Publication Information

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'https://openalex.org/W2146955477', 'https://openalex.org/W2150596288', 'https://openalex.org/W2161680868', 'https://openalex.org/W2162815565', 'https://openalex.org/W2164478123', 'https://openalex.org/W2168087300', 'https://openalex.org/W2171706623', 'https://openalex.org/W2178503716', 'https://openalex.org/W2415445523', 'https://openalex.org/W4240866326', 'https://openalex.org/W60373930'], 'related_works': ['https://openalex.org/W4313170912', 'https://openalex.org/W2465438320', 'https://openalex.org/W2394822779', 'https://openalex.org/W2139018071', 'https://openalex.org/W2128852790', 'https://openalex.org/W2062676698', 'https://openalex.org/W2033891817', 'https://openalex.org/W1998177934', 'https://openalex.org/W1606577628', 'https://openalex.org/W1578243658'], 'abstract_inverted_index': {'Amyloid': [0, 201], 'precursor': [1, 202, 404, 413, 417, 455, 459, 496], 'protein': [2, 29, 203, 230, 405, 2479, 4061, 4134, 4150], '(APP)': [3, 204, 406], 'processing': [4, 38, 73, 142, 170, 205, 239, 274, 343, 371, 883, 2172, 2267, 2402, 2442, 2554, 2588, 4098, 4172, 4380], 'is': [5, 82, 159, 206, 283, 360, 526, 886, 941, 1276, 1667, 1949, 2117, 2406, 2592, 4335, 4346], 'of': [6, 24, 39, 57, 74, 77, 83, 91, 163, 184, 191, 196, 207, 225, 240, 258, 275, 278, 284, 292, 364, 385, 392, 397, 529, 712, 884, 894, 960, 1194, 1257, 1267, 1311, 1458, 1475, 1492, 1568, 1673, 1719, 1730, 1968, 2087, 2268, 2281, 2340, 2346, 2354, 2362, 2403, 2443, 2478, 2537, 2555, 2568, 2577, 2589, 2596, 2614, 2654, 2664, 2754, 2885, 2921, 3119, 3130, 3204, 3215, 3271, 3282, 3303, 3326, 3362, 3401, 3421, 3471, 3512, 3571, 3636, 3640, 3684, 3697, 3771, 3778, 3995, 4015, 4069, 4073, 4079, 4084, 4146, 4149, 4158, 4173, 4213, 4218, 4224, 4265, 4324, 4328, 4343, 4360], 'major': [7, 208, 4358], 'interest': [8, 209], 'in': [9, 33, 107, 193, 210, 234, 308, 394, 564, 691, 957, 1272, 1286, 1489, 1531, 2075, 2351, 2369, 2482, 2610, 2791, 2868, 2879, 2925, 2950, 3036, 3105, 3133, 3146, 3218, 3223, 3232, 3257, 3285, 3308, 3336, 3352, 3393, 3414, 3502, 3691, 3694, 3715, 3760, 3775, 3839, 3880, 3975, 4002, 4023, 4048, 4090, 4281, 4332], "Alzheimer's": [10, 34, 211, 235, 498, 889], 'disease': [11, 35, 212, 236, 890], 'research,': [12, 213], 'since': [13, 214], 'sequential': [14, 215], 'cleavages': [15, 59, 216, 260], 'by': [16, 44, 124, 137, 174, 217, 245, 325, 338, 375, 944, 953, 982, 1279, 1290, 1486, 2120, 2167, 2173, 2466, 2502, 2659, 2678, 2745, 2821, 2891, 2935, 2955, 3066, 3108, 3151, 3236, 3260, 3300, 3323, 3578, 3742, 4389], 'β-': [17, 218], 'and': [18, 53, 93, 95, 126, 129, 149, 186, 188, 219, 254, 294, 296, 327, 330, 350, 387, 389, 639, 822, 952, 1175, 1260, 1305, 1307, 1424, 1460, 1469, 1557, 1575, 1724, 1878, 1959, 2079, 2107, 2140, 2178, 2186, 2273, 2308, 2342, 2445, 2459, 2539, 2557, 2570, 2580, 2624, 2634, 2638, 2715, 2722, 2730, 2749, 2828, 2861, 2873, 2961, 2987, 3001, 3088, 3112, 3136, 3174, 3197, 3221, 3264, 3288, 3311, 3339, 3430, 3544, 3551, 3624, 3638, 3643, 3700, 3720, 3749, 3754, 3785, 3818, 3837, 3901, 3961, 3985, 4007, 4028, 4040, 4053, 4076, 4086, 4180, 4230, 4267, 4269, 4276, 4307, 4330, 4340, 4362, 4383, 4422], 'γ-secretase': [19, 220, 1952, 3592], 'lead': [20, 221], 'to': [21, 48, 65, 144, 150, 180, 222, 249, 266, 345, 351, 381, 497, 888, 964, 1177, 1188, 1455, 1521, 1669, 1963, 2195, 2337, 2451, 2491, 2508, 2622, 2662, 3359, 3404, 3425, 3509, 3677, 3746, 3808, 3814, 3821, 3903, 4092, 4142, 4154, 4261, 4302, 4426], 'the': [22, 25, 72, 75, 78, 96, 146, 160, 164, 194, 223, 226, 273, 276, 279, 297, 347, 361, 365, 395, 495, 586, 714, 811, 895, 898, 937, 948, 958, 961, 1181, 1195, 1254, 1300, 1312, 1456, 1465, 1490, 1507, 1514, 1565, 1569, 1670, 1720, 1727, 1965, 2082, 2095, 2182, 2196, 2266, 2269, 2338, 2352, 2360, 2441, 2468, 2493, 2505, 2509, 2544, 2553, 2575, 2587, 2593, 2611, 2671, 2747, 2786, 2840, 2845, 2876, 2886, 2897, 2902, 2906, 2911, 2922, 2926, 2937, 2942, 2945, 2971, 2984, 3016, 3069, 3091, 3110, 3120, 3127, 3131, 3154, 3177, 3195, 3205, 3212, 3216, 3224, 3239, 3262, 3272, 3279, 3283, 3291, 3304, 3314, 3327, 3342, 3396, 3441, 3456, 3467, 3510, 3572, 3682, 3685, 3695, 3708, 3738, 3996, 4016, 4036, 4041, 4070, 4080, 4124, 4147, 4155, 4164, 4170, 4211, 4221, 4225, 4256, 4262, 4325, 4341, 4373], 'formation': [23, 224, 2663], '4-kDa': [26, 227, 899], 'amyloid': [27, 67, 228, 268, 403, 412, 416, 421, 454, 458, 463, 500, 904], 'Aβ': [28, 229, 422, 464, 499, 900, 949, 966, 1196, 1301, 1313, 1508, 2623], 'peptide': [30, 231, 1314, 3357, 3398, 3465, 3507], 'that': [31, 119, 130, 157, 232, 320, 331, 358, 552, 810, 1666, 1737, 2092, 2164, 2412, 2562, 2586, 2618, 2652, 2832, 4152, 4163, 4371], 'accumulates': [32, 233], 'brain.': [36, 237], 'The': [37, 238, 402, 881, 974, 1480, 1716, 1954, 2535, 2735, 2850, 2864, 2883, 2976, 2991, 3012, 3099, 3116, 3142, 3185, 3201, 3229, 3251, 3268, 3386, 3408, 3451, 3495, 3792, 3829, 3872, 3911, 3971, 4059, 4416], 'APP': [40, 79, 165, 241, 280, 366, 428, 470, 525, 584, 689, 715, 813, 885, 940, 1179, 1258, 1275, 1285, 1466, 1515, 1570, 1731, 2179, 2187, 2347, 2495, 2599, 2673, 3457, 4097, 4125, 4174, 4219, 4379], 'involves': [41, 242], 'proteolytic': [42, 103, 243, 304, 882, 4082, 4171], 'conversion': [43, 244], 'different': [45, 246, 2566], 'secretases': [46, 247], 'leading': [47, 248, 2661], 'α-,': [49, 250], 'β-,': [50, 251], 'γ-,': [51, 252], 'δ-,': [52, 253], 'ϵ-cleavages.': [54, 255], 'Since': [55, 256], 'modulation': [56, 257], 'these': [58, 259, 4270, 4344], 'represents': [60, 261], 'a': [61, 262, 527, 530, 818, 872, 1189, 1262, 1287, 1471, 1493, 1561, 1738, 2121, 2168, 2449, 2549, 2707, 2716, 2727, 2731, 2824, 2834, 2962, 2966, 3076, 3095, 3164, 3181, 3244, 3355, 3463, 3505, 3733, 4131, 4136, 4143, 4214, 4321], 'rational': [62, 263], 'therapeutic': [63, 264], 'approach': [64, 265], 'control': [66, 267], 'formation,': [68, 269], 'its': [69, 270, 4177], 'interference': [70, 271], 'with': [71, 114, 272, 315, 559, 688, 709, 831, 1180, 2071, 2408, 2415, 2475, 2543, 2565, 2823, 2857, 2875, 2895, 2910, 2918, 2931, 2957, 2981, 2999, 3010, 3022, 3126, 3211, 3278, 3331, 3433, 3553, 3566, 3615, 3633, 3718, 3732, 3768, 3833, 3862, 3898, 3918, 3922, 3940, 3958, 3963, 4026, 4051, 4135, 4291, 4299, 4314, 4348], 'members': [76, 277, 816], 'gene': [80, 166, 281, 367, 804, 814, 2600], 'family': [81, 167, 282, 368, 532, 815, 1457, 2601], 'considerable': [84, 285], 'importance.': [85, 286], 'By': [86, 287], 'using': [87, 288, 2642, 2680, 2746, 2936, 3068, 3109, 3153, 3194, 3238, 3261, 3354, 3395, 3416, 3504, 3673], 'C-terminally': [88, 289], 'tagged': [89, 290], 'constructs': [90, 291, 3123, 3208, 3275], 'APLP-1': [92, 158, 185, 293, 359, 386, 590, 742, 2272, 2282, 2364, 2417, 2444, 2538, 2655, 2788, 2841, 2899, 3030, 3034, 3121, 3297, 3306, 3319, 3329, 3364, 3427, 3513, 4037, 4085, 4266], 'APLP-2': [94, 141, 192, 295, 342, 393, 640, 778, 877, 2309, 2460, 2540, 2574, 3144, 3157, 3160, 3206, 3273, 3442, 3644, 4087], 'untagged': [97, 298], 'proteins,': [98, 299, 588, 2271, 3711], 'we': [99, 177, 300, 378, 1556, 1578, 2447, 2560, 2604, 2629, 2650, 4273], 'have': [100, 301, 817, 1559, 2348, 2630, 4161], 'characterized': [101, 302], 'their': [102, 131, 303, 332, 2193, 2463, 4182], 'C-terminal': [104, 305, 425, 467, 1264, 1473, 1566, 2365, 2453, 2496, 2541, 2582, 2636, 3333, 3468, 4071, 4081, 4178, 4222, 4308, 4326, 4374, 4427], 'fragments': [105, 183, 190, 306, 384, 391, 2280, 2345, 2454, 2542, 2609, 2637, 2641, 3003, 3102, 3188, 3254, 4083, 4179, 4309, 4327, 4345, 4359], 'produced': [106, 307], 'stably': [108, 197, 309, 398, 2645, 4289], 'transfected': [109, 198, 310, 399, 2355, 3552, 3756, 4290, 4313], 'SH-SY5Y': [110, 199, 311, 400, 2643, 3547, 3757, 4282, 4287], 'cells.': [111, 200, 312, 401, 4283], 'Pharmacological': [112, 313], 'manipulation': [113, 314], 'specific': [115, 316], 'protease': [116, 317, 1293, 3863, 3866], 'inhibitors': [117, 318, 2567, 3864], 'revealed': [118, 319, 2548], 'both': [120, 321, 3002], 'homologues': [121, 322], 'are': [122, 323, 581, 827, 835, 1961], 'processed': [123, 324, 942, 1278, 1485, 2119], 'α-': [125, 326, 2341, 2569, 2579, 2633, 4382], 'γ-secretase-like': [127, 328, 2123, 2174], 'cleavages,': [128, 329], 'intracellular': [132, 333, 429, 471, 2184, 2188], 'domains': [133, 334, 2077, 2465, 2470], 'can': [134, 171, 335, 372, 2200, 2656], 'be': [135, 145, 172, 336, 346, 373, 1483, 1964, 2657], 'released': [136, 337], 'cleavage': [138, 153, 339, 354, 896, 1252, 1463, 1512, 1563, 1672, 1970, 2166, 2461, 2653, 2720, 4375], 'at': [139, 340, 534, 969, 1185, 1192, 1501, 1517, 1564, 2504, 2905, 3798, 3801, 3826, 3908, 3987, 4220, 4381, 4420], 'ϵ-sites.': [140, 341], 'appears': [143, 344], 'most': [147, 348, 2594], 'elaborate': [148, 349], 'involve': [151, 352], 'alternative': [152, 353, 1292, 2665], 'sites.': [154, 355, 2752, 2939, 3115, 3200, 3267], 'We': [155, 356, 4160], 'show': [156, 357, 805, 2561, 2651], 'only': [161, 362, 1528], 'member': [162, 363, 528], 'for': [168, 369, 876, 1951, 2100, 2573, 3090, 3176, 3563, 3612, 3626, 3765, 3805, 3823, 3905, 3990, 4122], 'which': [169, 370, 683, 946, 955, 1297, 1452, 1523, 1577, 4123, 4272], 'influenced': [173, 374], 'N-glycosylation.': [175, 376], 'Additionally,': [176, 377], 'were': [178, 379, 3004, 3103, 3189, 3255, 3549, 3561, 3610, 3631, 3671, 3689, 3713, 3730, 3763, 3795, 3831, 3877, 3914, 3973, 4000, 4021, 4046, 4279, 4297, 4318, 4365], 'able': [179, 380], 'detect': [181, 382, 2452, 2492, 2606], 'p3-like': [182, 187, 383, 388, 2625, 2640, 2666], 'Aβ-like': [189, 390], 'media': [195, 396, 2353, 2613, 3794], '1The': [407, 449], 'abbreviations': [408, 450], 'used': [409, 451, 4319], 'are:': [410, 452], 'APP,': [411, 453, 2457, 3641], 'protein;': [414, 419, 423, 456, 461, 465], 'APLP,': [415, 457], 'like': [418, 460, 1506], 'Aβ,': [420, 462], 'CTF,': [424, 466], 'fragment;': [426, 468], 'AICD,': [427, 469], 'domain;': [430, 472], 'PMA,': [431, 473], 'phorbol': [432, 474, 3619], '12-myristate-13-acetate;': [433, 475], 'PS,': [434, 476], 'presenilin;': [435, 477], 'wt,': [436, 478], 'wild': [437, 479], 'type;': [438, 480], 'Tricine,': [439, 481], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine;': [440, 482], 'DAPT,': [441, 483], 'N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine': [442, 484], 't-butyl': [443, 485], 'ester;': [444, 486], 'BACE,': [445, 487], 'β-site': [446, 488], 'APP-cleaving': [447, 489, 978], 'enzyme.': [448, 490], 'was': [491, 980, 1524, 2367, 2676, 2739, 2819, 2855, 2870, 2889, 2908, 2933, 2953, 2979, 2997, 3019, 3064, 3124, 3149, 3209, 3234, 3276, 3298, 3321, 3350, 3391, 3412, 3445, 3460, 3500, 3645, 4062, 4088, 4128, 4259], 'first': [492], 'identified': [493, 981, 1560, 2631], 'as': [494, 892, 903, 1295, 2471, 2682, 3647, 3737, 4130, 4320, 4351, 4386], 'peptides': [501, 967], '(1Kang': [502], 'J.': [503, 633, 676, 746, 750, 771, 840, 844, 865, 925, 931, 1011, 1015, 1029, 1093, 1101, 1111, 1223, 1227, 1241, 1344, 1405, 1419, 1447, 1549, 1616, 1659, 1818, 1824, 1838, 1885, 1891, 1905, 1942, 2024, 2064, 2257, 2302, 2331, 2813, 3058, 3488, 3535], 'Lemaire': [504], 'H.G.': [505], 'Unterbeck': [506], 'A.': [507, 609, 631, 752, 846, 1378, 1437, 1439, 1582, 1630, 1708, 1757, 1767, 1801, 1873, 1937, 2030, 2214, 2230, 2250, 2300, 2419, 2513, 2685, 2761, 2811, 3056, 3533, 3651, 4100, 4185, 4233, 4394], 'Salbaum': [508, 3658], 'J.M.': [509, 3659], 'Masters': [510, 544, 572, 626, 699, 1593, 2295, 2428, 2524, 2696, 2772, 2806, 3051, 3480, 3528, 3660, 4111, 4196, 4244, 4405], 'C.L.': [511, 545, 573, 627, 700, 919, 1594, 2296, 2429, 2525, 2697, 2773, 2807, 3052, 3481, 3529, 3661, 4112, 4197, 4245, 4406], 'Grzeschik': [512], 'K.H.': [513], 'Multhaup': [514, 624, 920, 1541, 1631, 2293, 2804, 3049, 3526], 'G.': [515, 617, 625, 666, 789, 921, 923, 1031, 1109, 1167, 1243, 1542, 1592, 1598, 1632, 1747, 1816, 1883, 1935, 1999, 2245, 2286, 2294, 2321, 2375, 2427, 2523, 2529, 2695, 2701, 2771, 2777, 2797, 2805, 3042, 3050, 3519, 3527, 3653, 4110, 4116, 4195, 4201, 4243, 4249, 4404, 4410], 'Beyreuther': [516, 542, 570, 628, 697, 928, 1547, 1595, 2297, 2430, 2526, 2698, 2774, 2808, 3053, 3482, 3530, 3662, 4113, 4198, 4246, 4407], 'K.': [517, 541, 543, 569, 571, 594, 615, 629, 696, 698, 929, 1095, 1149, 1435, 1443, 1548, 1590, 1596, 1613, 1628, 1696, 1995, 2004, 2284, 2298, 2421, 2431, 2521, 2527, 2693, 2699, 2769, 2775, 2795, 2809, 3040, 3054, 3372, 3483, 3517, 3531, 3663, 4108, 4114, 4193, 4199, 4241, 4247, 4402, 4408], 'Muller-Hill': [518], 'B.': [519, 1540, 1688, 1830, 1897, 1991, 2111, 2134, 3477], 'Nature.': [520, 1069, 1681, 1711, 1807, 1984, 2008, 2049, 2215], '1987;': [521], '325:': [522], '733-736Google': [523], 'Scholar).': [524, 579, 706, 935, 1250, 1350, 1554, 1715, 2263, 2400, 2437, 2534, 2782, 3385, 3494, 3540, 3668, 4206, 4254, 4415], 'multigene': [531], 'comprising': [533, 1743, 3466], 'least': [535], '16': [536], 'orthologues': [537], '(2Coulson': [538], 'E.J.': [539, 567, 694], 'Paliga': [540, 568, 695, 1589, 2420, 2520, 2692, 2768, 3371, 4107, 4192, 4240, 4401], 'Neurochem.': [546, 574, 701], 'Int.': [547, 575, 702], '2000;': [548, 576, 703, 773, 867, 1171, 1808, 2050, 2067], '36:': [549, 577, 704], '175-184Google': [550, 578, 705], 'Scholar)': [551, 638, 803, 1174, 1948, 2116, 2307, 2335, 2818, 3063], 'encode': [553], 'type': [554, 2088], 'I': [555, 2089], 'integral': [556], 'membrane': [557, 1956, 2090], 'proteins': [558, 1957, 2091, 2474, 3670, 4306], 'similar': [560, 685], 'multidomain': [561], 'structures': [562, 687], '(reviewed': [563, 690], 'Ref.': [565, 692], '2Coulson': [566, 693], 'There': [580], 'two': [582, 1721, 2072, 2476, 3422, 4357, 4417], 'mammalian': [583, 812], 'homologues,': [585], 'APP-like': [587, 2270], 'termed': [589, 1525, 1579, 4274], '(3Wasco': [591], 'W.': [592, 642, 1690, 1836, 1903, 1975, 2001, 2057, 2325, 3378], 'Bupp': [593], 'Magendantz': [595], 'M.': [596, 719, 787, 1033, 1087, 1105, 1245, 1367, 1537, 1588, 1624, 1749, 1789, 1822, 1826, 1828, 1840, 1862, 1889, 1893, 1895, 1907, 1939, 2016, 2519, 2691, 2767, 4106, 4191, 4239, 4400], 'Gusella': [597], 'J.F.': [598, 1339], 'Tanzi': [599, 655, 672, 2326], 'R.E.': [600, 656, 673, 2327], 'Solomon': [601], 'F.': [602, 1027, 1239, 1371, 1763, 2007, 2208], 'Proc.': [603, 1372, 1867, 2224], 'Natl.': [604, 1373, 1868, 2225], 'Acad.': [605, 1374, 1869, 2226], 'Sci.': [606, 1375, 1870, 2227], 'U.': [607, 621, 770, 864, 1376, 1871, 2228, 2290, 2423, 2801, 3046, 3523], 'S.': [608, 619, 644, 733, 744, 762, 838, 856, 991, 993, 1001, 1009, 1013, 1075, 1119, 1203, 1205, 1213, 1221, 1225, 1357, 1363, 1377, 1429, 1441, 1445, 1584, 1751, 1799, 1872, 1933, 2204, 2229, 2288, 2373, 2515, 2687, 2763, 2799, 3044, 3374, 3521, 4102, 4187, 4235, 4396], '1992;': [610], '89:': [611], '10758-10762Google': [612], 'Scholar,': [613, 662, 917, 1038, 1073, 1129, 1335, 1411, 1603, 1622, 1644, 1685, 1858, 1925, 1988, 2012, 2053, 2219, 2234, 2243], '4Paliga': [614], 'Peraus': [616, 2285, 2796, 3041, 3518], 'Kreger': [618, 2287, 2798, 3043, 3520], 'Durrwang': [620, 2289, 2422, 2800, 3045, 3522], 'Hesse': [622, 2291, 2802, 3047, 3524], 'L.': [623, 1139, 1654, 1755, 1769, 2292, 2803, 3048, 3525], 'Weidemann': [630, 2299, 2810, 3055, 3532], 'Eur.': [632, 2301, 2812, 3057, 3534], 'Biochem.': [634, 910, 1418, 1446, 2303, 2330, 2814, 3059, 3536], '1997;': [635, 800, 2304, 2434, 2815, 3060, 3537], '250:': [636, 2305, 2816, 3061, 3538], '354-363Google': [637, 2306, 2817, 3062, 3539], '(5Wasco': [641], 'Gurubhagavatula': [643], 'Paradis': [645], 'M.D.': [646], 'Romano': [647], 'D.M.': [648, 1159, 1781, 2329, 3366], 'Sisodia': [649, 674, 761, 796, 855, 1342, 1657, 2394], 'S.S.': [650, 675, 797, 1343, 1658, 2395], 'Hyman': [651], 'B.T.': [652], 'Neve': [653], 'R.L.': [654, 1066, 1842, 1909], 'Nat.': [657, 2432], 'Genet.': [658], '1993;': [659], '5:': [660], '95-100Google': [661], '6Slunt': [663], 'H.H.': [664], 'Thinakaran': [665, 788, 2320, 2374], 'Von': [667, 2002], 'Koch': [668, 759, 780, 853], 'C.': [669, 760, 854, 1147, 1157, 1165, 1369, 1638, 1646, 1785, 1791, 1848, 1860, 1915, 1941, 2028, 2206, 2425], 'Lo': [670], 'A.C.': [671], 'Biol.': [677, 1345, 1406, 1617, 1660, 1943, 2065, 2258, 3489], 'Chem.': [678, 1346, 1407, 1618, 1661, 1944, 2066, 2259, 3490], '1994;': [679], '269:': [680], '2637-2644Google': [681], 'Scholar),': [682, 741, 776, 870, 1382, 1423, 1451, 1665, 1811, 1877, 2070, 2139, 2158, 2706, 4121], 'share': [684], 'domain': [686, 963, 1572, 1729, 2185, 2189, 4127], 'Transgenic': [707], 'mice': [708, 830], 'single': [710], 'knock-out': [711], 'either': [713, 970, 1500, 4292], '(7Zheng': [716], 'H.': [717, 757, 783, 785, 851, 1046, 1107, 1427, 1431, 1607, 1626, 1652, 1771, 1927, 1997], 'Jiang': [718], 'Trumbauer': [720, 786], 'M.E.': [721, 1044, 1068], 'Sirinathsinghji': [722], 'D.J.': [723, 1133, 1983, 2063, 3380], 'Hopkins': [724], 'R.': [725, 987, 1005, 1040, 1079, 1083, 1199, 1217, 1337, 1361, 1365, 1656, 1680, 1710, 1795, 1814, 1846, 1881, 1913, 2212, 2252], 'Smith': [726, 1788, 2039], 'D.W.': [727], 'Heavens': [728], 'R.P.': [729], 'Dawson': [730], 'G.R.': [731], 'Boyce': [732], 'Conner': [734], 'M.W.': [735], 'et': [736, 1124], 'al.Cell.': [737], '1995;': [738, 2216, 2332], '81:': [739], '525-531Google': [740], '(8Heber': [743, 837], 'Herms': [745, 839], 'Gajic': [747, 841], 'V.': [748, 842, 1123, 1702], 'Hainfellner': [749, 843], 'Aguzzi': [751, 845], 'Rulicke': [753, 847], 'T.': [754, 848, 1023, 1235, 1326, 1609, 1650, 1765, 2026, 2059, 2256, 2381, 2383, 3485], 'von': [755, 758, 849, 852], 'Kretzschmar': [756, 850], 'Tremml': [763, 857], 'P.': [764, 858, 997, 1003, 1099, 1115, 1209, 1215, 1692, 1694, 1777, 1803, 1806, 1993, 2248, 3657], 'Lipp': [765, 859], 'H.P.': [766, 860], 'Wolfer': [767, 861], 'D.P.': [768, 862, 1402], 'Muller': [769, 863], 'Neurosci.': [772, 866, 1170, 1550], '20:': [774, 868], '7951-7963Google': [775, 869], 'or': [777, 972, 1504, 2499, 3568, 3618, 4295], '(9von': [779], 'C.S.': [781, 1844, 1911], 'Zheng': [782], 'Chen': [784, 1762], 'van': [790], 'der': [791], 'Ploeg': [792], 'L.H.': [793], 'Price': [794, 2388], 'D.L.': [795, 1161, 2389], 'Neurobiol.': [798], 'Aging.': [799], '18:': [801], '661-669Google': [802], 'no': [806], 'severe': [807], 'phenotype,': [808], 'suggesting': [809, 871], 'redundant': [819], 'function.': [820], 'APLP-1(–/–)/APLP-2(–/–)': [821], 'APP(–/–)/APLP-2': [823], '(–/–)': [824], 'double': [825, 833], 'knock-outs': [826, 834], 'lethal,': [828], 'but': [829, 4175], 'APP(–/–)/APLP-1(–/–)': [832], 'viable': [836], 'physiological': [873], 'key': [874], 'role': [875], 'during': [878], 'embryonic': [879], 'development.': [880], 'central': [887], 'pathogenesis': [891], 'one': [893], 'products,': [897], 'fragment': [901, 1265, 1474, 1496, 2366, 2405, 2497, 2738, 3014], 'aggregates': [902], 'deposits': [905], '(10Glenner': [906], 'G.G.': [907], 'Wong': [908, 2392], 'C.W.': [909], 'Biophys.': [911], 'Res.': [912, 2154], 'Commun.': [913], '1984;': [914], '120:': [915], '885-890Google': [916], '11Masters': [918], 'Simms': [922], 'Pottgiesser': [924], 'Martins': [926], 'R.N.': [927], 'EMBO': [930, 1639], '1985;': [932], '4:': [933], '2757-2763Google': [934], 'In': [936, 2358, 2648], 'amyloidogenic': [938], 'pathway,': [939], 'consecutively': [943], 'β-secretase,': [945, 1280], 'releases': [947, 1253, 1464], 'N': [950], 'terminus,': [951], 'γ-secretase(s),': [954, 1487], 'cleaves': [956, 1298], 'middle': [959], 'transmembrane': [962, 1571, 1728, 2076, 2171, 2464, 4226], 'produce': [965], 'ending': [968, 1499], 'Val40': [971], 'Ala42.': [973], 'β-secretase': [975], 'BACE': [976, 1251], '(β-site': [977], 'enzyme)': [979], 'four': [983], 'independent': [984], 'groups': [985], '(12Vassar': [986, 1198], 'Bennett': [988, 1200], 'B.D.': [989, 1201], 'Babu-Khan': [990, 1202], 'Kahn': [992, 1204], 'Mendiaz': [994, 1206], 'E.A.': [995, 1207], 'Denis': [996, 1208], 'Teplow': [998, 1210, 1635], 'D.B.': [999, 1060, 1211, 1636], 'Ross': [1000, 1212], 'Amarante': [1002, 1214], 'Loeloff': [1004, 1216], 'Luo': [1006, 1218, 1389, 2376], 'Y.': [1007, 1219, 1390, 1605, 1615, 1779, 1793], 'Fisher': [1008, 1220], 'Fuller': [1010, 1222], 'Edenson': [1012, 1224], 'Lile': [1014, 1226], 'Jarosinski': [1016, 1228], 'M.A.': [1017, 1229], 'Biere': [1018, 1230], 'A.L.': [1019, 1231, 1834, 1901, 2040], 'Curran': [1020, 1232], 'E.': [1021, 1233, 1359, 1761, 1775, 1787, 1929], 'Burgess': [1022, 1234], 'Louis': [1024, 1236], 'J.C.': [1025, 1237], 'Collins': [1026, 1238], 'Treanor': [1028, 1240], 'Rogers': [1030, 1242], 'Citron': [1032, 1244], 'Science.': [1034, 1246, 1331, 2239], '1999;': [1035, 1070, 1126, 1247, 1379, 1448, 1712, 1985, 2155], '286:': [1036, 1248], '735-741Google': [1037, 1249], '13Yan': [1039], 'Bienkowski': [1041], 'M.J.': [1042, 3370], 'Shuck': [1043], 'Miao': [1045], 'Tory': [1047], 'M.C.': [1048, 1832, 1899], 'Pauley': [1049], 'A.M.': [1050], 'Brashier': [1051], 'J.R.': [1052, 1866], 'Stratman': [1053], 'N.C.': [1054], 'Mathews': [1055], 'W.R.': [1056], 'Buhl': [1057], 'A.E.': [1058], 'Carter': [1059], 'Tomasselli': [1061], 'A.G.': [1062], 'Parodi': [1063], 'L.A.': [1064], 'Heinrikson': [1065], 'Gurney': [1067, 1839, 1906], '402:': [1071, 1127], '533-537Google': [1072], '14Sinha': [1074], 'Anderson': [1076], 'J.P.': [1077], 'Barbour': [1078], 'Basi': [1080], 'G.S.': [1081], 'Caccavello': [1082], 'Davis': [1084], 'D.': [1085, 1113, 1121, 1153, 1328, 1753, 1852, 1919, 1931, 3655], 'Doan': [1086], 'Dovey': [1088], 'H.F.': [1089], 'Frigon': [1090], 'N.': [1091, 1097, 1611, 2254, 2313], 'Hong': [1092], 'Jacobson-Croak': [1094], 'Jewett': [1096], 'Keim': [1098, 1317], 'Knops': [1100], 'Lieberburg': [1102], 'I.': [1103, 1131], 'Power': [1104], 'Tan': [1106], 'Tatsuno': [1108], 'Tung': [1110], 'Schenk': [1112], 'Seubert': [1114], 'Suomensaari': [1116], 'S.M.': [1117], 'Wang': [1118, 1655], 'Walker': [1120], 'John': [1122], 'al.Nature.': [1125], '537-540Google': [1128], '15Hussain': [1130], 'Powell': [1132], 'Howlett': [1134], 'D.R.': [1135, 2391], 'Chapman': [1136, 1146], 'G.A.': [1137], 'Gilmour': [1138], 'Murdock': [1140], 'P.R.': [1141], 'Tew': [1142], 'D.G.': [1143], 'Meek': [1144], 'T.D.': [1145], 'Schneider': [1148], 'Ratcliffe': [1150], 'S.J.': [1151, 2048], 'Tattersall': [1152], 'Testa': [1154], 'T.T.': [1155], 'Southan': [1156], 'Ryan': [1158], 'Simmons': [1160], 'Walsh': [1162], 'F.S.': [1163, 1316], 'Dingwall': [1164], 'Christie': [1166], 'Mol.': [1168], 'Cell.': [1169, 1854, 1921, 3664], '16:': [1172, 1552], '609-619Google': [1173], 'shown': [1176, 4162, 4352], 'cleave': [1178], 'expected': [1182], 'specificity,': [1183], 'mainly': [1184], 'Met1/Asp1': [1186], 'and,': [1187], 'lesser': [1190], 'extent,': [1191], 'Tyr10/Glu11': [1193], 'sequence': [1197, 2884, 3399, 4391], 'large': [1255], 'ectodomain': [1256, 1467, 1516, 2165, 3511], '(sAPPβ)': [1259], 'creates': [1261, 1470], 'membrane-anchored': [1263], '(CTF)': [1266], '99': [1268], 'amino': [1269, 1477], 'acids.': [1270], 'Whereas': [1271], 'neuronal': [1273], 'cells': [1274, 1282, 2644, 3548, 3560, 3630, 3637, 3758, 3830], 'mostly': [1277], 'peripheral': [1281], 'preferentially': [1283], 'process': [1284], 'non-amyloidogenic': [1288], 'pathway': [1289], 'an': [1291, 2363, 2711, 2723, 2829, 3332, 3434, 4315], 'designated': [1294, 1497], 'α-secretase': [1296], 'within': [1299, 1513, 1726, 2462], 'domain,': [1302, 4227], 'between': [1303, 1573, 2552, 4228], 'Lys16': [1304], 'Leu17,': [1306], 'therefore': [1308, 2585], 'precludes': [1309], 'generation': [1310], '(16Esch': [1315], 'P.S.': [1318], 'Beattie': [1319], 'E.C.': [1320], 'Blacher': [1321], 'R.W.': [1322], 'Culwell': [1323], 'A.R.': [1324], 'Oltersdorf': [1325], 'McClure': [1327], 'Ward': [1329], 'P.J.': [1330, 1544], '1990;': [1332], '248:': [1333], '1122-1124Google': [1334], '17Wang': [1336], 'Meschia': [1338], 'Cotter': [1340], 'R.J.': [1341], '1991;': [1347], '266:': [1348], '16960-16964Google': [1349], 'α-Secretase': [1351, 1462], 'candidates': [1352], 'include': [1353], 'ADAM': [1354, 1383], '10': [1355, 3806], '(18Lammich': [1356], 'Kojro': [1358], 'Postina': [1360], 'Gilbert': [1362], 'Pfeiffer': [1364], 'Jasionowski': [1366], 'Haass': [1368, 1637, 1940], 'Fahrenholz': [1370], '96:': [1380], '3922-3927Google': [1381], '17/TACE': [1384], '(19Buxbaum': [1385], 'J.D.': [1386], 'Liu': [1387], 'K.N.': [1388], 'Slack': [1391], 'J.L.': [1392, 2022], 'Stocking': [1393], 'K.L.': [1394], 'Peschon': [1395], 'J.J.': [1396, 2377], 'Johnson': [1397], 'R.S.': [1398], 'Castner': [1399], 'B.J.': [1400], 'Cerretti': [1401], 'Black': [1403], 'R.A.': [1404], '1998;': [1408, 1682, 2009, 2397], '273:': [1409], '27765-27767Google': [1410], '20Slack': [1412], 'B.E.': [1413], 'Ma': [1414], 'L.K.': [1415], 'Seah': [1416], 'C.C.': [1417], '2001;': [1420, 1619, 1641, 1662, 2240, 2260], '357:': [1421], '787-794Google': [1422], 'MDC-9': [1425], '(21Koike': [1426], 'Tomioka': [1428], 'Sorimachi': [1430], 'Saido': [1432], 'T.C.': [1433, 2238], 'Maruyama': [1434], 'Okuyama': [1436], 'Fujisawa-Sehara': [1438], 'Ohno': [1440], 'Suzuki': [1442], 'Ishiura': [1444], '343:': [1449], '371-375Google': [1450], 'all': [1453, 2597], 'belong': [1454], 'disintegrin': [1459], 'metalloproteases.': [1461], '(sAPPα)': [1468], 'membrane-retained': [1472], '83': [1476], 'acids': [1478], '(C83).': [1479], 'latter': [1481], 'may': [1482], 'further': [1484, 2440], 'resulting': [1488, 2736, 3100, 3186, 3252], 'secretion': [1491], 'small': [1494, 2607, 4042], '3-kDa': [1495], 'p3,': [1498], 'position': [1502, 1518], '40': [1503, 3976], '42,': [1505], 'peptides.': [1509, 2626], 'An': [1510, 3438], 'additional': [1511, 2903, 3435], '–12': [1519], '(relative': [1520], 'Aβ),': [1522], 'δ-cleavage,': [1526], 'has': [1527, 2160, 2756, 4209], 'been': [1529, 2162, 2349, 2757], 'observed': [1530, 2368], 'hippocampal': [1532], 'neurons': [1533, 2371], 'so': [1534], 'far': [1535, 2265], '(22Simons': [1536], 'de': [1538, 2246], 'Strooper': [1539, 1687, 1990, 2110, 2133], 'Tienari': [1543], 'Dotti': [1545], 'C.G.': [1546], '1996;': [1551, 2231], '899-908Google': [1553], 'Recently,': [1555], 'others': [1558], 'presenilin-dependent': [1562, 1722], 'end': [1567, 4223], 'Leu49': [1574, 4229], 'Val50,': [1576], 'ϵ-cleavage': [1580, 2180, 4216], '(23Weidemann': [1581, 2512, 2684, 2760, 4099, 4184, 4232, 4393], 'Eggert': [1583, 2514, 2686, 2762, 3373, 4101, 4186, 4234, 4395], 'Reinhard': [1585, 2516, 2688, 2764, 4103, 4188, 4236, 4397], 'F.B.': [1586, 2517, 2689, 2765, 4104, 4189, 4237, 4398], 'Vogel': [1587, 2518, 2690, 2766, 4105, 4190, 4238, 4399], 'Baier': [1591, 2522, 2694, 2770, 4109, 4194, 4242, 4403], 'Evin': [1597, 2426, 2528, 2700, 2776, 4115, 4200, 4248, 4409], 'Biochemistry.': [1599, 2530, 2702, 2778, 3381, 4117, 4202, 4250, 4411], '2002;': [1600, 1855, 1874, 1922, 1945, 2531, 2703, 2779, 4118, 4203, 4251, 4412], '41:': [1601, 2532, 2704, 2780, 4119, 4204, 4252, 4413], '2825-2835Google': [1602, 2533, 2705, 2781, 4120, 4205, 4253, 4414], '24Gu': [1604], 'Misonou': [1606], 'Sato': [1608, 1784], 'Dohmae': [1610], 'Takio': [1612], 'Ihara': [1614], '276:': [1620, 1663, 2261], '35235-35238Google': [1621], '25Sastre': [1623], 'Steiner': [1625], 'Fuchs': [1627], 'Capell': [1629], 'Condron': [1633], 'M.M.': [1634], 'Rep.': [1640], '2:': [1642], '835-841Google': [1643], '26Yu': [1645], 'Kim': [1647], 'S.H.': [1648], 'Ikeuchi': [1649], 'Xu': [1651, 1782, 1835, 1902, 2015], 'Gasparini': [1653], '43756-43760Google': [1664], 'homologous': [1668], 'S3': [1671, 2177], 'Notch': [1674, 2176, 2183], '(27Schroeter': [1675], 'E.H.': [1676, 1700, 2210], 'Kisslinger': [1677], 'J.A.': [1678, 2046], 'Kopan': [1679, 1709, 2211], '393:': [1683], '382-386Google': [1684], '28De': [1686], 'Annaert': [1689, 2000], 'Cupers': [1691], 'Saftig': [1693, 1992], 'Craessaerts': [1695, 1994], 'Mumm': [1697], 'J.S.': [1698, 1850, 1917], 'Schroeter': [1699, 2209], 'Schrijvers': [1701], 'Wolfe': [1703, 2060], 'M.S.': [1704, 1973, 2038, 2061], 'Ray': [1705], 'W.J.': [1706], 'Goate': [1707], '398:': [1713, 1986], '518-522Google': [1714], 'exact': [1717], 'mechanism': [1718], 'γ-': [1723], 'ϵ-cleavages': [1725], 'remains': [1732, 2275], 'unclear.': [1733], 'Accumulating': [1734], 'evidence': [1735], 'suggests': [1736], 'high': [1739, 2550], 'molecular': [1740], 'weight': [1741], 'complex': [1742, 2595], 'presenilin,': [1744], 'nicastrin': [1745], '(29Yu': [1746], 'Nishimura': [1748], 'Arawaka': [1750], 'Levitan': [1752], 'Zhang': [1754, 1780, 1792, 1817, 1884], 'Tandon': [1756], 'Song': [1758], 'Y.Q.': [1759], 'Rogaeva': [1760], 'Kawarai': [1764], 'Supala': [1766], 'Levesque': [1768], 'Yu': [1770], 'Yang': [1772], 'D.S.': [1773], 'Holmes': [1774], 'Milman': [1776], 'Liang': [1778], 'D.H.': [1783], 'Rogaev': [1786], 'Janus': [1790], 'Aebersold': [1794], 'Farrer': [1796], 'L.S.': [1797], 'Sorbi': [1798], 'Bruni': [1800], 'Fraser': [1802], 'St.': [1804], 'George-Hyslop': [1805], '407:': [1809], '48-54Google': [1810], 'APH-1': [1812], '(30Francis': [1813, 1880], 'McGrath': [1815, 1882], 'Ruddy': [1819, 1886], 'D.A.': [1820, 1887, 2151], 'Sym': [1821, 1888], 'Apfeld': [1823, 1890], 'Nicoll': [1825, 1892], 'Maxwell': [1827, 1894], 'Hai': [1829, 1896], 'Ellis': [1831, 1898], 'Parks': [1833, 1900], 'Li': [1837, 1904], 'Myers': [1841, 1908], 'Himes': [1843, 1910], 'Hiebsch': [1845, 1912], 'Ruble': [1847, 1914], 'Nye': [1849, 1916], 'Curtis': [1851, 1918], 'Dev.': [1853, 1920], '3:': [1856, 1923, 2435], '85-97Google': [1857, 1924], '31Goutte': [1859], 'Tsunozaki': [1861], 'Hale': [1863], 'V.A.': [1864], 'Priess': [1865], '99:': [1875], '775-779Google': [1876], 'PEN-2': [1879], '32Steiner': [1926], 'Winkler': [1928], 'Edbauer': [1930], 'Prokop': [1932], 'Basset': [1934], 'Yamasaki': [1936], 'Kostka': [1938], '277:': [1946], '39062-39065Google': [1947], 'responsible': [1950], 'activity.': [1953, 2124, 2175], 'polytopic': [1955], 'PS1': [1958], 'PS2': [1960], 'thought': [1962], 'catalytic': [1966, 2083], 'component': [1967], 'this': [1969, 2404, 2590], 'machinery': [1971], '(33Wolfe': [1972], 'Xia': [1974, 2056], 'Ostaszewski': [1976], 'B.L.': [1977], 'Diehl': [1978], 'T.S.': [1979], 'Kimberly': [1980, 3375], 'W.T.': [1981, 2055, 3376], 'Selkoe': [1982, 2062, 3379], '513-517Google': [1987], '34De': [1989], 'Vanderstichele': [1996], 'Guhde': [1998], 'Figura': [2003], 'Van': [2005], 'Leuven': [2006], '391:': [2010], '387-390Google': [2011], '35Li': [2013], 'Y.M.': [2014], 'Lai': [2017], 'M.T.': [2018, 2311], 'Huang': [2019], 'Q.': [2020], 'Castro': [2021], 'DiMuzio-Mower': [2023], 'Harrison': [2025], 'Lellis': [2027], 'Nadin': [2029], 'Neduvelil': [2031], 'J.G.': [2032], 'Register': [2033], 'R.B.': [2034], 'Sardana': [2035], 'M.K.': [2036], 'Shearman': [2037], 'Shi': [2041], 'X.P.': [2042], 'Yin': [2043], 'K.C.': [2044], 'Shafer': [2045], 'Gardell': [2047], '405:': [2051], '689-694Google': [2052], '36Kimberly': [2054], 'Rahmati': [2058], '275:': [2068], '3173-3178Google': [2069], 'critical': [2073], 'aspartates': [2074], '6': [2078], '7': [2080, 3564, 3766], 'representing': [2081], 'site.': [2084, 2734], 'A': [2085, 2480, 3882, 4151], 'subset': [2086], 'includes': [2093], 'Notch,': [2094, 2126], 'ErbB4': [2096], 'tyrosine': [2097], 'kinase': [2098], 'receptor': [2099], 'neuregulins,': [2101], 'E-cadherin,': [2102, 2128], 'LRP,': [2103], 'CD44,': [2104, 2129], 'Delta,': [2105, 2130], 'Jagged,': [2106], 'Nectin-1-α': [2108], '(37De': [2109, 2132], 'Neuron.': [2112, 2135, 2396], '2003;': [2113, 2136, 3382, 3491], '38:': [2114, 2137], '9-12Google': [2115, 2138], 'also': [2118, 2161], 'presenilin-dependent,': [2122], 'For': [2125, 2627, 3557, 3681, 3993, 4013, 4354], 'ErbB4,': [2127], 'Jagged': [2131], 'LRP': [2141], '(38Quinn': [2142], 'K.A.': [2143], 'Pye': [2144], 'V.J.': [2145], 'Dai': [2146], 'Y.P.': [2147], 'Chesterman': [2148], 'C.N.': [2149], 'Owensby': [2150], 'Exp.': [2152], 'Cell': [2153, 3541, 4284], '251:': [2156], '433-441Google': [2157], 'it': [2159], 'demonstrated': [2163], 'metalloprotease': [2169], 'precedes': [2170], 'liberate': [2181], '(AICD),': [2190], 'respectively,': [2191, 4278, 4385], 'enabling': [2192], 'translocation': [2194], 'nucleus': [2197], 'where': [2198], 'they': [2199], 'activate': [2201], 'transcription': [2202], '(39Jarriault': [2203], 'Brou': [2205], 'Logeat': [2207], 'Israel': [2213], '377:': [2217], '355-358Google': [2218], '40Lu': [2220], 'F.M.': [2221], 'Lux': [2222], 'S.E.': [2223], '93:': [2232], '5663-5667Google': [2233], '41Cao': [2235], 'X.': [2236, 2385], 'Sudhof': [2237], '293:': [2241], '115-120Google': [2242], '42Minopoli': [2244], 'Candia': [2247], 'Bonetti': [2249], 'Faraonio': [2251], 'Zambrano': [2253], 'Russo': [2255], '6545-6550Google': [2262], 'So': [2264], 'APLP-2,': [2274, 2446], 'poorly': [2276], 'understood.': [2277], 'Large': [2278], 'secretory': [2279, 2344], '(4Paliga': [2283, 2794, 3039, 3516], '(43Webster': [2310], 'Groome': [2312], 'Francis': [2314], 'P.T.': [2315], 'Pearce': [2316], 'B.R.': [2317], 'Sherriff': [2318], 'F.E.': [2319], 'Felsenstein': [2322], 'K.M.': [2323], 'Wasco': [2324, 3377], 'Bowen': [2328], '310:': [2333], '95-99Google': [2334], 'corresponding': [2336, 2851, 3358, 3424], 'size': [2339, 4342], 'β-secretase-processed': [2343], 'detected': [2350], 'cell': [2356, 2616], 'lines.': [2357], 'addition,': [2359, 2649], 'accumulation': [2361], 'PS-1(–/–)': [2370], '(44Naruse': [2372], 'Kusiak': [2378], 'J.W.': [2379], 'Tomita': [2380], 'Iwatsubo': [2382], 'Qian': [2384], 'Ginty': [2386], 'D.D.': [2387], 'Borchelt': [2390], 'P.C.': [2393], '21:': [2398], '1213-1221Google': [2399], 'Presenilin-dependent': [2401], 'consistent': [2407], 'our': [2409, 4093], 'previous': [2410, 4094], 'finding': [2411], 'PS-2': [2413], 'interacts': [2414], 'immature': [2416], '(45Weidemann': [2418], 'Czech': [2424], 'Med.': [2433], '328-332Google': [2436], 'To': [2438, 2783, 2940, 3706, 4034], 'elucidate': [2439], 'developed': [2448], 'method': [2450, 2487, 4208], 'derived': [2455, 4377], 'from': [2456, 3447, 4286, 4378], 'APLP-1,': [2458, 2628, 3642, 4075], 'stabilizing': [2467], 'cytosolic': [2469, 4126], 'chimeric': [2472, 4132], 'fusion': [2473, 4133], 'z-domains': [2477], 'fused': [2481, 4260], 'tandem': [2483, 4144], '(2z': [2484], 'tag).': [2485], 'This': [2486, 4139, 4207], 'previously': [2488, 2759, 3649, 4388], 'enabled': [2489, 4210], 'us': [2490], 'soluble': [2494], '(ϵ-CTF': [2498], 'AICD)': [2500], 'generated': [2501, 3299, 3322], 'proteolysis': [2503], 'ϵ-site,': [2506], 'distal': [2507], 'γ-cleavage': [2510], 'site': [2511, 2837, 2969, 3118, 3129, 3203, 3214, 3270, 3281, 4217], 'analysis': [2536, 3683, 3994, 4014, 4392], '2z': [2545, 2847, 2973, 4137, 4165, 4257], 'tag': [2546, 2848, 2974, 3335, 4140, 4166, 4258], 'system': [2547], 'similarity': [2551], 'APLPs': [2556], 'APP.': [2558], 'Here': [2559], 'pharmacological': [2563, 4338], 'studies': [2564], 'γ-secretases': [2571], 'suggest': [2572], 'production': [2576], 'several': [2578], 'ϵ-like': [2581, 2635], 'fragments,': [2583], 'indicating': [2584], 'homologue': [2591], 'three': [2598, 3916], 'members.': [2602], 'Furthermore,': [2603], 'could': [2605], 'secreted': [2608, 2639, 4043], 'conditioned': [2612, 3793], 'APLP-2-transfected': [2615], 'lines': [2617], 'very': [2619], 'likely': [2620], 'correspond': [2621, 4425], 'cellular': [2632, 3810], 'overexpressing': [2646], 'APLP-1.': [2647], 'regulated': [2658], 'N-glycosylation,': [2660], 'fragments.': [2667], 'DNA': [2668], 'Constructs—To': [2669], 'generate': [2670, 2784, 2941], '2z-tagged': [2672, 3669, 3686, 3710, 3997, 4017], 'derivatives,': [2674], '2z-cDNA': [2675, 2912, 3023], 'amplified': [2677, 2820, 2954, 3065, 3150, 3235], 'PCR': [2679, 2737, 2822, 2853, 2877, 2956, 2977, 3067, 3101, 3152, 3187, 3237, 3253], 'pQE60–2z': [2681], 'template': [2683, 3230], 'sense': [2708, 3073, 3161], 'primer': [2709, 2725, 2827, 2831, 2960, 2964, 3074, 3093, 3162, 3179], 'encoding': [2710, 2726, 2901, 2965, 3015], 'XhoI': [2712, 2748, 3128, 3213, 3280], 'restriction': [2713, 2733, 2751, 2836, 2968, 3078, 3097, 3114, 3166, 3183, 3199, 3246, 3266], 'site,': [2714], 'thrombin': [2717], '(LVPR': [2718], 'GS)': [2719], '(5′-CCCCTCGAGCTGGTTCCGCGTGGATCGAAAGAGGAGAAATTAACC-3′)': [2721], 'antisense': [2724, 2830, 3092, 3178, 3248], 'stop': [2728], 'codon': [2729], 'ClaI': [2732, 2750], 'subcloned': [2740, 3104, 3190, 3256, 3312, 3340], 'into': [2741, 2914, 3006, 3026, 3138, 3191, 3290, 3313, 3341], 'pBluescript': [2742, 2792, 2880, 2915, 2951, 2994, 3007, 3037, 3106, 3134, 3140, 3147, 3192, 3219, 3226, 3258, 3286, 3293, 3309, 3337], 'SK+': [2743, 2793, 2881, 2952, 2995, 3008, 3038, 3148, 3227, 3310, 3338], '(Stratagene)': [2744], 'Generation': [2753], 'APP695–2z': [2755], 'described': [2758, 3648], 'APLP-1-2z,': [2785, 4294], 'human': [2787, 2946, 3033, 3143, 3305, 3328, 3346, 3363, 3387, 3426, 3496, 3674], 'cDNA': [2789, 2866, 2900, 2948, 3018, 3035, 3145, 3307, 3330], 'cloned': [2790, 2949, 3005, 3020, 3137, 3222, 3289], 'T7': [2825], 'universal': [2826], 'encoded': [2833], 'SalI': [2835, 2862, 2967, 2988, 3096, 3113, 3117, 3182, 3198, 3202, 3265, 3269], 'just': [2838], 'after': [2839], 'coding': [2842, 2985], 'region': [2843], '(for': [2844, 2970], 'following': [2846, 2972, 3070, 3155, 3240, 3573], 'ligation).': [2849, 2975], '640-bp': [2852, 2887], 'product': [2854, 2878, 2888, 2978], 'digested': [2856, 2871, 2917, 2980, 2998], 'BamHI': [2858], '(coding': [2859], 'region)': [2860, 2986], '(3′-end).': [2863], 'original': [2865, 2992], '(APLP-1': [2867], 'pBluescript)': [2869], 'KpnI/BamHI': [2872], 'ligated': [2874, 2909, 3125, 3210, 3277], '(KpnI/SalI).': [2882], 'verified': [2890], 'sequencing.': [2892], 'After': [2893, 3726], 'digestion': [2894], 'KpnI/SalI,': [2896], 'full-length': [2898, 3017, 3709, 4018, 4060, 4305], 'SalI-site': [2904], '3′-end': [2907], '(XhoI/ClaI)': [2913, 3135, 3220, 3287], 'SK+,': [2916, 3107, 3193, 3259], 'KpnI/ClaI.': [2919, 3228], 'Subcloning': [2920], 'APLP-1-2z': [2923, 3072, 4275, 4329], 'construct': [2924], 'expression': [2927], 'vector': [2928, 3225, 3292, 3315, 3343, 4317], 'pCEP4': [2929, 3027, 3233], 'cleaved': [2930], 'KpnI/NheI': [2932], 'performed': [2934, 3646, 4089], 'KpnI/XbaI': [2938], 'APLP-2-763-2z': [2943], 'construct,': [2944], 'APLP-2-763': [2947, 2993], 'T3': [2958], 'reverse': [2959], '3′-antisense': [2963], 'AatII': [2982], '(in': [2983], '(3′-coding': [2989], 'region).': [2990], 'clone': [2996], 'BamHI/AatII,': [3000], '(cleaved': [3009], 'BamHI/SalI).': [3011], 'XbaI/SalI': [3013], 'together': [3021], '(XhoI/SalI': [3024], 'cleaved)': [3025], '(NheI/BamHI': [3028], 'cleaved).': [3029], 'Deletion': [3031], 'Mutants—The': [3032], 'primer,': [3071, 3156, 3249], '(encoding': [3075, 3094, 3163, 3180], 'KpnI': [3077, 3111, 3165, 3196, 3245, 3263], 'site):': [3079, 3167], 'D568-APLP-1-2z,': [3080], '5′-GGGGGTACCCACCATGGATGAGCTGGCACCAGCTGGG-3′;': [3081], 'R579-APLP-1-2z,': [3082], '5′-GGGGGTACCCACCATGCGTGAGGCTGTATCGGCGTCTG-3′;': [3083], 'M588-APLP-1-2z,': [3084], '5′-GGGGGTACCCACCATGGGAGCGGGCGGAGGCTCCCTC-3′;': [3085], 'M600-APLP-1-2z,': [3086], '5′-GGGGGTACCCACCATGCTGCTCCTGCGCAGGAAGAAG-3′;': [3087], '3′-CGGACCTCCTTGCTGGGCAGCTGGGG-5′': [3089], 'site).': [3098, 3184], 'deletion': [3122, 3158, 3207, 3274, 4349], '2z-DNA': [3132, 3217, 3284], 'KpnI/ClaI-cleaved': [3139], 'SK+.': [3141], 'mutants,': [3159], 'M664-APLP-2-2z,': [3168], '5′-CCCGGTACCACCATGATTTTCAATGCCGAGAGAG-3′;': [3169], 'S691-APLP-2-2z,': [3170], '5′-CCCGGTACCACCATGAGTAGCAGTGCTCTCATTGG-3′;': [3171], 'M715-APLP-2-2z,': [3172], '5′-CCCGGTACCACCATGCTGAGGAAGAGGCAGTATGG-3′;': [3173], '3′-GGACCTCGTCTACGTCTAAACAGCTGGGG-5′': [3175], 'APLP-2-2z': [3231, 4331], 'primer:': [3241], 'R678-APLP-2-2z,': [3242], '5′-CCCGGTACCACCATGCGGGAATCCGTGGGCCCAC-3′(encoding': [3243], 'site);': [3247], '3′-CCCTCCTAGGTCTAGAACTTAGCTACCG-5′.': [3250], 'SK+KpnI/ClaI.': [3294], 'Mutant': [3295, 3317], 'N551Q': [3296], 'site-directed': [3301, 3324], 'mutagenesis': [3302, 3325], 'pCEP4.': [3316, 3344], 'R567E': [3318], 'c-Myc': [3320], 'Myc': [3334], 'Antibodies—The': [3345], 'APLP-1-specific': [3347, 3409, 3497], 'antiserum': [3348, 3389, 3410, 3498, 3736], '150': [3349, 3848, 3888, 3948], 'raised': [3351, 3392, 3413, 3461, 3501, 3508], 'rabbits': [3353, 3394, 3415, 3503], 'synthetic': [3356, 3397, 3464, 3506], 'residues': [3360, 3428, 3431, 3470], '553–592': [3361], '(46Walsh': [3365], 'Fadeeva': [3367], 'J.V.': [3368], 'LaVoie': [3369], '42:': [3383], '6664-6673Google': [3384], 'APLP-2-specific': [3388], '158': [3390], '672–696': [3400], 'APLP-2-763,': [3402, 4268], 'coupled': [3403, 3745], 'keyhole': [3405, 3417], 'limpet': [3406, 3418], 'hemocyanin.': [3407], '57': [3411], 'hemocyanin': [3419], 'conjugates': [3420], 'peptides,': [3423, 4044], '642–650': [3429], '604–614': [3432], 'N-terminal': [3436, 4390], 'cysteine.': [3437], 'antibody': [3439, 3453, 3740], 'recognizing': [3440], 'C': [3443, 3458, 3965, 4263], 'terminus': [3444, 3459], 'purchased': [3446], 'Calbiochem': [3448], '(residues': [3449, 3514], '752–763).': [3450], 'polyclonal': [3452], 'CT13': [3454], 'against': [3455, 3462], '13': [3469], 'A4CT': [3472], '(Eurogenetech,': [3473], 'Brussels,': [3474], 'Belgium)': [3475], '(47Grziwa': [3476], 'Grimm': [3478], 'M.O.': [3479], 'Hartmann': [3484], 'Lichtenthaler': [3486], 'S.F.': [3487], '278:': [3492], '6803-6808Google': [3493], '42464': [3499], '499–557)': [3515], 'Culture,': [3542], 'Transfection,': [3543], 'Inhibitor': [3545], 'Treatment—Human': [3546], 'cultivated': [3550, 3759], 'LipofectAMINE': [3554], 'Plus': [3555], '(Invitrogen).': [3556], 'inhibitor': [3558, 3587, 3593, 3603, 3867], 'experiments': [3559], 'treated': [3562, 3632], 'h': [3565, 3614, 3767, 3825, 3907], 'Me2SO': [3567, 3569], 'solutions': [3570], 'compounds:': [3574], 'L-685,458,': [3575], 'batimastat': [3576], '(provided': [3577], 'Merck,': [3579], 'Sharp': [3580], '&': [3581], 'Dohne),': [3582], 'TAPI-2': [3583], '(Peptides': [3584], 'International),': [3585], 'MDL28170/calpain': [3586], 'III': [3588], '(benzyloxycarbonyl-Val-Phe-CHO,': [3589], 'carbobenzoxy-valinyl-phenylalanyl,': [3590], 'Calbiochem),': [3591, 3600, 3606], 'IX': [3594], '(DAPT)': [3595], '(Calbiochem),': [3596], 'MG132': [3597], '(benzyloxycarbonyl-LLL-CHO,': [3598], 'carbobenzoxy-l-leucyl-l-leucyl-l-leucinal,': [3599], 'ALLN': [3601], '(calpain': [3602], 'I,': [3604], 'N-acetyl-leucyl-leucyl-norleucinal-CHO,': [3605], 'lactacystin': [3607], '(Calbiochem).': [3608], 'Cells': [3609, 4312], 'pretreated': [3611], '1': [3613, 4334], 'tunicamycin': [3616], '(Sigma)': [3617], '12-myristate': [3620], '13-acetate': [3621], '(PMA)': [3622], '(Calbiochem)': [3623], 'chased': [3625], '4': [3627, 3799], 'h.': [3628], 'Control': [3629], 'Me2SO.': [3634], 'Immunoblotting—Lysis': [3635], 'immunoprecipitation': [3639, 3822, 3904], '(48Weidemann': [3650], 'Konig': [3652], 'Bunke': [3654], 'Fischer': [3656], '1989;': [3665], '57:': [3666], '115-126Google': [3667], 'immunoprecipitated': [3672, 4366], 'IgG': [3675], 'immobilized': [3676], 'Sepharose': [3678, 3912, 4301], '(Amersham': [3679, 3773], 'Biosciences).': [3680], 'CTFs,': [3687, 3998], 'samples': [3688, 3712, 3729, 3999, 4020, 4045], 'denatured': [3690, 3714, 4001, 4022, 4047], 'sample': [3692, 3716, 3981, 4003, 4024, 4049], 'buffer': [3693, 3717, 3842, 3881, 3919, 3923, 3941, 3964, 3982, 4004, 4025, 4050], 'absence': [3696], 'reducing': [3698], 'agents': [3699], 'electrophoresed': [3701, 4008, 4029, 4054], 'on': [3702, 3722, 4009, 4030, 4055, 4064, 4096, 4337], '15%': [3703, 4010], 'Tris/glycine': [3704, 3724, 4011, 4032, 4066], 'gels.': [3705, 3725, 4012, 4033, 4058, 4067], 'investigate': [3707, 4035], 'β-mercaptoethanol': [3719, 3984, 4006, 4027, 4052], 'separated': [3721], '8%': [3723, 4031, 4065], 'Western': [3727], 'blotting,': [3728], 'incubated': [3731, 3764, 4298], 'nonspecific': [3734], 'rabbit': [3735], 'primary': [3739], 'followed': [3741], 'anti-rabbit': [3743], 'serum': [3744, 3790], 'horseradish': [3747], 'peroxidase': [3748], 'ECL': [3750], 'detection.': [3751], 'Metabolic': [3752], 'Labeling': [3753], 'Immunoprecipitation—Stably': [3755], '6-cm': [3761], 'dishes': [3762], '200': [3769], 'μCi': [3770], '[35S]methionine/dish': [3772], 'Biosciences)': [3774], '1.5': [3776], 'ml': [3777], 'minimum': [3779], 'essential': [3780], 'medium': [3781], 'lacking': [3782], 'methionine': [3783], '(Sigma),': [3784, 3854], '5%': [3786], 'dialyzed': [3787], 'fetal': [3788], 'calf': [3789], '(Sigma).': [3791], 'harvested,': [3796, 3836], 'centrifuged': [3797], '°C': [3800, 3989], '10,000': [3802, 3873], '×': [3803, 3874], 'g': [3804, 3875], 'min': [3807], 'remove': [3809], 'debris,': [3811], 'subsequently': [3812], 'transferred': [3813], 'new': [3815], 'microcentrifuge': [3816], 'tubes,': [3817], 'finally': [3819], 'subjected': [3820, 3902], '3': [3824, 3906], 'room': [3827, 3909], 'temperature.': [3828, 3910], 'washed': [3832, 3915], 'phosphate-buffered': [3834], 'saline,': [3835], 'lysed': [3838], 'ice-cold': [3840], 'lysis': [3841], '(50': [3843], 'mm': [3844, 3849, 3856, 3884, 3889, 3895, 3926, 3931, 3937, 3944, 3949, 3955, 3967], 'Tris/HCl,': [3845, 3885, 3927, 3945, 3968], 'pH': [3846, 3886, 3928, 3946, 3969], '7.5,': [3847, 3887, 3929, 3947], 'NaCl,': [3850, 3890, 3932, 3950], '1%': [3851, 3858], 'Nonidet': [3852, 3892, 3934, 3952], 'P-40': [3853], '5': [3855, 3991], 'EDTA,': [3857, 3896, 3956], 'Triton': [3859], 'X-100),': [3860], 'supplemented': [3861, 3897, 3957], '(Complete™': [3865], 'mixture,': [3868], 'Roche': [3869], 'Applied': [3870], 'Science).': [3871], 'supernatants': [3876], 'diluted': [3878], '1:5': [3879], '(10': [3883, 3925, 3943, 3966], '0.2%': [3891], 'P-40,': [3893, 3935, 3953], '2': [3894, 3936, 3954], '0.05%': [3899], 'SDS)': [3900], 'beads': [3913, 3972], 'times': [3917], 'A,': [3920], 'twice': [3921], 'B': [3924], '500': [3930], '0,2%': [3933, 3951, 3959], 'EDTA),': [3938], 'once': [3939, 3962], 'A′': [3942], 'SDS),': [3960], '7.5).': [3970], 'resuspended': [3974], 'μl': [3977], '2×': [3978], 'Laemmli': [3979], 'SDS': [3980], 'plus': [3983], 'heated': [3986], '95': [3988], 'min.': [3992], 'without': [4005], 'protein,': [4019], 'wt': [4038], 'CTFs': [4039], '16.5%': [4056], 'Tris/Tricine': [4057], 'analyzed': [4063], 'Detection': [4068], 'Fragments': [4072], 'APP695,': [4074], 'APLP-2-763—The': [4077], 'investigation': [4078], 'analogy': [4091], 'study': [4095], 'stabilized': [4129], 'tag.': [4138], 'corresponds': [4141], 'repeat': [4145], 'z-domain': [4148], 'binds': [4153], 'heavy': [4156], 'chain': [4157], 'immunoglobulins.': [4159], 'does': [4167], 'not': [4168], 'alter': [4169], 'stabilizes': [4176], 'enhances': [4181], 'detection': [4183, 4212], 'novel': [4215], 'Val50': [4231], 'Thus,': [4255], 'termini': [4264], 'constructs,': [4271], 'APLP-2-2z,': [4277, 4296], 'overexpressed': [4280], 'lysates': [4285], 'cells,': [4288, 4356], 'APP-2z,': [4293], 'IgG-coupled': [4300], 'precipitate': [4303], '2z-encoding': [4304], '(Fig.': [4310, 4367], '1).': [4311], 'empty': [4316], 'control.': [4322], 'Classification': [4323], 'Fig.': [4333], 'based': [4336], 'studies,': [4339], 'compared': [4347], 'mutants': [4350], 'below.': [4353], 'APP-2z': [4355], '27': [4361], '23': [4363], 'kDa': [4364, 4424], '1A,': [4368], 'lane': [4369], '1)': [4370], 'represent': [4372], 'products': [4376], 'ϵ-sites,': [4384], 'determined': [4387], 'upper': [4418], 'bands': [4419], '29': [4421], '28': [4423]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018647432', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-12T06:35:21.825815', 'created_date': '2016-06-24'}