Title: Poliovirus: Guanidine Dependence and Loss of Neurovirulence for Monkeys
Abstract:Guanidine-dependent polioviruses are obtained in vitro by subculturing Brunenders, Mahoney, and Sabin strains in the presence of increasing concentrations of guanidine. Mahoney viruses dependent on gu...Guanidine-dependent polioviruses are obtained in vitro by subculturing Brunenders, Mahoney, and Sabin strains in the presence of increasing concentrations of guanidine. Mahoney viruses dependent on guanidine lose virulence (as indicated by paralysis) for monkeys inoculated intramuscularly or intracerebrally. Protection against virulent Mahoney viruses is induced by treatment with guanidine-dependent strains, and serum antibodies against the virulent strains are present in the treated animalsRead More
Publication Year: 1964
Publication Date: 1964-08-28
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 6
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