Publication Information

{'id': 'https://openalex.org/W2017576713', 'doi': 'https://doi.org/10.1111/j.1440-1681.1998.tb02306.x', 'title': 'REGULATION OF ALDOSTERONE BIOSYNTHESIS: THE END OF THE ROAD?', 'display_name': 'REGULATION OF ALDOSTERONE BIOSYNTHESIS: THE END OF THE ROAD?', 'publication_year': 1998, 'publication_date': '1998-11-01', 'ids': {'openalex': 'https://openalex.org/W2017576713', 'doi': 'https://doi.org/10.1111/j.1440-1681.1998.tb02306.x', 'mag': '2017576713', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9809198'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1440-1681.1998.tb02306.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168193669', 'display_name': 'Clinical and Experimental Pharmacology and Physiology', 'issn_l': '0305-1870', 'issn': ['0305-1870', '1440-1681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071660959', 'display_name': 'Jürg Müller', 'orcid': 'https://orcid.org/0000-0003-2391-4641'}, 'institutions': [{'id': 'https://openalex.org/I4210100468', 'display_name': 'University Hospital of Zurich', 'ror': 'https://ror.org/01462r250', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100468']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Jürg Müller', 'raw_affiliation_strings': ['Department of Internal Medicine University Hospital, Zurich, Switzerland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine University Hospital, Zurich, Switzerland.', 'institution_ids': ['https://openalex.org/I4210100468']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5071660959'], 'corresponding_institution_ids': ['https://openalex.org/I4210100468'], 'apc_list': {'value': 3760, 'currency': 'USD', 'value_usd': 3760, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.091, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.419048, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '25', 'issue': 'S1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/steroid-11-beta-hydroxylase', 'display_name': 'Steroid 11-beta-hydroxylase', 'score': 0.93923855}, {'id': 'https://openalex.org/keywords/zona-fasciculata', 'display_name': 'Zona fasciculata', 'score': 0.8407676}, {'id': 'https://openalex.org/keywords/aldosterone-synthase', 'display_name': 'Aldosterone synthase', 'score': 0.6501122}, {'id': 'https://openalex.org/keywords/mineralocorticoid', 'display_name': 'Mineralocorticoid', 'score': 0.5753226}], 'concepts': [{'id': 'https://openalex.org/C2780178468', 'wikidata': 'https://www.wikidata.org/wiki/Q3551060', 'display_name': 'Zona glomerulosa', 'level': 4, 'score': 0.9796299}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.9634623}, {'id': 'https://openalex.org/C155392382', 'wikidata': 'https://www.wikidata.org/wiki/Q904925', 'display_name': 'Steroid 11-beta-hydroxylase', 'level': 4, 'score': 0.93923855}, {'id': 'https://openalex.org/C2778736161', 'wikidata': 'https://www.wikidata.org/wiki/Q3301573', 'display_name': 'Zona fasciculata', 'level': 3, 'score': 0.8407676}, {'id': 'https://openalex.org/C2777977426', 'wikidata': 'https://www.wikidata.org/wiki/Q19065', 'display_name': 'Adrenal cortex', 'level': 2, 'score': 0.79661727}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.74530494}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7306641}, {'id': 'https://openalex.org/C2780249997', 'wikidata': 'https://www.wikidata.org/wiki/Q14904983', 'display_name': 'Aldosterone synthase', 'level': 4, 'score': 0.6501122}, {'id': 'https://openalex.org/C2776069600', 'wikidata': 'https://www.wikidata.org/wiki/Q422519', 'display_name': 'Mineralocorticoid', 'level': 3, 'score': 0.5753226}, {'id': 'https://openalex.org/C2780546910', 'wikidata': 'https://www.wikidata.org/wiki/Q185690', 'display_name': 'Adrenocorticotropic hormone', 'level': 3, 'score': 0.5529042}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53706014}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.4622092}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32860014}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15074629}, {'id': 'https://openalex.org/C2780902042', 'wikidata': 'https://www.wikidata.org/wiki/Q177911', 'display_name': 'Steroid', 'level': 3, 'score': 0.1299235}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.12390518}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.08659336}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D019405', 'descriptor_name': 'Cytochrome P-450 CYP11B2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013252', 'descriptor_name': 'Steroid 11-beta-Hydroxylase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000302', 'descriptor_name': 'Adrenal Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000302', 'descriptor_name': 'Adrenal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019405', 'descriptor_name': 'Cytochrome P-450 CYP11B2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013252', 'descriptor_name': 'Steroid 11-beta-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1440-1681.1998.tb02306.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168193669', 'display_name': 'Clinical and Experimental Pharmacology and Physiology', 'issn_l': '0305-1870', 'issn': ['0305-1870', '1440-1681'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9809198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.46, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1577500416', 'https://openalex.org/W1727014271', 'https://openalex.org/W1889408717', 'https://openalex.org/W1900162889', 'https://openalex.org/W1960609698', 'https://openalex.org/W1973231845', 'https://openalex.org/W1979069430', 'https://openalex.org/W1980328605', 'https://openalex.org/W1984699518', 'https://openalex.org/W1984893030', 'https://openalex.org/W1985858914', 'https://openalex.org/W1988999900', 'https://openalex.org/W1989657305', 'https://openalex.org/W1990953561', 'https://openalex.org/W1994617028', 'https://openalex.org/W1995810012', 'https://openalex.org/W2000752600', 'https://openalex.org/W2004746739', 'https://openalex.org/W2022445965', 'https://openalex.org/W2023063360', 'https://openalex.org/W2024324591', 'https://openalex.org/W2026924049', 'https://openalex.org/W2034052089', 'https://openalex.org/W2041855256', 'https://openalex.org/W2042823460', 'https://openalex.org/W2044827976', 'https://openalex.org/W2046612073', 'https://openalex.org/W2046922552', 'https://openalex.org/W2049642674', 'https://openalex.org/W2049726482', 'https://openalex.org/W2056666051', 'https://openalex.org/W2058714485', 'https://openalex.org/W2061318360', 'https://openalex.org/W2064137712', 'https://openalex.org/W2070818730', 'https://openalex.org/W2072861904', 'https://openalex.org/W2073103717', 'https://openalex.org/W2073280986', 'https://openalex.org/W2074965608', 'https://openalex.org/W2082078635', 'https://openalex.org/W2083585713', 'https://openalex.org/W2086745298', 'https://openalex.org/W2130792052', 'https://openalex.org/W2150373956', 'https://openalex.org/W2171026308', 'https://openalex.org/W2291114795', 'https://openalex.org/W4235585260', 'https://openalex.org/W4237286268', 'https://openalex.org/W4251125029', 'https://openalex.org/W4251634690'], 'related_works': ['https://openalex.org/W4387361053', 'https://openalex.org/W3157334049', 'https://openalex.org/W3022706109', 'https://openalex.org/W2536112776', 'https://openalex.org/W2519578718', 'https://openalex.org/W2152585030', 'https://openalex.org/W2073280986', 'https://openalex.org/W2073103717', 'https://openalex.org/W2026924049', 'https://openalex.org/W2009364340'], 'abstract_inverted_index': {'SUMMARY': [0], '1.': [1], 'Because': [2], 'aldosterone': [3, 26, 46, 92, 108, 248], 'is': [4, 109, 124, 133, 142, 167], 'the': [5, 9, 29, 33, 68, 81, 84, 88, 98, 103, 128, 155, 160, 165, 171, 191, 218, 245], 'minority': [6], 'hormone': [7, 63], 'of': [8, 25, 32, 60, 74, 83, 91, 105, 115, 147, 150, 164, 181, 194, 210, 217, 225, 241, 247], 'adrenal': [10, 34], 'cortex,': [11], 'its': [12, 175], 'proper': [13], 'function': [14], 'depends': [15, 177], 'on': [16, 178, 244], 'protective': [17], 'physiological': [18, 179, 235], 'mechanisms.': [19], 'These': [20], 'include': [21], 'a': [22, 39], 'particular': [23], 'site': [24], 'biosynthesis': [27], 'in': [28, 53, 80, 87, 127, 170, 208, 221, 229, 232], 'zona': [30, 129, 172, 211], 'glomerulosa': [31], 'cortex': [35], 'as': [36, 38, 97], 'well': [37], 'complex': [40], 'multifactorial': [41], 'control': [42], 'system,': [43], 'which': [44, 203], 'adapts': [45], 'production': [47], 'to': [48, 107, 234], 'acute': [49], 'and': [50, 56, 101, 138, 174], 'chronic': [51], 'changes': [52], 'body': [54], 'sodium': [55, 136], 'potassium': [57, 139], 'content,': [58], 'irrespective': [59], 'pituitary': [61], 'adrenocorticotropic': [62], '(ACTH)': [64], 'secretion.': [65], '2.': [66], 'Over': [67], 'past': [69], 'decade,': [70], 'an': [71, 112, 199], 'important': [72, 239], 'element': [73], 'these': [75], 'mechanisms': [76, 219], 'has': [77], 'been': [78], 'identified': [79], 'form': [82], 'enzyme': [85, 123], 'involved': [86, 220], 'final': [89], 'steps': [90], 'biosynthesis.': [93, 249], 'In': [94, 153, 184], 'species': [95, 187], 'such': [96], 'human,': [99], 'rat': [100], 'mouse,': [102], 'conversion': [104], 'deoxycorticosterone': [106], 'catalysed': [110], 'by': [111, 135, 144], 'isozyme': [113], '(CYP11B2)': [114], 'cytochrome': [116, 195], 'P450up': [117], '(CYP11B1).': [118], 'The': [119, 215], 'gene': [120, 156], 'encoding': [121, 157], 'this': [122, 222], 'expressed': [125, 168], 'only': [126], 'glomerulosa.': [130], 'Its': [131], 'transcription': [132], 'enhanced': [134], 'deficiency': [137], 'intake,': [140], 'but': [141], 'suppressed': [143, 207], 'long‐term': [145], 'administration': [146], 'high': [148], 'doses': [149], 'ACTH.': [151, 182], '3.': [152], 'contrast,': [154], 'CYP11B1': [158], '(i.e.': [159], 'major': [161, 192], '(non‐aldosterone‐producing)': [162], 'type': [163], 'enzyme)': [166], 'mainly': [169], 'fasciculata': [173, 212], 'expression': [176, 231], 'concentrations': [180], '4.': [183], 'other': [185], 'animal': [186], '(cattle,': [188], 'pig,': [189], 'sheep),': [190], 'forms': [193], 'P450': [196], '11β': [197], 'have': [198], 'inherent': [200], 'aldosterone‐synthesizing': [201], 'activity,': [202], 'is,': [204], 'however,': [205], 'selectively': [206], 'mitochondria': [209], 'cells.': [213], '5.': [214], 'elucidation': [216], 'suppression': [223], 'or': [224], 'those': [226], 'mediating': [227], 'alterations': [228], 'CYP11B2': [230], 'response': [233], 'stimuli': [236], 'may': [237], 'be': [238], 'areas': [240], 'future': [242], 'research': [243], 'regulation': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2017576713', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-08T20:58:42.066274', 'created_date': '2016-06-24'}