Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2017764792', 'doi': 'https://doi.org/10.1016/j.bmc.2007.11.043', 'title': 'Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist', 'display_name': 'Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist', 'publication_year': 2007, 'publication_date': '2007-11-26', 'ids': {'openalex': 'https://openalex.org/W2017764792', 'doi': 'https://doi.org/10.1016/j.bmc.2007.11.043', 'mag': '2017764792', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18068993'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2007.11.043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101874500', 'display_name': 'Jinglan Li', 'orcid': 'https://orcid.org/0000-0002-6571-8772'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jinglan Li', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065725761', 'display_name': 'Kaname Isozaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kaname Isozaki', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004907055', 'display_name': 'Kazushi Okada', 'orcid': 'https://orcid.org/0000-0002-7682-8264'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazushi Okada', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073418734', 'display_name': 'Ayami Matsushima', 'orcid': 'https://orcid.org/0000-0001-9751-577X'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ayami Matsushima', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069654436', 'display_name': 'Takeru Nose', 'orcid': 'https://orcid.org/0000-0001-9771-7267'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeru Nose', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066835130', 'display_name': 'Tommaso Costa', 'orcid': 'https://orcid.org/0000-0002-8729-3357'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tommaso Costa', 'raw_affiliation_strings': ['Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma, Italy'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio di Farmacologia, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5042570402', 'display_name': 'Yasuyuki Shimohigashi', 'orcid': 'https://orcid.org/0000-0003-2948-0733'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuyuki Shimohigashi', 'raw_affiliation_strings': ['Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Structure-Function Biochemistry, Department of Chemistry, Research-Education Centre of Risk Science, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan.', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.333, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.588487, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '16', 'issue': '5', 'first_page': '2635', 'last_page': '2644'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10196', 'display_name': 'Mechanisms and Management of Neuropathic Pain', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nociceptin-receptor', 'display_name': 'Nociceptin receptor', 'score': 0.9738281}, {'id': 'https://openalex.org/keywords/competitive-antagonist', 'display_name': 'Competitive antagonist', 'score': 0.6751669}, {'id': 'https://openalex.org/keywords/nociception', 'display_name': 'Nociception', 'score': 0.478738}, {'id': 'https://openalex.org/keywords/opioid-antagonist', 'display_name': 'Opioid antagonist', 'score': 0.44573075}, {'id': 'https://openalex.org/keywords/inverse-agonist', 'display_name': 'Inverse agonist', 'score': 0.42395288}], 'concepts': [{'id': 'https://openalex.org/C125439840', 'wikidata': 'https://www.wikidata.org/wiki/Q14911984', 'display_name': 'Nociceptin receptor', 'level': 5, 'score': 0.9738281}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.877365}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.84415036}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.77452624}, {'id': 'https://openalex.org/C86811712', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Competitive antagonist', 'level': 4, 'score': 0.6751669}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.55147845}, {'id': 'https://openalex.org/C58732023', 'wikidata': 'https://www.wikidata.org/wiki/Q770260', 'display_name': 'Partial agonist', 'level': 4, 'score': 0.5133149}, {'id': 'https://openalex.org/C2778122271', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Receptor antagonist', 'level': 4, 'score': 0.4593755}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.45343626}, {'id': 'https://openalex.org/C88016717', 'wikidata': 'https://www.wikidata.org/wiki/Q417189', 'display_name': 'Opioid peptide', 'level': 4, 'score': 0.44657132}, {'id': 'https://openalex.org/C2775962371', 'wikidata': 'https://www.wikidata.org/wiki/Q908096', 'display_name': 'Opioid antagonist', 'level': 5, 'score': 0.44573075}, {'id': 'https://openalex.org/C2779886867', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opioid receptor', 'level': 4, 'score': 0.44374096}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.42406166}, {'id': 'https://openalex.org/C89951826', 'wikidata': 'https://www.wikidata.org/wiki/Q1671731', 'display_name': 'Inverse agonist', 'level': 4, 'score': 0.42395288}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.29442772}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25804892}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.122062266}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.05094409}], 'mesh': [{'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044385', 'descriptor_name': 'GTP-Binding Protein alpha Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044385', 'descriptor_name': 'GTP-Binding Protein alpha Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2007.11.043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18068993', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.72, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320320912', 'funder_display_name': 'Ministry of Education, Culture, Sports, Science and Technology', 'award_id': None}, {'funder': 'https://openalex.org/F4320321945', 'funder_display_name': 'Ministry of Health, Labour and Welfare', 'award_id': None}, {'funder': 'https://openalex.org/F4320323467', 'funder_display_name': 'Mochida Memorial Foundation for Medical and Pharmaceutical Research', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1606326824', 'https://openalex.org/W1837890348', 'https://openalex.org/W1967823368', 'https://openalex.org/W1968344910', 'https://openalex.org/W1973370124', 'https://openalex.org/W1979495245', 'https://openalex.org/W1988402607', 'https://openalex.org/W1990402206', 'https://openalex.org/W1990815263', 'https://openalex.org/W2000176929', 'https://openalex.org/W2001049824', 'https://openalex.org/W2001534358', 'https://openalex.org/W2007694679', 'https://openalex.org/W2013374571', 'https://openalex.org/W2013568805', 'https://openalex.org/W2016562510', 'https://openalex.org/W2017456562', 'https://openalex.org/W2017526841', 'https://openalex.org/W2017932757', 'https://openalex.org/W2032647219', 'https://openalex.org/W2032761582', 'https://openalex.org/W2039648325', 'https://openalex.org/W2039764387', 'https://openalex.org/W2049609378', 'https://openalex.org/W2057971042', 'https://openalex.org/W2066624199', 'https://openalex.org/W2070542410', 'https://openalex.org/W2072158907', 'https://openalex.org/W2075963772', 'https://openalex.org/W2076527193', 'https://openalex.org/W2077581224', 'https://openalex.org/W2077858461', 'https://openalex.org/W2079317155', 'https://openalex.org/W2089467147', 'https://openalex.org/W2094167697', 'https://openalex.org/W2112344802', 'https://openalex.org/W2118218199', 'https://openalex.org/W2125712538', 'https://openalex.org/W2163811098', 'https://openalex.org/W2223822401'], 'related_works': ['https://openalex.org/W3136719764', 'https://openalex.org/W2998966145', 'https://openalex.org/W2147298606', 'https://openalex.org/W2141337456', 'https://openalex.org/W2076175580', 'https://openalex.org/W2061592539', 'https://openalex.org/W2046793214', 'https://openalex.org/W2022025038', 'https://openalex.org/W1994783066', 'https://openalex.org/W1970691296'], 'abstract_inverted_index': {'Nociceptin': [0], 'is': [1, 16, 28], 'an': [2, 37], 'endogenous': [3], 'agonist': [4, 125], 'ligand': [5], 'of': [6, 20, 67, 86, 122, 127], 'the': [7, 33, 41, 48, 60, 65, 68, 77, 99, 124], 'ORL1': [8], '(opioid': [9], 'receptor-like': [10], '1)': [11], 'receptor,': [12], 'and': [13, 24, 74, 111, 129], 'its': [14], 'antagonist': [15, 38, 54, 114, 132], 'a': [17, 29, 84, 107, 112, 119], 'potential': [18], 'target': [19], 'therapeutics': [21], 'for': [22, 52], 'analgesic': [23], 'antineuropathy': [25], 'drugs.': [26], 'Ac-RYYRIK-NH2': [27, 128], 'hexapeptide': [30], 'isolated': [31], 'from': [32], 'peptide': [34, 117], 'library': [35], 'as': [36], 'that': [39], 'inhibits': [40], 'nociceptin': [42], 'activities': [43], 'mediated': [44], 'through': [45], 'ORL1.': [46], 'However,': [47], 'structural': [49], 'elements': [50], 'required': [51], 'this': [53], 'activity': [55, 126], 'are': [56], 'still': [57], 'indeterminate.': [58], 'In': [59], 'present': [61], 'study,': [62], 'we': [63], 'evaluated': [64], 'importance': [66], 'acetyl-methyl': [69], 'group': [70, 102], 'in': [71], 'receptor': [72], 'binding': [73], 'activation,': [75], 'examining': [76], 'peptides': [78], 'acyl-RYYRIK-NH2,': [79], 'where': [80], 'acyl': [81], '(R-CO)': [82], 'possesses': [83], 'series': [85], 'alkyl': [87], 'groups,': [88], 'R': [89], '=': [90, 93], 'CnH2n+1': [91], '(n': [92], '0–5).': [94], 'The': [95], 'isovaleryl': [96], 'derivative': [97], 'with': [98], 'C4H9': [100], '(=(CH3)2CHCH2–)': [101], 'was': [103], 'found': [104], 'to': [105], 'reveal': [106], 'high': [108], 'receptor-binding': [109], 'affinity': [110], 'strong': [113], 'nature.': [115], 'This': [116], 'achieved': [118], 'primary': [120], 'goal': [121], 'eliminating': [123], 'producing': [130], 'pure': [131], 'activity.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2017764792', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-18T12:15:27.148416', 'created_date': '2016-06-24'}