2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

Name: Work Video:
Duration: 3 min 30 s
Neil J. Stone; Jennifer G. Robinson; Alice H. Lichtenstein; C. Noel Bairey Merz; Conrad B. Blum; Robert H. Eckel; Anne C. Goldberg; David Gordon; Daniel Levy; Donald M. Lloyd‐Jones; Patrick E. McBride; J. Sanford Schwartz; Susan T. Shero; Sidney C. Smith; Karol E. Watson; Peter W.F. Wilson
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1070, 1078, 1093, 1099, 1104, 1107, 1120, 1125, 1144, 1151, 1155, 1159, 1176, 1202, 1206, 1223, 1243, 1251, 1260, 1264, 1289, 1308, 1319, 1329, 1336, 1342, 1362, 1365, 1376, 1380, 1385, 1391, 1402, 1430, 1438, 1470, 1475, 1491, 1500, 1514, 1527, 1540, 1596, 1623, 1682, 1700, 1703, 1710, 1713, 1733, 1736, 1742, 1763, 1780, 1785, 1796, 1816, 1831, 1847, 1860, 1873, 1889, 1903, 1910, 1929, 1951, 1967, 1976, 2004, 2007, 2015, 2028, 2051, 2064, 2068, 2101, 2114, 2124, 2138, 2152, 2160, 2208, 2220, 2240, 2289, 2295, 2311, 2323, 2332, 2340, 2344, 2347, 2355, 2370, 2373, 2396, 2399, 2402, 2405, 2409, 2431, 2435, 2442, 2488, 2501, 2525, 2548, 2555, 2676, 2690, 2716, 2730, 2784, 2817, 2831, 2843, 2852, 2873, 2906, 2921, 2961, 2966, 3006, 3011, 3037, 3056, 3066, 3070, 3082, 3102, 3114, 3118, 3155, 3185, 3233, 3242, 3256, 3292, 3295, 3310, 3316, 3341, 3353, 3361, 3405, 3411, 3414, 3424, 3458, 3464, 3478, 3481, 3547, 3590, 3604, 3640, 3650, 3665, 3669, 3672, 3684, 3703, 3706, 3716, 3756, 3765, 3781, 3805, 3812, 3818, 3823, 3847, 3907, 3921, 3951, 3989, 4011, 4017, 4020, 4033, 4037, 4056, 4075, 4092, 4111, 4183, 4187], 'Treatment': [8, 44, 496, 2227, 2235, 2326, 2616, 3356, 3947, 4057, 4093, 4125, 4136, 4151, 4162], 'of': [9, 45, 56, 60, 371, 380, 392, 407, 417, 426, 440, 450, 475, 484, 508, 596, 641, 658, 662, 679, 734, 744, 751, 796, 801, 939, 945, 958, 992, 1004, 1021, 1106, 1128, 1130, 1143, 1170, 1184, 1188, 1193, 1197, 1212, 1226, 1262, 1274, 1288, 1304, 1339, 1364, 1387, 1404, 1422, 1437, 1477, 1490, 1499, 1502, 1504, 1604, 1612, 1663, 1671, 1702, 1712, 1735, 1762, 1795, 1815, 1818, 1820, 1842, 1849, 1862, 1884, 1891, 1905, 1946, 1953, 1969, 2055, 2067, 2071, 2083, 2085, 2094, 2128, 2151, 2207, 2228, 2247, 2294, 2310, 2322, 2346, 2372, 2382, 2404, 2434, 2445, 2450, 2464, 2482, 2572, 2630, 2639, 2679, 2689, 2732, 2752, 2768, 2783, 2796, 2803, 2855, 2875, 2889, 2917, 2957, 2968, 2991, 3008, 3016, 3041, 3072, 3075, 3084, 3094, 3098, 3113, 3124, 3177, 3187, 3222, 3225, 3236, 3258, 3294, 3325, 3346, 3385, 3403, 3426, 3466, 3477, 3483, 3507, 3526, 3589, 3622, 3671, 3686, 3698, 3705, 3752, 3755, 3792, 3804, 3807, 3811, 3817, 3849, 3883, 3894, 3909, 3960, 3992, 4010, 4019, 4032, 4039, 4052, 4058, 4083, 4088, 4094, 4119, 4126, 4152], 'Blood': [10, 46, 719, 1809, 2198, 2210, 2230, 2837, 2844, 4059, 4095, 4127, 4153], 'Cholesterol': [11, 47, 2211, 2231, 2838, 2845, 4060, 4096, 4128, 4154], 'to': [12, 25, 48, 396, 399, 532, 565, 573, 650, 653, 672, 727, 739, 776, 789, 825, 841, 846, 859, 889, 909, 918, 973, 1017, 1124, 1209, 1255, 1279, 1397, 1473, 1532, 1630, 1751, 1829, 1855, 1959, 1974, 2023, 2166, 2171, 2283, 2288, 2302, 2331, 2354, 2408, 2500, 2513, 2541, 2587, 2622, 2626, 2645, 2653, 2669, 2695, 2725, 2759, 2771, 2776, 2842, 2858, 2868, 2900, 2959, 2972, 2999, 3026, 3031, 3043, 3060, 3063, 3091, 3100, 3196, 3228, 3251, 3279, 3308, 3314, 3340, 3367, 3372, 3451, 3497, 3555, 3694, 3772, 3777, 3786, 3868, 3905, 3914, 3926, 3930, 3936, 3964, 3998, 4006, 4041, 4061, 4097, 4129, 4155], 'Reduce': [13, 49, 400, 654, 4062, 4098, 4130, 4156], 'Atherosclerotic': [14, 50, 4131, 4157], 'Cardiovascular': [15, 51, 401, 655, 2451, 2468, 4132, 4158], 'Risk': [16, 52, 402, 536, 2559, 2681, 2832, 4024, 4064, 4100, 4133, 4159], 'in': [17, 53, 458, 467, 487, 504, 517, 524, 538, 576, 644, 747, 755, 829, 879, 895, 1030, 1139, 1147, 1165, 1175, 1222, 1233, 1239, 1257, 1284, 1307, 1406, 1435, 1450, 1462, 1642, 1695, 1859, 1902, 1944, 1966, 2060, 2063, 2130, 2232, 2263, 2292, 2420, 2547, 2554, 2591, 2605, 2649, 2675, 2700, 2764, 2809, 2816, 2882, 2898, 2920, 3018, 3065, 3135, 3160, 3184, 3218, 3319, 3352, 3664, 3798, 3822, 3831, 3841, 3859, 4002, 4047, 4065, 4101, 4134, 4145, 4160, 4171, 4182], 'Adults': [18, 2233, 4066, 4102], 'Open': [19], 'AccessResearch': [20, 38], 'ArticlePDF/EPUBAboutView': [21], 'PDFView': [22], 'EPUBSections': [23], 'ToolsAdd': [24], 'favoritesDownload': [26], 'citationsTrack': [27], 'citationsPermissionsDownload': [28], 'Articles': [29], '+': [30], 'Supplements': [31], 'ShareShare': [32], 'onFacebookTwitterLinked': [33], 'InMendeleyReddit': [34], 'Jump': [35], 'toSupplemental': [36], 'MaterialOpen': [37], 'ArticlePDF/EPUB2013': [39], 'AdultsA': [54], 'Report': [55, 2506], 'American': [58, 660, 667, 2443, 2448, 2455, 2458], 'College': [59, 661], 'Cardiology/American': [61], 'Heart': [62, 542, 668, 2479, 3864], 'Association': [63, 669, 2449, 2463, 3865], 'Task': [64, 899, 998, 1331, 1373], 'Force': [65, 900, 999, 1332, 1374], 'Practice': [67, 902, 3487], 'Guidelines': [68, 398, 652, 903, 3488], 'Neil': [69, 156], 'J.': [70, 128, 157, 159, 297], 'Stone,': [71], 'MD,': [72, 79, 91, 97, 102, 107, 112, 115, 119, 125, 131, 140, 145, 154], 'MACP,': [73], 'FAHA,': [74, 81, 86, 92, 98, 103, 109, 122, 127, 142], 'FACC,': [75, 93, 121, 141, 147], 'Jennifer': [76, 169], 'G.': [77, 170, 172], 'Robinson,': [78], 'MPH,': [80, 126], 'Alice': [82, 182], 'H.': [83, 100, 183, 185, 224, 226], 'Lichtenstein,': [84], 'DSc,': [85], 'C.': [87, 105, 138, 195, 237, 239, 326, 328], 'Noel': [88, 196, 199], 'Bairey': [89, 197, 200], 'Merz,': [90], 'Conrad': [94, 210], 'B.': [95, 211, 213], 'Blum,': [96], 'Robert': [99, 223], 'Eckel,': [101], 'Anne': [104, 236], 'Goldberg,': [106], 'FACP,': [108], 'David': [110, 249], 'Gordon,': [111], 'Daniel': [113, 260], 'Levy,': [114], 'Donald': [116, 273], 'M.': [117, 274, 276], 'Lloyd-Jones,': [118], 'SCM,': [120], 'Patrick': [123, 286], 'McBride,': [124], 'Sanford': [129, 298, 300], 'Schwartz,': [130], 'Susan': [132, 310], 'T.': [133, 311, 313], 'Shero,': [134], 'MS,': [135], 'RN,': [136], 'Sidney': [137, 325], 'SmithJr,': [139], 'Karol': [143, 338], 'Watson,': [144], 'PhD,': [146], 'FAHA': [148, 155], 'and': [149, 348, 394, 413, 421, 446, 455, 464, 473, 489, 494, 528, 544, 582, 587, 589, 603, 616, 627, 648, 665, 688, 690, 694, 701, 709, 718, 722, 724, 749, 753, 784, 820, 839, 848, 855, 885, 916, 922, 925, 932, 966, 1032, 1053, 1059, 1136, 1150, 1161, 1186, 1195, 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235, 248, 259, 272, 285, 296, 309, 324, 337], 'RobinsonJennifer': [171], 'Robinson': [173], 'LichtensteinAlice': [184], 'Lichtenstein': [186], 'MerzC.': [198], 'Merz': [201], 'BlumConrad': [212], 'Blum': [214], 'EckelRobert': [225], 'Eckel': [227], 'GoldbergAnne': [238], 'Goldberg': [240], 'GordonDavid': [250], 'Gordon': [251], 'LevyDaniel': [261], 'Levy': [262], '*Ex-Officio': [263, 315], 'Members.': [264, 316], 'Lloyd-JonesDonald': [275], 'Lloyd-Jones': [277], 'McBridePatrick': [287], 'McBride': [288], 'SchwartzJ.': [299], 'Schwartz': [301], 'SheroSusan': [312], 'Shero': [314], 'SmithJrSidney': [327], 'SmithJr': [329], 'WatsonKarol': [339], 'Watson': [340], 'WilsonPeter': [352], 'Wilson': [355], 'Originally': [363], 'published12': [364], 'Nov': [365], '2013https://doi.org/10.1161/01.cir.0000437738.63853.7aCirculation.': [366], '2014;129:S1–S45is': [367], 'corrected': [368], 'byCorrectionCorrectionOther': [369], 'version(s)': [370], 'articleYou': [373], 'are': [374, 671, 1026, 1173, 1220, 1282, 1395, 1410, 1728, 1833, 2037, 2076, 2097, 2116, 2140, 2813, 2896, 2997, 3422, 3439, 4045, 4143, 4169], 'viewing': [375], 'most': [377, 1407, 1465, 1698, 2651, 2723, 3029, 3476, 4004], 'recent': [378, 3282], 'version': [379], 'article.': [382], 'Previous': [383, 388], 'versions:': [384], 'January': [385, 3609], '1,': [386, 3610, 3614], '2013:': [387], 'Version': [389], '1': [390, 3213], 'Table': [391, 2536, 4048, 4079, 4115, 4146, 4172], 'ContentsPreamble': [393], 'Transition': [395, 649], 'S21.': [403], 'Introduction': [404], 'S31.1': [405], 'Organization': [406, 2206], 'Panel': [409, 2213, 2222, 2236, 2244, 2277, 2327, 2329, 2349, 2490, 2505, 2619, 2941, 3116, 3244, 3328, 3357, 3407, 3460, 3551, 3559, 3642, 3713, 3783, 3923, 3948, 3953, 3982, 4013], 'S31.2': [410], 'Document': [411, 2358], 'Review': [412, 423, 2359], 'Approval': [414], 'S31.3': [415], 'Scope': [416, 2481], 'S31.4': [419], 'Methodology': [420, 3454], 'Evidence': [422, 601, 635, 1131, 2528, 3456], 'S52.': [424], 'Overview': [425, 3816], 'S62.1.': [429], 'Lifestyle': [430, 4021], 'as': [431, 877, 1015, 1098, 1273, 1748, 1760, 1791, 1983, 2219, 2495, 2656, 2828, 3047, 3049, 3276, 3301, 3349, 3657, 3679, 3723, 3802, 3943], 'Foundation': [433], 'ASCVD': [435, 2558, 2589, 2647, 2665, 2698, 2773, 2860, 2908, 2974, 2979, 3017, 3053, 3150, 3168, 3198, 3230, 3259, 3320, 3379, 3500, 3510, 3620, 3832, 3851, 3978, 4000, 4043, 4063, 4099], 'Risk-Reduction': [436], 'Efforts': [437], 'S62.2.': [438], 'Initiation': [439], 'Statin': [441, 479, 485, 551, 556, 560, 566, 2562, 4141, 4167, 4179, 4190, 4192, 4194], 'Therapy': [442, 486, 557, 561, 567, 4180], 'S73.': [443], 'Critical': [444], 'Questions': [445], 'Conclusions': [447, 608], 'S103.1.': [448], 'Identification': [449], 'CQs': [451, 1036, 3553], 'S103.1.1.': [452], 'CQ1:': [453], 'LDL-C': [454, 463, 493, 511, 530, 2613, 2632, 3917, 3939, 3970], 'Non–HDL-C': [456, 465, 495, 2615], 'Goals': [457, 466, 497], 'Secondary': [459, 490, 499], 'Prevention': [460, 469, 491, 500, 503, 516, 523, 540], 'S103.1.2.': [461], 'CQ2:': [462], 'Primary': [468, 488, 502, 515, 522, 539, 2684], 'S103.1.3.': [470], 'CQ3:': [471], 'Efficacy': [472], 'Safety': [474], 'Cholesterol-Lowering': [476], 'Medications': [477], 'S104.': [478], 'Treatment:': [480], 'Recommendations': [481, 548, 553, 1046, 4054, 4090, 4123, 4149], 'S104.1.': [482], 'Intensity': [483], 'S124.2.': [492], 'S124.3.': [498], 'S134.4.': [501], 'Individuals': [505, 518, 525, 578, 593], '≥21': [506], 'Years': [507, 595], 'Age': [509, 597], 'With': [510, 519, 529, 614, 625], '≥190': [512], 'mg/dL': [513, 534], 'S144.5.': [514], 'Diabetes': [520, 527], 'S164.6.': [521], 'Without': [526], '70': [531], '189': [533], 'S164.7.': [535], 'Assessment': [537, 2682, 2833, 4025], 'S174.8.': [541], 'Failure': [543], 'Hemodialysis': [545], 'S175.': [546], 'Safety:': [547], 'S186.': [549], 'Managing': [550], 'Therapy:': [552], 'S216.1.': [554], 'Monitoring': [555], 'S216.2.': [558], 'Optimizing': [559], 'S216.3.': [562], 'Insufficient': [563], 'Response': [564], 'S216.3.1': [568], 'Testing': [569], 'S216.3.2': [570], 'Nonstatins': [571], 'Added': [572], 'Statins': [574], 'or': [575, 1534, 1576, 1586, 1590, 1619, 1647, 1653, 1657, 1678, 1756, 1870, 1926, 1992, 1998, 2088, 2119, 2132, 2143, 2633, 3431, 3435, 3522, 3659, 3710, 3872, 3887, 3890, 3918, 3940], 'Statin-Intolerant': [577], 'S227.': [579], 'Selected': [580], 'Clinical': [581], 'Population': [583], 'Subgroups': [584, 591], 'S237.1.': [585], 'Sex': [586], 'Racial': [588], 'Ethnic': [590], 'S237.2.': [592], '>75': [594], 'S238.': [598], 'Limitations': [599], 'S249.': [600], 'Gaps': [602], 'Future': [604, 3303], 'Research': [605], 'Needs': [606], 'S2410.': [607], 'S24References': [609], 'S25Appendix': [610], '1.': [611, 1181, 1190, 1286], 'Author': [612], 'Relationships': [613, 624, 1277], 'Industry': [615, 626], 'Other': [617, 628], 'Entities': [618, 629], '(Relevant)': [619], 'S28Appendix': [620], '2.': [621, 2551], 'Expert': [622, 867, 2212, 2221, 2243, 2276, 2335, 2348, 2356, 2618, 2839, 2940, 3115, 3243, 3327, 3406, 3459, 3550, 3558, 3641, 3673, 3712, 3757, 3782, 3922, 3952, 3981, 4012, 4188], 'Reviewer': [623], 'S32Appendix': [630], '3.': [631, 4050, 4086], 'Abbreviations': [632], 'S33Appendix': [633, 637], '4.': [634, 4122, 4148], 'Statements': [636], '5.': [638, 4174], 'Expanded': [639], 'Discussion': [640], 'What’s': [642, 2552], 'New': [643, 2553, 2610, 3862], 'S43Preamble': [647], 'RiskThe': [656], 'goals': [657], 'Cardiology': [663], '(ACC)': [664], '(AHA)': [670], 'prevent': [673], 'cardiovascular': [674, 702, 735, 741, 1479, 1753, 2268, 2925, 3104, 3628], 'diseases;': [675], 'improve': [676], 'management': [678, 743, 750, 2403, 2795, 2874, 3374], 'people': [680], 'who': [681, 2812], 'have': [682, 711, 1896, 1960, 2044, 3200], 'these': [683, 705, 761, 892, 976, 1005, 1024, 1171, 1454, 3248], 'diseases': [684], 'through': [685, 3612, 3795], 'professional': [686, 725, 1358, 1369], 'education': [687], 'research;': [689], 'develop': [691, 728, 777, 826, 3252, 3695], 'guidelines,': [692, 1007, 3471], 'standards,': [693], 'policies': [695, 1203, 1231], 'that': [696, 810, 865, 948, 1096, 1267, 1375, 1400, 1442, 1513, 1526, 1539, 1554, 1570, 1577, 1727, 1825, 2025, 2058, 2096, 2584, 2738, 3140, 3163, 3263, 3330, 3421, 3444, 3632, 3648, 3676, 3958, 3988], 'promote': [697], 'optimal': [698, 3311], 'patient': [699, 1425, 1434, 1769], 'care': [700, 1421, 2257, 3045], 'health.': [703], 'Toward': [704], 'objectives,': [706], 'ACC': [708, 838, 1337, 2397, 2412, 2436], 'AHA': [710, 840, 1343, 2400, 2414, 2438], 'collaborated': [712], 'with': [713, 822, 836, 843, 1200, 1214, 1709, 1732, 1771, 1864, 1912, 1920, 2050, 2159, 2298, 2343, 2478, 2658, 2944, 3052, 3148, 3322, 3446, 3499, 3509, 3516, 3618, 3846, 3861, 3885, 3897], 'National': [715, 1805, 2194, 2474], 'Heart,': [716, 1806, 2195], 'Lung,': [717, 1807, 2196], 'Institute': [720, 795, 3465, 3482], '(NHLBI)': [721], 'stakeholder': [723], 'organizations': [726, 824, 845, 934], 'clinical': [729, 803, 1022, 1152, 1415, 1632, 1931, 2264, 2266, 2962, 3067, 3556], 'practice': [730, 2963, 3470], 'guidelines': [731, 762, 852, 893, 1377, 1394, 1455, 2904, 3254], 'assessment': [733, 3077], 'risk,': [736, 742], 'lifestyle': [737], 'modifications': [738], 'reduce': [740, 1474, 1752, 2588, 2646, 2772, 2859, 2973, 3197, 3229, 3977, 3999, 4042], 'blood': [745, 2769, 2856, 2969], 'cholesterol': [746, 2770, 2857, 2970, 3009, 3145, 3165, 4040], 'adults,': [748], 'overweight': [752], 'obesity': [754], 'adults.In': [756], '2008,': [757], 'NHLBI': [759, 806, 812, 833, 960, 1121, 1160, 1492, 1497, 1812, 2324, 2374, 2526, 3103, 3766, 3813], 'initiated': [760, 834, 3858], 'sponsoring': [764], 'rigorous': [765], 'systematic': [766, 2341, 2953, 3428, 3493, 3503, 3539, 3586, 3824], 'evidence': [767, 819, 873, 1044, 1065, 1079, 1094, 1310, 1512, 1525, 1553, 1569, 1585, 1587, 1652, 1654, 1737, 1743, 2008, 2516, 2625, 3237, 3394, 3429, 3666, 3690, 3699, 3707, 3717, 3740, 3825, 3929, 3957, 3987], 'reviews': [768, 2954, 3504], 'each': [770, 949, 1038, 1073, 1081, 1227, 3566, 3580, 3598], 'topic': [771], 'expert': [773, 940, 1291, 1320, 2378, 2392, 2792, 2870, 3386], 'panels': [774, 921, 1208, 1321], 'convened': [775, 2218, 3462], 'critical': [778, 2887], 'questions': [779, 1153, 3416], '(CQs),': [780], 'interpret': [781], 'evidence,': [783, 1614, 1616, 1618, 1621, 1673, 1675, 1677, 1680, 1981, 3296], 'craft': [785], 'recommendations.': [786, 1102], 'In': [787, 1259, 1349, 2001], 'response': [788], '2011': [791, 875], 'report': [792], 'from': [793, 975, 1010, 1049, 1110, 1119, 1354, 1453, 1990, 2305, 2574, 2576, 2787, 2947, 3033, 3122, 3239, 3269, 3410, 3480, 3593, 3834], 'Medicine': [797, 3467, 3484], 'development': [800, 1003], 'trustworthy': [802], 'guidelines,1': [804], 'Advisory': [807, 961, 1345], 'Council': [808], 'recommended': [809, 1641, 1694, 2829, 3944], 'focus': [813, 1033, 2585], 'specifically': [814], 'reviewing': [816], 'highest-quality': [818, 1043], 'partner': [821, 933], 'other': [823, 844, 1011, 1111, 1217, 1355, 1980, 2826, 3377], 'recommendations.2,3': [827], 'Accordingly,': [828], 'June': [830], '2013': [831, 3797], 'collaboration': [835], 'work': [842, 4009], 'complete': [847, 4076, 4112], 'publish': [849, 927], '4': [851, 2391, 2561, 2578, 2818], 'noted': [853, 1174], 'above': [854], 'make': [856, 1635], 'them': [857], 'available': [858], 'widest': [861, 1381], 'possible': [862, 1382, 1772], 'constituency.': [863], 'Recognizing': [864], 'Panels/Work': [868], 'Groups': [869], 'did': [870, 3333, 3954, 3974], 'not': [871, 1061, 1067, 1411, 1729, 2077, 2098, 2177, 2662, 2740, 2814, 3274, 3334, 3396, 3903, 3975], 'consider': [872], 'beyond': [874, 3423], '(except': [876], 'specified': [878], 'methodology),': [881], 'ACC,': [883], 'AHA,': [884], 'collaborating': [886], 'societies': [887], 'plan': [888], 'begin': [890], 'updating': [891], 'starting': [894], '2014.The': [896], 'joint': [897], '(Task': [904], 'Force)': [905], 'appointed': [906, 2238], 'a': [907, 936, 1302, 1412, 1423, 1445, 1557, 1636, 1768, 2056, 2315, 2569, 2744, 2848, 3001, 3073, 3173, 3266, 3277, 3337, 3369, 3400, 3534, 3538, 3571, 3585, 3696, 3750, 3828], 'subcommittee': [908], 'shepherd': [910], 'transition,': [912], 'communicate': [913], 'rationale': [915, 1781, 2005, 3156], 'expectations': [917], 'writing': [920, 970, 1207, 1244, 1366], 'partnering': [923], 'organizations,': [924, 1370], 'expeditiously': [926], 'documents.': [929], 'The': [930, 1083, 1324, 1417, 2242, 2275, 2411, 2473, 2503, 3086, 3281, 3492, 3600, 3877, 3980, 4008], 'recruited': [935], 'limited': [937, 1029, 1778, 2078, 3383, 3496], 'number': [938, 2125, 3384], 'reviewers': [941, 1292, 2379, 2393], 'fiduciary': [943], 'examination': [944], 'content,': [946, 2514], 'recognizing': [947], 'document': [950, 2386, 2422, 2425], 'had': [951, 1293, 3408], 'undergone': [952], 'extensive': [953, 1019, 3985], 'peer': [954, 2363], 'review': [955, 2342, 2364, 2888, 3494, 3540, 3826], 'representatives': [957, 2381], 'Council,': [962], 'key': [963], 'federal': [964, 2383], 'agencies,': [965], 'scientific': [967], 'experts.': [968], 'Each': [969, 1114], 'panel': [971, 1228, 1268, 2281, 2291], 'responded': [972], 'comments': [974], 'reviewers.': [977], 'Clarifications': [978], 'were': [979, 985, 1047, 1060, 1232, 1316, 2300, 2582, 3024, 3058, 3389, 3528, 3635, 3654, 3662, 3677, 3682, 3745, 3770, 3902], 'incorporated': [980], 'where': [981, 1179, 2169], 'appropriate,': [982], 'but': [983, 1592, 1622, 2075], 'there': [984, 1535, 1555, 1571, 1719], 'no': [986, 1573, 1613, 1672, 1686, 3436, 3850], 'substantive': [987], 'changes': [988], 'because': [989, 1611, 1670], 'bulk': [991], 'content': [994], 'was': [995, 1066, 1253, 1326, 1628, 2216, 2245, 2366, 2387, 2426, 2620, 2942, 3350, 3364, 3395, 3461, 3495, 3531, 3608, 3692, 3784, 3857, 3924, 3972, 4014], 'undisputed.Although': [996], 'led': [1000], 'final': [1002, 3739], 'prevention': [1006, 2678, 3015, 3083], 'they': [1008, 2147], 'differ': [1009], 'guidelines.': [1013, 1113], 'First,': [1014], 'opposed': [1016], 'an': [1018, 1488, 1758, 1897, 1934, 1961, 2496, 2539, 2914, 3969], 'compendium': [1020], 'information,': [1023], 'documents': [1025], 'significantly': [1027], 'scope': [1031, 3425], 'selected': [1035, 2810], 'topic,': [1039], 'based': [1040, 1510, 1523, 1551, 1567, 2109, 2122, 2486, 2567, 2885, 3575], 'available.': [1045, 1068], 'derived': [1048], 'randomized': [1050, 2202, 2937, 2948], 'trials,': [1051, 2267], 'meta-analyses,': [1052], 'observational': [1054, 1882, 1918, 3129], 'studies': [1055, 1916, 1919, 1943, 2024, 2154, 2164, 2168, 2183, 3153, 3513], 'evaluated': [1056, 3217], 'quality': [1058, 1711, 1734, 1744, 3661, 3681], 'formulated': [1062], 'when': [1063, 1235, 1741, 2401, 3392, 3854], 'sufficient': [1064], 'Second,': [1069], 'text': [1071], 'accompanying': [1072, 1313], 'recommendation': [1074, 1115, 1177, 1493, 1645, 1687, 1704, 1740], 'is': [1075, 1137, 1164, 1361, 1507, 1517, 1520, 1530, 1536, 1543, 1546, 1556, 1562, 1572, 1583, 1588, 1594, 1601, 1640, 1650, 1655, 1660, 1693, 1745, 1789, 1853, 1957, 1972, 2121, 2176, 2418, 2485, 2493, 2522, 2545, 2566, 2847, 3089, 3442], 'succinct,': [1076], 'summarizing': [1077], 'question.': [1082], 'Full': [1084, 2489, 2504], 'Panel/Work': [1085], 'Group': [1086, 1598, 1625, 1684, 2017, 2835], 'Reports': [1087], 'include': [1088, 2048, 2074, 2184, 3787], 'detailed': [1090], 'information': [1091, 2287, 2417], 'about': [1092, 1420, 1846, 1888, 1950, 3417], 'statements': [1095, 3700, 3718, 3741], 'serve': [1097], 'basis': [1100, 2731, 3293], 'Third,': [1103], 'format': [1105, 1123], 'recommendations': [1108, 1471, 1726, 2964, 2996, 3038, 3057, 3388, 3744, 4035], 'differs': [1109], 'has': [1116, 3215, 3287], 'been': [1117, 3201, 3216], 'mapped': [1118], 'grading': [1122, 1148, 1494, 3810], 'Classification': [1127, 1183, 1192], 'Recommendation/Level': [1129], '(COR/LOE)': [1132], 'construct': [1133], '(Table': [1134], '1)': [1135], 'expressed': [1138], 'both': [1140, 2701], 'formats.': [1141], 'Because': [1142, 3232], 'inherent': [1145], 'differences': [1146], 'systems': [1149], 'driving': [1154], 'recommendations,': [1156, 1249], 'alignment': [1157], 'between': [1158, 2746], 'formats': [1163], 'some': [1166, 1717, 1978], 'cases': [1167], 'imperfect.': [1168], 'Explanations': [1169], 'variations': [1172], 'tables,': [1178], 'applicable.Table': [1180], 'Applying': [1182, 1191], 'Recommendation': [1185, 1194], 'Level': [1187, 1196], 'EvidenceTable': [1189], 'EvidenceIn': [1198], 'consultation': [1199], 'NHLBI,': [1201, 1371, 1804], 'adopted': [1204], 'manage': [1210], 'relationships': [1211], 'authors': [1213, 1269], 'industry': [1215], 'entities': [1218], '(RWI)': [1219], 'outlined': [1221], 'methods': [1224], 'section': [1225], 'report.': [1229], 'These': [1230, 1459, 2995, 3152, 3900], 'effect': [1234, 1906, 1970, 3908], 'effort': [1237], 'began': [1238, 3643], '2008': [1240], 'throughout': [1242], 'process': [1245, 1252, 2365, 3332, 3474, 3806], 'voting': [1247, 2306, 3753], 'until': [1250, 3639], 'transferred': [1254], '2013.': [1258, 1276], 'interest': [1261, 2095], 'transparency,': [1263], 'requested': [1266], 'resubmit': [1270], 'RWI': [1271, 1295, 2416], 'disclosures': [1272], 'July': [1275, 3796], 'relevant': [1278, 1294, 3554, 3594, 3646], 'guideline': [1281, 1325, 2273, 2312, 2334, 2406, 2484, 2565, 2596, 2686, 2717, 2742, 2756, 2790, 2850, 3088, 3107, 3283, 3299, 3363, 3778], 'disclosed': [1283], 'Appendix': [1285, 1299, 2911], 'None': [1287], '(Appendix': [1296, 2423], '2).': [1297], 'See': [1298], '3': [1300, 2251], 'list': [1303], 'abbreviations': [1305], 'used': [1306, 2644, 2757, 3025, 3693, 3997], 'guideline.Systematic': [1309], 'reports': [1311, 3468, 4018], 'summary': [1314, 4031], 'tables': [1315, 3667], 'developed': [1317, 2157, 3570], 'NHLBI.': [1323, 2241], 'reviewed': [1327, 2389], 'approved': [1334, 2427, 3746], 'Board': [1338], 'Trustees,': [1340], 'Science': [1344], 'Coordinating': [1347], 'Committee.': [1348], 'addition,': [1350, 3780], 'sought': [1352], 'endorsement': [1353], 'stakeholders,': [1356, 1368], 'including': [1357, 2800, 3203], 'organizations.': [1359], 'It': [1360], 'hope': [1363], 'panels,': [1367], 'will': [1378, 2148, 2155, 2863, 3039, 3305], 'garner': [1379], 'readership': [1383], 'benefit': [1386, 1529, 1542, 1575, 1600, 1659, 1788, 2580, 2786, 2820, 3032], 'patients,': [1388, 1466], 'providers,': [1389], 'public': [1392], 'health.These': [1393], 'meant': [1396], 'define': [1398], 'practices': [1399], 'meet': [1401], 'needs': [1403], 'patients': [1405, 2749], 'circumstances': [1408, 1439], 'replacement': [1413], 'judgment.': [1416], 'ultimate': [1418], 'decision': [1419], 'particular': [1424], 'must': [1426], 'be': [1427, 1457, 1609, 1668, 1689, 1706, 1721, 1777, 2012, 2156, 2532, 2643, 2823, 3040, 3061, 3306, 3368, 3996], 'made': [1428, 3390], 'healthcare': [1431], 'provider': [1432], 'light': [1436], 'presented': [1440], 'patient.': [1443], 'As': [1444], 'result,': [1446], 'situations': [1447, 1775], 'might': [1448, 2317, 2739], 'arise': [1449], 'which': [1451, 1830, 2254, 2314, 2492, 2530, 2577, 3159, 3433], 'deviations': [1452], 'may': [1456, 1720, 1895, 1908, 2822], 'appropriate.': [1458], 'considerations': [1460, 2763], 'notwithstanding,': [1461], 'caring': [1463], 'clinicians': [1467, 2747, 3046, 3445], 'can': [1468, 1995, 2531, 3449], 'employ': [1469], 'confidently': [1472], 'risks': [1476], 'atherosclerotic': [1478, 2924, 2993], 'disease': [1480, 1754, 2983], '(ASCVD)': [1481], 'events.See': [1482], 'Tables': [1483, 4068, 4104], '1a': [1484], '1b': [1486], 'explanation': [1489], 'methodology.Table': [1495], '1a.': [1496], 'Grading': [1498], 'Strength': [1501, 1817], 'RecommendationsGradeStrength': [1503], 'Recommendation*AStrong': [1505], 'recommendationThere': [1506, 1519, 1545], 'high': [1508, 1537, 2045], 'certainty': [1509, 1522, 1538, 1550, 1566, 1949], 'net': [1515, 1528, 1541, 1559, 1574, 2785], 'benefit‡': [1516], 'substantial.BModerate': [1518], 'moderate': [1521, 1531, 1549, 1565], 'substantial,': [1533], 'moderate.CWeak': [1544], 'at': [1547, 1563, 2534, 3748], 'least': [1548, 1564, 3749], 'small': [1558], 'benefit.DRecommendation': [1560], 'againstThere': [1561], 'risks/harms': [1578, 1794], 'outweigh': [1579], 'benefits.EExpert': [1580], 'opinion': [1581, 3387], '(“There': [1582, 1649], 'insufficient': [1584, 1615, 1651, 1674], 'unclear': [1589, 1617, 1656, 1676], 'conflicting,': [1591], 'what': [1595, 2544, 3404], 'Work': [1597, 1624, 1683, 1786, 2016, 2834, 3768, 4026], 'recommends.”)Net': [1599], 'unclear.': [1602, 1661], 'Balance': [1603, 1662], 'benefits': [1605, 1664, 1792, 2667], 'harms': [1607, 1666], 'cannot': [1608, 1667], 'determined': [1610, 1669], 'conflicting': [1620, 1679], 'thought': [1626, 1685], 'it': [1627, 3441], 'important': [1629, 2761, 3119], 'provide': [1631, 2663, 2869, 3000, 3315, 3335], 'guidance': [1633, 2353, 2793, 2871], 'recommendation.': [1637], 'Further': [1638, 1691, 1851, 1893, 1955], 'research': [1639, 1692, 1852, 1894, 1956], 'area.NNo': [1644], 'against': [1648], 'conflicting.”)Net': [1658], 'should': [1688, 1705, 1776, 2011, 2642, 3273, 3995], 'made.': [1690], 'area.*In': [1697], 'cases,': [1699, 1979, 2003], 'strength': [1701], 'closely': [1707, 1730], 'aligned': [1708, 1731], 'evidence;': [1714], 'however,': [1715], 'under': [1716, 2369], 'circumstances,': [1718], 'valid': [1722], 'reasons': [1723], 'making': [1725], '(eg,': [1738, 1938, 1988, 2179, 3962], 'strong': [1739], 'moderate,': [1746], 'such': [1747, 1843, 1885, 1947, 1982, 2002, 2072], 'smoking': [1749], 'cessation': [1750], 'risk': [1755, 2648, 2699, 2883, 3076, 3380, 4001, 4044], 'ordering': [1757], 'ECG': [1759], 'part': [1761, 3803], 'initial': [1764], 'diagnostic': [1765], 'work-up': [1766], 'presenting': [1770], 'MI).': [1773], 'Those': [1774], 'explained': [1782, 2013], 'clearly': [1783, 2019], 'Group.†Net': [1787], 'defined': [1790], 'minus': [1793], 'service/intervention.ECG': [1797], 'indicates': [1798, 2193, 2923], 'electrocardiogram;': [1799], 'MI,': [1800], 'myocardial': [1801, 3623], 'infarction;': [1802], 'Institute.Table': [1810], '1b.': [1811], 'Quality': [1813], 'Rating': [1814], 'EvidenceType': [1819], 'EvidenceQuality': [1821], 'Rating*Well-designed,': [1822], 'well-executed‡': [1823], 'RCT': [1824, 2624, 2733, 3022, 3393, 3437, 3928, 3956, 3986], 'adequately': [1826, 2038], 'represent': [1827, 1996], 'populations': [1828], 'results': [1832], 'applied': [1834], 'directly': [1836, 2026], 'assess': [1837], 'effects': [1838, 2674, 2780], 'health': [1840, 3105], 'outcomes.Meta-analyses': [1841], 'studies.Highly': [1844], 'certain': [1845, 1887], 'estimate': [1848, 1861, 1890, 1904, 1952, 1968, 2066, 2696], 'effect.': [1850, 1892, 1954, 2069], 'unlikely': [1854], 'change': [1856, 1909, 1975], 'our': [1857, 1900, 1964, 3331, 3427, 3472, 3799], 'confidence': [1858, 1868, 1901, 1924, 1965, 2062], 'effect.>HighRCT': [1863], 'minor': [1865, 2118, 2142], 'limitations‡': [1866], 'affecting': [1867, 1923], 'in,': [1869, 1925], 'applicability': [1871, 1927], 'of,': [1872, 1928], 'results.Well-designed,': [1874], 'well-executed': [1875, 1881], 'nonrandomized': [1876], 'controlled': [1877, 1915, 2163, 2203, 2938, 2949], 'studies§': [1878], 'well-designed,': [1880], 'studies‖.Meta-analyses': [1883], 'studies.Moderately': [1886], 'impact': [1898, 1962], 'estimate.>ModerateRCT': [1911], 'major': [1913, 1921, 2120, 2144, 3788, 4034], 'limitations.Nonrandomized': [1914], 'limitations': [1922, 2073, 2115, 2139], 'results.Uncontrolled': [1930], 'observations': [1932], 'without': [1933], 'appropriate': [1935, 2637, 3990], 'comparison': [1936, 2174], 'group': [1937], 'case': [1939, 1941, 1986], 'series,': [1940], 'reports).Physiological': [1942], 'humans.Meta-analyses': [1945], 'studies.Low': [1948], 'likely': [1958, 1973, 2652, 2724, 3030, 4005], 'estimate.Low*In': [1977], 'large': [1984], 'all-or-none': [1985], 'series': [1987, 3697], 'jumping': [1989], 'airplanes': [1991], 'tall': [1993], 'structures),': [1994], 'high-': [1997], 'moderate-quality': [1999], 'evidence.': [2000], 'rating': [2009, 2150], 'exception': [2010, 3848], 'justified.†“Well-designed,': [2020], 'well-executed”': [2021], 'refers': [2022], 'address': [2027, 3092, 3775], 'question;': [2029], 'use': [2030, 2040, 2604, 2629, 2688, 3064, 3221, 3959], 'adequate': [2031], 'randomization,': [2032, 2081], 'blinding,': [2033], 'allocation': [2035], 'concealment;': [2036], 'powered;': [2039], 'intention-to-treat': [2041], 'analyses;': [2042], 'follow-up': [2046, 2105, 3527], 'rates.‡Limitations': [2047], 'concerns': [2049], 'design': [2052, 2131], 'execution': [2054], 'study': [2057, 2086, 2181], 'result': [2059], 'decreased': [2061], 'true': [2065], 'Examples': [2070], 'to:': [2079], 'inadequate': [2080, 2091], 'lack': [2082], 'blinding': [2084], 'participants': [2087], 'outcome': [2089], 'assessors,': [2090], 'power,': [2092], 'outcomes': [2093, 3501, 3621], 'prespecified': [2099, 3916], 'primary': [2102, 2256, 2594, 2608, 3012, 3044], 'outcomes,': [2103], 'low': [2104], 'rates,': [2106], 'findings': [2108], 'subgroup': [2111], 'analyses.': [2112], 'Whether': [2113], 'considered': [2117, 2141], 'severity': [2127], 'flaws': [2129], 'execution.': [2133], 'Rules': [2134], 'determining': [2136, 3808], 'whether': [2137], 'how': [2146], 'affect': [2149], 'individual': [2153], 'collaboratively': [2158], 'methodology': [2161, 3535], 'team.§Nonrandomized': [2162], 'refer': [2165], 'intervention': [2167, 2172], 'assignment': [2170], 'groups': [2175, 2581, 2737, 2821], 'random': [2178], 'quasi-experimental': [2180], 'design).‖Observational': [2182], 'prospective': [2185], 'retrospective': [2187], 'cohort,': [2188], 'case-control,': [2189], 'cross-sectional': [2191], 'studies.NHLBI': [2192], 'Institute;': [2199], 'RCT,': [2201, 2936], 'trials.1.': [2204], 'Introduction1.1.': [2205], 'PanelThe': [2209], '(Expert': [2214], 'Panel)': [2215], 'originally': [2217], 'Detection,': [2224], 'Evaluation,': [2225], 'High': [2229], '(Adult': [2234], 'IV)': [2237], 'composed': [2246], '13': [2248], 'members': [2249, 2282, 2297, 2321, 3112, 3754], 'ex-officio': [2252], 'members,': [2253], 'included': [2255, 2376, 2815, 3546, 3663], 'physicians,': [2258], 'cardiologists,': [2259], 'endocrinologists,': [2260], 'experts': [2262], 'lipidology,': [2265], 'epidemiology': [2269], 'nutrition,': [2271], 'development.': [2274], 'chair': [2278], 'asked': [2279, 2301], 'all': [2280, 2990], 'disclose': [2284], 'any': [2285, 2308], 'conflict-of-interest': [2286], 'full': [2290], 'advance': [2293], 'deliberations;': [2296], 'conflicts': [2299], 'recuse': [2303], 'themselves': [2304], 'aspect': [2309], 'conflict': [2316], 'exist.': [2318], 'All': [2319], '16': [2320], 'Adult': [2325, 3355, 3946], 'IV': [2328, 3869], 'transitioned': [2330, 2407], 'Panel.': [2336, 3674], 'Independent': [2337], 'contractors': [2338], 'performed': [2339, 3771], 'assistance': [2345, 3685], 'provided': [2351, 2494, 3154, 3532, 4046], 'methodological': [2352], 'Panel.1.2.': [2357], 'ApprovalA': [2361], 'formal': [2362], 'initially': [2367], 'completed': [2368], 'auspices': [2371], '23': [2377], 'agencies.': [2384], 'This': [2385, 3272], 'also': [2388, 2727, 3983], 'nominated': [2394], 'ACC/AHA.': [2410], 'reviewers’': [2415], 'published': [2419, 3591, 3630, 3794], '2).This': [2424], 'publication': [2429], 'governing': [2432], 'bodies': [2433], 'endorsed': [2440], 'Academy': [2444], 'Physician': [2446], 'Assistants,': [2447], 'Pulmonary': [2453], 'Rehabilitation,': [2454], 'Pharmacists': [2456], 'Association,': [2457, 2470], 'Society': [2459], 'Preventive': [2461, 2467], 'Cardiology,': [2462], 'Black': [2465], 'Cardiologists,': [2466], 'Nurses': [2469], 'WomenHeart:': [2472], 'Coalition': [2475], 'Women': [2477], 'Disease.1.3.': [2480], 'GuidelineThis': [2483, 2846], 'Report,': [2491], 'online-only': [2497], 'data': [2498, 2573, 2946, 3023, 3438], 'supplement': [2499], 'guideline.': [2502], 'contains': [2507], 'background': [2508], 'additional': [2510], 'material': [2511], 'related': [2512], 'methodology,': [2515], 'synthesis,': [2517], 'rationale,': [2518], 'references': [2520], 'supported': [2523], 'Systematic': [2527], 'Review,': [2529], 'found': [2533, 3984], 'http://www.nhlbi.nih.gov/guidelines/cholesterol/ser/.': [2535], '2': [2537], 'provides': [2538, 2791], 'overview': [2540], 'facilitate': [2542], 'understanding': [2543, 2782], 'new': [2546, 2691, 2919], 'present': [2549, 3087, 3362, 3397], 'guideline.Table': [2550], 'Guideline?*Focus': [2556], 'Reduction:': [2560], 'Benefit': [2563], 'GroupsThis': [2564], 'comprehensive': [2570, 2849, 3338, 3370], 'set': [2571], 'RCTs': [2575, 2758, 2775, 2958, 3250, 3304, 3498, 3508, 3617, 3675, 3789, 3793, 3820, 3878, 4184], 'statin': [2579, 2601, 2640, 2659, 2714, 2719, 2753, 2778, 2788, 2819, 3035, 3240, 3249, 3855, 3912, 3993, 4084, 4120], 'identified': [2583, 3560, 3821], 'efforts': [2586], 'events': [2590, 3169, 3199, 3321, 3833], 'secondary': [2592, 2606, 3014], 'prevention.This': [2595], 'identifies': [2597], 'high-intensity': [2598], 'moderate-intensity': [2600, 3898], 'therapy': [2602, 2641, 2720, 3195, 3840, 3856, 3935, 3961, 3994], 'prevention.A': [2609], 'Perspective': [2611], 'and/or': [2614], 'GoalsThe': [2617], 'unable': [2621, 3925], 'find': [2623, 3927, 3955], 'support': [2627, 3543, 3931], 'continued': [2628], 'specific': [2631], 'non–HDL-C': [2634, 3919, 3941], 'treatment': [2635, 2767, 2854, 2894, 2967, 3007, 3079, 3093, 3209, 3312, 3345, 3720, 3743, 3913, 4038], 'targets.The': [2636], 'intensity': [2638, 3991], 'those': [2650, 2722, 2735, 3028, 3515, 3860, 3873, 4003], 'benefit.Nonstatin': [2654], 'therapies,': [2655], 'compared': [2657, 3880, 3891], 'therapy,': [2660, 2715, 3036], 'do': [2661], 'acceptable': [2664], 'risk-reduction': [2666, 2909, 3106], 'relative': [2668], 'their': [2670, 3452], 'potential': [2671], 'adverse': [2673, 2779, 2798], 'routine': [2677], 'ASCVD.Global': [2680], 'PreventionThis': [2685], 'recommends': [2687, 2743], 'Pooled': [2692], 'Cohort': [2693], 'Equations': [2694], '10-year': [2697], 'white': [2702], 'black': [2704], 'men': [2705], 'women.By': [2707], 'accurately': [2709], 'identifying': [2710], 'higher-risk': [2711], 'individuals': [2712, 2765, 2811], 'focuses': [2718], 'benefit.It': [2726], 'indicates,': [2728], 'data,': [2734], 'high-risk': [2736], 'benefit.This': [2741], 'discussion': [2745, 2916, 3800], 'before': [2750, 3463], 'initiation': [2751], 'therapy.Safety': [2754], 'RecommendationsThis': [2755], 'identify': [2760, 3027, 3773], 'safety': [2762], 'receiving': [2766, 3874], 'risk.Using': [2774], 'determine': [2777, 3309], 'facilitates': [2781], 'therapy.This': [2789], 'statin-associated': [2797], 'effects,': [2799], 'muscle': [2801], 'symptoms.Role': [2802], 'Biomarkers': [2804], 'Noninvasive': [2806], 'TestsTreatment': [2807], 'decisions': [2808], 'informed': [2824, 4015], 'factors': [2827], 'Panel.Future': [2840], 'Updates': [2841], 'evidence-based': [2853, 2903, 3003, 3253, 3473], 'risk.Future': [2861], 'updates': [2862], 'build': [2864], 'foundation': [2867, 3004], 'complex': [2876, 3418], 'lipid': [2877, 3347, 3373, 3419, 3447], 'disorders': [2878, 3348, 3420], 'incorporate': [2880], 'refinements': [2881], 'stratification': [2884], 'emerging': [2890], 'data.RCTs': [2891], 'comparing': [2892], 'alternative': [2893], 'strategies': [2895, 3191], 'needed': [2897, 3307], 'order': [2899], 'inform': [2901], 'future': [2902], 'optimum': [2907], 'approach.*See': [2910], '5,': [2912], 'expanded': [2915], 'what’s': [2918], 'guideline.ASCVD': [2922], 'disease;': [2926], 'HDL-C,': [2927], 'high-density': [2928], 'lipoprotein': [2929, 2933, 3144, 3180], 'cholesterol;': [2930, 2934], 'LDL-C,': [2931, 4198], 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'implementability': [3759], 'appraisals,': [3760], 'planned': [3761], 'coordinated': [3763], 'Implementation': [3767], 'Group,': [3769], 'barriers': [3776], 'implementation.In': [3779], 'able': [3785], 'expert-level': [3814], 'recommendations.2.': [3815], 'GuidelineThe': [3819], 'indicated': [3827], 'consistent': [3829], '3-hydroxy-3-methylglutaryl-coenzyme': [3835], 'reductase': [3837], 'inhibitor': [3838], '(statin)': [3839], 'secondary-': [3842], 'primary-prevention': [3844], 'populations,': [3845], 'event': [3852], 'York': [3863], 'class': [3866], 'II': [3867], 'maintenance': [3875], 'hemodialysis.': [3876], 'either': [3879], 'statins': [3884, 3896], 'placebo': [3886], 'untreated': [3888], 'controls,': [3889], 'higher-intensity': [3895], 'statins.': [3899], 'evaluate': [3906], 'titrated': [3910], '(dose-adjusted)': [3911], 'achieve': [3915, 3937], 'goals.Therefore,': [3920], 'titrating': [3932], 'target': [3938, 3971], 'levels,': [3942], 'III.6–8': [3949], 'Notably,': [3950], 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