Prediction of Amyloid Fibril-forming Proteins

Name: Work Video:
Duration: 3 min 30 s
Yvonne Kallberg; Magnus Gustafsson; Bengt Persson; Johan Thyberg; Jan Johansson
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'abstract_inverted_index': {'In': [0, 37, 83, 196, 233, 279, 1126, 1649, 2814, 2833, 2879, 3041, 4708, 4784], "Alzheimer's": [1, 197, 409, 659, 3866], 'disease': [2, 198, 410, 660, 1036], 'and': [3, 75, 149, 199, 271, 345, 400, 411, 421, 430, 526, 581, 610, 712, 828, 984, 1024, 1087, 1230, 1266, 1288, 1388, 1458, 1558, 1574, 1578, 1583, 1652, 1677, 1761, 1774, 1859, 1949, 2014, 2069, 2075, 2080, 2109, 2180, 2245, 2264, 2345, 2373, 2392, 2422, 2564, 2573, 2608, 2614, 2657, 2710, 2721, 2726, 2805, 2866, 2892, 2901, 2936, 2971, 2993, 3000, 3020, 3039, 3060, 3065, 3253, 3329, 3373, 3381, 3415, 3425, 3435, 3446, 3482, 3533, 3539, 3556, 3641, 3706, 3772, 3786, 3804, 3833, 3868, 3880, 3893, 3920, 4033, 4040, 4062, 4193, 4320, 4333, 4401, 4517, 4577, 4603, 4637, 4649, 4727, 4822, 4928, 4964, 5107, 5133, 5136, 5144, 5156, 5166], 'spongiform': [4, 200, 423, 3861], 'encephalopathies': [5, 201], 'proteins': [6, 19, 109, 202, 215, 305, 399, 449, 559, 765, 923, 1327, 1391, 1426, 1440, 1476, 1748, 1866, 1882, 1956, 1972, 2095, 2305, 2375, 2399, 2536, 2555, 2638, 2730, 2741, 2809, 2917, 2926, 3012, 3036, 3359, 3394, 3410, 3453, 3830, 3840, 3856, 3974, 4013, 4021, 4207, 4216, 5106, 5142], 'transform': [7, 203], 'from': [8, 93, 204, 289, 397, 495, 523, 942, 950, 1031, 1328, 1479, 1537, 1607, 1840, 1864, 1877, 1930, 1954, 1967, 1994, 2066, 2087, 2319, 2548, 2578, 2951, 2990, 3366, 3370, 3819, 5176, 5208], 'their': [9, 205, 566, 2737, 3076, 5137], 'native': [10, 206, 486, 567, 3525], 'states': [11, 207, 568], 'into': [12, 208, 1017, 4243], 'fibrils.': [13, 166, 209, 362, 1293, 3429], 'We': [14, 185, 210, 381, 1716, 3811, 4056, 5149], 'find': [15, 211], 'that': [16, 27, 187, 212, 223, 383, 450, 560, 585, 891, 900, 1214, 1392, 1432, 1889, 1979, 2136, 2537, 3322, 3330, 3439, 3637, 3716, 3848, 3871, 4059, 4081, 4180, 4187, 4200, 4215, 4236, 4378, 4394, 4467, 4493, 4527, 4620, 4674, 4816, 4886, 5039, 5059, 5076, 5095, 5108], 'several': [17, 213, 3042, 3147], 'amyloid-forming': [18, 214, 558, 729, 2637], 'harbor': [20, 216, 897, 3047, 3070], 'an': [21, 144, 217, 340, 776, 956, 1453, 1630, 2907, 3530, 5121], 'α-helix': [22, 145, 218, 341, 571, 608, 663, 957, 1061, 1226, 1541, 2311, 2344, 2944, 3847], 'in': [23, 49, 118, 126, 135, 219, 245, 314, 322, 331, 416, 419, 461, 485, 565, 607, 612, 728, 735, 826, 1022, 1085, 1089, 1097, 1271, 1275, 1372, 1427, 1441, 1452, 1506, 1674, 1700, 1712, 1734, 1752, 1766, 1885, 1899, 1903, 1975, 1989, 2098, 2118, 2127, 2137, 2183, 2209, 2257, 2266, 2325, 2353, 2413, 2483, 2619, 2661, 2756, 2783, 2797, 2806, 2871, 2876, 2906, 2946, 2953, 3009, 3028, 3075, 3178, 3191, 3263, 3341, 3401, 3462, 3520, 3865, 3874, 4048, 4206, 4256, 4324, 4385, 4391, 4530, 4573, 4656, 4812, 4870, 4877, 4896, 5069, 5100, 5113, 5139], 'a': [24, 30, 105, 177, 220, 226, 301, 373, 938, 943, 1032, 1066, 1138, 1144, 1282, 1323, 1378, 1624, 1682, 1753, 1841, 1878, 1904, 1931, 1968, 2063, 2124, 2131, 2210, 2234, 2267, 2307, 2317, 2542, 2631, 2652, 2665, 2947, 2991, 3004, 3015, 3334, 3443, 3471, 3608, 3632, 3766, 3834, 3845, 3853, 3884, 4076, 4183, 4244, 4482, 4588, 4657, 4724, 4881], 'polypeptide': [25, 221, 898], 'segment': [26, 222, 1132, 2407, 2488, 3188, 3465, 4711], 'should': [28, 224], 'form': [29, 115, 124, 158, 225, 311, 320, 354, 591, 766, 1101, 1154, 1291, 3007, 3398, 3427, 3529, 3654, 3710, 3852, 3898, 4043, 4221, 4260, 4383, 4388, 5182, 5191], 'β-strand': [31, 227, 573, 665, 1228, 1732, 2326, 2346, 4230], 'according': [32, 228, 1822, 1912], 'to': [33, 114, 123, 176, 229, 310, 319, 372, 529, 597, 664, 719, 815, 894, 905, 926, 1082, 1224, 1290, 1321, 1401, 1436, 1823, 1913, 2135, 2296, 2321, 2323, 2335, 2485, 2552, 2580, 2602, 2758, 2829, 3326, 3351, 3387, 3397, 3522, 3528, 3548, 3719, 3843, 3851, 3955, 3965, 3976, 4024, 4042, 4075, 4241, 4266, 4382, 4643, 4720, 4756, 4824, 4858, 4924, 4960, 5056, 5078, 5125, 5152, 5167], 'secondary': [34, 151, 230, 347, 1470, 1534, 1565, 1596, 2299, 2394, 2712, 2973, 3782, 3824, 4662], 'structure': [35, 152, 231, 348, 614, 992, 1471, 1535, 1597, 2132, 2300, 2340, 2713, 2974, 3783, 3796], 'predictions.': [36, 153, 232, 349], '1324': [38, 234, 1272, 1466], 'nonredundant': [39, 235, 1273, 2277, 3815], 'protein': [40, 63, 78, 236, 259, 274, 497, 595, 779, 934, 2157, 2280, 2592, 2702, 3142, 3816, 4263, 4787, 5185, 5189, 5194, 5197], 'structures,': [41, 237, 487], '37': [42, 238, 2162, 2302], 'β-strands': [43, 239, 524, 1086, 1218, 1775, 2841], 'with': [44, 142, 192, 240, 338, 388, 403, 453, 658, 990, 1034, 1137, 1148, 1366, 1395, 1629, 2253, 2282, 2356, 2376, 2400, 2556, 2708, 2888, 2918, 3026, 3378, 3411, 3417, 3448, 3468, 3474, 3699, 3792, 3823, 3860, 3907, 3979, 4217, 4647, 4862, 5066], '≥7': [45, 241], 'residues': [46, 170, 242, 366, 854, 1711, 1727, 2659, 3074, 3148, 3421, 3461, 3639, 3770, 4080, 4110], 'were': [47, 121, 243, 317, 1029, 1393, 1399, 1448, 1477, 1567, 1601, 1749, 1820, 1910, 2085, 2096, 2111, 2159, 2170, 2192, 2207, 2226, 2250, 2262, 2380, 3385, 3395, 3841, 4038, 4641, 4666, 4892, 4931], 'predicted': [48, 244, 1220, 1267, 1602, 2312, 2393, 2711, 2842, 2887, 3527, 3767, 3826, 3850, 4642], 'segments': [50, 246, 899, 2370, 2379, 2419, 2540, 2626, 2779, 2865, 3384, 3414, 3418, 5112, 5130], 'where': [51, 162, 247, 358, 1129, 2817, 2850, 3660, 4223, 4606], 'the': [52, 61, 68, 136, 248, 257, 264, 332, 407, 412, 488, 530, 586, 589, 593, 720, 985, 1035, 1130, 1276, 1329, 1376, 1396, 1402, 1428, 1439, 1442, 1459, 1474, 1480, 1592, 1670, 1693, 1706, 1735, 1856, 1872, 1893, 1946, 1962, 1983, 2015, 2092, 2168, 2184, 2205, 2248, 2357, 2397, 2417, 2486, 2532, 2590, 2620, 2624, 2734, 2759, 2775, 2785, 2795, 2798, 2807, 2815, 2823, 2830, 2834, 2837, 2840, 2851, 2916, 2972, 3029, 3044, 3055, 3138, 3179, 3186, 3220, 3223, 3231, 3254, 3264, 3342, 3358, 3451, 3463, 3523, 3534, 3551, 3571, 3597, 3646, 3760, 3793, 3828, 3959, 3966, 3970, 4070, 4094, 4098, 4194, 4224, 4278, 4327, 4475, 4509, 4533, 4597, 4607, 4669, 4709, 4716, 4728, 4738, 4744, 4752, 4871, 4889, 4968, 4973, 4976, 5046, 5101, 5128, 5140, 5172, 5177], 'experimentally': [53, 148, 249, 344, 1263, 2776, 3794, 3813, 4016, 5173], 'determined': [54, 250, 1264, 2193, 2391, 2709, 2777, 3795, 3814, 4017, 5174], 'structures': [55, 251, 564, 1270, 1566, 1600, 2285, 2395, 2546, 2622, 2884, 2905, 3817, 3825, 5175], 'show': [56, 252, 4058], 'helices.': [57, 253, 1090], 'These': [58, 108, 254, 304, 1211, 3855], 'discordances': [59, 255], 'include': [60, 256, 3857], 'prion': [62, 258, 413, 594, 820, 2591, 4866, 5184, 5188, 5193], '(helix': [64, 260], '2,': [65, 261, 3348, 4715], 'positions': [66, 73, 81, 262, 269, 277, 959, 3703], '179–191),': [67, 263], 'Alzheimer': [69, 265], 'amyloid': [70, 193, 266, 389, 454, 489, 895, 1018, 1231, 1292, 2744, 3008, 3399, 3428, 3656, 3873, 3980, 4044, 4188, 4209, 4334, 4468, 4622, 5042, 5118, 5186], 'β-peptide': [71, 267, 653, 5187], '(Aβ,': [72, 268], '16–23),': [74, 270], 'lung': [76, 272, 3869, 5195], 'surfactant': [77, 273, 933, 5196], 'C': [79, 275, 935, 5198], '(SP-C,': [80, 276], '12–27).': [82, 278], 'addition,': [84, 280], 'human': [85, 281, 819, 2081, 2421, 2727, 3374, 3904, 4027, 4915], 'coagulation': [86, 282, 2082, 3375, 4028], 'factor': [87, 283, 2083, 3182, 3376, 4029], 'XIII': [88, 284, 2084], '(positions': [89, 96, 102, 285, 292, 298, 3888], '258–266),': [90, 286], 'triacylglycerol': [91, 287, 2076, 3368, 4036], 'lipase': [92, 288, 2077, 3369], 'Candida': [94, 290], 'antarctica': [95, 291, 2079, 4035], '256–266),': [97, 293], 'andd-alanyl-d-alanine': [98, 294], 'transpeptidase': [99, 295, 2059, 3260, 3365], 'fromStreptomyces': [100, 296, 2060], 'R61': [101, 297, 2061, 3259], '92–106)': [103, 299], 'contain': [104, 300, 562, 2538, 3844], 'discordant': [106, 137, 302, 333, 2364, 2378, 2402, 2406, 2418, 2487, 2596, 2625, 2701, 2719, 2738, 2920, 3045, 3187, 3265, 3353, 3362, 3383, 3452, 3464, 3524, 3886, 3960, 4095, 4218, 4608, 4710], 'helix.': [107, 303], 'have': [110, 306, 456, 3422, 4610, 4758, 5053], 'not': [111, 157, 307, 353, 760, 823, 830, 857, 1434, 3593, 3653, 3709, 3891, 3897, 4284, 4380, 4471, 4653, 4741], 'been': [112, 308, 717, 2747, 3423, 4271, 4465, 4611, 4759, 5054], 'reported': [113, 309], 'fibrils': [116, 125, 159, 180, 312, 321, 355, 376, 393, 490, 519, 1019, 1025, 3400, 3578, 3582, 3602, 3657, 3664, 3715, 4045, 4189, 4335, 4384, 4389, 5070], 'but': [117, 313, 811, 1100, 3563, 4326, 4479], 'this': [119, 315, 1256, 1745, 5164], 'study': [120, 316], 'found': [122, 147, 318, 343, 718, 2530, 2660, 3013, 3350, 3396, 3842, 4023, 4041, 4760], 'buffered': [127, 323], 'saline': [128, 324], 'at': [129, 325, 1723, 2103, 2113, 2161, 2172, 2186, 2273, 3403, 3588, 3603, 3702, 4051, 4528, 4743, 4880, 4887], 'pH': [130, 326, 2101, 3405, 4053, 4400], '7.4.': [131, 327], 'By': [132, 328], 'replacing': [133, 329], 'valines': [134, 330, 1078], 'helical': [138, 334, 1139, 1151, 2550, 2778, 3475, 4245, 4645, 5114], 'part': [139, 335, 1140, 3344], 'of': [140, 336, 588, 592, 775, 818, 921, 955, 1027, 1062, 1071, 1133, 1141, 1298, 1326, 1363, 1381, 1438, 1455, 1465, 1473, 1489, 1564, 1626, 1633, 1684, 1695, 1709, 1722, 1728, 1755, 1843, 1880, 1933, 1970, 2072, 2105, 2198, 2203, 2213, 2223, 2279, 2289, 2303, 2363, 2408, 2420, 2489, 2545, 2575, 2623, 2655, 2699, 2723, 2736, 2771, 2794, 2839, 2996, 3018, 3140, 3222, 3257, 3345, 3357, 3419, 3450, 3458, 3466, 3537, 3554, 3568, 3586, 3635, 3645, 3762, 3779, 3784, 3797, 3962, 3969, 4073, 4079, 4097, 4108, 4185, 4203, 4232, 4277, 4399, 4403, 4485, 4520, 4591, 4596, 4600, 4630, 4639, 4660, 4677, 4712, 4734, 4754, 4853, 4865, 4873, 4975, 5041, 5050, 5110, 5183, 5192, 5204], 'SP-C': [141, 163, 337, 359, 948, 980, 1015, 1028, 1064, 1093, 1134, 1991, 2019, 2108, 2129, 2179, 2609, 3467, 3526, 3538, 3546, 3870, 4074, 4279, 4512, 4576, 5205], 'leucines,': [143, 339], 'is': [146, 342, 603, 848, 917, 937, 953, 981, 1075, 2410, 2821, 2857, 2988, 3003, 3189, 3261, 3333, 3339, 3519, 3643, 3849, 4065, 4091, 4101, 4178, 4283, 4470, 4500, 4536, 4632, 4718, 4730, 4958], 'by': [150, 346, 605, 946, 1258, 1485, 1591, 1705, 2194, 2215, 2233, 2531, 2664, 2751, 2843, 2847, 3479, 3722, 4068, 4106, 4286, 5064, 5072], 'This': [154, 350, 731, 1280, 1360, 1450, 1530, 2330, 4269, 5037], 'analogue': [155, 351, 2020, 3634, 4580, 5203], 'does': [156, 352, 759, 3652, 3708, 3896], 'under': [160, 356, 3658, 4390, 4495, 4625], 'conditions': [161, 357, 3659, 4393], 'forms': [164, 360, 817, 988, 3576, 3600, 3663, 3714, 3872, 4330, 4864], 'abundant': [165, 361, 3601], 'Likewise,': [167, 363, 4088, 4913], 'when': [168, 364, 4093, 4894], 'Aβ': [169, 365, 2409, 2605, 3863, 4099, 5143], '14–23': [171, 367, 855, 3640], 'are': [172, 181, 190, 368, 377, 386, 401, 451, 491, 520, 829, 856, 924, 1079, 1095, 1219, 1433, 1589, 1690, 1764, 1867, 1883, 1897, 1957, 1973, 1987, 2481, 2731, 2749, 2789, 2812, 2845, 2874, 2923, 2979, 3022, 3717, 3917, 4009, 4182, 4238, 4248, 4253, 4379, 4740, 5098, 5146, 5150], 'removed': [173, 369, 4102], 'or': [174, 370, 467, 576, 1143, 1731, 2115, 2309, 2594, 2754, 2927, 3033, 3050, 3072, 3579, 3913, 4014, 4103, 4310, 5071], 'changed': [175, 371], 'nondiscordant': [178, 374, 4105], 'sequence,': [179, 375, 464], 'no': [182, 378, 457, 713, 3566, 3577], 'longer': [183, 379, 2310], 'formed.': [184, 380], 'propose': [186, 382], 'α-helix/β-strand-discordant': [188, 384], 'stretches': [189, 385, 1721, 2365, 4202], 'associated': [191, 387, 402, 452, 657, 3859, 3978, 4861, 4962], 'fibril': [194, 390, 578, 655, 773, 3436, 4060, 4089, 4210, 4267, 4498, 4524, 4592, 4598, 4623, 5062], 'formation.': [195, 391, 579, 4211, 4268, 4593, 5119], 'Amyloid': [392, 518, 652, 686, 4957], 'can': [394, 771, 4220, 4387, 4679, 4810, 5060], 'be': [395, 1083, 1222, 2324, 2333, 2628, 2696, 3352, 3442, 3956, 3977, 4025, 4191, 4481, 4644, 4819, 4961], 'formed': [396, 3721], 'different': [398, 2187], 'severe': [404], 'diseases': [405, 414, 455, 687, 821, 3981, 4978], 'like': [406, 4397], 'neurodegenerative': [408], 'Creutzfeld-Jakob': [415], 'humans,': [417], 'scrapie': [418, 600, 5190], 'sheep,': [420], 'bovine': [422], 'encephalopathy,': [424], 'as': [425, 427, 1504, 1569, 1692, 2024, 2336, 2388, 2390, 2568, 2570, 2780, 3477, 4587, 5127], 'well': [426, 1080, 2389, 2569], 'other': [428, 3034, 3598, 4510, 4890], 'organ-specific': [429], 'systemic': [431], 'amyloidoses': [432], '(1Kelly': [433, 3982, 4979], 'J.W.': [434, 741, 3983, 4980], 'Curr.': [435, 3984, 4981], 'Opin.': [436, 3985, 4982], 'Struct.': [437, 2961, 3168, 3986, 4983], 'Biol.': [438, 677, 875, 1521, 1615, 1663, 1834, 1924, 2962, 3127, 3169, 3286, 3682, 3741, 3987, 4128, 4160, 4555, 4942, 4984], '1996;': [439, 2473, 3743, 3988, 4162, 4557, 4796, 4985], '6:': [440, 3171, 3989, 4986], '11-17Crossref': [441, 3990, 4987], 'PubMed': [442, 477, 513, 552, 647, 681, 707, 752, 806, 841, 885, 973, 1010, 1055, 1121, 1173, 1206, 1248, 1313, 1355, 1421, 1499, 1525, 1619, 1644, 2009, 2054, 2151, 2456, 2476, 2525, 2646, 2690, 2966, 3093, 3111, 3173, 3215, 3248, 3294, 3316, 3513, 3626, 3692, 3751, 3948, 3991, 4004, 4138, 4170, 4305, 4353, 4372, 4426, 4455, 4565, 4703, 4779, 4804, 4847, 4908, 4952, 4988, 5006, 5032, 5087], 'Scopus': [443, 478, 514, 553, 648, 682, 708, 753, 807, 842, 886, 974, 1011, 1056, 1122, 1174, 1207, 1249, 1314, 1356, 1422, 1500, 1526, 1620, 1645, 2010, 2055, 2152, 2457, 2477, 2526, 2647, 2691, 2967, 3094, 3112, 3134, 3174, 3216, 3249, 3317, 3514, 3627, 3693, 3752, 3949, 3992, 4005, 4139, 4171, 4306, 4354, 4373, 4427, 4456, 4566, 4704, 4780, 4805, 4848, 4909, 4953, 4989, 5007, 5033, 5088], '(568)': [444, 3993, 4990], 'Google': [445, 480, 516, 555, 650, 684, 710, 755, 809, 844, 888, 976, 1013, 1058, 1124, 1176, 1209, 1251, 1316, 1358, 1424, 1502, 1528, 1622, 1647, 1667, 1838, 1928, 2012, 2057, 2154, 2459, 2479, 2528, 2649, 2693, 2969, 3096, 3114, 3136, 3176, 3218, 3251, 3295, 3319, 3516, 3629, 3695, 3754, 3951, 3994, 4007, 4141, 4173, 4308, 4356, 4375, 4429, 4458, 4568, 4706, 4782, 4807, 4850, 4911, 4955, 4991, 5009, 5035, 5090], 'Scholar).': [446, 481, 517, 556, 651, 685, 845, 889, 977, 1014, 1059, 1125, 1210, 1252, 1359, 1529, 1648, 2155, 3296, 3517, 3630, 3696, 3755, 3952, 4376, 4459, 4569, 4707, 4783, 4808, 4851, 4912, 4956, 5036, 5091], 'The': [447, 846, 1060, 1294, 1469, 1687, 1758, 1907, 2156, 2259, 2361, 2404, 2535, 2582, 2729, 2740, 2768, 2791, 2859, 2940, 3011, 3430, 3972, 4228, 4488, 4570, 4732], '∼20': [448], 'obvious': [458], 'common': [459, 4502], 'properties': [460], 'amino': [462, 1671, 1697, 1854, 1944, 2195, 2291, 2385, 2786, 4476], 'acid': [463, 1672, 1698, 1855, 1945, 2196, 2292, 2386, 2705, 2787, 4477], 'three-dimensional': [465, 2284, 4018], 'structure,': [466, 3532, 4663], 'function': [468], '(2Sipe': [469], 'J.D.': [470, 2675, 3997, 5024], 'Annu.': [471, 3998], 'Rev.': [472, 3999], 'Biochem.': [473, 503, 1116, 1168, 1202, 2050, 3244, 3509, 4000, 4996], '1992;': [474, 678, 1310, 3090, 3245, 4001], '61:': [475, 4002], '947-975Crossref': [476, 4003], '(408)': [479, 4006], 'Despite': [482], 'these': [483, 922, 1586, 1718, 2304, 2880, 3757, 4233, 4461, 4531, 4735, 5111], 'differences': [484, 3543], 'very': [492, 1067, 2133], 'similar': [493, 2134, 3718], 'irrespective': [494], 'which': [496, 1074, 1217, 2128, 2743, 2784, 2987, 3002, 4251, 4888], 'they': [498, 4237], 'originate': [499], '(3Dobson': [500], 'C.M.': [501, 542, 795, 2959, 3937, 4415, 4444, 4994], 'Trends': [502, 4995], 'Sci.': [504, 640, 700, 745, 1006, 1309, 1414, 2449, 2518, 2683, 3107, 4301, 4349, 4419, 4448, 4696, 4997], '1999;': [505, 549, 704, 838, 877, 1052, 1245, 2687, 3170, 3623, 3684, 4130, 4369, 4452, 4905, 4998, 5084], '24:': [506, 4999], '329-332Abstract': [507, 5000], 'Full': [508, 510, 880, 882, 3131, 3291, 3687, 3689, 3746, 3748, 4133, 4135, 4165, 4167, 4560, 4562, 4799, 4801, 4947, 4949, 5001, 5003], 'Text': [509, 511, 881, 883, 3132, 3292, 3688, 3690, 3747, 3749, 4134, 4136, 4166, 4168, 4561, 4563, 4800, 4802, 4948, 4950, 5002, 5004], 'PDF': [512, 884, 3133, 3293, 3691, 3750, 4137, 4169, 4564, 4803, 4951, 5005], '(1692)': [515, 5008], 'built': [521], 'up': [522], 'perpendicular': [525], 'β-sheets': [527, 4261], 'parallel': [528], 'fiber': [531], 'axis': [532], '(4Jiménez': [533], 'J.L.': [534], 'Guijarro': [535], 'J.I.': [536, 4407], 'Orlova': [537], 'E.': [538, 1047, 1185, 1240, 2033, 3492, 3618, 4318, 4364], 'Zurdo': [539], 'J.': [540, 548, 620, 675, 871, 874, 962, 1004, 1043, 1045, 1049, 1105, 1117, 1157, 1169, 1189, 1199, 1201, 1236, 1238, 1242, 1336, 1519, 1613, 1998, 2037, 2047, 2049, 2141, 2673, 3195, 3197, 3243, 3285, 3496, 3506, 3508, 3614, 3616, 3620, 3678, 3681, 3727, 3731, 3735, 3740, 4124, 4127, 4146, 4150, 4154, 4159, 4299, 4316, 4321, 4347, 4360, 4362, 4366, 4541, 4545, 4549, 4554, 4830, 4941, 5012, 5025], 'Dobson': [541, 794, 3936, 4414, 4443], 'Sunde': [543, 782, 3924, 4408], 'M.': [544, 618, 622, 783, 1041, 1181, 1234, 1303, 1518, 2029, 2439, 2467, 3162, 3166, 3199, 3304, 3488, 3612, 3925, 4358, 4409, 4440], 'Saibil': [545], 'H.R.': [546], 'EMBO': [547], '18:': [550], '815-821Crossref': [551], '(445)': [554], 'Thus,': [557, 3408], 'mainly': [561, 2981], 'α-helical': [563, 979, 3531], 'must': [569], 'undergo': [570, 906, 927, 1225], '→': [572, 725, 908, 929, 1227, 2017, 3911, 3915, 4514, 5200], 'conversions': [574, 910], 'before': [575], 'during': [577, 3550, 3570, 4972], 'Tinctorial': [580], 'spectroscopic': [582], 'studies': [583, 2091, 4462], 'indicate': [584, 4235, 4492], 'conversion': [587, 666, 727, 732, 4753], 'cellular': [590, 738, 5181], '(PrPC)1': [596], 'its': [598, 2997, 4578], 'fibrillar': [599], 'counterpart': [601], '(PrPSc)': [602], 'accompanied': [604], 'reduction': [606], 'content': [609], 'increase': [611], 'β-sheet': [613, 991, 4331], '(5Pan': [615], 'K.M.': [616], 'Baldwin': [617, 4685, 4763, 4835], 'Nguyen': [619], 'Gasset': [621], 'Serban': [623], 'A.': [624, 643, 670, 703, 748, 863, 1417, 2428, 2452, 2521, 2686, 3160, 3670, 4116, 4422, 4438, 4451, 4699], 'Groth': [625, 2507, 4833], 'D.': [626, 2508, 4834], 'Mehlhorn': [627, 2509, 4831], 'I.': [628, 2510, 4832], 'Huang': [629], 'Z.': [630, 1338, 4682], 'Fletterick': [631, 4687], 'R.J.': [632, 4688], 'Cohen': [633, 2513, 4691, 4841], 'F.E.': [634, 2514, 4692, 4842], 'Prusiner': [635, 2511, 4689, 4773, 4837], 'S.B.': [636, 2512, 4690, 4774, 4838], 'Proc.': [637, 697, 742, 1411, 2446, 2515, 2680, 4416, 4445, 4693], 'Natl.': [638, 698, 743, 1412, 2447, 2516, 2681, 4417, 4446, 4694], 'Acad.': [639, 699, 744, 1413, 2448, 2517, 2682, 4418, 4447, 4695], 'U.': [641, 701, 746, 1301, 1415, 2450, 2519, 2684, 4420, 4449, 4697], 'S.': [642, 702, 747, 834, 865, 1416, 2451, 2463, 2500, 2520, 2685, 3204, 3206, 3302, 3672, 4118, 4421, 4450, 4698, 4901], '1993;': [644, 1616, 4776], '90:': [645], '10962-10966Crossref': [646], '(2063)': [649], '(Aβ)': [654], 'formation': [656, 774, 1099, 1232, 2745, 2945, 3437, 4061, 4085, 4090, 4469, 4499, 4599, 4624, 5043, 5063], 'also': [661, 2411, 4057, 4494], 'involves': [662, 4789], '(6Barrow': [667], 'C.J.': [668], 'Yasuda': [669], 'Kenny': [671], 'P.T.': [672, 696], 'Zagorski': [673], 'M.G.': [674], 'Mol.': [676, 1520, 1614, 1662, 1833, 1923], '225:': [679], '1075-1093Crossref': [680], '(607)': [683], 'mostly': [688], 'occur': [689, 734], 'without': [690, 1869, 1959], 'known': [691, 1081, 2283, 2587, 3975, 4381, 4742], 'precipitating': [692], 'factors': [693], '(7Lansbury': [694], 'Jr.,': [695], '96:': [705, 2688, 4453], '3342-3344Crossref': [706], '(512)': [709], 'Scholar),': [711, 756, 810, 1425, 1503, 1623, 2970], 'explanation': [714], 'has': [715, 2746, 4226, 4270, 4464], 'yet': [716], 'occurrence': [721, 5047], 'ofde': [722], 'novo': [723], 'α': [724, 907, 928], 'β': [726, 909, 930, 1551, 4012], 'proteins.': [730, 913, 1468, 1686, 1757, 2984], 'may': [733, 896, 1221, 3441, 4613, 4818, 5044], 'partially': [736], 'denaturing': [737], 'environments': [739], '(8Kelly': [740], '1998;': [749, 1007, 1203, 2051, 2643, 3108, 3212, 3313, 3510, 4302, 4350, 4423, 4944], '95:': [750, 4424], '930-932Crossref': [751], '(117)': [754], 'which,': [757], 'however,': [758], 'explain': [761], 'why': [762], 'only': [763, 2374, 2818, 3580], 'certain': [764], 'amyloid.': [767, 3899], 'Destabilizing': [768], 'point': [769, 812, 3908, 4855], 'mutations': [770, 813, 4519], 'cause': [772], 'otherwise': [777], 'stable': [778], '(9Booth': [780, 3922], 'D.R.': [781, 3923], 'Bellotti': [784, 3926], 'V.': [785, 3105, 3927, 5014], 'Robinson': [786, 3928], 'C.V.': [787, 3929], 'Hutchinson': [788, 3930], 'W.L.': [789, 3931], 'Fraser': [790, 3932], 'P.E.': [791, 1348, 3933], 'Hawkins': [792, 3934], 'P.N.': [793, 3935], 'Radford': [796, 3938], 'S.E.': [797, 3939], 'Blake': [798, 3940], 'C.C.F.': [799, 3941], 'Pepys': [800, 3942], 'M.B.': [801, 3943], 'Nature.': [802, 2472, 3089, 3211, 3944, 5083], '1997;': [803, 2522, 3945, 4844], '385:': [804, 3946], '787-793Crossref': [805, 3947], '(972)': [808, 3950], 'related': [814], 'inherited': [816, 4863], 'do': [822], 'induce': [824], 'PrPSc': [825, 4757], 'vitro': [827, 4392], 'generally': [831], 'destabilizing': [832], '(10Liemann': [833, 4900], 'Glockshuber': [835, 2468, 4902], 'R.': [836, 1109, 1161, 1305, 1516, 2426, 2432, 2461, 2469, 3084, 3086, 3156, 3300, 3306, 4794, 4903, 5016], 'Biochemistry.': [837, 969, 2005, 4775, 4843, 4904], '38:': [839, 4906], '3258-3267Crossref': [840, 4907], '(295)': [843, 4910], 'Aβ-(1–42)-peptide': [847], 'highly': [849], 'fibrillogenic,': [850], 'whereas': [851, 3712, 4634, 4926], 'peptides': [852, 1094, 1128, 2551, 2663, 5080], 'lacking': [853], '(11Tjernberg': [858, 3665, 4111], 'L.O.': [859, 3666, 3725, 4112, 4144, 4539], 'Callaway': [860, 3667, 4113], 'D.J.': [861, 1410, 3668, 4114, 5082], 'Tjernberg': [862, 3669, 4115, 5159], 'Hahne': [864, 3671, 4117], 'Lilliehook': [866, 3673, 4119], 'C.': [867, 873, 1307, 1494, 1612, 1639, 2435, 3164, 3371, 3674, 3680, 3739, 4034, 4120, 4126, 4158, 4553], 'Terenius': [868, 3675, 3736, 4121, 4155, 4550], 'L.': [869, 2441, 3676, 3737, 4122, 4156, 4551, 4768], 'Thyberg': [870, 1042, 1235, 3613, 3677, 3734, 4123, 4153, 4359, 4548], 'Nordstedt': [872, 3679, 3738, 4125, 4157, 4552], 'Chem.': [876, 3126, 3287, 3683, 3742, 4129, 4161, 4556, 4943], '274:': [878, 3685, 4131], '12619-12625Abstract': [879, 3686, 4132], '(330)': [887, 3694, 4140], 'Proteins': [890, 1490, 4377], 'give': [892], 'rise': [893, 4923], 'make': [901], 'them': [902], 'more': [903, 4501, 4615], 'prone': [904, 1223, 4823], 'than': [911, 1368, 4247, 4503, 4885], 'nonamyloidogenic': [912], 'A': [914, 2276, 3143], 'key': [915], 'question': [916], 'whether': [918, 3958], 'specific': [919, 5134], 'helices': [920, 1155, 2796, 3046, 4219, 4252, 4609, 4635, 5097], 'predisposed': [925], 'conversions.': [931], 'Lung': [932], '(SP-C)': [936], '35-residue': [939], 'lipopeptide': [940], 'derived': [941, 1875, 1965, 2989], 'larger': [944], 'precursor': [945, 2998], 'proteolysis.': [947], 'isolated': [949, 1030, 1550], 'natural': [951], 'sources': [952], 'composed': [954, 1026, 4078], 'covering': [958], '9–34': [960], '(12Johansson': [961, 1997], 'Szyperski': [963, 1999, 2142], 'T.': [964, 966, 994, 998, 1115, 1167, 1197, 2000, 2002, 2045, 2143, 2430, 3504, 4289, 4293, 4337, 4341], 'Curstedt': [965, 997, 1114, 1166, 1196, 2001, 2044, 3503, 4292, 4340], 'Wüthrich': [967, 1001, 2003, 2144, 2444, 2470, 4296, 4344, 5155], 'K.': [968, 1002, 2004, 2145, 2445, 2471, 2506, 3310, 4297, 4345], '1994;': [970, 1522, 1641, 2006, 2963, 4700], '33:': [971, 2007], '6015-6023Crossref': [972, 2008], '(176)': [975, 2011, 4954], 'Monomeric': [978], 'thermodynamically': [982], 'unstable,': [983], 'peptide': [986, 4063, 4100, 4328], 'irreversibly': [987], 'aggregates': [989, 1103, 4332], '(13Szyperski': [993, 4288, 4336], 'Vandenbussche': [995, 1182, 2030, 3489, 4290, 4338], 'G.': [996, 1107, 1159, 1179, 1183, 1340, 2027, 2031, 2443, 2465, 3202, 3308, 3486, 3490, 4291, 4339, 4442], 'Ruysschaert': [999, 1192, 2040, 3499, 4294, 4342], 'J.-M.': [1000, 1193, 2041, 3500, 4295, 4343, 4684], 'Johansson': [1003, 1048, 1198, 1241, 2046, 3505, 3619, 3730, 4149, 4298, 4346, 4365, 4544], 'Protein': [1005, 1277, 1308, 1481, 1736, 2760, 2799, 2824, 3106, 3820, 4300, 4348, 5178], '7:': [1008, 3109, 4303, 4351], '2533-2540Crossref': [1009, 4304, 4352], '(69)': [1012, 4307, 4355], 'assembles': [1016], 'upon': [1020, 4046], 'incubation': [1021, 3555, 3587, 4047], 'solution,': [1023], 'patient': [1033], 'pulmonary': [1037, 3875], 'alveolar': [1038, 3876], 'proteinosis': [1039, 3877], '(14Gustafsson': [1040, 1233, 3611], 'Näslund': [1044, 1237, 3615, 3726, 4145, 4361, 4540], 'Eliasson': [1046, 1239, 3617, 4363], 'FEBS': [1050, 1243, 2146, 2641, 3311, 3621, 4367], 'Lett.': [1051, 1244, 2147, 2642, 3312, 3622, 4368], '464:': [1053, 1246, 3624, 4370], '138-142Crossref': [1054, 1247, 3625, 4371], '(96)': [1057, 1250, 3628, 4374], 'mature': [1063], 'contains': [1065, 3146, 3883], 'long': [1068, 2700, 3361, 4201], 'continuous': [1069], 'stretch': [1070, 3648, 4072, 4096], 'valine': [1072, 3460], 'residues,': [1073], 'unusual': [1076], 'since': [1077, 1585], 'overrepresented': [1084], 'underrepresented': [1088], 'Intriguingly,': [1091, 3756], 'synthetic': [1092, 3633], 'inefficient': [1096], 'helix': [1098, 1571, 1729, 2603, 3078, 3139, 3221, 3266, 3347, 3768, 3887, 3961, 4077, 4084, 4225, 4280, 4670, 4714, 4721, 4874, 4920], 'insoluble': [1102], '(15Johansson': [1104, 1156], 'Nilsson': [1106, 1158], 'Strömberg': [1108, 1160], 'Robertson': [1110, 1162, 1194, 2042, 3501], 'B.': [1111, 1163, 1195, 1610, 1637, 2043, 3208, 3280, 3502], 'Jörnvall': [1112, 1164], 'H.': [1113, 1165, 1344, 2496, 2502, 3278, 4828], '1995;': [1118, 1170, 2148, 3128], '307:': [1119, 1171], '535-541Crossref': [1120, 1172], '(87)': [1123, 1175], 'contrast,': [1127], 'polyvaline': [1131, 4513], 'was': [1135, 1318, 1383, 1992, 2022, 2062, 2240, 2294], 'replaced': [1136], 'bacteriorhodopsin': [1142, 3227], 'polyleucine': [1145, 4515, 4579], 'stretch,': [1146], 'both': [1147, 3918, 4646], 'high': [1149, 2889, 4229], 'statistical': [1150], 'propensities,': [1152], 'readily': [1153, 3662], 'Scholar,': [1177, 3097, 3115, 3995, 4142, 4430, 4992, 5010], '16Nilsson': [1178], 'Gustafsson': [1180, 2028, 3487], 'Veldhuizen': [1184, 2032, 3491], 'Griffiths': [1186, 2034, 3493], 'W.J.': [1187, 2035, 3494], 'Sjövall': [1188, 2036, 3495], 'Haagsman': [1190, 2038, 3497], 'H.P.': [1191, 2039, 3498], 'Eur.': [1200, 2048, 3242, 3507], '255:': [1204, 2052, 3511], '116-124Crossref': [1205, 2053, 3512], '(84)': [1208, 2056, 3515], 'features': [1212], 'suggest': [1213, 4199, 5094], 'α-helices': [1215, 1265, 1701, 1713, 1772], 'for': [1216, 1260, 1389, 1595, 1771, 1850, 1940, 2164, 2176, 2219, 2298, 2368, 2396, 2636, 2715, 2742, 2765, 2854, 2863, 2943, 3150, 3389, 3801, 3827, 4250, 4273, 4668, 4737, 4751, 5104, 5160, 5170], 'transition': [1229], 'Here': [1253, 1561], 'we': [1254], 'tested': [1255], 'hypothesis': [1257], 'searching': [1259], 'discrepancies': [1261], 'between': [1262, 1285, 1892, 1982, 3432, 3769, 4575], 'extended': [1268, 1547], '(β-strand)': [1269], 'entries': [1274, 2802, 2827], 'Data': [1278, 1482, 1737, 2761, 2800, 2825, 3821, 5179], 'Bank.': [1279, 5180], 'revealed': [1281], 'striking': [1283, 3542], 'correlation': [1284, 3431], 'α/β': [1286, 2558, 3433], 'discordance': [1287, 3434, 3761, 4205], 'ability': [1289], 'May': [1295, 1397, 1443, 1739], '1999': [1296, 1386, 1430], 'list': [1297, 1361, 1398], 'PDB_SELECT': [1299, 1382], '(17Hobohm': [1300], 'Scharf': [1302], 'Schneider': [1304], 'Sander': [1306, 1493, 1611, 1638], '1:': [1311, 2964], '409-417Crossref': [1312], '(774)': [1315], 'Scholar)': [1317, 1668, 2013, 2480, 2529, 2650, 2694, 3320, 4008, 4174, 4309], 'initially': [1319], 'used': [1320, 1568, 1594, 2977], 'obtain': [1322], 'nonhomologous': [1324, 1467], 'set': [1325, 1431, 1444, 1462, 1683, 1741, 1754, 1842, 1879, 1932, 1969, 2278, 2583], 'Brookhaven': [1330], 'data': [1331, 1403, 1461, 1740, 1895, 1985, 3031, 3890, 4195], 'base': [1332], '(18Berman': [1333], 'H.M.': [1334], 'Westbrook': [1335], 'Feng': [1337], 'Gilliland': [1339], 'Bhat': [1341], 'T.N.': [1342], 'Weissig': [1343], 'Shindyalov': [1345], 'I.N.': [1346], 'Bourne': [1347], 'Nucleic': [1349], 'Acids': [1350], 'Res.': [1351], '2000;': [1352, 2453, 5029], '28:': [1353], '235-242Crossref': [1354], '(26946)': [1357], 'consists': [1362], '1106': [1364], 'sequences': [1365, 2281, 2387, 2788], 'less': [1367, 4239], '25%': [1369], 'residue': [1370, 1699, 2856, 2869], 'identity': [1371], 'pairwise': [1373], 'comparisons.': [1374], 'During': [1375], 'project': [1377], 'new': [1379, 1905], 'version': [1380], 'released': [1384], '(November': [1385], 'set),': [1387], 'completeness,': [1390], 'nonoverlapping': [1394], 'added': [1400], 'set.': [1404], 'Using': [1405], 'FASTA': [1406], '(19Pearson': [1407], 'W.R.': [1408], 'Lipman': [1409], '1988;': [1418], '85:': [1419], '2444-2448Crossref': [1420], '(9362)': [1423], 'November': [1429], 'homologous': [1435], 'any': [1437], '(expect': [1445], 'value': [1446], '>0.1)': [1447], 'selected.': [1449], 'resulted': [1451, 4876], 'addition': [1454, 2484, 2757], '218': [1456], 'proteins,': [1457, 1846, 1936, 2287, 2567, 4602], 'final': [1460], 'thus': [1463, 3642], 'consisted': [1464], 'elements': [1472, 2714], 'selected': [1475], 'extracted': [1478], 'Bank': [1483, 1738, 2762, 2801, 2826, 3822], 'files': [1484], 'Defined': [1486], 'Secondary': [1487, 1599, 2339], 'Structure': [1488], '(20Kabsch': [1491], 'W.': [1492, 2671, 3080, 3088, 4315, 4934], 'Biopolymers.': [1495], '1983;': [1496], '22:': [1497], '2577-2637Crossref': [1498], '(12173)': [1501], 'implemented': [1505], 'ICM': [1507], '(version': [1508], '2.7,': [1509], 'Molsoft': [1510], 'LLC,': [1511], 'San': [1512], 'Diego,': [1513], 'CA)': [1514], '(21Abagyan': [1515], 'Totrov': [1517], '235:': [1523], '983-1002Crossref': [1524], '(803)': [1527], 'method': [1531, 1593], 'defines': [1532], 'eight': [1533, 4854], 'classes': [1536, 1563, 1588], 'hydrogen': [1538], 'bond': [1539], 'patterns:': [1540], '(H),': [1542], '310-helix': [1543], '(G),': [1544], 'π-helix': [1545], '(I),': [1546], 'strand': [1548, 1576], '(E),': [1549, 1577], 'bridge': [1552], '(B),': [1553], 'turn': [1554], '(T),': [1555], 'bend': [1556], '(S),': [1557], 'coil': [1559], '(_).': [1560], 'three': [1562, 1587, 2094, 2585, 3393, 4109], 'follows:': [1570], '(H,': [1572], 'G,': [1573], 'I),': [1575], 'loop': [1579], '(B,': [1580], 'T,': [1581], 'S,': [1582], '_),': [1584], 'employed': [1590], 'prediction.': [1598, 2301], 'using': [1603, 1720, 3831], 'PHD': [1604, 2297, 2358, 2844, 3832, 4648], '(Profile': [1605], 'network': [1606, 5207], 'HeiDelberg)': [1608], '(22Rost': [1609], '232:': [1617], '584-599Crossref': [1618], '(2639)': [1621], 'system': [1625], 'neural': [1627], 'networks': [1628], 'overall': [1631], 'accuracy': [1632], 'about': [1634], '72%': [1635], '(23Rost': [1636], 'Proteins.': [1640], '19:': [1642], '55-77Crossref': [1643], '(1337)': [1646], '1978,': [1650], 'Chou': [1651], 'Fasman': [1653, 1656, 1827, 1917], '(24Chou': [1654], 'P.Y.': [1655, 1826, 1916], 'G.D.': [1657, 1828, 1918], 'Adv.': [1658, 1829, 1919], 'Enzymol.': [1659, 1830, 1920], 'Relat.': [1660, 1831, 1921], 'Areas': [1661, 1832, 1922], '1978;': [1664, 1835, 1925], '47:': [1665, 1836, 1926], '45-148PubMed': [1666, 1837, 1927], 'calculated': [1669, 1821, 1863, 1911, 1953], 'distributions': [1673], 'helices,': [1675, 3363], 'Pα,': [1676], 'β-strands,': [1678], 'Pβ,': [1679], 'based': [1680, 2342, 2980], 'on': [1681, 2228, 2316, 2343, 2599, 2982, 3596, 4474, 4617, 5163], '29': [1685, 1881, 1971], 'P': [1688, 1887, 1977], 'values': [1689, 1719, 1763, 1770, 1819, 1861, 1874, 1888, 1909, 1951, 1964, 1978, 2348], 'defined': [1691], 'frequency': [1694, 1708], 'each': [1696, 1853, 1943, 2772, 2855, 2872], '(or': [1702, 1714], 'β-strands)': [1703, 2886], 'divided': [1704], 'average': [1707], 'all': [1710, 2716, 2766, 3426, 3459, 4011], 'β-strands).': [1715], 'recalculated': [1717], 'least': [1724, 4529], 'five': [1725, 2922], 'consecutive': [1726], '(H)': [1730], '(E)': [1733], 'described': [1742, 2025, 3800], 'above.': [1743], 'For': [1744, 1852, 1942, 2089, 2201, 3053], 'purpose': [1746], 'transmembrane': [1747, 3005], 'removed,': [1750], 'resulting': [1751, 1759], '1091': [1756, 1844, 1865, 1934, 1955], 'Pα': [1760, 1858, 1948], 'Pβ': [1762, 1860, 1950], 'given': [1765, 1868, 1884, 1958, 1974, 2764, 2875], 'Table': [1767], 'I.Table': [1768], 'IPropensity': [1769], '(Pα)': [1773], '(Pβ)Amino': [1776], 'acidPαPβA1.46': [1777], '(1.42)0.78': [1778], '(0.83)C0.75': [1779], '(0.70)1.26': [1780], '(1.19)D0.83': [1781], '(1.01)0.51': [1782], '(0.54)E1.37': [1783], '(1.51)0.69': [1784], '(0.37)F0.97': [1785], '(1.13)1.49': [1786], '(1.38)G0.43': [1787], '(0.57)0.69': [1788], '(0.75)H0.90': [1789], '(1.00)1.05': [1790], '(0.87)I1.07': [1791], '(1.08)1.65': [1792], '(1.60)K1.14': [1793], '(1.16)0.78': [1794], '(0.74)L1.36': [1795], '(1.21)1.13': [1796], '(1.30)M1.25': [1797], '(1.45)1.10': [1798], '(1.05)N0.72': [1799], '(0.67)0.64': [1800], '(0.89)P0.40': [1801], '(0.57)0.32': [1802], '(0.55)Q1.34': [1803], '(1.11)0.82': [1804], '(1.10)R1.24': [1805], '(0.98)0.88': [1806], '(0.93)S0.76': [1807], '(0.77)0.88': [1808], '(0.75)T0.76': [1809], '(0.83)1.21': [1810], '(1.19)V0.94': [1811], '(1.06)1.89': [1812], '(1.70)W1.05': [1813], '(1.08)1.39': [1814], '(1.37)Y0.95': [1815], '(0.69)1.47': [1816], '(1.47)The': [1817], 'propensity': [1818, 1908, 2347], 'Ref.': [1824, 1914], '24Chou': [1825, 1915], 'Scholar': [1839, 1929], 'non-redundant': [1845, 1935], 'see': [1847, 1937], '“Experimental': [1848, 1938], 'Procedures”': [1849, 1939], 'details.': [1851, 1941], 'updated': [1857, 1947], 'now': [1862, 1952, 3349, 4022, 5147], 'parentheses,': [1870, 1960], 'while': [1871, 1961], 'corresponding': [1873, 1963, 2601, 4857, 4977], 'originally': [1876, 1966], 'parentheses.': [1886, 1976], 'differ': [1890, 1980, 2950], '≥0.15': [1891, 1981], 'two': [1894, 1984, 3449, 3901], 'sets': [1896, 1986], 'written': [1898, 1988], 'bold.': [1900, 1990], 'Open': [1901], 'table': [1902], 'tab': [1906], 'purified': [1993], 'porcine': [1995], 'lungs': [1996], 'poly(Val': [2016], 'Leu)-substituted': [2018], '(SP-C(Leu))': [2021], 'synthesized': [2023], '(16Nilsson': [2026, 3485], 'Scholar).d-Alanyl-d-alanine': [2058], 'kind': [2064], 'gift': [2065], 'Drs.': [2067], 'Frère': [2068], 'Joris,': [2070], 'University': [2071], 'Liege,': [2073], 'Belgium,': [2074], 'fromCandida': [2078], 'purchased': [2086], 'Sigma.': [2088], 'fibrillation': [2090, 3390, 4534, 5102], 'latter': [2093], 'dissolved': [2097, 2112], 'phosphate-buffered': [2099], 'saline,': [2100], '7.4,': [2102], 'concentrations': [2104], '10–100': [2106], 'μm.': [2107], 'SP-C(Leu)': [2110, 2181, 3518, 3540, 3564, 3575], '100': [2114, 3604], '250': [2116, 3589], 'μm': [2117, 3590, 3605], 'chloroform/methanol/0.1m': [2119], 'HCl,': [2120], '32:64:5': [2121], '(by': [2122], 'volume),': [2123], 'solvent': [2125], 'mixture': [2126], 'retains': [2130], 'phospholipid': [2138], 'bilayers': [2139], '(25Johansson': [2140], '362:': [2149], '261-265Crossref': [2150], '(65)': [2153], 'solutions': [2158, 2169], 'incubated': [2160], '°C': [2163], '3': [2165, 2870, 3584, 4638, 4722], 'days;': [2166], 'thereafter': [2167], 'centrifuged': [2171], '20,000': [2173], '×': [2174], 'g': [2175], '20': [2177, 3707], 'min.': [2178], 'contents': [2182], 'supernatants': [2185], 'time': [2188], 'points': [2189], 'after': [2190, 2242, 2246, 2733, 3560, 3583, 3607], 'solubilization': [2191], 'analysis': [2197], 'triplicate': [2199], 'samples.': [2200], 'analyses': [2202], 'fibrils,': [2204, 3711], 'pellets': [2206], 'suspended': [2208], 'small': [2211, 5132], 'volume': [2212], 'water': [2214], 'low': [2216, 2895], 'energy': [2217], 'sonication': [2218], '5': [2220], 's.': [2221], 'Aliquots': [2222], '8': [2224], 'μl': [2225], 'placed': [2227], 'electron': [2229, 2270], 'microscopy': [2230], 'grids': [2231, 2249, 2261], 'covered': [2232], 'carbon-stabilized': [2235], 'Formvar': [2236], 'film.': [2237], 'Excess': [2238], 'fluid': [2239], 'withdrawn': [2241], '30': [2243], 's,': [2244], 'air-drying': [2247], 'negatively': [2251], 'stained': [2252, 2260], '2%': [2254], 'uranyl': [2255], 'acetate': [2256], 'water.': [2258], 'examined': [2263], 'photographed': [2265], 'Philips': [2268], 'CM120TWIN': [2269], 'microscope': [2271], 'operated': [2272], '80': [2274], 'kV.': [2275], '(1324': [2286], 'total': [2288], '269,058': [2290], 'residues)': [2293], 'submitted': [2295], 'contained': [2306], '7-residue': [2308], '(reliability': [2313], 'index': [2314, 2853], '≥5': [2315], 'scale': [2318], '1': [2320, 2613, 3038, 3879, 4636], '9)': [2322], 'conformation': [2327, 3476, 4246, 5115], '(Fig.': [2328, 2371, 3354, 3406, 3544, 4054, 4086, 4175, 4506, 4581], '1).': [2329], 'discrepancy': [2331], 'will': [2332], 'referred': [2334], 'α-helix/β-strand': [2337, 4204], 'discordance.': [2338], 'predictions': [2341], '(Table': [2349], 'I)': [2350], 'gave': [2351, 4922], 'results': [2352, 2359, 4665, 5093], 'excellent': [2354], 'agreement': [2355], '(Fig.2).': [2360], 'number': [2362, 2820, 4184], 'increases': [2366], 'steeply': [2367], '≤6-residue': [2369], '1),': [2372], '≥7-residue': [2377, 2919, 3846], 'analyzed': [2381], 'further.': [2382], 'Fig.': [2383, 2414, 3650], '2shows': [2384], '17': [2398], '≥9-residue': [2401, 2718], 'segments.': [2403, 2703], '8-residue': [2405], 'included': [2412], '2.': [2415], 'Moreover,': [2416, 3697], 'mouse': [2423, 4898], 'PrP': [2424, 2492, 3323, 3346, 3858, 4631, 4640, 4661, 4678, 4713, 4809, 5145], '(26Zahn': [2425], 'Liu': [2427, 2495], 'Luhrs': [2429], 'Riek': [2431, 3305], 'von': [2433], 'Schroetter': [2434], 'Garcia': [2436], 'F.': [2437, 3729, 4148, 4432, 4543], 'Billeter': [2438, 2466, 3303], 'Calzolai': [2440], 'Wider': [2442, 2464, 3307], '97:': [2454], '145-150Crossref': [2455], '(942)': [2458], 'Scholar,27Riek': [2460], 'Hornemann': [2462, 3301], '382:': [2474], '180-182Crossref': [2475], '(1121)': [2478], 'shown,': [2482], 'Syrian': [2490], 'hamster': [2491], '(28James': [2493], 'T.L.': [2494, 4840], 'Ulyanov': [2497], 'N.B.': [2498], 'Farr-Jones': [2499], 'Zhang': [2501], 'Donne': [2503], 'D.G.': [2504], 'Kaneko': [2505], '94:': [2523], '10086-10091Crossref': [2524], '(429)': [2527], 'initial': [2533], 'search.': [2534], 'α/β-discordant': [2539, 3413, 3647, 4071, 4601, 5096, 5129], 'represent': [2541, 2903, 5131], 'wide': [2543], 'selection': [2544], '(ranging': [2547, 2577], 'single': [2549], 'large': [2553], 'globular': [2554], 'complex': [2557], 'architectures),': [2559], 'localizations': [2560, 5138], '(nuclear,': [2561], 'cytosolic,': [2562], 'integral': [2563, 2924], 'peripheral': [2565], 'membrane': [2566, 2925, 2948], 'extracellular': [2571], 'proteins),': [2572], 'species': [2574, 4258], 'origin': [2576], 'virus': [2579], 'human).': [2581], 'encompasses': [2584], 'previously': [2586, 4504], 'amyloidogenic': [2588, 3921, 3967, 5079], 'proteins,i.e.': [2589], '(13-': [2593], '15-residue': [2595], 'segment,': [2597, 2873], 'depending': [2598], 'species,': [2600], '2),': [2604], '(8-residue': [2606], 'segment),': [2607], '(16-residue': [2610], 'segment)': [2611], '(Figs.': [2612, 3037, 3878], '2).': [2615, 3040, 3355, 3881], 'No': [2616, 4746], 'consensus': [2617, 2634], 'pattern': [2618, 2654], 'primary': [2621], 'could': [2627, 2695, 4190, 4259, 4480, 5116], 'detected.': [2629], 'Neither': [2630], 'recently': [2632], 'proposed': [2633], 'sequence': [2635, 2792, 4478], '(29Kurochkin': [2639], 'I.G.': [2640], '427:': [2644], '153-156Crossref': [2645], '(73)': [2648], 'nor': [2651], 'binary': [2653], 'hydrophobic': [2656], 'hydrophilic': [2658], 'fibrillating': [2662], 'combinatorial': [2666], 'approach': [2667, 5122], '(30West': [2668], 'M.W.': [2669], 'Wang': [2670], 'Patterson': [2672], 'Mancias': [2674], 'Beasley': [2676], 'J.R.': [2677, 3270], 'Hecht': [2678], 'M.H.': [2679], '11211-11216Crossref': [2689], '(318)': [2692], 'observed.Figure': [2697], '2Characteristics': [2698], 'Amino': [2704], 'sequences,': [2706], 'together': [2707], 'identified': [2717, 2750], 'segments,': [2720, 2921], 'those': [2722, 2952, 3720], 'Aβ,': [2724, 2935, 2986, 3763], 'mouse,': [2725], 'PrP.': [2728], 'grouped': [2732], 'length': [2735], 'stretch.': [2739], 'demonstrated': [2748], 'full': [2752], 'names': [2753], 'abbreviations,': [2755], 'codes': [2763], 'entries.': [2767], 'bottom': [2769], 'row': [2770], 'case': [2773], 'shows': [2774, 3324, 3541, 3557, 3565], 'blue': [2781], 'cylinders': [2782], 'given.': [2790, 2813], 'locations': [2793, 2838], '(upper': [2803], 'numbers)': [2804, 2811], 'full-length': [2808, 2831], '(lower': [2810], 'cases': [2816, 3043, 4532, 4786], 'one': [2819], 'given,': [2822], 'correspond': [2828], 'protein.': [2832], 'middle': [2835, 4872], 'row,': [2836], 'visualized': [2846], 'yellow': [2848], 'strands,': [2849], 'reliability': [2852], 'shown.': [2858], 'propensity-based': [2860], 'predictions,': [2861, 2881], 'averaged': [2862], '6-residue': [2864], 'plotted': [2867], 'above': [2868], 'thetop': [2877], 'row.': [2878], 'E': [2882], 'denotesextended': [2883], '(i.e.': [2885], '(average': [2890, 2896], '>1.0)': [2891], 'e': [2893], 'denotes': [2894], '≤': [2897], '1.0)': [2898], 'probability.': [2899], 'H': [2900], 'h': [2902], 'predictedhelical': [2904], 'analogous': [2908], 'manner.View': [2909], 'Large': [2910, 3806], 'Image': [2911, 3807], 'Figure': [2912, 3808], 'ViewerDownload': [2913, 3809], '(PPT)': [2914, 3810], 'Among': [2915], 'parts': [2928], 'thereof': [2929], '(bacteriorhodopsin,': [2930], 'cytochrome': [2931], 'c': [2932], 'oxidase,': [2933], 'SP-C,': [2934, 3001, 3595], 'parathyroid': [2937], 'hormone': [2938], 'receptor).': [2939], 'driving': [2941], 'forces': [2942], 'environment': [2949], 'aqueous': [2954, 4049], 'solution': [2955, 4050], '(31Li': [2956], 'S.C.': [2957], 'Deber': [2958], 'Nat.': [2960, 3167], '368-373Crossref': [2965], '(139)': [2968], 'prediction': [2975, 4659], 'methods': [2976, 4651], 'here': [2978], 'soluble': [2983, 4893, 4932], 'However,': [2985, 3900], 'trans-': [2992], 'juxtamembrane': [2994], 'region': [2995], 'protein,': [2999], 'peptide,': [3006, 3472], 'vivo.': [3010], 'cover': [3014], 'broad': [3016], 'range': [3017], 'functions': [3019], 'many': [3021, 4785], 'enzymes': [3023], '(59%': [3024], 'compared': [3025, 3791, 3812], '47%': [3027], 'starting': [3030], 'set)': [3032], 'ligand-binding': [3035], 'active': [3048], 'site': [3049], 'ligand-interacting': [3051], 'residues.': [3052], 'example,': [3054], 'metalloproteases': [3056], 'astacin': [3057], '(code': [3058, 3063, 3068, 3144, 3184, 3228], '1iab)': [3059], 'adamalysin': [3061], 'II': [3062], '3aig)': [3064], 'methane': [3066], 'monooxygenase': [3067], '1mty)': [3069], 'zinc-': [3071], 'iron-binding': [3073], 'respective': [3077], '(32Bode': [3079], 'Gomis-Ruth': [3081], 'F.X.': [3082, 3099], 'Huber': [3083], 'Zwilling': [3085], 'Stocker': [3087], '358:': [3091], '164-167Crossref': [3092], '(293)': [3095], '33Gomis-Ruth': [3098], 'Meyer': [3100], 'E.F.': [3101], 'Kress': [3102], 'L.F.': [3103], 'Politi': [3104], '283-289Crossref': [3110], '(52)': [3113], '34Rosenzweig': [3116], 'A.C.': [3117], 'Nordlund': [3118], 'P.': [3119, 3154, 3210, 4434, 4938, 5020, 5022], 'Takahara': [3120], 'P.M.': [3121], 'Frederick': [3122], 'C.A.': [3123], 'Lippard': [3124], 'S.J.': [3125], '2:': [3129], '409-418Abstract': [3130], '(427)': [3135], 'Scholar);': [3137, 3177, 3219, 3252], 'heme-binding': [3141], '1b2v)': [3145], 'important': [3149], 'heme': [3151], 'binding': [3152, 3193], '(35Arnoux': [3153], 'Haser': [3155], 'Izadi': [3157], 'N.': [3158, 4436, 4762], 'Lecroisey': [3159], 'Delepierre': [3161], 'Wandersman': [3163], 'Czjzek': [3165], '516-520Crossref': [3172], '(162)': [3175], 'Arf': [3180, 3192], 'exchange': [3181], 'ARNO': [3183], '1pbv)': [3185], 'involved': [3190, 3864, 5099], '(36Cherfils': [3194], 'Menetrey': [3196], 'Mathieu': [3198], 'Le': [3200], 'Bras': [3201], 'Robineau': [3203], 'Beraud-Dufour': [3205], 'Antonny': [3207], 'Chardin': [3209], '392:': [3213], '101-105Crossref': [3214], '(149)': [3217], 'light-driven': [3224], 'ion': [3225], 'pump': [3226], '1bct)': [3229], 'binds': [3230], 'photo-sensitive': [3232], 'retinal': [3233], '(37Barsukov': [3234], 'I.L.': [3235], 'Nolde': [3236], 'D.E.': [3237], 'Lomize': [3238], 'A.L.': [3239, 4772], 'Arseniev': [3240], 'A.S.': [3241], '206:': [3246], '665-672Crossref': [3247], '(58)': [3250], 'active-site': [3255, 3336], 'serine': [3256], 'Streptomyces': [3258], 'located': [3262, 3340], '(38Kelly': [3267], 'J.A.': [3268, 4411], 'Knox': [3269], 'Moews': [3271], 'P.C.': [3272], 'Hite': [3273], 'G.J.': [3274], 'Bartolone': [3275], 'J.B.': [3276], 'Zhao': [3277], 'Joris': [3279], 'Frere': [3281], 'J.M.': [3282, 3284], 'Ghuysen': [3283], '1985;': [3288], '260:': [3289], '6449-6458Abstract': [3290], 'Glockshuberet': [3297], 'al.': [3298], '(39Glockshuber': [3299], 'Wütrich': [3309], '426:': [3314], '291-296Crossref': [3315], '(24)': [3318], 'observed': [3321, 4272, 4285], 'similarities': [3325], 'signal': [3327], 'peptidases': [3328], 'His-177': [3331, 3338], 'then': [3332], 'putative': [3335], 'residue.': [3337], 'N-terminal': [3343], 'Three': [3356, 4020], 'harboring': [3360], 'i.e.': [3364], 'StreptomycesR61,': [3367], 'antarctica,': [3372], 'XIII,': [3377, 4030], '15-,': [3379], '11-,': [3380], '9-residue': [3382], 'available': [3386, 3818], 'us': [3388], 'studies.': [3391], 'All': [3392], 'buffer': [3402], 'physiological': [3404, 4496, 4626], '3).': [3407, 4055, 4507], '6/37': [3409], '≥7-residue-long': [3412], '4/10': [3416], '≥11': [3420], 'analyzed,': [3424], 'suggests': [3438], 'there': [3440, 4181], 'causal': [3444], 'connection,': [3445], 'experiments': [3447], 'support': [3454], 'this.': [3455], 'First,': [3456], 'replacement': [3457, 4107], 'leucine': [3469], 'yields': [3470], 'SP-C(Leu),': [3473], 'judged': [3478], 'circular': [3480], 'dichroism': [3481], 'infrared': [3483], 'spectroscopy': [3484], 'contrast': [3521], 'time-dependent': [3535], 'aggregation': [3536, 3559, 4064, 4574, 4788, 4879], '4).': [3545, 4087], 'starts': [3547], 'precipitate': [3549], 'first': [3552], 'hours': [3553, 3610], 'extensive': [3558, 4878], '5–10': [3561], 'days,': [3562], 'signs': [3567], 'precipitation': [3569], 'same': [3572, 3829], 'period.': [3573], 'Consistently,': [3574], 'occasional': [3581], 'days': [3585], 'concentration': [3591, 3606, 4882], '(data': [3592, 4652], 'shown).': [3594, 4654], 'hand,': [3599, 4511], 'few': [3609], 'Second,': [3631], 'Aβ-(1–42)': [3636, 3661, 3723], 'lacks': [3638], 'devoid': [3644], '(cf.': [3649], '2)': [3651, 4921], 'detectable': [3655], 'Aβ-(1–28)': [3698, 3713, 3785, 4521], 'alanine': [3700], 'substitutions': [3701, 3758, 3776], '16,': [3704], '17,': [3705], '(40Tjernberg': [3724, 4538], 'Lindqvist': [3728, 4147, 4542], 'Karlström': [3732, 4151, 4546], 'A.R.': [3733, 4152, 4547], '271:': [3744, 4163, 4558], '8545-8548Abstract': [3745, 4164, 4559], '(836)': [3753, 4172, 4567], 'revert': [3759], 'giving': [3764], 'instead': [3765, 4329], '15': [3771], '21': [3773], '(Fig.5).Figure': [3774], '5Ala': [3775], 'reverts': [3777], 'α/β-discordance': [3778, 4739], 'Aβ.': [3780], 'Predicted': [3781], 'Aβ-(1–28,': [3787], 'K16A,': [3788], 'L17A,': [3789], 'F20A)': [3790], 'Aβ-(1–42).': [3798], 'Symbolsas': [3799], 'Figs.': [3802], '2': [3803, 4629, 4671, 4875], '4.View': [3805], 'Chou-Fasman': [3835], 'approach.': [3836], 'Thereby': [3837], '37/1324': [3838], '(2.8%)': [3839], 'β-strand.': [3854], 'encephalopathies,': [3862], 'disease,': [3867, 4867], 'Lysozyme': [3882], '5-residue-long': [3885], '30–34;': [3889], 'shown),': [3892], 'wild-type': [3894], 'lysozyme': [3895, 3905, 3963], 'naturally': [3902], 'occurring': [3903], 'variants,': [3906], 'mutation': [3909, 4918], 'Ile-56': [3910], 'Thr': [3912], 'Asp-67': [3914], 'His,': [3916], 'unstable': [3919], 'It': [3953, 4177, 4212], 'remains': [3954], 'investigated': [3957, 4039], 'contributes': [3964], 'nature': [3968], 'mutants.': [3971], 'remaining': [3973], '2Sipe': [3996], 'either': [4010], 'lack': [4015], 'structures.': [4019], 'α/β-discordant,i.e.': [4026], 'StreptomycesR61': [4031], 'transpeptidase,': [4032], 'lipase,': [4037], 'neutral': [4052], 'practically': [4066, 4522], 'abolished': [4067, 4092], 'converting': [4069], 'statistically': [4082], 'favor': [4083, 4395], 'rendered': [4104], '40Tjernberg': [4143], '5).': [4176], 'clear': [4179], 'ways': [4186], 'formed,': [4192], 'presented': [4196, 4490], 'herein': [4197, 4491], 'strongly': [4198], 'predict': [4208], 'appears': [4213, 5123], 'reasonable': [4214], 'intermediates': [4222, 4792], 'unfolded.': [4227], 'propensities': [4231], 'regions': [4234, 4249], 'likely': [4240], 'refold': [4242], 'predicted.': [4254], 'β-Strands': [4255], 'such': [4257], 'via': [4262, 4723], 'oligomerization,': [4264], 'leading': [4265], 'SP-C;': [4274], 'once': [4275], 'unfolding': [4276], 'occurs,': [4281], 'refolding': [4282], 'NMR': [4287], 'mass': [4311], 'spectrometry,': [4312], '2M.': [4313], 'Gustafsson,': [4314], 'Griffiths,': [4317], 'Furusjó,': [4319], 'Johansson,': [4322], 'manuscript': [4323, 5165], 'preparation.': [4325], 'Scholar,14Gustafsson': [4357], 'vivo': [4386], 'destabilization,': [4396], 'extremes': [4398], 'presence': [4402], 'organic': [4404], 'cosolvents': [4405], '(41Guijarro': [4406], 'Jones': [4410], 'Campbell': [4412], 'I.D.': [4413], '4224-4228Crossref': [4425], '(625)': [4428], '42Chiti': [4431], 'Webster': [4433], 'Taddei': [4435], 'Clark': [4437], 'Stefani': [4439], 'Ramponi': [4441], '3590-3594Crossref': [4454], '(987)': [4457], 'From': [4460], 'it': [4463], 'suggested': [4466], 'primarily': [4472], 'dependent': [4473], 'generic': [4483], 'trait': [4484], 'destabilized': [4486], 'polypeptides.': [4487], 'findings': [4489], 'conditions,': [4497], 'anticipated': [4505], 'On': [4508], 'substitution': [4516], 'K16A/L17A/F20A': [4518], 'abolish': [4523], 'formation,': [4525], 'showing': [4526], 'process': [4535, 5103], 'sequence-dependent': [4537], 'clear-cut': [4571], 'difference': [4572], '4)': [4582], 'contradicts': [4583], 'side': [4584], 'chain': [4585], 'hydrophobicity': [4586], 'general': [4589, 4618], 'determinant': [4590], 'Further': [4594], 'investigations': [4595], 'site-directed': [4604], 'mutants': [4605, 4891, 4930], 'modulated,': [4612], 'shed': [4614], 'light': [4616], 'principles': [4619], 'underlie': [4621], 'conditions.': [4627], 'Helix': [4628], 'discordant,': [4633], 'Chou-Fasman-based': [4650], 'Strikingly,': [4655], 'previous': [4658], 'contradictory': [4664], 'obtained': [4667], 'region,': [4672], 'suggesting': [4673, 4815], 'alternative': [4675], 'conformations': [4676], 'coexist': [4680], '(43Huang': [4681], 'Gabriel': [4683], 'M.A.': [4686, 4764, 4836], '91:': [4701], '7139-7143Crossref': [4702], '(181)': [4705], 'Cys': [4717], 'connected': [4719], 'disulfide': [4725], 'bond,': [4726], 'Asn': [4729], 'glycosylated.': [4731], 'consequences': [4733], 'modifications': [4736, 4749], 'present.': [4745], 'posttranslational': [4747], 'chemical': [4748], 'responsible': [4750, 4966], 'PrPC': [4755, 4817], '(44Stahl': [4761], 'Teplow': [4765], 'D.B.': [4766], 'Hood': [4767], 'Gibson': [4769], 'B.W.': [4770], 'Burlingame': [4771], '32:': [4777], '1991-2002Crossref': [4778], '(534)': [4781], 'structured': [4790], 'folding': [4791], '(45Wetzel': [4793], 'Cell.': [4795], '86:': [4797], '699-702Abstract': [4798], '(158)': [4806], 'exist': [4811], 'multiple': [4813], 'conformations,': [4814], 'intrinsically': [4820], 'flexible': [4821], 'structural': [4825], 'transitions': [4826], '(46Zhang': [4827], 'Stockel': [4829], 'James': [4839], '36:': [4845], '3543-3553Crossref': [4846], '(168)': [4849], 'Out': [4852], 'mutations,': [4856], 'polymorphic': [4859], 'sites': [4860], 'T183A': [4868], 'localized': [4869], '160-fold': [4883], 'lower': [4884], 'introduced': [4895], 'recombinant': [4897, 4914], 'PrP-(121–231)': [4899], 'PrP-(90–231)': [4916], 'D178N': [4917], '(in': [4919], 'aggregation,': [4925], 'P102L': [4927], 'E200K': [4929], '(47Swietnicki': [4933], 'Petersen': [4935], 'R.B.': [4936], 'Gambetti': [4937], 'Surewicz': [4939], 'W.K.': [4940], '273:': [4945], '31048-31052Abstract': [4946], 'believed': [4959], 'with,': [4963], 'even': [4965], 'for,': [4967], 'pathological': [4969], 'changes': [4970], 'seen': [4971], 'course': [4974], '3Dobson': [4993], '48Näslund': [5011], 'Haroutunian': [5013], 'Mohs': [5015], 'Davis': [5017], 'K.L.': [5018], 'Davies': [5019], 'Greengard': [5021], 'Buxbaum': [5023], 'Am.': [5026], 'Med.': [5027], 'Assoc.': [5028], '283:': [5030], '1571-1577Crossref': [5031], '(1105)': [5034], 'implies': [5038], 'obstruction': [5040], 'prevent': [5045, 5117], 'and/or': [5048], 'progression': [5049], 'amyloidoses.': [5051], 'Attempts': [5052], 'made': [5055], 'identify': [5057], 'compounds': [5058], 'abrogate': [5061], 'interfering': [5065], 'peptide-peptide': [5067], 'contacts': [5068], 'inhibiting': [5073], 'proteolytic': [5074], 'processing': [5075], 'leads': [5077], '(49Selkoe': [5081], '399:': [5085], '23-31Crossref': [5086], '(1520)': [5089], 'Our': [5092], 'some': [5105], 'stabilization': [5109], 'Such': [5120], 'worthwhile': [5124], 'explore,': [5126], 'regions,': [5135], 'disease-associated': [5141], 'identified.': [5148], 'grateful': [5151], 'Prof.': [5153], 'Kurt': [5154], 'Dr.': [5157], 'Lars': [5158], 'constructive': [5161], 'comments': [5162], 'Erik': [5168], 'Nordling': [5169], 'extracting': [5171], 'poly-Val': [5199], 'poly-Leu': [5201], 'substituted': [5202], 'Profile': [5206], 'HeiDelberg': [5209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018769240', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-09T22:19:11.651974', 'created_date': '2016-06-24'}
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