Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2018620079', 'doi': 'https://doi.org/10.1161/hc0702.104183', 'title': 'Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE', 'display_name': 'Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE', 'publication_year': 2002, 'publication_date': '2002-02-19', 'ids': {'openalex': 'https://openalex.org/W2018620079', 'doi': 'https://doi.org/10.1161/hc0702.104183', 'mag': '2018620079', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11854121'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc0702.104183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1161/hc0702.104183', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041078416', 'display_name': 'Giuseppina Basta', 'orcid': 'https://orcid.org/0000-0003-0809-4374'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppina Basta', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Giuseppina Basta From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Giuseppina Basta From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}, {'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023132848', 'display_name': 'Guido Lazzerini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Guido Lazzerini', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Guido Lazzerini From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Guido Lazzerini From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035619683', 'display_name': 'Marika Massaro', 'orcid': 'https://orcid.org/0000-0001-6124-5077'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marika Massaro', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'Marika Massaro From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': 'Marika Massaro From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}, {'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004083793', 'display_name': 'Tommaso Simoncini', 'orcid': 'https://orcid.org/0000-0002-2971-0079'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tommaso Simoncini', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'Tommaso Simoncini From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Tommaso Simoncini From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103798402', 'display_name': 'Piero Tanganelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Piero Tanganelli', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'Piero Tanganelli From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Piero Tanganelli From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086060905', 'display_name': 'Caifeng Fu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Caifeng Fu', 'raw_affiliation_strings': ['Caifeng Fu From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Caifeng Fu From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041682013', 'display_name': 'Thomas Kislinger', 'orcid': 'https://orcid.org/0000-0003-3525-5540'}, 'institutions': [{'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Thomas Kislinger', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'Thomas Kislinger From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)'], 'affiliations': [{'raw_affiliation_string': 'Thomas Kislinger From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}, {'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111575966', 'display_name': 'David M. Stern', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'David M. Stern', 'raw_affiliation_strings': ['David M. Stern From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I4210106076', 'https://openalex.org/I102064193']}, {'raw_affiliation_string': 'David M. Stern From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007603996', 'display_name': 'Ann Marie Schmidt', 'orcid': 'https://orcid.org/0000-0001-8902-070X'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ann Marie Schmidt', 'raw_affiliation_strings': ['Ann Marie Schmidt From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Ann Marie Schmidt From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067302152', 'display_name': 'Raffaele De Caterina', 'orcid': 'https://orcid.org/0000-0003-1637-574X'}, 'institutions': [{'id': 'https://openalex.org/I102064193', 'display_name': 'University of Siena', 'ror': 'https://ror.org/01tevnk56', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I102064193']}, {'id': 'https://openalex.org/I4210106076', 'display_name': 'Istituto di Fisiologia Clinica', 'ror': 'https://ror.org/01kdj2848', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210106076', 'https://openalex.org/I4210155236']}, {'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Raffaele De Caterina', 'raw_affiliation_strings': ['From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'Raffaele De Caterina From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)'], 'affiliations': [{'raw_affiliation_string': 'From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.); Institute of Pathology, University of Siena, Siena, Italy (P.T.); G. d’Annunzio University, Chieti, Italy (R.D.C.); and College of Physicians and Surgeons, Columbia University, New York, NY (C.F., T.K., D.M.S., A.M.S.).', 'institution_ids': ['https://openalex.org/I102064193', 'https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Raffaele De Caterina From CNR Institute of Clinical Physiology, Pisa, Italy (G.B., G.L., M.M., T.S., R.D.C.)', 'institution_ids': ['https://openalex.org/I4210106076']}, {'raw_affiliation_string': 'Institute of Pathology, University of Siena, Siena, Italy (P.T.)', 'institution_ids': ['https://openalex.org/I102064193']}, {'raw_affiliation_string': "G. d'Annunzio University, Chieti, Italy (R.D.C.)", 'institution_ids': ['https://openalex.org/I39387349']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 16.937, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 524, 'citation_normalized_percentile': {'value': 0.999259, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '105', 'issue': '7', 'first_page': '816', 'last_page': '822'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11597', 'display_name': 'Neutrophil, Myeloperoxidase and Oxidative Mechanisms', 'score': 0.9318, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10227', 'display_name': 'Acute Ischemic Stroke Management', 'score': 0.9143, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rage', 'display_name': 'RAGE', 'score': 0.86087024}, {'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.71953917}, {'id': 'https://openalex.org/keywords/advanced-glycation-end-product', 'display_name': 'Advanced glycation end-product', 'score': 0.6150693}, {'id': 'https://openalex.org/keywords/immunoglobulin-superfamily', 'display_name': 'Immunoglobulin superfamily', 'score': 0.5724102}], 'concepts': [{'id': 'https://openalex.org/C2778857457', 'wikidata': 'https://www.wikidata.org/wiki/Q153641', 'display_name': 'Rage (emotion)', 'level': 2, 'score': 0.86087024}, {'id': 'https://openalex.org/C147990577', 'wikidata': 'https://www.wikidata.org/wiki/Q25790', 'display_name': 'Glycation', 'level': 3, 'score': 0.8544951}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.71953917}, {'id': 'https://openalex.org/C16224149', 'wikidata': 'https://www.wikidata.org/wiki/Q187637', 'display_name': 'Cell adhesion molecule', 'level': 2, 'score': 0.69161576}, {'id': 'https://openalex.org/C2776997535', 'wikidata': 'https://www.wikidata.org/wiki/Q2556837', 'display_name': 'Advanced glycation end-product', 'level': 4, 'score': 0.6150693}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6029866}, {'id': 'https://openalex.org/C2776992346', 'wikidata': 'https://www.wikidata.org/wiki/Q111140', 'display_name': 'Endothelium', 'level': 2, 'score': 0.5871862}, {'id': 'https://openalex.org/C91682701', 'wikidata': 'https://www.wikidata.org/wiki/Q41797304', 'display_name': 'Immunoglobulin superfamily', 'level': 3, 'score': 0.5724102}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5700906}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4841917}, {'id': 'https://openalex.org/C132155493', 'wikidata': 'https://www.wikidata.org/wiki/Q7558942', 'display_name': 'Soluble cell adhesion molecules', 'level': 4, 'score': 0.48225123}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.4808684}, {'id': 'https://openalex.org/C2909375385', 'wikidata': 'https://www.wikidata.org/wiki/Q187637', 'display_name': 'Intercellular Adhesion Molecule-1', 'level': 3, 'score': 0.45648384}, {'id': 'https://openalex.org/C85789140', 'wikidata': 'https://www.wikidata.org/wiki/Q187640', 'display_name': 'Cell adhesion', 'level': 3, 'score': 0.45206177}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.4317337}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.42955837}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4128325}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24681196}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20642671}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20295379}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.17457405}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.07667416}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017127', 'descriptor_name': 'Glycation End Products, Advanced', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002448', 'descriptor_name': 'Cell Adhesion', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019040', 'descriptor_name': 'E-Selectin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019040', 'descriptor_name': 'E-Selectin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019040', 'descriptor_name': 'E-Selectin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D017127', 'descriptor_name': 'Glycation End Products, Advanced', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017127', 'descriptor_name': 'Glycation End Products, Advanced', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018799', 'descriptor_name': 'Intercellular Adhesion Molecule-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000067759', 'descriptor_name': 'Receptor for Advanced Glycation End Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011971', 'descriptor_name': 'Receptors, Immunologic', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012501', 'descriptor_name': 'Saphenous Vein', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D012501', 'descriptor_name': 'Saphenous Vein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013583', 'descriptor_name': 'Synovial Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013583', 'descriptor_name': 'Synovial Membrane', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013583', 'descriptor_name': 'Synovial Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020298', 'descriptor_name': 'U937 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc0702.104183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11854121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hc0702.104183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.8, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1502047387', 'https://openalex.org/W1503258737', 'https://openalex.org/W1511533680', 'https://openalex.org/W1533977973', 'https://openalex.org/W1557253076', 'https://openalex.org/W1572011530', 'https://openalex.org/W1902029503', 'https://openalex.org/W1966551335', 'https://openalex.org/W1984830754', 'https://openalex.org/W1990852282', 'https://openalex.org/W1995180560', 'https://openalex.org/W1997842962', 'https://openalex.org/W2025016154', 'https://openalex.org/W2026782054', 'https://openalex.org/W2028257547', 'https://openalex.org/W2054498786', 'https://openalex.org/W2057616008', 'https://openalex.org/W2062219794', 'https://openalex.org/W2065012620', 'https://openalex.org/W2071675524', 'https://openalex.org/W2080937909', 'https://openalex.org/W2089878313', 'https://openalex.org/W2099753885', 'https://openalex.org/W2106697731', 'https://openalex.org/W2114053318', 'https://openalex.org/W2120833123', 'https://openalex.org/W2122708604', 'https://openalex.org/W2131868847', 'https://openalex.org/W2134812217', 'https://openalex.org/W2138928713', 'https://openalex.org/W2156592815', 'https://openalex.org/W2162581823', 'https://openalex.org/W2164745047', 'https://openalex.org/W2168994316', 'https://openalex.org/W3024383408', 'https://openalex.org/W4248451563', 'https://openalex.org/W4294216491', 'https://openalex.org/W90630212'], 'related_works': ['https://openalex.org/W4302319898', 'https://openalex.org/W3008484206', 'https://openalex.org/W2361597252', 'https://openalex.org/W2348783817', 'https://openalex.org/W2289257906', 'https://openalex.org/W2057844010', 'https://openalex.org/W2037257630', 'https://openalex.org/W1995801352', 'https://openalex.org/W15885275', 'https://openalex.org/W144927554'], 'abstract_inverted_index': {'Background': [0], '—': [1, 81, 162], 'The': [2], 'products': [3, 15], 'of': [4, 9, 68, 111, 118, 129, 146, 159], 'nonenzymatic': [5], 'glycation': [6, 13], 'and': [7, 25, 79, 91, 131, 141, 179], 'oxidation': [8, 40], 'proteins,': [10], 'the': [11, 42, 64, 106], 'advanced': [12], 'end': [14], '(AGEs),': [16], 'form': [17, 34], 'under': [18], 'diverse': [19], 'circumstances': [20], 'such': [21], 'as': [22], 'aging,': [23], 'diabetes,': [24], 'kidney': [26], 'failure.': [27], 'Recent': [28], 'studies': [29], 'suggested': [30], 'that': [31, 66], 'AGEs': [32, 50, 69, 122, 143], 'may': [33, 166], 'in': [35, 95, 99, 153, 170, 177], 'inflamed': [36, 101], 'foci,': [37], 'driven': [38], 'by': [39, 48, 120], 'or': [41, 123], 'myeloperoxidase': [43], 'pathway.': [44], 'A': [45], 'principal': [46], 'means': [47], 'which': [49], 'alter': [51], 'cellular': [52], 'properties': [53], 'is': [54], 'through': [55, 164], 'interaction': [56, 67], 'with': [57, 70], 'their': [58], 'signal-transduction': [59], 'receptor': [60], 'RAGE.': [61, 160], 'We': [62], 'tested': [63], 'hypothesis': [65], 'RAGE': [71, 119], 'on': [72, 157], 'endothelial': [73, 115, 151, 171], 'cells': [74, 152], 'enhances': [75], 'vascular': [76, 84, 134], 'activation.': [77], 'Methods': [78], 'Results': [80], 'AGEs,': [82, 163], 'RAGE,': [83, 165], 'cell': [85, 135], 'adhesion': [86, 89, 136, 139, 145], 'molecule-1,': [87, 90, 137, 140], 'intercellular': [88, 138], 'E-selectin': [92], 'are': [93], 'expressed': [94], 'an': [96], 'overlapping': [97], 'manner': [98, 155], 'human': [100, 112], 'rheumatoid': [102], 'synovia,': [103], 'especially': [104], 'within': [105], 'endothelium.': [107], 'In': [108], 'primary': [109], 'cultures': [110], 'saphenous': [113], 'vein': [114], 'cells,': [116, 172], 'engagement': [117], 'heterogeneous': [121], 'N': [124], 'ε(carboxymethyl)lysine–modified': [125], 'adducts': [126], 'enhanced': [127], 'levels': [128], 'mRNA': [130], 'antigen': [132], 'for': [133], 'E-selectin.': [142], 'increased': [144], 'polymorphonuclear': [147], 'leukocytes': [148], 'to': [149], 'stimulated': [150], 'a': [154], 'reduced': [156], 'blockade': [158], 'Conclusions': [161], 'prime': [167], 'proinflammatory': [168, 175], 'mechanisms': [169, 176], 'thereby': [173], 'amplifying': [174], 'atherogenesis': [178], 'chronic': [180], 'inflammatory': [181], 'disorders.': [182]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018620079', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 33}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 38}, {'year': 2012, 'cited_by_count': 30}], 'updated_date': '2024-12-18T18:04:47.920100', 'created_date': '2016-06-24'}