Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2018354902', 'doi': 'https://doi.org/10.1021/bi0355995', 'title': 'Structural and Dynamic Studies on Ligand-Free Adenylate Kinase from <i>Mycobacterium tuberculosis </i>Revealed a Closed Conformation that Can Be Related to the Reduced Catalytic Activity<sup>,</sup>', 'display_name': 'Structural and Dynamic Studies on Ligand-Free Adenylate Kinase from <i>Mycobacterium tuberculosis </i>Revealed a Closed Conformation that Can Be Related to the Reduced Catalytic Activity<sup>,</sup>', 'publication_year': 2003, 'publication_date': '2003-12-09', 'ids': {'openalex': 'https://openalex.org/W2018354902', 'doi': 'https://doi.org/10.1021/bi0355995', 'mag': '2018354902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/414791'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0355995', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024772987', 'display_name': 'Simona Miron', 'orcid': 'https://orcid.org/0000-0003-0565-9958'}, 'institutions': [{'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Simona Miron', 'raw_affiliation_strings': ['Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France', 'institution_ids': ['https://openalex.org/I80043', 'https://openalex.org/I1294671590', 'https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055713674', 'display_name': 'Hélène Munier‐Lehmann', 'orcid': 'https://orcid.org/0000-0001-7579-8561'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Hélène Munier-Lehmann', 'raw_affiliation_strings': ['Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I80043', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109042902', 'display_name': 'Constantin T. Craescu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Constantin T. Craescu', 'raw_affiliation_strings': ['Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie-Recherche, Centre Universitaire, Bâtiments 110-112, F-91405 Orsay, France, and Laboratoire de Chimie Structurale des Macromolécules (CNRS, URA 218), Institut Pasteur, Paris, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I80043', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.681, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.693236, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '43', 'issue': '1', 'first_page': '67', 'last_page': '77'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12318', 'display_name': 'Quinazolinone synthesis and applications', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C180526460', 'wikidata': 'https://www.wikidata.org/wiki/Q356240', 'display_name': 'Adenylate kinase', 'level': 3, 'score': 0.74858034}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.67803824}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6086588}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.51387095}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.49058166}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4102186}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.36501318}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.26576972}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.09102613}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.059330285}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004492', 'descriptor_name': 'Edetic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004492', 'descriptor_name': 'Edetic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005399', 'descriptor_name': 'Fishes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008930', 'descriptor_name': 'Mitochondria, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012270', 'descriptor_name': 'Ribosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0355995', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/414791', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1536832486', 'https://openalex.org/W1568082615', 'https://openalex.org/W1975459052', 'https://openalex.org/W1977670956', 'https://openalex.org/W1982843071', 'https://openalex.org/W1993844919', 'https://openalex.org/W2006629069', 'https://openalex.org/W2011109781', 'https://openalex.org/W2015693792', 'https://openalex.org/W2019813447', 'https://openalex.org/W2028231353', 'https://openalex.org/W2054388656', 'https://openalex.org/W2055100088', 'https://openalex.org/W2069602336', 'https://openalex.org/W2080717344', 'https://openalex.org/W2097294533', 'https://openalex.org/W2099047634', 'https://openalex.org/W2114303720', 'https://openalex.org/W2140147242', 'https://openalex.org/W2148521301', 'https://openalex.org/W2401365884', 'https://openalex.org/W250385500', 'https://openalex.org/W251682888', 'https://openalex.org/W2949250147', 'https://openalex.org/W322900245'], 'related_works': ['https://openalex.org/W4211088770', 'https://openalex.org/W3103481565', 'https://openalex.org/W2462113033', 'https://openalex.org/W2159620470', 'https://openalex.org/W2102928855', 'https://openalex.org/W1983113419', 'https://openalex.org/W1983001537', 'https://openalex.org/W1963693682', 'https://openalex.org/W180243494', 'https://openalex.org/W1578076358'], 'abstract_inverted_index': {'The': [0, 14, 38, 52], 'in': [1, 9, 16, 22], 'vitro': [2], 'transport': [3], 'into': [4, 47, 91], 'mitochondria': [5, 26, 50, 71], 'of': [6, 25, 45, 54, 57, 63, 70, 79, 86], 'proteins': [7, 74, 93], 'synthesized': [8], 'the': [10, 18, 23, 29, 34, 43, 48, 58, 61, 68, 76, 80, 84, 87, 99, 104], 'cytoplasm': [11], 'was': [12], 'studied.': [13], 'system,': [15], 'which': [17], 'microsomes': [19, 101], 'synthesize': [20], 'protein': [21, 64], 'presence': [24], 'directly': [27], 'during': [28], 'experiment': [30], 'proved': [31], 'to': [32, 98], 'be': [33], 'most': [35], 'efficient': [36], 'one.': [37], 'microsomal': [39, 73], 'fraction': [40], 'significantly': [41], 'stimulated': [42], 'incorporation': [44, 90], '14C-valine': [46], 'isolated': [49], 'proteins.': [51], 'effects': [53], 'EDTA': [55], 'treatment': [56], 'mitochondrial': [59, 92], 'fraction,': [60], 'dependence': [62], 'synthesis': [65], 'stimulation': [66, 85], 'on': [67, 103], 'ratio': [69], 'and': [72, 75], 'kinetic': [77], 'pattern': [78], 'reaction': [81], 'suggest': [82], 'that': [83], 'labelled': [88, 100], 'precursor': [89], 'is': [94], 'not': [95], 'probably': [96], 'due': [97], 'adsorption': [102], 'mitochondria.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018354902', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T05:20:27.603924', 'created_date': '2016-06-24'}