JTT-751 for Treatment of Patients with Hyperphosphatemia on Peritoneal Dialysis

Name: Work Video:
Duration: 3 min 30 s
Keitaro Yokoyama; Takashi Akiba; Masafumi Fukagawa; Masaaki Nakayama; Hideki Hirakata
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'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nephrology', 'display_name': 'Nephrology', 'score': 0.47518006}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9304466}, {'id': 'https://openalex.org/C2776036575', 'wikidata': 'https://www.wikidata.org/wiki/Q1641062', 'display_name': 'Hyperphosphatemia', 'level': 3, 'score': 0.91042876}, {'id': 'https://openalex.org/C2779056158', 'wikidata': 'https://www.wikidata.org/wiki/Q1756474', 'display_name': 'Peritoneal dialysis', 'level': 2, 'score': 0.87994015}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 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{'descriptor_ui': 'D054559', 'descriptor_name': 'Hyperphosphatemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010530', 'descriptor_name': 'Peritoneal Dialysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005290', 'descriptor_name': 'Ferric Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054559', 'descriptor_name': 'Hyperphosphatemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 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[5], 'a': [6], 'novel': [7], 'iron-based': [8], 'phosphate': [9, 55, 84, 97, 114, 124, 141, 205], 'approved': [10], 'in': [11, 18, 44, 62, 95, 118, 176, 179, 200, 203], 'Japan': [12], 'for': [13, 87], 'the': [14, 38, 63, 79, 107, 165], 'treatment': [15, 196], 'of': [16, 42, 50, 67, 82, 102, 109, 136, 164], 'hyperphosphatemia': [17], 'dialysis': [19, 46, 191], 'and': [20, 40, 57, 74, 116, 161, 182], 'nondialysis': [21], 'patients': [22, 52, 110, 137, 192], 'with': [23, 53, 173, 193, 197], 'chronic': [24], 'kidney': [25], 'disease.': [26], '&lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt;': [27], 'In': [28, 189], 'this': [29], 'phase': [30], '3,': [31], 'multicenter,': [32], 'open-label,': [33], 'dose-adjusted': [34], 'study,': [35], 'we': [36], 'investigated': [37], 'efficacy': [39], 'safety': [41], 'peritoneal': [45, 190], 'patients.': [47], 'A': [48], 'total': [49], '56': [51], 'serum': [54, 83, 96, 113, 140, 180, 204, 209], '≥5.6': [56], '&lt;10.0': [58], 'mg/dl': [59, 130], 'were': [60, 159, 167], 'enrolled': [61], 'study.': [64], 'The': [65, 90, 134, 153], 'dose': [66], 'was': [69, 93, 125, 143, 213], 'adjusted': [70], 'to': [71, 78, 100, 169], 'between': [72], '1.5': [73], '6.0': [75], 'g/day,': [76], 'according': [77], 'target': [80, 112, 139], 'range': [81], '(3.5-5.5': [85], 'mg/dl),': [86], '12': [88], 'weeks.': [89], 'primary': [91], 'endpoint': [92], 'change': [94], 'from': [98], 'baseline': [99], 'end': [101], 'treatment.': [103], 'Secondary': [104], 'endpoints': [105], 'included': [106], 'percentage': [108, 135], 'achieving': [111, 138], 'levels': [115, 142], 'changes': [117], 'intact': [119], 'parathyroid': [120, 146], 'hormone.': [121], '&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt;': [122], 'Serum': [123], 'significantly': [126, 149], 'reduced': [127], 'by': [128], '2.26': [129], '(p': [131, 150, 185], '&lt;': [132, 151, 186], '0.001).': [133, 152, 187], '76.8%.': [144], 'Intact': [145], 'hormone': [147], 'decreased': [148], 'most': [154], 'common': 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{'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-14T03:15:21.821135', 'created_date': '2016-06-24'}
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