Title: The effects of quinine and 4-aminopyridine on conditioned place preference and changes in motor activity induced by morphine in rats
Abstract: 1. The effects of two unselective potassium (K+-) channel blockers, quinine (12.5, 25 and 50 mg/kg) and 4-aminopyridine (1 and 2 mg/kg), on conditioned place preference and biphasic changes in motor activity induced by morphine (10 mg/kg) were tested in Wistar rats. Quinine is known to block voltage-, calcium- and ATP-sensitive K+-channels while 4-aminopyridine is known to block voltage- sensitive K+-channels. 2. In the counterbalanced method, quinine attenuated morphine-induced place preference, whereas 4-aminopyridine was ineffective. In the motor activity test measured with an Animex-activity meter neither of the K+-channel blockers affected morphine-induced hypoactivity, but both K+- channel blockers prevented morphine-induced secondary hyperactivity. 3. These results suggest the involvement of quinine-sensitive but not 4-aminopyridine-sensitive K+-channels in morphine reward. It is also suggested that the blockade of K+-channels sensitive to these blockers is not sufficient to prevent morphine-induced hypoactivity whereas morphine- induced hyperactivity seems to be connected to both quinine- and 4-aminopyridine-sensitive K+-channels.
Publication Year: 1999
Publication Date: 1999-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 3
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