose Do Rio Preto, Sao Paulo, Brazil,'], 'affiliations': [{'raw_affiliation_string': '1Universidade Estadual Paulista, Sao Jose Do Rio Preto, Sao Paulo, Brazil,', 'institution_ids': ['https://openalex.org/I879563668']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025286087', 'display_name': 'Thaiz F. Borin', 'orcid': 'https://orcid.org/0000-0003-1464-9823'}, 'institutions': [{'id': 'https://openalex.org/I1340031499', 'display_name': 'Faculdade de Medicina de São José do Rio Preto', 'ror': 'https://ror.org/052e6h087', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I1340031499']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Thaiz Ferraz Borin', 'raw_affiliation_strings': ['3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': '3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I1340031499']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015112955', 'display_name': 'Naiane N Gonçalves', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1340031499', 'display_name': 'Faculdade de Medicina de São José do Rio Preto', 'ror': 'https://ror.org/052e6h087', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I1340031499']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Naiane Nascimento Gonçalves', 'raw_affiliation_strings': ['3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': '3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I1340031499']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089610609', 'display_name': 'Ravi Sankara Varma Nadimpalli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ravi Sankara Varma Nadimpalli', 'raw_affiliation_strings': ['2Henry Ford Hospital, Detroit, MI,'], 'affiliations': [{'raw_affiliation_string': '2Henry Ford Hospital, Detroit, MI,', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056640148', 'display_name': 'Débora Aparecida Pires de Campos Zuccari', 'orcid': 'https://orcid.org/0000-0002-0146-9041'}, 'institutions': [{'id': 'https://openalex.org/I1340031499', 'display_name': 'Faculdade de Medicina de São José do Rio Preto', 'ror': 'https://ror.org/052e6h087', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I1340031499']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Debora Aparecida Pires de Campos Zuccari', 'raw_affiliation_strings': ['3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.'], 'affiliations': [{'raw_affiliation_string': '3Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil.', 'institution_ids': ['https://openalex.org/I1340031499']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.439, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.487238, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '75', 'issue': '1_Supplement', 'first_page': 'A02', 'last_page': 'A02'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 0.9715, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11319', 'display_name': "Curcumin's Biomedical Applications", 'score': 0.9715, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9459, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9153, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/angiogenesis-inhibitor', 'display_name': 'Angiogenesis inhibitor', 'score': 0.4523781}], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.90829456}, {'id': 'https://openalex.org/C2778250585', 'wikidata': 'https://www.wikidata.org/wiki/Q312266', 'display_name': 'Curcumin', 'level': 2, 'score': 0.7023706}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.6074256}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.5717731}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.55047613}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5354429}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5287896}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.5032229}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.45575115}, {'id': 'https://openalex.org/C2776056115', 'wikidata': 'https://www.wikidata.org/wiki/Q574834', 'display_name': 'Angiogenesis inhibitor', 'level': 3, 'score': 0.4523781}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.4138329}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38469023}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.28719175}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28075674}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24083179}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.07027134}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.chtme14-a02', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W73242545', 'https://openalex.org/W2460667757', 'https://openalex.org/W2414879916', 'https://openalex.org/W2388520405', 'https://openalex.org/W2114498041', 'https://openalex.org/W2104752154', 'https://openalex.org/W2051449188', 'https://openalex.org/W1971898819', 'https://openalex.org/W1946062636', 'https://openalex.org/W13443198'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Angiogenesis': [2], 'plays': [3], 'an': [4, 140], 'important': [5], 'role': [6], 'in': [7, 67, 106, 141, 146, 168, 205, 234, 241, 320, 338, 351, 364, 367, 388, 411, 432, 436, 461, 515], 'the': [8, 17, 31, 42, 77, 96, 169, 194, 213, 273, 279, 284, 289, 321, 327, 339, 347, 365, 368, 371, 425, 428, 444, 451, 498, 516], 'pathogenesis': [9], 'of': [10, 19, 33, 98, 130, 156, 209, 215, 253, 269, 283, 297, 318, 326, 336, 349, 383, 403, 427, 495, 503], 'breast': [11, 107, 111, 274, 429, 445, 504], 'cancer.': [12, 108, 505], 'For': [13], 'growth,': [14, 276], 'tumor': [15, 102, 173, 236, 275, 295, 446, 499], 'requires': [16], 'formation': [18], 'new': [20], 'blood': [21], 'vessels,': [22], 'which': [23, 51], 'are': [24, 41, 64], 'stimulated': [25], 'by': [26, 122, 232, 278, 394], 'angiogenic': [27], 'factors': [28], 'to': [29, 39, 203, 245, 288, 324, 442, 450], 'initiate': [30], 'proliferation': [32, 228, 409], 'endothelial': [34, 44], 'cells.': [35], 'The': [36, 293, 334], 'major': [37], 'contributors': [38], 'angiogenesis': [40, 61, 105, 207, 216, 462, 502], 'vascular': [43], 'growth': [45, 103, 447, 500], 'factor': [46], '(VEGF)': [47], 'and': [48, 57, 62, 104, 117, 175, 191, 193, 221, 226, 299, 386, 407, 456, 501], 'its': [49, 256], 'receptors,': [50], 'promote': [52], 'cell': [53, 113, 118, 227, 248, 408], 'proliferation,': [54], 'migration,': [55], 'permeability': [56], 'survival.': [58], 'Controlling': [59], 'tumor-associated': [60], 'metastasis': [63], 'promising': [65], 'tactics': [66], 'limiting': [68], 'cancer': [69, 112, 430], 'progression.': [70], 'Curcumin,': [71], 'a': [72, 184, 401], 'polyphenolic': [73], 'compound': [74], 'derived': [75], 'from': [76], 'spice': [78], 'plant': [79], 'Curcuma': [80], 'longa,': [81], 'displays': [82], 'multiple': [83], 'actions': [84], 'on': [85, 101, 187, 497, 512], 'solid': [86], 'tumours': [87], 'including': [88], 'anti-angiogenic': [89], 'effects.': [90], 'In': [91, 211, 397, 417, 434], 'this': [92], 'study': [93, 143], 'we': [94], 'evaluated': [95, 231], 'benefits': [97], 'curcumin': [99, 131, 157, 271, 314, 355, 389, 412, 423, 439, 496], 'treatment': [100, 240, 464], 'Methods:': [109], 'MDA-MB-231': [110], 'line': [114], 'was': [115, 120, 243, 342, 356, 362, 377, 392, 400], 'cultured': [116], 'viability': [119, 426], 'measured': [121, 182], 'MTT': [123], 'assay': [124], 'after': [125, 250, 261], 'incubation': [126], 'with': [127, 153, 183, 199, 313, 332, 354, 465], 'different': [128], 'concentrations': [129], '(25': [132], 'uM,': [133, 135], '50': [134], '100': [136], 'uM).': [137], 'We': [138], 'performed': [139], 'vivo': [142, 206, 437], 'implanting': [144], 'cells': [145, 431], 'athymic': [147], 'nude': [148], 'mice.': [149], 'Mice': [150], 'were': [151, 181, 230, 302, 330], 'treated': [152, 285, 300, 312, 331, 353, 390, 413], '300': [154], 'mg/kg': [155], '(n': [158, 163], '=': [159, 164], '5)': [160], 'or': [161], 'vehicle': [162], '8)': [165], 'daily,': [166], 'starting': [167], 'same': [170], 'day': [171, 188], 'as': [172], 'implantation': [174], 'continued': [176], 'for': [177], '21': [178, 192, 267], 'days.': [179], 'Tumors': [180], 'digital': [185], 'caliper': [186], '7,': [189], '14': [190], 'animals': [195, 301, 328, 341, 352], 'underwent': [196], 'SPECT': [197, 455], 'scanning': [198], 'Tc-99m': [200], 'tagged': [201], 'VEGF-c': [202], 'detect': [204], '(expression': [208], 'VEGFR2/3).': [210], 'addition,': [212, 398, 435], 'markers': [214], '(VEGF-A,': [217], 'VEGF-C,': [218], 'VEGFR2,': [219], 'VEGFR3': [220], 'von': [222], 'Willebrand': [223], 'Factor': [224], '(vWF))': [225], '(Ki-67)': [229, 410], 'immunohistochemistry': [233, 395], 'mammary': [235], 'tissues.': [237], 'Results:': [238], 'Curcumin': [239], 'vitro': [242], 'able': [244, 441], 'significantly': [246], 'decrease': [247, 382, 402, 460], 'viability,': [249], '4': [251], 'hours': [252, 263], 'exposure,': [254], 'maintaining': [255], 'efficacy': [257], 'at': [258], 'higher': [259], 'doses': [260], '24': [262], 'exposure': [264], '(p<0.05).': [265, 292, 396, 415], 'After': [266], 'days': [268], 'treatment,': [270], 'retards': [272, 443], 'showed': [277, 315], 'slower': [280], 'tumoral': [281], 'development': [282], 'group': [286, 291], 'compared': [287, 323, 449], 'control': [290, 298, 340, 452], 'mean': [294], 'volume': [296], '282.00': [303], '±': [304, 344, 358], '88.53': [305], 'mm3': [306], '232.5±': [307], '53.2': [308], 'mm3,': [309], 'respectively.': [310], 'Animals': [311], 'lower': [316], 'activity': [317], 'Tc-99-VEGF-C': [319], 'tumors': [322, 369, 414], 'that': [325, 329, 422], 'vehicle.': [333], 'intensity': [335, 348], 'radioactivity': [337, 350, 366], '183.55': [343], '20.92%,': [345], 'while': [346], '134.9': [357], '10.3%.': [359], 'Although': [360], 'there': [361, 399], 'difference': [363, 376], 'between': [370], 'two': [372], 'group,': [373], 'statistically': [374], 'significant': [375], 'not': [378], 'achieved': [379], '(p>0.05).': [380], 'However,': [381], 'VEGF-A,': [384], 'VEGF-C': [385], 'VEGFR2': [387], 'mice': [391], 'confirmed': [393], 'micro-vessel': [404], 'density': [405], '(vWF)': [406], 'Conclusion:': [416], 'summary,': [418], 'our': [419], 'results': [420], 'demonstrate': [421], 'affect': [424], 'vitro.': [433], 'study,': [438], 'is': [440], 'when': [448], 'group.': [453], 'Both': [454], 'histochemical': [457], 'analysis': [458], 'indicate': [459], 'following': [463], 'curcumin.': [466], 'Citation': [467], 'Format:': [468], 'Lívia': [469], 'Carvalho': [470], 'Ferreira,': [471], 'Ali': [472], 'Syed': [473], 'Arbab,': [474], 'Bruna': [475], 'Victorasso': [476], 'Jardim-Perassi,': [477], 'Thaiz': [478], 'Ferraz': [479], 'Borin,': [480], 'Naiane': [481], 'Nascimento': [482], 'Gonçalves,': [483], 'Ravi': [484], 'Sankara': [485], 'Varma': [486], 'Nadimpalli,': [487], 'Debora': [488], 'Aparecida': [489], 'Pires': [490], 'de': [491], 'Campos': [492], 'Zuccari.': [493], 'Effect': [494], '[abstract].': [506], 'In:': [507], 'Abstracts:': [508], 'AACR': [509], 'Special': [510], 'Conference': [511], 'Cellular': [513], 'Heterogeneity': [514], 'Tumor': [517], 'Microenvironment;': [518], '2014': [519], 'Feb': [520], '26-Mar': [521], '1;': [522], 'San': [523], 'Diego,': [524], 'CA.': [525], 'Philadelphia': [526], '(PA):': [527], 'AACR;': [528], 'Cancer': [529], 'Res': [530], '2015;75(1': [531], 'Suppl):Abstract': [532], 'nr': [533], 'A02.': [534], 'doi:10.1158/1538-7445.CHTME14-A02': [535]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019129446', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-12T07:33:19.959761', 'created_date': '2016-06-24'}