Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase

Name: Work Video:
Duration: 3 min 30 s
Aron B. Fisher; Chandra Dodia; Yefim Manevich; Jinwen Chen; Sheldon I. Feinstein
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3338], 'NSGPx': [20, 192, 250, 422, 922, 1320, 1390, 1992, 2033, 2186, 2211, 2219, 2241, 2556, 2816, 3303, 4326, 4334, 4501], 'expressed': [21, 251, 1085, 1248, 1840, 2074, 2582, 2748, 3448, 3501], 'in': [22, 184, 252, 414, 541, 847, 1086, 1249, 1645, 1730, 1793, 1810, 1831, 1852, 1911, 2000, 2019, 2081, 2151, 2331, 2386, 2565, 2630, 2695, 2704, 2866, 2904, 2955, 3206, 3255, 3404, 3451, 3513, 3592, 3598, 3643, 3773, 3802, 3843, 3851, 3942, 3971, 4114, 4122, 4133, 4194, 4360, 4412, 4462, 4465, 4472, 4492], 'Escherichia': [23, 253], 'coli': [24, 254, 1088, 1702, 2584, 3269, 4088], 'from': [25, 149, 194, 255, 379, 424, 799, 926, 1070, 1377, 1449, 1461, 1474, 1484, 1492, 1518, 1528, 1544, 1555, 1565, 1575, 1676, 1683, 1963, 2174, 2194, 2214, 2519, 2777, 3025, 3224, 3362, 3417, 3421, 3636, 3758, 3785, 3835, 3927, 3954, 4004, 4295], 'a': [26, 59, 150, 155, 203, 210, 256, 289, 380, 385, 433, 440, 470, 626, 636, 729, 789, 876, 889, 927, 1025, 1071, 1097, 1252, 1262, 1372, 1378, 1569, 1573, 1692, 1842, 1846, 1865, 2013, 2022, 2028, 2035, 2076, 2096, 2148, 2303, 2332, 2387, 2420, 2427, 2434, 2500, 2663, 2672, 2743, 3045, 3165, 3198, 3217, 3227, 3282, 3333, 3479, 3609, 3829, 3844, 3998, 4249, 4261, 4282, 4381, 4397, 4463], 'cDNA': [28, 145, 196, 258, 375, 426, 912, 1069, 1083, 1254, 1375, 1381, 1551, 1584, 2190, 3047, 3154, 3203, 3279], 'clone': [29, 259, 1159, 1255, 1324, 1376, 1585, 3167], '(HA0683)': [30, 260, 914, 1325, 1586, 3280], 'showed': [31, 160, 261, 390, 4248], 'activity': [34, 108, 117, 264, 338, 347, 553, 588, 731, 885, 1102, 2200, 2557, 2625, 2722, 2746, 2817, 2954, 2992, 3506, 3552, 3588, 3658, 3762, 3789, 3931, 3958, 4081, 4111, 4121, 4199, 4210, 4293, 4327, 4335, 4502], 'withsn-2-linolenoyl-': [35, 265], 'orsn-2-arachidonoyl-phosphatidylcholine': [36, 266], 'substrate;': [39, 269, 3534], 'NADPH': [40, 270, 2564, 2716, 2726, 2752, 3514, 3601, 3605], 'or': [41, 271, 479, 2034, 2266, 2340, 2863, 2876, 2940, 3497, 4366], 'thioredoxin': [42, 272], 'could': [43, 273], 'not': [44, 50, 173, 209, 274, 280, 403, 439, 841, 1164, 1275, 3312, 3608, 3815, 3876, 3984], 'substitute': [45, 275], 'GSH.': [47, 277, 4189], 'Activity': [48, 122, 278, 352, 836, 3888, 4144], 'did': [49, 279], 'saturate': [51, 281, 3816, 3985], 'with': [52, 58, 100, 112, 123, 132, 282, 288, 330, 342, 353, 362, 600, 854, 888, 1099, 1153, 1251, 1270, 1385, 1627, 1673, 1742, 1845, 1907, 1925, 1936, 1949, 2075, 2233, 2268, 2344, 2419, 2433, 2485, 2493, 2650, 2731, 2769, 2874, 2999, 3257, 3286, 3300, 3332, 3355, 3555, 3594, 3659, 3724, 3817, 3893, 3986, 4014, 4021, 4027, 4126, 4149, 4173, 4186, 4266, 4310, 4336, 4351, 4390, 4396, 4483], 'GSH,': [53, 85, 283, 315, 1406, 2608, 2964, 3590, 3818, 3987], 'and': [54, 72, 91, 102, 168, 171, 212, 284, 302, 321, 332, 398, 401, 442, 464, 546, 592, 738, 804, 813, 1022, 1089, 1093, 1168, 1305, 1388, 1400, 1440, 1455, 1469, 1511, 1523, 1534, 1632, 1650, 1662, 1680, 1710, 1715, 1740, 1769, 1803, 1818, 1829, 1933, 1943, 1966, 2167, 2177, 2205, 2255, 2311, 2316, 2325, 2377, 2398, 2456, 2479, 2510, 2513, 2570, 2585, 2609, 2691, 2717, 2880, 2890, 3055, 3157, 3253, 3296, 3420, 3463, 3536, 3542, 3578, 3614, 3640, 3736, 3753, 3806, 3873, 3905, 3922, 3975, 4109, 4207, 4216, 4232, 4281, 4356, 4384, 4400, 4447, 4470, 4496], 'kinetics': [55, 285], 'were': [56, 65, 286, 295, 1447, 1459, 1472, 1490, 1516, 1526, 1542, 1689, 1698, 1716, 1779, 1961, 2004, 2257, 2294, 2320, 2380, 2506, 2517, 2894, 2923, 3214, 3232, 3243, 3545, 3570, 3581, 3756, 3783, 3925, 3952, 4393], 'compatible': [57, 287], 'ping-pong': [60, 290], 'mechanism;': [61, 291], 'kinetic': [62, 292, 3750, 3777, 3919, 3946], 'constants': [63, 293, 3778, 3947], '(mM−1min−1)': [64, 294], 'k': [66, 73, 296, 303, 3779, 3948], '1': [67, 297, 1765, 1953, 1959, 2424, 3780, 3949, 4140, 4349], '=': [68, 75, 298, 305, 3745, 3914, 4102, 4142, 4161], '1–3': [69, 299], '×': [70, 77, 300, 307, 2440, 2530, 3674, 3676, 3681, 3683, 3688, 3690, 3695, 3697, 3702, 3704, 3709, 3711, 3716, 3718], '105': [71, 301], '2': [74, 304, 2597, 2862, 2888, 2959, 3529, 3575, 3603, 3626, 3782, 3853, 3951, 4097], '4–11': [76, 306], '104.': [78, 308], 'In': [79, 309, 779, 1125, 2813, 3628], 'the': [80, 175, 195, 310, 405, 425, 585, 595, 647, 733, 800, 809, 848, 1128, 1132, 1154, 1169, 1173, 1177, 1207, 1210, 1268, 1271, 1303, 1322, 1535, 1628, 1633, 1647, 1664, 1669, 1677, 1684, 1824, 1861, 1869, 1878, 1882, 1887, 1895, 1898, 1903, 1908, 1912, 1921, 1944, 1964, 2009, 2042, 2082, 2160, 2168, 2175, 2188, 2202, 2206, 2215, 2223, 2243, 2262, 2454, 2471, 2477, 2483, 2497, 2514, 2520, 2566, 2579, 2634, 2637, 2678, 2683, 2692, 2709, 2770, 2773, 2787, 2794, 2821, 2828, 2884, 2899, 2905, 2956, 3018, 3161, 3250, 3258, 3263, 3273, 3277, 3301, 3315, 3337, 3349, 3356, 3407, 3410, 3418, 3422, 3429, 3447, 3452, 3469, 3489, 3493, 3510, 3517, 3524, 3556, 3562, 3612, 3644, 3725, 3811, 3819, 3836, 3894, 3980, 3988, 4005, 4022, 4083, 4105, 4115, 4168, 4177, 4182, 4195, 4240, 4244, 4271, 4275, 4296, 4307, 4311, 4323, 4387, 4420, 4424, 4466, 4478, 4493], 'presence': [81, 311, 2083, 2498, 2567, 2906, 2957, 3408, 3494, 3645], 'of': [82, 97, 190, 225, 312, 327, 420, 455, 462, 578, 589, 594, 721, 811, 845, 891, 1157, 1318, 1398, 1580, 1640, 1668, 1733, 1796, 1813, 1848, 1860, 1897, 1928, 1952, 1958, 2008, 2032, 2084, 2099, 2104, 2159, 2184, 2201, 2210, 2222, 2249, 2261, 2299, 2309, 2336, 2391, 2423, 2499, 2528, 2563, 2568, 2643, 2685, 2715, 2751, 2754, 2775, 2823, 2827, 2830, 2886, 2898, 2907, 2958, 3021, 3052, 3164, 3236, 3265, 3291, 3358, 3409, 3431, 3443, 3458, 3495, 3519, 3538, 3561, 3567, 3600, 3616, 3646, 3761, 3788, 3798, 3864, 3930, 3957, 3967, 4082, 4099, 4117, 4124, 4135, 4158, 4165, 4179, 4197, 4239, 4243, 4264, 4274, 4303, 4325, 4333, 4386, 4432, 4477], '0.36': [83, 313, 2606, 3737, 3768, 3906, 3937, 4357], 'mm': [84, 314, 1766, 1799, 1816, 1833, 1889, 1930, 1940, 2086, 2393, 2595, 2600, 2607, 2868, 2871, 2878, 2892, 2925, 2930, 2936, 2942, 2960, 3769, 3938, 4131, 4151, 4188, 4358, 4362, 4368], 'apparentK': [86, 316], 'm': [87, 317, 1954, 3755, 3821, 3827, 3924, 3990, 3996], 'was': [88, 94, 118, 127, 318, 324, 348, 357, 796, 805, 840, 850, 874, 923, 1077, 1084, 1163, 1179, 1212, 1221, 1256, 1274, 1483, 1553, 1563, 1572, 1625, 1635, 1728, 1758, 1808, 1827, 1839, 1905, 1918, 1923, 1947, 1998, 2073, 2155, 2163, 2172, 2192, 2236, 2447, 2467, 2549, 2558, 2593, 2621, 2626, 2645, 2654, 2676, 2680, 2697, 2706, 2729, 2747, 2780, 2818, 2859, 2909, 2916, 2949, 2993, 3024, 3155, 3311, 3318, 3328, 3456, 3550, 3607, 3623, 3722, 3891, 4094, 4112, 4137, 4153, 4171, 4193, 4200, 4211, 4227, 4278, 4300, 4317, 4346, 4376, 4427, 4438, 4489], '120–130': [89, 319], 'μm': [90, 320, 3733, 3902, 4353], 'apparentV': [92, 322], 'max': [93, 323, 3752, 3921], '1.5–1.6': [95, 325], 'μmol/min/mg': [96, 326], 'protein.': [98, 328, 2228, 2755], 'Assays': [99, 329], 'H2O2': [101, 331, 812, 1399, 2824, 3535, 3639, 3874, 4013, 4180], 'organic': [103, 333, 814, 1401, 3520], 'substrate': [106, 126, 336, 356, 1316, 2552, 2686, 3001, 3522, 3734, 3765, 3792, 3903, 3934, 3961, 4247, 4267, 4339, 4435], 'indicated': [107, 337, 1160, 1994, 3508, 4411], 'similar': [109, 339, 2230, 3323, 4305], 'to': [110, 163, 340, 393, 472, 642, 646, 807, 920, 1095, 1127, 1206, 1258, 1722, 1764, 1892, 1894, 2021, 2238, 2272, 2452, 2460, 2719, 2918, 2951, 3048, 3160, 3249, 3336, 3406, 3466, 3523, 3630, 4090, 4236, 4306, 4444, 4452], 'that': [111, 207, 341, 437, 639, 1161, 1172, 1302, 1326, 1392, 2786], 'hydroperoxides.': [114, 216, 344, 446, 1405], 'Maximal': [115, 345], 'enzymatic': [116, 346, 587, 2554], 'at': [119, 349, 1718, 1744, 1750, 1771, 1783, 1789, 2347, 2449, 2457, 2657, 2688, 2790, 2911, 3262, 3484, 3731, 3767, 3794, 3900, 3936, 3963, 4204, 4213, 4229, 4253, 4268, 4286, 4319, 4416, 4428, 4440, 4448, 4458, 4485, 4503], 'pH': [120, 350, 2920, 4166, 4191, 4205, 4214, 4221, 4230, 4269, 4320, 4459, 4486], '7–8.': [121, 351], 'hydroperoxide': [125, 355, 504, 628, 2515, 2779, 3521, 3532, 3642, 3654, 3661, 3871, 3878, 4225, 4251, 4276, 4338, 4355, 4434, 4468, 4495], 'inhibited': [128, 358], 'noncompetitively': [129, 359], 'by': [130, 360, 477, 852, 1081, 1760, 1781, 1876, 1881, 1968, 1995, 2102, 2165, 2179, 2259, 2296, 2322, 2327, 2382, 2560, 2682, 2782, 2820, 2825, 2995, 3172, 3509, 3572, 4176, 4202, 4341, 4378, 4403], 'mercaptosuccinate': [131, 361], 'K': [133, 363, 3754, 3820, 3826, 3923, 3989, 3995], 'i': [134, 364], '4': [135, 365, 1790, 1811], 'μm.': [136, 366], 'The': [137, 187, 367, 417, 460, 794, 843, 871, 1312, 1480, 1582, 1654, 1777, 1805, 1836, 1915, 2182, 2247, 2292, 2307, 2375, 2504, 2546, 2587, 2702, 2855, 2896, 3153, 3267, 3344, 3500, 3776, 3945, 4119, 4163, 4190, 4220, 4374, 4407, 4414], 'had': [139, 369, 881, 3649], 'no': [140, 370, 552, 882, 2153, 3650, 4110, 4209, 4257, 4490, 4500], 'S-transferase': [142, 372, 742, 884, 1436, 2991], 'activity.': [143, 373], 'Bovine': [144, 374], 'encoding': [146, 376], 'NSGPx,': [147, 377, 495], 'isolated': [148, 378, 798, 925, 1374, 3044, 3156, 3171], 'lung': [151, 381, 1380, 1550, 2245, 3202], 'expression': [152, 382, 1757, 2079, 3270], 'library': [153, 383, 1552, 3204], 'using': [154, 384, 816, 1131, 1321, 1691, 1868, 2242, 2302, 2662, 2739, 3216, 3272, 3854, 4129, 4181, 4234], 'polymerase': [156, 386, 1709, 3173, 3219], 'chain': [157, 387, 3174, 3220], 'reaction': [158, 388, 2589, 2679, 3175, 3221, 3813, 3982, 4170, 4375], 'probe,': [159, 389], '>95%': [161, 391], 'similarity': [162, 392], 'previously': [164, 394, 1329, 2014, 2273, 2967], 'published': [165, 395], 'human,': [166, 396, 3053], 'rat,': [167, 397, 3054], 'mouse': [169, 399, 2036, 3056], 'sequences': [170, 400], 'does': [172, 402, 3814, 3983], 'contain': [174, 404], 'TGA': [176, 406], 'stop': [177, 407], 'codon,': [178, 408], 'which': [179, 409, 873, 1705, 2003, 2152, 3591], 'is': [180, 197, 208, 410, 427, 438, 1301, 1394, 2793, 3402, 3822, 3991, 4410], 'translated': [181, 411, 2161, 2189, 3563], 'selenocysteine': [183, 413], 'selenium-containing': [185, 415], 'peroxidases.': [186, 416], 'molecular': [188, 418, 2798, 3289, 3486], 'mass': [189, 419, 1496, 3290, 3347, 3357, 3430, 3487], 'bovine': [191, 421, 801, 1253, 1306, 1379, 1389, 1433, 1549, 2240, 2244, 2740, 3026, 3046, 3166, 3201, 3241, 3855], 'deduced': [193, 423, 2213, 3361], '25,047': [198, 428], 'Da.': [199, 429, 3438], 'These': [200, 430], 'results': [201, 431, 1384, 2768], 'identify': [202, 432], 'new': [204, 434, 3845], 'selenoenzyme': [211, 441, 638, 734], 'can': [213, 443, 581, 3832, 3868, 4001], 'reduce': [214, 444, 643, 3869], 'Thus,': [217, 447], 'this': [218, 448, 549, 780, 1082, 1158, 2093, 3022, 3169, 3464, 4127, 4504], 'may': [220, 450], 'be': [221, 451, 582, 1096, 3833, 4002], 'important': [223, 453, 539], 'component': [224, 454], 'cellular': [226, 456, 467], 'antioxidant': [227, 457], 'defense': [228, 458], 'systems.': [229, 459], 'integrity': [461], 'biomembranes': [463], 'other': [465], 'phospholipid-enriched': [466], 'components': [468], 'requires': [469], 'mechanism': [471], 'repair': [473], 'oxidized': [474, 2494, 4479], 'phospholipids': [475, 645], 'generated': [476, 2095, 3281], 'spontaneous': [478], 'pathologic': [480], 'oxidation.': [481], 'Intracellular': [482], 'glutathione': [483, 493, 497, 505, 1407, 3595], '(GSH': [485], 'Px)': [486], '1The': [487], 'abbreviations': [488], 'used': [489, 2237, 2550, 2578, 2718, 2917, 2950, 3319], 'are:': [490], 'Px,': [492], 'peroxidase;': [494, 498, 506], 'hNSGPx,': [499, 3631], 'NSGPx;': [501], 'PHGPx,': [502], 'PLA2,': [507], 'phospholipase': [508, 590], 'A2;': [509], 'DTT,': [510, 2961], 'dithiothreitol;': [511], 'PLPC,': [512, 2254], '1-palmitoyl-2-linolenoyl-sn-glycerol-3-phosphocholine;': [513], 'PAPC,': [514, 2495], '1-palmitoyl-2-arachidonoyl-snglycerol-3-phosphocholine;': [515], 'DENP,': [516], 'diethyl': [517], 'p-nitrophenyl': [518], 'phosphate;': [519], 'MJ33,': [520], '1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol;': [521], 'pBPB,': [522], 'p-bromophenacyl': [523, 1415], 'bromide;': [524], 'PAGE,': [525], 'polyacrylamide': [526], 'gel': [527, 2176], 'electrophoresis;': [528], 'HPLC,': [529], 'high': [530], 'pressure': [531], 'liquid': [532], 'chromatography;': [533], 'MES,': [534], '4-morpholinoethanesulfonic': [535], 'acid': [536, 544, 598, 1468, 1471, 2024, 2265, 2315, 2338, 2342, 3544], 'plays': [537], 'role': [540], 'reducing': [542], 'fatty': [543, 597, 2264], 'H2O2,': [547, 1420], 'although': [548, 1267, 1299], 'has': [551, 632, 725, 1327], 'toward': [554, 837, 3652], '(1Michiels': [557], 'C.': [558, 656, 671, 1035, 1338, 1594, 1973, 2052, 2114, 2279, 3065, 3099, 3371], 'Raes': [559], 'M.': [560, 654, 669, 693, 697, 1039, 1342, 1598, 1979, 2058, 2118, 2277, 2405, 3069, 3105, 3375], 'Toussaint': [561], 'O.': [562], 'Remacle': [563], 'J.': [564, 708, 770, 1050, 1109, 1187, 1229, 1281, 1353, 1609, 1985, 2064, 2129, 2839, 2974, 3080, 3111, 3144, 3180, 3386, 4036], 'Free': [565, 4068], 'Radical': [566, 4069], 'Biol.': [567, 709, 1051, 1110, 1188, 1230, 1282, 1354, 1610, 2130, 2840, 2975, 3081, 3181, 3387, 4037, 4070], 'Med.': [568, 4071], '1994;': [569, 711, 955, 1014], '17:': [570], '235-248Crossref': [571], 'PubMed': [572, 663, 679, 717, 754, 774, 831, 866, 905, 958, 990, 1017, 1061, 1120, 1145, 1198, 1240, 1292, 1364, 1620, 2140, 2287, 2370, 2414, 2541, 2808, 2850, 2985, 3012, 3038, 3091, 3128, 3148, 3191, 3397, 4047, 4075], 'Scopus': [573, 621, 664, 680, 755, 775, 832, 867, 906, 959, 991, 1018, 1062, 1121, 1146, 1199, 1241, 1293, 1365, 1621, 2141, 2288, 2371, 2415, 2542, 2809, 2851, 2986, 3013, 3039, 3092, 3129, 3149, 3192, 3398, 4048, 4076], '(1044)': [574], 'Google': [575, 623, 666, 682, 718, 757, 777, 834, 869, 908, 961, 993, 1020, 1064, 1123, 1148, 1201, 1243, 1295, 1367, 1623, 1990, 2069, 2143, 2290, 2373, 2417, 2544, 2811, 2853, 2988, 3015, 3041, 3094, 3116, 3131, 3151, 3194, 3400, 4050, 4078], 'Scholar).': [576, 624, 719, 778, 835, 870, 909, 1065, 1124, 1202, 1244, 1296, 1991, 2070, 2144, 2291, 2374, 2545, 2812, 2854, 2989, 3016, 3152, 3195, 4079], 'Detoxification': [577], 'accomplished': [583], 'through': [584, 4380], 'combined': [586], 'A2(PLA2)': [591], 'reduction': [593, 810, 1397, 4226, 4476], 'resultant': [596], 'Px': [602, 630, 737, 879, 3634, 3858], '(2van': [603], 'Kuijk': [604], 'F.J.G.M.': [605], 'Sevanian': [606], 'A.': [607, 699, 940, 968, 1013, 2366, 3775, 3944], 'Handelman': [608], 'G.J.': [609], 'Dratz': [610], 'E.A.': [611], 'Trends': [612], 'Biochem.': [613, 749, 769, 3143], 'Sci.': [614, 1010, 2363], '1987;': [615], '12:': [616], '31-34Abstract': [617], 'Full': [618, 714, 1056, 1058, 1115, 1117, 1193, 1195, 1235, 1237, 1287, 1289, 1359, 1361, 1615, 1617, 2135, 2137, 2845, 2847, 2980, 2982, 3086, 3088, 3186, 3188, 3392, 3394, 4042, 4044], 'Text': [619, 715, 1057, 1059, 1116, 1118, 1194, 1196, 1236, 1238, 1288, 1290, 1360, 1362, 1616, 1618, 2136, 2138, 2846, 2848, 2981, 2983, 3087, 3089, 3187, 3189, 3393, 3395, 4043, 4045], 'PDF': [620, 716, 1060, 1119, 1197, 1239, 1291, 1363, 1619, 2139, 2849, 2984, 3090, 3190, 3396, 4046], '(372)': [622], 'Recently,': [625], '(PHGPx)': [631], 'been': [633, 726, 1328], 'described': [634, 727, 1023, 1330, 2015, 2091, 2274, 2966, 3807, 3976], '19-kDa': [637], 'uses': [640], 'peroxidized': [644], 'nontoxic': [648], 'hydroxy': [649], 'derivative': [650], '(3Ursini': [651], 'F.': [652, 673, 703, 2281, 2409], 'Maiorino': [653, 696], 'Gregolin': [655, 670, 2278], 'Biochim.': [657, 2535, 2802], 'Biophys.': [658, 750, 2536, 2803], 'Acta.': [659, 2537, 2804], '1985;': [660], '839:': [661], '62-70Crossref': [662], '(765)': [665], 'Scholar,': [667, 683, 758, 962, 994, 3095, 3117, 3132, 4051], '4Maiorino': [668], 'Ursini': [672, 702, 2280], 'Methods': [674, 2282], 'Enzymol.': [675, 2283], '1990;': [676, 828, 863, 902, 1142, 2284, 3009, 3035], '186:': [677, 2285], '448-457Crossref': [678, 2286], '(227)': [681, 2289], '5Brigelius-Flohé': [684], 'R.': [685, 701, 760], 'Aumann': [686], 'K-D.': [687, 695], 'Blöcker': [688], 'H.': [689, 822, 857, 896, 982, 1136, 1280, 2353, 2355, 3003, 3029, 3179], 'Gross': [690], 'G.': [691, 768, 1002, 1004, 3138], 'Kiess': [692], 'Klöppel': [694], 'Roveri': [698], 'Schuckelt': [700], 'Wingender': [704], 'E.': [705, 1087, 1701, 2043, 3140, 3268], 'Flohé': [706], 'L.': [707], 'Chem.': [710, 1052, 1111, 1189, 1231, 1283, 1355, 1611, 2131, 2841, 2976, 3082, 3182, 3388, 4038], '269:': [712], '7342-7348Abstract': [713], 'Reduction': [720], 'minor': [730], 'plasma': [735], 'some': [740, 2814], 'enzymes': [743, 1307], '(6Yamamoto': [744], 'Y.': [745, 762, 942, 980], 'Takahashi': [746], 'K.': [747, 950, 978, 998, 1045, 1348, 1604, 2124, 3075, 3381], 'Arch.': [748], '1993;': [751, 2411], '305:': [752], '541-545Crossref': [753], '(134)': [756], '7Hurst': [759], 'Bao': [761], 'Jemth': [763], 'P.': [764, 2403], 'Mannervik': [765], 'B.': [766, 2359, 3121, 3134], 'Williamson': [767], '1998;': [771, 1112, 1190, 1232, 1284, 1987, 2066, 2842, 2977, 3113, 3183, 4039, 4072], '332:': [772], '97-100Crossref': [773], '(128)': [776], 'report,': [781], 'we': [782, 3043, 3427], 'novel': [790], '25-kDa': [791], 'Px.': [793], 'protein': [795, 849, 1079, 1134, 1155, 1247, 1502, 1756, 1844, 1863, 1946, 2011, 2101, 2170, 2735, 3283, 3309, 3340, 3351, 3450, 3460, 4100, 4125, 4159], 'first': [797, 924], 'ciliary': [802], 'body': [803], 'shown': [806, 919, 1094, 3801, 3970], 'catalyze': [808], 'electron': [819, 4017], 'donor': [820, 4018], '(8Shichi': [821, 856, 895, 1135, 3002, 3028], 'Demar': [823, 858, 897, 1137, 3004, 3030], 'J.C.': [824, 859, 898, 1138, 3005, 3031], 'Exp.': [825, 860, 899, 1139, 3006, 3032], 'Eye': [826, 861, 900, 1140, 3007, 3033], 'Res.': [827, 862, 901, 954, 986, 1141, 3008, 3034], '50:': [829, 864, 903, 1143, 3010, 3036], '513-520Crossref': [830, 865, 904, 1144, 3011, 3037], '(57)': [833, 868, 907, 1147, 3014, 3040], 'tested.': [842], 'absence': [844, 4116, 4324], 'selenium': [846], 'demonstrated': [851, 3503], 'assay': [853, 1152, 1504, 2615, 2915, 2947, 2998, 3525, 3727, 3896, 4185], '2,3-diaminonaphthalene': [855], 'enzyme,': [872, 3613], 'when': [886, 3314, 3330], 'assayed': [887, 2559, 4148], 'spectrum': [890], 'potential': [892], 'SH': [893], 'acceptors': [894], 'A': [910, 1548, 1725, 2229, 3322, 3530], 'full-length': [911], 'sequence': [913, 1667, 2031], '2GenBankTM': [915], 'accession': [916], 'numberD14662.': [917], 'ultimately': [918], 'encode': [921], 'myeloblast': [929], 'cell': [930, 1074, 1806, 1825, 3454, 4085], 'line': [931, 1075, 2675], '(KG-1)': [932], '(9Nomura': [933], 'N.': [934, 936, 948, 966, 972, 984, 1043, 1047, 1346, 1350, 1602, 1606, 2122, 2126, 3073, 3077, 3379, 3383], 'Miyajima': [935, 965], 'Sazuka': [937, 969], 'T.': [938, 946, 964, 970, 1041, 1344, 1600, 2120, 2357, 3071, 3377], 'Tanaka': [939, 967], 'Kawarabayasi': [941, 979], 'Sato': [943, 973], 'S.': [944, 952, 974, 976, 1012, 2365, 3119, 3123, 3136, 3142], 'Nagase': [945, 1040, 1343, 1599, 2119, 3070, 3376], 'Seki': [947, 971, 1042, 1345, 1601, 2121, 3072, 3378], 'Ishikawa': [949, 977, 1044, 1347, 1603, 2123, 3074, 3380], 'Tabata': [951, 975], 'DNA': [953, 985, 3259], '1:': [956], '27-35Crossref': [957], '(272)': [960], '10Nagase': [963], 'Kotani': [981], 'Nomura': [983, 1046, 1349, 1605, 2125, 3076, 3382], '1995;': [987], '2:': [988], '37-43Crossref': [989], '(114)': [992], '11Chae': [995], 'H.Z.': [996], 'Robison': [997], 'Poole': [999], 'L.B.': [1000], 'Church': [1001], 'Storz': [1003], 'Rhee': [1005, 1107, 1185, 1227, 2837, 2972, 4034], 'S.G.': [1006], 'Proc.': [1007, 2360], 'Natl.': [1008, 2361], 'Acad.': [1009, 2362], 'U.': [1011, 2364], '91:': [1015], '7017-7021Crossref': [1016], '(706)': [1019], 'Scholar)': [1021, 1368, 1624, 2418, 3401], 'Ca2+-independent': [1026], 'PLA2': [1027, 1101, 1570], '(12Kim': [1028, 1331, 1587, 2107, 3058, 3364], 'T-S.': [1029, 1332, 1588, 1971, 2050, 2108, 3059, 3097, 3365], 'Sundaresh': [1030, 1333, 1589, 2109, 3060, 3366], 'C.S.': [1031, 1334, 1590, 2110, 3061, 3367], 'Feinstein': [1032, 1335, 1591, 1980, 2059, 2111, 3062, 3106, 3368], 'S.I.': [1033, 1336, 1592, 1981, 2060, 2112, 3063, 3107, 3369], 'Dodia': [1034, 1337, 1593, 1972, 2051, 2113, 3064, 3098, 3370], 'Skach': [1036, 1339, 1595, 2115, 3066, 3372], 'W.R.': [1037, 1340, 1596, 2116, 3067, 3373], 'Jain': [1038, 1341, 1578, 1597, 1978, 2057, 2117, 3068, 3104, 3374], 'Fisher': [1048, 1351, 1607, 1982, 2061, 2127, 3078, 3108, 3384], 'A.B.': [1049, 1352, 1608, 1983, 2062, 2128, 3079, 3109, 3385], '1997;': [1053, 1356, 1612, 2132, 3083, 3125, 3145, 3389], '272:': [1054, 1357, 1613, 2133, 3084, 3390], '2542-2550Abstract': [1055, 1358, 1614, 2134, 3085, 3391], '(121)': [1063, 1366, 1622, 2142, 3093, 3399], 'Subsequently,': [1066], 'identical': [1068], 'lymphoma': [1073], '(U937)': [1076], 'described;': [1078], 'encoded': [1080], 'NIH': [1090], '3T3': [1091], 'cells': [1092, 1778], 'minimal': [1100], '(13Kang': [1103, 1181, 1223, 2833, 2968, 4030], 'S-W.': [1104, 1182, 1224, 2834, 2969, 4031], 'Baines': [1105, 1183, 1225, 2835, 2970, 4032], 'I.C.': [1106, 1184, 1226, 2836, 2971, 4033], 'S-G.': [1108, 1186, 1228, 2838, 2973, 4035], '273:': [1113, 1191, 1233, 1285, 2843, 2978, 3184, 4040], '6303-6311Abstract': [1114, 1192, 1234, 2844, 2979, 4041], '(411)': [1122, 1200, 1242, 2852, 2987, 4049], 'contrast': [1126, 3629], 'prior': [1129, 3159, 4089], 'publication': [1130], 'native': [1133, 1874], 'Scholar),': [1149, 3042], 'anin': [1150], 'vitro': [1151, 1250], 'product': [1156, 1838, 2046, 2191, 2581, 3222, 4389], 'effective': [1166, 1395, 3547, 3583], 'reductant,': [1167], 'report': [1170, 3163], 'concluded': [1171], 'physiologic': [1174], 'reductant': [1175, 1263], 'unknown': [1180], 'Based': [1203, 3439], 'on': [1204, 1864, 2426, 2524, 2724, 3294, 3352, 3440, 3488, 4167], 'homology': [1205], 'peroxiredoxin': [1208], 'family,': [1209], 'peroxiredoxin,': [1215], 'since': [1216, 2624, 3482], 'only': [1217], 'one': [1218], 'Cys': [1219], 'residue': [1220], 'conserved': [1222, 2029], 'More': [1245], 'recently,': [1246], 'found': [1257], 'utilize': [1259], 'activity,': [1266], 'discrepancy': [1269], 'previous': [1272, 3050, 4028], 'explained': [1276], '(14Singh': [1277, 3176], 'A.K.': [1278, 3177], 'Shichi': [1279, 3178], '26171-26178Abstract': [1286, 3185], '(67)': [1294, 3193], 'One': [1297], 'possibility,': [1298], 'unlikely,': [1300], 'have': [1308], 'different': [1309, 3795, 3964], 'cofactor': [1310, 3610], 'requirements.': [1311], 'present': [1313], 'utilization': [1317], 'recombinant': [1319], 'well': [1370], 'newly': [1373], 'library.': [1382], 'Our': [1383], 'both': [1386, 1646, 2797], 'show': [1391, 4453], 'including': [1403], 'reductase,': [1408], 'β-NADPH,': [1409], 'isopropyl': [1410, 1762], 'β-d-thiogalactopyranoside,': [1411], 'diethylp-nitrophenyl': [1412], 'phosphate': [1413], '(DENP),': [1414], 'bromide': [1416], '(pBPB),': [1417], 'dithiothreitol': [1418], '(DTT),': [1419], 'cumene': [1421], 'hydroperoxide,': [1422, 1424, 2484, 4422], 't-butyl': [1423, 3641, 3870], 'linolenic': [1425, 2250, 2310, 3540], 'acid,': [1426, 1428, 2251, 2253, 2318, 3541], 'arachidonic': [1427, 2252, 2312, 3543], '1-chloro-2,4-dinitrobenzene,': [1429], '(from': [1432, 1437], 'erythrocytes),': [1434], 'rat': [1438], 'liver),': [1439], 'soybean': [1441, 2269], 'lipoxidase': [1442], '(EC': [1443], '1.1311.12': [1444], 'type': [1445], 'V)': [1446], 'purchased': [1448, 1460, 1473, 1491, 1517, 1527, 1543, 1554], 'Sigma.': [1450], 'Phospholipids,': [1451], '1-palmitoyl-2-arachidonoyl': [1452], 'PC': [1453, 1457, 2616], '(PAPC)': [1454], '1-palmitoyl-2-linolenoyl': [1456], '(PLPC),': [1458], 'Avanti': [1462], 'Polar': [1463], 'Lipids': [1464], '(Alabaster,': [1465], 'AL).': [1466], '13-Hydroperoxyoctadecanoic': [1467], '15-hydroperoxyeicosatetranoic': [1470, 2317], 'Cayman': [1475], 'Chemicals': [1476], '(Ann': [1477], 'Arbor,': [1478], 'MI).': [1479], 'C18': [1481, 2437, 4382], 'Sep-Pack': [1482, 4383], 'Millipore': [1485], 'Corp.': [1486], '(Milford,': [1487], 'MA).': [1488], 'Radiochemicals': [1489], 'DuPont': [1493], 'NEN.': [1494], 'Molecular': [1495], 'standards': [1497, 2324], 'SDS-PAGE,': [1499, 2166], 'transblot': [1500], 'membrane,': [1501], 'dye-binding': [1503], 'kit,': [1505], 'horseradish': [1506], 'peroxidase-conjugated': [1507], 'goat': [1508], 'anti-rabbit': [1509], 'IgG,': [1510], 'Triton': [1512, 2619], 'X-100': [1513, 2620], '(electrophoretically': [1514], 'purified)': [1515], 'Bio-Rad.': [1519], 'Enhanced': [1520], 'chemiluminescence': [1521], 'kit': [1522, 1538, 1872], 'x-ray': [1524], 'film': [1525], 'Amersham': [1529], 'Pharmacia': [1530], 'Biotech.': [1531], 'pET28C': [1532, 1641, 1712], 'vector': [1533, 3419], 'His': [1536, 1870], 'bind': [1537, 1871], 'containing': [1539, 1736], 'imidazole': [1540, 1834, 1890, 1931, 1941, 1955], 'buffer': [1541, 1891, 1932, 2590, 2873, 3526], 'Novagen': [1545], '(Madison,': [1546], 'WI).': [1547], 'Stratagene': [1556], '(La': [1557], 'Jolla,': [1558], 'CA).': [1559, 2445], 'Lennox': [1560], 'LB': [1561, 1734], 'broth': [1562, 1735], 'obtained': [1564, 3329, 4309], 'Fisher.': [1566], '1-Hexadacyl-3-trifluoroethylglycero-sn-2-phosphomethanol': [1567], '(MJ33),': [1568], 'inhibitor,': [1571], 'gift': [1574], 'Dr.': [1576], 'Mahendra': [1577], '(University': [1579], 'Delaware).': [1581], 'digested': [1626], 'restriction': [1629], 'HindIII,': [1631], 'insert': [1634], 'recloned': [1636], 'into': [1637, 1700, 3245], 'theHindIII': [1638], 'site': [1639], '(Novagen,': [1642], 'Madison,': [1643], 'WI)': [1644], 'forward': [1648], '(sense)': [1649], 'reverse': [1651, 2328, 2383], '(antisense)': [1652], 'directions.': [1653], 'inserted': [1655], 'fragment': [1656], 'contained': [1657], 'about': [1658], '1040': [1659], 'nucleotide': [1660], 'pairs': [1661], 'included': [1663, 2147], 'entire': [1665], 'coding': [1666], 'along': [1672], '43': [1674], 'nucleotides': [1675, 1682], '5′-untranslated': [1678], 'region': [1679], '320': [1681], '3′-untranslated': [1685], 'region.': [1686], 'Plasmid': [1687], 'DNAs': [1688], 'prepared': [1690, 1909, 2018, 2258], 'QIAGEN': [1693], 'column': [1694, 1867, 1899, 1904, 1922, 1965, 2438, 3471], '(QIAGEN,': [1695], 'Chatsworth,': [1696], 'CA);': [1697], 'transformed': [1699], 'BL21(DE3)': [1703], 'cells,': [1704], 'produce': [1706], 'T7': [1707], 'RNA': [1708, 2154], 'express': [1711, 2239], 'inserts': [1713], 'efficiently;': [1714], 'incubated': [1717, 1741, 2860, 4347], '37': [1719, 1745, 1772], '°C': [1720, 1746, 1773], 'overnight': [1721], 'get': [1723], 'colonies.': [1724], 'single': [1726, 2097], 'colony': [1727], 'inoculated': [1729], '50': [1731, 1798, 1815, 2594, 2867, 2924, 2929, 2935, 2941, 4361, 4367], 'ml': [1732, 1795, 1812, 1927, 1938, 1951, 1960], 'kanamycin': [1737], '(30': [1738], 'μg/ml)': [1739, 2858, 4345], 'shaking': [1743], 'until': [1747], 'optical': [1748], 'density': [1749], '600': [1751], 'nm': [1752, 2349, 2451, 2459, 2659, 2792, 4442, 4450], 'reached': [1753], '0.6.': [1754], 'induced': [1759], 'adding': [1761], 'β-d-thiogalactopyranoside': [1763], 'final': [1767, 4388], 'concentration': [1768, 3735, 3766, 3793, 3904, 3935, 3962], 'incubating': [1770], '3': [1775, 3746, 3915], 'h.': [1776], 'harvested': [1780], 'centrifugation': [1782], '5000': [1784], '×g': [1785], '5': [1787, 1832, 1888, 1929, 2648, 2877, 4130, 4215, 4231, 4290, 4329], 'min': [1788, 2469, 2475, 2481, 2649, 2865, 4255, 4288, 4418], '°C,': [1791], 'resuspended': [1792, 1809, 1828], '12.5': [1794], 'cold': [1797, 1814], 'Tris-HCl': [1800, 1817, 2943, 4363], '(pH': [1801, 2396, 2602, 2927, 2933, 2938, 2944, 4364, 4371], '8.0),': [1802, 2603], 'recentrifuged.': [1804], 'pellet': [1807, 1826], 'sonicated': [1819, 1830], 'three': [1820], 'times.': [1821], 'For': [1822, 2633], 'purification,': [1823], 'buffer.': [1835, 1914, 1956, 4373], 'HA0683': [1837, 2045, 2071, 2580, 3225, 3363], 'fusion': [1843, 1862, 3339, 3350], 'series': [1847], 'six': [1849], 'histidine': [1850], 'residues': [1851], 'pET28C.': [1853], '"His': [1855, 3411], 'tag"': [1856, 3412], 'allowed': [1857], 'affinity': [1858, 4092], 'purification': [1859, 4093], 'Ni2+': [1866, 3470], 'under': [1873, 3808, 3977], 'conditions': [1875, 3849], 'following': [1877, 3516], 'protocols': [1879], 'recommended': [1880], 'manufacturer.': [1883], 'Briefly,': [1884], 'after': [1885, 3468], 'allowing': [1886], 'drain': [1893], 'top': [1896], 'bed': [1900], '(2.5': [1901], 'ml),': [1902], 'loaded': [1906], 'extract': [1910, 2227], 'same': [1913, 2795], 'flow': [1916, 2421], 'rate': [1917, 2422], '10': [1919, 2392, 2864], 'ml/h,': [1920], 'washed': [1924, 1935], '25': [1926], 'then': [1934, 4401], '15': [1937, 1950], '60': [1939, 4138], 'buffer,': [1942], 'bound': [1945], 'eluted': [1948], 'Fractions': [1957], 'collected': [1962], 'analyzed': [1967, 2178, 4340, 4402], 'SDS-PAGE': [1969, 2105, 3295], '(15Kim': [1970, 2049], 'Chen': [1974, 2053, 3100], 'X.': [1975, 2054, 3101], 'Hennigan': [1976, 2055, 3102], 'B.B.': [1977, 2056, 3103], 'Am.': [1984, 2063, 3110], 'Physiol.': [1986, 2065, 3112], '274:': [1988, 2067, 3114], 'L750-L761PubMed': [1989, 2068, 3115], 'Western': [1996, 2006, 3297, 3326, 3490], 'blot': [1997, 2007, 3298, 3327, 3491], 'concentrated': [1999, 4394], 'fractions': [2001], '2–5,': [2002], 'pooled.': [2005], 'purified': [2010, 4245], 'utilized': [2012], 'polyclonal': [2016, 3302], 'antibody': [2017, 2038, 3305, 3335], 'rabbits': [2020], '15-amino': [2023], 'synthetic': [2025], 'peptide': [2026], 'representing': [2027, 2187, 3234], 'internal': [2030], 'monoclonal': [2037, 3334], '(8H11)': [2039], 'raised': [2040], 'against': [2041], 'coli-expressed': [2044], '(human': [2047], 'NSGPx)': [2048], 'wheat': [2077, 2225], 'germ': [2078, 2226], 'system': [2080, 2431, 3271], '0.5': [2085], '[35S]methionine': [2087, 2198], '(63': [2088], 'Ci/mmol)': [2089], 'previously;': [2092], 'procedure': [2094], 'band': [2098, 2171, 3310], '35S-labeled': [2100], 'autoradiography': [2103], 'gels': [2106], 'Each': [2145], 'translation': [2146], 'negative': [2149], 'control': [2150], 'added.': [2156, 2895], 'An': [2157], 'aliquot': [2158], 'proteins': [2162], 'separated': [2164, 2326, 2381], 'radiolabeled': [2169, 2185], 'cut': [2173], 'scintillation': [2180], 'counting.': [2181], 'amount': [2183], 'calculated': [2193, 3757, 3784, 3834, 3926, 3953, 4003, 4294], 'total': [2195, 2224, 3459], 'incorporated': [2196], '35S,': [2197], 'specific': [2199], 'starting': [2203, 2472], 'material,': [2204], 'fractional': [2207], 'methionine': [2208], 'content': [2209], 'cDNA.': [2216, 2246], 'After': [2217, 2671, 4260], 'translation,': [2218], 'represented': [2220], '0.05%': [2221], 'protocol,': [2231], 'but': [2232, 3648, 3875, 4256], 'nonlabeled': [2234], 'methionine,': [2235], 'PAPC': [2256, 2378, 3579], 'treatment': [2260], 'corresponding': [2263, 4120], '15-lipoxidase': [2270], 'according': [2271, 3248], 'methods': [2275], '(4Maiorino': [2276], 'reactions': [2293], 'monitored': [2295], 'continuous': [2297, 2651, 2996], 'recording': [2298], 'oxygen': [2300, 2305], 'consumption': [2301, 2562], 'standard': [2304, 2588, 2635, 3726, 3895], 'electrode.': [2306], 'acids,': [2313], '13-hydroperoxyoctadecanoic': [2314], 'respectively,': [2319], 'identified': [2321], 'authentic': [2323, 2725, 3632], 'phase': [2329, 2334, 2384, 2389, 4405], 'HPLC': [2330, 2385, 2783, 4235, 4242], 'mobile': [2333, 2388], 'consisting': [2335, 2390], 'acetonitrile/water/acetic': [2337], '(60:40:0.1)': [2339], 'methanol/water/acetic': [2341], '(85:15:0.1)': [2343], 'UV': [2345], 'detection': [2346], '235': [2348, 2458, 2791, 4449], '(16Funk': [2350], 'C.D.': [2351], 'Gunne': [2352], 'Steiner': [2354], 'Izumi': [2356], 'Samuelsson': [2358], '1989;': [2367, 2538, 2805], '86:': [2368], '2592-2596Crossref': [2369], '(41)': [2372], 'PLPC': [2376, 2778, 3577, 3653, 3877, 4224, 4337, 4354, 4421, 4433, 4467, 4480, 4494], 'ammonium': [2394], 'acetate': [2395, 2932, 4370], '5.0)': [2397], 'methanol': [2399], '(1:20,': [2400], 'v/v)': [2401], '(17Therod': [2402], 'Couturier': [2404], 'Demelier': [2406], 'T.F.': [2407], 'Lemonnier': [2408], 'Lipids.': [2410], '28:': [2412], '245-249Crossref': [2413], '(45)': [2416], 'ml/min': [2425], 'Hewlett-Packard': [2428], 'Series': [2429], '1050': [2430], 'equipped': [2432], 'Columbus': [2435], '5-μm': [2436], '(250': [2439], '4.6': [2441], 'mm)': [2442], '(Phenomenex,': [2443], 'Torrance,': [2444], 'Absorbance': [2446, 4431], 'measured': [2448, 2730, 2910, 2994, 3723, 3892, 4439], '205': [2450, 4441], 'detect': [2453, 2461], 'conjugated': [2462, 4454], 'dienes.': [2463, 4455], 'Peak': [2464], 'retention': [2465], 'time': [2466, 4409], '28.6': [2468], 'phospholipid,': [2473], '23.4': [2474, 4287, 4429], 'hydroxyphospholipid,': [2478], '20.9': [2480, 4254, 4417], 'additional': [2487, 3414, 3433], 'peak': [2488, 4252, 4272, 4284, 4299, 4316, 4415, 4426, 4469, 4474], 'coming': [2489], 'earlier': [2490], '(17.3': [2491], 'min)': [2492], 'suggesting': [2496], 'double': [2501], 'hydroperoxidation': [2502], 'product.': [2503], 'products': [2505], 'recovered': [2507], 'between': [2508], '20': [2509], '23': [2511], 'min,': [2512], 'concentrations': [2516, 3797, 3966], 'estimated': [2518], 'integrated': [2521, 4297], 'peaks': [2522], 'based': [2523, 2723], 'extinction': [2526, 2788], 'coefficient': [2527, 2789], '2.3': [2529], '104': [2531], 'cm−1m−1': [2532], '(18Gardner': [2533, 2800], 'H.W.': [2534, 2801], '1001:': [2539, 2806], '274-281Crossref': [2540, 2807], '(176)': [2543, 2810], 'HPLC-purified': [2547], 'lipid': [2548], 'assays.': [2555], 'measuring': [2561], 'reductase.': [2572, 2613], 'Unless': [2573], 'otherwise': [2574], 'noted,': [2575], 'all': [2576], 'assays': [2577], 'inE.': [2583], 'affinity-purified.': [2586], '(3': [2591], 'ml)': [2592], 'Tris-HCl,': [2596], 'mmNaN3,': [2598], '0.1': [2599, 2870], 'EDTA': [2601, 2872], '0.3': [2604], 'mmNADPH,': [2605], '0.23': [2610], 'units/ml': [2611], 'To': [2614, 2766], 'hydroperoxides,': [2617], '0.1%': [2618], 'routinely': [2622], 'added,': [2623], 'approximately': [2627], '40%': [2628], 'less': [2629], 'its': [2631], 'absence.': [2632], 'assay,': [2636, 2772, 4025, 4108], 'mixture': [2638], 'plus': [2639, 3413], '(2': [2641, 4344], 'μg': [2642], 'protein/ml)': [2644], 'preincubated': [2646], 'stirring.': [2652], 'Fluorescence': [2653], 'continuously': [2655], 'recorded': [2656, 2698], '460': [2658], '(340-nm': [2660], 'excitation)': [2661], 'fluorescence': [2664, 2696, 2705, 2771, 3515, 4312], 'spectrophotometer': [2665], '(Photon': [2666], 'Technology': [2667], 'Instruments,': [2668], 'Bricktown,': [2669], 'NJ).': [2670], 'steady': [2673], 'base': [2674], 'achieved,': [2677], 'started': [2681], 'addition': [2684, 3518], 'generally': [2687], '250': [2689, 2881, 3732, 3901, 4352], 'μm,': [2690], 'linear': [2693, 3511], 'change': [2694, 2703, 4491], '5–10': [2700], 'min.': [2701, 4430], 'corrected': [2707], 'relatively': [2710], 'small': [2711], 'base-line': [2712], 'nonenzymatic': [2713], 'oxidation': [2714, 3599], 'calculate': [2720], 'standards.': [2727], 'Protein': [2728], 'Coomassie': [2732, 3444], 'Blue': [2733], '(Bio-Rad': [2734], 'dye': [2736], 'binding': [2737], 'kit)': [2738], 'γ-globulin': [2741], 'standard.': [2744], 'Enzymatic': [2745, 3587], 'nmol': [2750], 'oxidized/min/mg': [2753], 'Data': [2756], 'multiple': [2758], 'replications': [2759], 'are': [2760], 'presented': [2761], 'mean': [2763, 3741, 3910], '±': [2764, 3672, 3679, 3686, 3693, 3700, 3707, 3714, 4096, 4139, 4155], 'S.E.': [2765], 'confirm': [2767], 'production': [2774], 'hydroxy-PLPC': [2776, 4473, 4497], 'determined': [2781, 2819, 4020], 'analysis,': [2784], 'assuming': [2785], 'species': [2799], 'assays,': [2815], 'disappearance': [2822, 4178], 'modification': [2826], 'method': [2829], 'Kanget': [2831], 'al.': [2832], '(6': [2857], 'Tris,': [2869], '0.2': [2875, 4150, 4187], 'μmH2O2.': [2882], 'At': [2883], 'end': [2885, 4023, 4106, 4183], 'incubation,': [2887], 'mmFe(NH4)2(SO4)2': [2889], '0.25': [2891], 'KSCN': [2893], 'absorbance': [2897], 'red': [2900], 'ferrithiocyanate': [2901], 'complex': [2902], 'formed': [2903], 'peroxides': [2908], '480': [2912], 'nm.': [2913], 'test': [2919], 'dependence;': [2921], 'buffers': [2922], 'glycine': [2926], '3),': [2928], 'sodium': [2931, 4369], '4–5),': [2934], 'MES': [2937], '6),': [2939], '7–10).': [2945], 'measure': [2952], 'substituting': [2962], 'spectrophotometric': [2997], '1-chloro-2,4-dinitrobenzene': [3000], 'Since': [3017, 3810, 3979], 'initial': [3019], 'isolation': [3020], 'sources': [3027], 'complement': [3049], 'descriptions': [3051], 'clones': [3057, 3231, 3242], '15Kim': [3096], '19Frank': [3118], 'Munz': [3120], 'Werner': [3122, 3141], 'Oncogene.': [3124], '14:': [3126], '915-921Crossref': [3127], '(109)': [3130], '20Munz': [3133], 'Frank': [3135], 'Hübner': [3137], 'Olsen': [3139], '326:': [3146], '579-585Crossref': [3147], '(106)': [3150], 'sequenced': [3158, 3254], 'recent': [3162], 'We': [3196], 'screened': [3197, 3215], 'commercially': [3199], 'available': [3200], 'cloned': [3205], 'bacteriophage': [3207], 'λ': [3208], 'Uni-ZAP': [3209], 'XR.': [3210], 'Approximately': [3211], '50,000': [3212], 'plaques': [3213], '589-nucleotide': [3218], 'derived': [3223], 'probe.': [3228], 'Forty': [3229], 'positive': [3230, 3240], 'obtained,': [3233], '0.08%': [3235], 'those': [3237], 'screened.': [3238], 'Selected': [3239], '"zapped"': [3244], 'Bluescript': [3246], 'plasmid': [3247], "supplier's": [3251], 'instructions': [3252], 'cooperation': [3256], 'Sequencing': [3260], 'Facility': [3261], 'University': [3264], 'Pennsylvania.': [3266], 'sense': [3274], 'orientation': [3275, 3317], '(called': [3284], 'hNSGPx)': [3285], 'apparent': [3288, 3346, 3825, 3994], '33': [3292], 'kDa': [3293], 'probed': [3299, 3331], 'anti-peptide': [3304], '(Fig.': [3306, 3472, 3574, 3602, 3625, 3655, 4218, 4289, 4328], '1).': [3307, 3473], 'visible': [3313], 'antisense': [3316, 3557], '(not': [3320, 3342, 3461, 3553], 'shown).': [3321, 3343], 'result': [3324], '(hNSGPx)': [3341], 'larger': [3345], 'PAGE': [3353], 'compared': [3354], '25,032': [3359], 'Da': [3360], 'due': [3403], 'part': [3405], 'amino': [3415, 3434], 'acids': [3416, 3435], '5′': [3423], 'normally': [3424], 'untranslated': [3425], 'region;': [3426], 'estimate': [3428], 'these': [3432], '5996': [3437], 'densitometric': [3441], 'scanning': [3442], 'Blue-stained': [3445], 'gels,': [3446], 'hNSGPx': [3449, 3502, 3573, 3721, 3890, 4010, 4091, 4147, 4175, 4265, 4292, 4343], 'crude': [3453, 4084], 'homogenate': [3455], '13%': [3457], 'shown),': [3462], 'increased': [3465], '85%': [3467], 'figure': [3475], 'purity': [3477], 'represents': [3478], 'lower': [3480], 'limit,': [3481], 'immunoreactivity': [3483], 'higher': [3485], 'suggests': [3492], 'dimers': [3496], 'multimeric': [3498], 'forms.': [3499], 'decrease': [3512, 4464], '(Fig.2).': [3527], 'Fig.': [3528, 3729, 3803, 3852, 3898, 3972], 'showst-butyl': [3531], 'cumene,': [3539], 'equally': [3546, 3582], '(TableI).': [3548], 'There': [3549], 'zero': [3551], 'shown)': [3554], 'preparation,': [3558], 'indicating': [3559, 4322, 4475, 4499], 'specificity': [3560], 'gene': [3564], 'fragment.': [3565], 'Hydroperoxides': [3566], 'phosphatidylcholine': [3568], 'likewise': [3569], 'reduced': [3571, 3638, 4012, 4201], 'B).': [3576], '(Table': [3585], 'I).': [3586], 'required': [3589], 'combination': [3593], 'reductase': [3596, 3618, 3621], 'resulted': [3597, 4461], 'C).': [3604], 'itself': [3606], 'substitution': [3615], 'thioredoxin/thioredoxin': [3617], 'GSH/glutathione': [3620], 'ineffective': [3624], 'D).': [3627], '(selenoenzyme': [3635], 'erythrocytes)': [3637], 'reactivity': [3651], '3).Table': [3656], 'INSGPx': [3657], 'various': [3660], '(HP)': [3662], 'substratesSubstrateNSGPx': [3663], 'activityV': [3664], 'max(app)K': [3665], 'm(app)k': [3666], '1k': [3667], '2nmol/min/mg': [3668], 'proteinnmol/min/mg': [3669], 'proteinμmmm−1min−1mm−1': [3670], 'min−1H2O21850': [3671], '3218101801.8': [3673], '1059.0': [3675], '104Cumene': [3677], 'HP1140': [3678], '3011201201.2': [3680], '1054.0': [3682], '104t-Butyl': [3684], 'HP1320': [3685], '3912701421.6': [3687], '1056.1': [3689], '104Linolenoyl': [3691], 'HP1400': [3692], '2113901411.7': [3694], '1056.8': [3696], '104Arachidonoyl': [3698], 'HP1360': [3699], '3013801351.8': [3701], '1057.2': [3703], '104PLPC': [3705], 'HP1470': [3706], '3715001203.2': [3708], '10511': [3710], '104PAPC': [3712], 'HP1670': [3713], '2916401292.3': [3715], '1057.9': [3717], '104Activity': [3719], '(see': [3728, 3897], '2)': [3730, 3899], 'mmGSH.': [3738, 3907], 'Values': [3739, 3908], 'represent': [3740, 3909], '±S.E.': [3742, 3911], 'n': [3744, 3913], 'separate': [3747, 3916], 'experiments.': [3748, 3917], 'Apparent': [3749, 3918], 'constantsV': [3751, 3920], 'double-reciprocal': [3759, 3786, 3928, 3955], 'plots': [3760, 3787, 3929, 3956], 'versus': [3763, 3790, 3932, 3959], 'varying': [3764, 3791, 3933, 3960], 'illustrated': [3772, 3941], 'Fig.6': [3774, 3943], 'andk': [3781, 3950], 'fixed': [3796, 3965], '6': [3804, 3973], 'C': [3805, 3974], '"Results."': [3809, 3978], 'indefinite;': [3823, 3992], 'given': [3830, 3999], '[GSH]': [3831, 4000], 'relationship': [3837, 4006], '[GSH]k': [3838, 4007], '2/k': [3839, 4008], '1.': [3840, 4009], 'Open': [3841], 'table': [3842], 'tab': [3846], 'Figure': [3847, 3882], '3Same': [3848], 'erythrocyte': [3856], '(0.1': [3859], 'unit/ml)': [3860], 'instead': [3863], 'NSGPx.': [3865], '(t-BUOOH)': [3872], '(PLPCOOH).View': [3879], 'Large': [3880, 4506], 'Image': [3881], 'ViewerDownload': [3883], 'Hi-res': [3884], 'image': [3885], 'Download': [3886], '(PPT)': [3887], 'DTT': [4015, 4136], 'point': [4024, 4107, 4184], 'consistent': [4026], 'reports': [4029], '23Peshenko': [4052], 'I.V.': [4053], 'Novoselov': [4054], 'V.I.': [4055], 'Evdokimov': [4056], 'V.A.': [4057], 'Nikolaev': [4058], 'Y.V.': [4059], 'Kamzalov': [4060], 'S.S.': [4061], 'Shuvaeva': [4062], 'T.M.': [4063], 'Lipkin': [4064], 'V.M.': [4065], 'Fesenko': [4066], 'E.E.': [4067], '25:': [4073], '654-659Crossref': [4074], '(48)': [4077], 'Peroxidase': [4080], 'lysate': [4086], 'fromE.': [4087], '61': [4095], 'nmol/min/mg': [4098, 4123, 4157, 4302], '(n': [4101, 4141, 4160], '4)': [4103], 'seen': [4113, 4212], 'DTT.': [4118], 'preparation': [4128], 'place': [4134], '4).': [4143, 4162, 4219], 'affinity-purified': [4146, 4174], '1275': [4154], '16': [4156], 'effect': [4164], 'evaluated': [4172, 4228], 'optimum': [4192], 'range': [4196], '7–8;': [4198], '65%': [4203], '6,': [4206], 'virtually': [4208], 'below': [4217], 'dependence': [4222, 4332], '8': [4233, 4460], 'determine': [4237], 'formation': [4238], 'hydroxyphospholipid.': [4241], 'original': [4246], 'hydroxyphospholipid': [4258, 4283, 4298, 4315, 4425], 'peak.': [4259], '1-h': [4262], 'incubation': [4263, 4437, 4457, 4484], '8,': [4270], 'height': [4273], 'signal': [4277], 'significantly': [4279], 'decreased,': [4280], 'appeared': [4285], 'C);': [4291], '1400': [4301], 'protein,': [4304], 'value': [4308], 'assay.': [4313], 'No': [4314], 'detected': [4318], '5,': [4321, 4487], 'D).Figure': [4330], '5pH': [4331], 'HPLC.': [4342, 4406], 'h': [4350], '8)': [4365], '5)': [4372], 'stopped': [4377], 'passage': [4379], 'elution': [4385, 4408], 'methanol.': [4391], 'Samples': [4392], '5-fold': [4395], 'Speed': [4398], 'Vac': [4399], 'reversed': [4404], 'minutes.': [4413], 'indicates': [4419], 'while': [4423], 'before': [4436], '(A)': [4443], 'demonstrate': [4445], '(B)': [4451], 'C,': [4456], 'increase': [4471], 'substrate.': [4481], 'D,': [4482], 'there': [4488], 'peaks,': [4498], 'pH.View': [4505]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2016241657', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-14T03:24:52.344499', 'created_date': '2016-06-24'}
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