Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2017572018', 'doi': 'https://doi.org/10.1021/jm8009298', 'title': 'Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor', 'display_name': 'Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor', 'publication_year': 2008, 'publication_date': '2008-11-20', 'ids': {'openalex': 'https://openalex.org/W2017572018', 'doi': 'https://doi.org/10.1021/jm8009298', 'mag': '2017572018', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19053766'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm8009298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030310636', 'display_name': 'Les P. Miranda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Les P. Miranda', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091884376', 'display_name': 'Jerry Ryan Holder', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jerry Ryan Holder', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111505410', 'display_name': 'Licheng Shi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Licheng Shi', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072185125', 'display_name': 'Brian D. Bennett', 'orcid': 'https://orcid.org/0000-0002-0182-658X'}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian Bennett', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025259898', 'display_name': 'Jennifer Aral', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Aral', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079383989', 'display_name': 'Colin V. Gegg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Colin V. Gegg', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008855410', 'display_name': 'Marie Wright', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marie Wright', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069291880', 'display_name': 'Kenneth W. Walker', 'orcid': 'https://orcid.org/0000-0001-8539-1095'}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth Walker', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019352189', 'display_name': 'George J. Doellgast', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Doellgast', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111664629', 'display_name': 'Rick Rogers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rick Rogers', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100455582', 'display_name': 'Hongyan Li', 'orcid': 'https://orcid.org/0000-0002-2191-1247'}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongyan Li', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022231028', 'display_name': 'Violeta G. Valladares', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Violeta Valladares', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028937676', 'display_name': 'Kevin L. Salyers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin Salyers', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084528758', 'display_name': 'Eileen Johnson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eileen Johnson', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045190566', 'display_name': 'Kenneth D. Wild', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth Wild', 'raw_affiliation_strings': ['Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320'], 'affiliations': [{'raw_affiliation_string': 'Chemistry Research and Discovery, Protein Sciences, Pharmacokinetics and Drug Metabolism, and Neuroscience, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320', 'institution_ids': ['https://openalex.org/I1320553840']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.256, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.650525, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '51', 'issue': '24', 'first_page': '7889', 'last_page': '7897'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C163170386', 'wikidata': 'https://www.wikidata.org/wiki/Q419432', 'display_name': 'Calcitonin gene-related peptide', 'level': 4, 'score': 0.95257306}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.8477709}, {'id': 'https://openalex.org/C2779627488', 'wikidata': 'https://www.wikidata.org/wiki/Q315860', 'display_name': 'Calcitonin', 'level': 2, 'score': 0.7339754}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.6841684}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.65816605}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.5941063}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.49057952}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.43204865}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37855825}, {'id': 'https://openalex.org/C118303440', 'wikidata': 'https://www.wikidata.org/wiki/Q419968', 'display_name': 'Neuropeptide', 'level': 3, 'score': 0.3275513}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.27943045}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.094313204}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000077221', 'descriptor_name': 'Calcitonin Gene-Related Peptide Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002626', 'descriptor_name': 'Chemistry, Pharmaceutical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D018015', 'descriptor_name': 'Receptors, Calcitonin Gene-Related Peptide', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002626', 'descriptor_name': 'Chemistry, Pharmaceutical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003412', 'descriptor_name': 'Cricetulus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020128', 'descriptor_name': 'Inhibitory Concentration 50', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008968', 'descriptor_name': 'Molecular Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018015', 'descriptor_name': 'Receptors, Calcitonin Gene-Related Peptide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm8009298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19053766', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W100605716', 'https://openalex.org/W1518071796', 'https://openalex.org/W1584764339', 'https://openalex.org/W173746587', 'https://openalex.org/W1884389194', 'https://openalex.org/W1985517517', 'https://openalex.org/W2004610998', 'https://openalex.org/W2004674974', 'https://openalex.org/W2004972165', 'https://openalex.org/W2012319235', 'https://openalex.org/W2029911765', 'https://openalex.org/W2034103805', 'https://openalex.org/W2040853447', 'https://openalex.org/W2054392530', 'https://openalex.org/W2055122753', 'https://openalex.org/W2059053844', 'https://openalex.org/W2059862840', 'https://openalex.org/W2060711158', 'https://openalex.org/W2062456452', 'https://openalex.org/W2067160446', 'https://openalex.org/W2068558854', 'https://openalex.org/W2073974687', 'https://openalex.org/W2077480796', 'https://openalex.org/W2078304896', 'https://openalex.org/W2078868250', 'https://openalex.org/W2081235875', 'https://openalex.org/W2082285987', 'https://openalex.org/W2084172070', 'https://openalex.org/W2102917831', 'https://openalex.org/W2109979991', 'https://openalex.org/W2119565450', 'https://openalex.org/W2136649405', 'https://openalex.org/W2154577215', 'https://openalex.org/W2155648984', 'https://openalex.org/W2167465587', 'https://openalex.org/W2167955328', 'https://openalex.org/W2224294045', 'https://openalex.org/W2920822596', 'https://openalex.org/W3027742832', 'https://openalex.org/W4239379760'], 'related_works': ['https://openalex.org/W4295268645', 'https://openalex.org/W2792285217', 'https://openalex.org/W2125422521', 'https://openalex.org/W2082086395', 'https://openalex.org/W2081724718', 'https://openalex.org/W2055844537', 'https://openalex.org/W2043051945', 'https://openalex.org/W2011566627', 'https://openalex.org/W1991014862', 'https://openalex.org/W1990739055'], 'abstract_inverted_index': {'Calcitonin': [0], 'gene-related': [1], 'peptide': [2, 59, 72], '(CGRP)': [3], 'is': [4, 36], 'a': [5, 13, 28, 53, 130], '37-residue': [6], 'neuropeptide': [7], 'that': [8, 63], 'can': [9], 'be': [10], 'converted': [11], 'to': [12, 51], 'CGRP1': [14, 29, 74, 87], 'receptor': [15, 30, 75, 88], 'antagonist': [16], 'by': [17], 'the': [18, 64, 70, 85], 'truncation': [19], 'of': [20, 48, 66, 139], 'its': [21], 'first': [22], 'seven': [23], 'residues.': [24], 'CGRP(8−37),': [25], '1,': [26], 'has': [27], 'Ki': [31], '=': [32, 43, 81, 117], '3.2': [33], 'nM': [34], 'but': [35], 'rapidly': [37], 'degraded': [38], 'in': [39, 55, 69, 92, 95, 135], 'human': [40, 134], 'plasma': [41, 112, 137], '(t1/2': [42], '20': [44], 'min).': [45], 'As': [46], 'part': [47], 'an': [49], 'effort': [50], 'identify': [52], 'prolonged': [54], 'vivo': [56, 96], 'circulating': [57], 'CGRP': [58, 71], 'antagonist,': [60], 'we': [61, 99], 'found': [62], 'substitution': [65], 'multiple': [67], 'residues': [68], 'increased': [73, 122], 'affinity': [76, 107], '>50-fold.': [77], 'Ac-Trp-[Arg24,Lys25,Asp31,Pro34,Phe35]CGRP(8−37)-NH2,': [78], '5': [79], '(Ki': [80, 116], '0.06': [82], 'nM)': [83], 'had': [84, 120], 'highest': [86], 'affinity.': [89], 'Using': [90], 'complimentary': [91], 'vitro': [93, 136], 'and': [94, 104, 133, 141], 'metabolic': [97], 'studies,': [98], 'iteratively': [100], 'identified': [101], 'degradation': [102], 'sites': [103], 'prepared': [105], 'high': [106], 'analogues': [108], 'with': [109, 129], 'significantly': [110, 121], 'improved': [111], 'stability.': [113], 'Ac-Trp-[Cit11,18,hArg24,Lys25,2-Nal27,37,Asp31,Oic29,34,Phe35]CGRP(8−37)-NH2,': [114], '32': [115], '3.3': [118], 'nM),': [119], '(>100-fold)': [123], 'stability': [124], 'over': [125], '1': [126], 'or': [127], '5,': [128], 'cynomolgus': [131], 'monkey': [132], 'half-life': [138], '38': [140], '68': [142], 'h,': [143], 'respectively.': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2017572018', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-17T03:14:22.695598', 'created_date': '2016-06-24'}