Title: Synthesis and Biological Activity of N6- (n -Alkylureido) purine Ribonucleosides and Their 5′-Phosphates
Abstract: Syntheses and biological activities of 12 N6-(n-alkylureido) purine ribonucleosides (alkyl chain length of 1-10, 16, and 18 carbons) and three N6-(n-alkylureido)purine ribonucleoside 5′-phosphates (chain length of 4,9, and 10 carbons) are described. The N6-(nalkylureido) purine ribonucleosides were prepared by a reaction of (2′,3′,5′-tri-O-acetyl-β-ribofuranosyl)-9H-purine-6-carabnadm ate n-alkylamine in refluxing pyridine. The 5′-nucleotides were prepared by direct phosphorylation of the corresponding ribonucleoside with phosphorus oxychloride and triethyl phosphate. Some N6-(n-alkylureido) purine ribonucleosides (n-octyl, n-nonyl, and n-decyl) and their nucleotides showed a marked antiproliferative activity against L-1210 cells in culture.
Publication Year: 1978
Publication Date: 1978-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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