Title: Sequence of amino acids in the new peptides of camel globin
Abstract: Tryptic digests of camel globin when separated by the fingerprint technique were found to contain some new peptides. These were identified by the determination of the sequence of amino acids. It was observed that in position 1 of the β-polypeptide chain valine had been replaced by methionine. At position 70, alanine present in Hb A had been replaced by arginine. Similarly at positions 75 and 76 leucine and alanine of Hb A had been replaced respectively by isoleucine and lysine. The camel haemoglobin is likely to possess more net positive charge than Hb A due to the replacement of alanine by arginine at position 70. This might be helpful for the formation of oxyhaemoglobin even in conditions of diminished water supply to the animal. In the evolution of haemoglobin, camel haemoglobin may be placed in between foetal haemoglobin and human adult haemoglobin.
Publication Year: 1965
Publication Date: 1965-05-04
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 3
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