Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2016940902', 'doi': 'https://doi.org/10.7326/0003-4819-113-2-124', 'title': 'The Clinical Spectrum of the Eosinophilia-Myalgia Syndrome Associated with<scp>L</scp>-Tryptophan Ingestion', 'display_name': 'The Clinical Spectrum of the Eosinophilia-Myalgia Syndrome Associated with<scp>L</scp>-Tryptophan Ingestion', 'publication_year': 1990, 'publication_date': '1990-07-15', 'ids': {'openalex': 'https://openalex.org/W2016940902', 'doi': 'https://doi.org/10.7326/0003-4819-113-2-124', 'mag': '2016940902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2360751'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-113-2-124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035688309', 'display_name': 'Richard W. Martin', 'orcid': 'https://orcid.org/0000-0002-0411-7519'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Richard W. Martin', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5035688309'], 'corresponding_institution_ids': ['https://openalex.org/I1330342723'], 'apc_list': None, 'apc_paid': None, 'fwci': 26.74, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 151, 'citation_normalized_percentile': {'value': 0.967339, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '113', 'issue': '2', 'first_page': '124', 'last_page': '124'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10870', 'display_name': 'Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis', 'score': 0.9529, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9442, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/myalgia', 'display_name': 'myalgia', 'score': 0.8020812}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8642158}, {'id': 'https://openalex.org/C2777129736', 'wikidata': 'https://www.wikidata.org/wiki/Q505142', 'display_name': 'Eosinophilia', 'level': 2, 'score': 0.8424903}, {'id': 'https://openalex.org/C2778616394', 'wikidata': 'https://www.wikidata.org/wiki/Q474959', 'display_name': 'myalgia', 'level': 2, 'score': 0.8020812}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.62709856}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.57646513}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.52113986}, {'id': 'https://openalex.org/C60483475', 'wikidata': 'https://www.wikidata.org/wiki/Q1886099', 'display_name': 'Major basic protein', 'level': 4, 'score': 0.48343953}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.44762748}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.44527394}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.40421322}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004802', 'descriptor_name': 'Eosinophilia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D009135', 'descriptor_name': 'Muscular Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D014364', 'descriptor_name': 'Tryptophan', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004802', 'descriptor_name': 'Eosinophilia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004802', 'descriptor_name': 'Eosinophilia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004802', 'descriptor_name': 'Eosinophilia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004802', 'descriptor_name': 'Eosinophilia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D005208', 'descriptor_name': 'Fasciitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005208', 'descriptor_name': 'Fasciitis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009135', 'descriptor_name': 'Muscular Diseases', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009135', 'descriptor_name': 'Muscular Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009135', 'descriptor_name': 'Muscular Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009135', 'descriptor_name': 'Muscular Diseases', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009205', 'descriptor_name': 'Myocarditis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009205', 'descriptor_name': 'Myocarditis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D009422', 'descriptor_name': 'Nervous System Diseases', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D009422', 'descriptor_name': 'Nervous System Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059408', 'descriptor_name': 'Pain Management', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014364', 'descriptor_name': 'Tryptophan', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D014364', 'descriptor_name': 'Tryptophan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-113-2-124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2360751', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1982493133', 'https://openalex.org/W1983210656', 'https://openalex.org/W1995122752', 'https://openalex.org/W2033481851', 'https://openalex.org/W2039097119', 'https://openalex.org/W2050998666', 'https://openalex.org/W2058905414', 'https://openalex.org/W2070072956', 'https://openalex.org/W2106068114', 'https://openalex.org/W2330664818', 'https://openalex.org/W2338549889', 'https://openalex.org/W2395752830', 'https://openalex.org/W2402255702', 'https://openalex.org/W2402978321', 'https://openalex.org/W2411394030', 'https://openalex.org/W2418639671', 'https://openalex.org/W2764465688', 'https://openalex.org/W2992312472', 'https://openalex.org/W47581517'], 'related_works': ['https://openalex.org/W41379289', 'https://openalex.org/W3211486609', 'https://openalex.org/W2398492611', 'https://openalex.org/W2319022116', 'https://openalex.org/W2151290236', 'https://openalex.org/W2129245456', 'https://openalex.org/W2107128487', 'https://openalex.org/W2033104843', 'https://openalex.org/W2007974220', 'https://openalex.org/W1974919129'], 'abstract_inverted_index': {'We': [0], 'describe': [1], 'the': [2, 6, 20, 29, 76, 92, 157], 'clinical': [3], 'spectrum': [4], 'of': [5, 88, 132, 161, 185, 203], 'L-tryptophan-associated': [7], 'eosinophilia-myalgia': [8, 93], 'syndrome': [9], 'in': [10, 69, 100, 121, 134, 156, 187, 197, 205], '20': [11], 'patients.': [12, 226], 'In': [13], 'all': [14, 206], 'but': [15], 'one': [16], 'case,': [17], 'patients': [18, 50, 61, 105, 123, 162, 213, 228], 'met': [19], 'Centers': [21], 'for': [22, 28, 211, 217, 224], 'Disease': [23], 'Control': [24], '(CDC)': [25], 'case': [26], 'definition': [27], 'syndrome:': [30], 'peripheral': [31], 'blood': [32], 'eosinophilia': [33, 52], '(eosinophil': [34], 'count': [35], 'greater': [36], 'than': [37, 170, 175], '1.0': [38], 'x': [39], '10(9)/L)': [40], 'and': [41, 53, 58, 65, 73, 91, 141, 151, 159, 172, 214, 238], 'generalized,': [42], 'disabling': [43], 'myalgias': [44], 'without': [45], 'other': [46, 60], 'recognized': [47], 'causes.': [48], 'Three': [49], 'with': [51, 128, 164], 'myalgia': [54], 'developed': [55], 'eosinophilic': [56], 'fasciitis,': [57], '4': [59], 'developed,': [62], 'respectively,': [63], 'pneumonitis': [64], 'myocarditis,': [66], 'neuropathy': [67], 'culminating': [68], 'respiratory': [70], 'failure,': [71], 'encephalopathy,': [72], 'fibrosis': [74], 'about': [75], 'common': [77], 'bile': [78], 'duct.': [79], 'No': [80, 95], 'relation': [81], 'was': [82], 'apparent': [83], 'between': [84], 'dose': [85], 'or': [86, 106, 116, 235], 'duration': [87], 'L-tryptophan': [89, 101, 204], 'exposure': [90], 'syndrome.': [94], 'organic': [96], 'contaminants': [97], 'were': [98, 112, 154, 209, 222], 'identified': [99], 'preparations': [102, 111], 'taken': [103], 'by': [104, 114], 'asymptomatic': [107], 'users': [108], 'when': [109], 'these': [110], 'examined': [113], 'chromatography': [115], 'mass': [117], 'spectroscopy.': [118], 'Biopsy': [119], 'specimens': [120], '12': [122], 'showed': [124, 179], 'a': [125, 129], 'mononuclear': [126], 'exudate': [127], 'variable': [130], 'admixture': [131], 'eosinophils': [133, 186], 'affected': [135, 188], 'tissues,': [136, 189], 'including': [137], 'skin,': [138], 'fascia,': [139], 'muscle,': [140], 'some': [142], 'viscera.': [143], 'Eosinophil': [144], 'toxic': [145, 192], 'granule': [146, 193], 'proteins,': [147], 'major': [148, 180], 'basic': [149, 181], 'protein,': [150], 'eosinophil-derived': [152], 'neurotoxin': [153], 'elevated': [155], 'serum': [158], 'urine': [160], 'compared': [163], 'normal': [165], 'control': [166], 'subjects': [167], '(P': [168], 'less': [169, 174], '0.01': [171], 'P': [173], '0.02,': [176], 'respectively).': [177], 'Immunofluorescence': [178], 'protein': [182], 'deposited': [183], 'outside': [184], 'indicating': [190], 'that': [191], 'proteins': [194], 'are': [195, 233], 'released': [196], 'diseased': [198], 'organs.': [199], 'Treatment': [200], 'included': [201], 'withdrawal': [202], 'cases.': [207], 'Corticosteroids': [208], 'prescribed': [210, 223], '16': [212], 'diuretics': [215], 'alone': [216], '1': [218, 239], 'patient;': [219], 'no': [220], 'drugs': [221], '3': [225], 'Four': [227], 'have': [229], 'recovered': [230], 'fully,': [231], 'others': [232], 'stable': [234], 'slowly': [236], 'recovering,': [237], 'is': [240], 'gravely': [241], 'ill': [242], 'despite': [243], 'prolonged': [244], 'treatment.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2016940902', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 5}], 'updated_date': '2024-12-12T17:54:14.426327', 'created_date': '2016-06-24'}