Title: THE INTERRELATIONSHIP OF THE ADRENAL CORTEX AND THE ANTERIOR LOBE OF THE HYPOPHYSIS*†
Abstract: The Adrenals in Hypophysectomized Animals and in Hypopituiturism. That a very intimate relationship exists between the adrenal cortex and the anterior lobe of the hypophysis has been suspected from both clinical and experimental observations. It has been very definitely established that a rapid and extensive atrophy of the adrenal cortex follows total hypophysectomy in the tadpole (1, 2), rat (3, 4, 5, 6, 7, 8, 9), rabbit (10, 11), and dog (12, 13, 14). The histological changes in the adrenals of rats have been carefully studied by Smith (5). The medulla appears normal. The cortex, which is probably solely responsible for the diminution in the size of the gland, is altered in a pronounced way. The cells of all three zones show diminution in cytoplasm, but are not decreased in number. Fat deposits are limited to a central zone. In our hypophysectomized rats we have found the same changes. To determine the site of the initial alterations of the adrenal glands, eighteen totally hypophysectomized rats were examined at varying postoperative periods. Five days after hypophysectomy the gland showed minimal histological changes. There was some distortion of the reticular zone, and the cells in this layer and in the inner part of the fascicular zone were smaller than normal.
Publication Year: 1934
Publication Date: 1934-11-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 37
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