Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2017735936', 'doi': 'https://doi.org/10.1038/254440a0', 'title': 'Pre- and postsynaptic components in effect of drugs with α adrenoceptor affinity', 'display_name': 'Pre- and postsynaptic components in effect of drugs with α adrenoceptor affinity', 'publication_year': 1975, 'publication_date': '1975-04-01', 'ids': {'openalex': 'https://openalex.org/W2017735936', 'doi': 'https://doi.org/10.1038/254440a0', 'mag': '2017735936', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/235100'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/254440a0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049724951', 'display_name': 'Klaus Starke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119759', 'display_name': 'Essen University Hospital', 'ror': 'https://ror.org/02na8dn90', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119759']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'KLAUS STARKE', 'raw_affiliation_strings': ['Pharmakologisches Institut, Klinikum der Universität Essen, Essen'], 'affiliations': [{'raw_affiliation_string': 'Pharmakologisches Institut, Klinikum der Universität Essen, Essen', 'institution_ids': ['https://openalex.org/I4210119759']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013650415', 'display_name': 'Takahiko Endo', 'orcid': 'https://orcid.org/0000-0002-6520-6048'}, 'institutions': [{'id': 'https://openalex.org/I4210119759', 'display_name': 'Essen University Hospital', 'ror': 'https://ror.org/02na8dn90', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119759']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'TAKAHIKO ENDO', 'raw_affiliation_strings': ['Pharmakologisches Institut, Klinikum der Universität Essen, Essen'], 'affiliations': [{'raw_affiliation_string': 'Pharmakologisches Institut, Klinikum der Universität Essen, Essen', 'institution_ids': ['https://openalex.org/I4210119759']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000589721', 'display_name': 'H. D. Taube', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119759', 'display_name': 'Essen University Hospital', 'ror': 'https://ror.org/02na8dn90', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119759']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'HANS DETLEF TAUBE', 'raw_affiliation_strings': ['Pharmakologisches Institut, Klinikum der Universität Essen, Essen'], 'affiliations': [{'raw_affiliation_string': 'Pharmakologisches Institut, Klinikum der Universität Essen, Essen', 'institution_ids': ['https://openalex.org/I4210119759']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.764, 'has_fulltext': False, 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.960573, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '254', 'issue': '5499', 'first_page': '440', 'last_page': '441'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10581', 'display_name': 'Neuronal Oscillations in Cortical Networks', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/receptor-activation', 'display_name': 'Receptor Activation', 'score': 0.509579}], 'concepts': [{'id': 'https://openalex.org/C197341189', 'wikidata': 'https://www.wikidata.org/wiki/Q863533', 'display_name': 'Postsynaptic potential', 'level': 3, 'score': 0.96812046}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.53321016}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.50935686}, {'id': 'https://openalex.org/C112592302', 'wikidata': 'https://www.wikidata.org/wiki/Q1207387', 'display_name': 'Excitatory postsynaptic potential', 'level': 3, 'score': 0.49604067}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.48369557}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.46995425}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.42115468}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.39058048}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2324534}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08785027}], 'mesh': [{'descriptor_ui': 'D000316', 'descriptor_name': 'Adrenergic alpha-Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011941', 'descriptor_name': 'Receptors, Adrenergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000316', 'descriptor_name': 'Adrenergic alpha-Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003000', 'descriptor_name': 'Clonidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003000', 'descriptor_name': 'Clonidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003345', 'descriptor_name': 'Corticosterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003345', 'descriptor_name': 'Corticosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008729', 'descriptor_name': 'Methoxamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008729', 'descriptor_name': 'Methoxamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009638', 'descriptor_name': 'Norepinephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010109', 'descriptor_name': 'Oxymetazoline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010109', 'descriptor_name': 'Oxymetazoline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010656', 'descriptor_name': 'Phenylephrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011433', 'descriptor_name': 'Propranolol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011433', 'descriptor_name': 'Propranolol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': 'Q000294', 'qualifier_name': 'innervation', 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/254440a0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/235100', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.48, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W2002417562', 'https://openalex.org/W2017997122', 'https://openalex.org/W2023140990', 'https://openalex.org/W2039709582', 'https://openalex.org/W2052325698', 'https://openalex.org/W2052397672', 'https://openalex.org/W2075558404', 'https://openalex.org/W2075721330', 'https://openalex.org/W2076071445', 'https://openalex.org/W2106150793', 'https://openalex.org/W2269956783', 'https://openalex.org/W2743144537', 'https://openalex.org/W4255898486'], 'related_works': ['https://openalex.org/W4303432678', 'https://openalex.org/W4285127779', 'https://openalex.org/W2974163011', 'https://openalex.org/W2950596497', 'https://openalex.org/W2436760910', 'https://openalex.org/W2142526561', 'https://openalex.org/W2082329602', 'https://openalex.org/W2043066229', 'https://openalex.org/W2023878078', 'https://openalex.org/W1546859207'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2017735936', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-12T23:19:10.372666', 'created_date': '2016-06-24'}