Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2015891968', 'doi': 'https://doi.org/10.1016/0196-9781(89)90109-5', 'title': 'Structural requirements for galanin interaction with receptors from pancreatic beta cells and from brain tissue of the rat', 'display_name': 'Structural requirements for galanin interaction with receptors from pancreatic beta cells and from brain tissue of the rat', 'publication_year': 1989, 'publication_date': '1989-07-01', 'ids': {'openalex': 'https://openalex.org/W2015891968', 'doi': 'https://doi.org/10.1016/0196-9781(89)90109-5', 'mag': '2015891968', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2479930'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0196-9781(89)90109-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S120382301', 'display_name': 'Peptides', 'issn_l': '0196-9781', 'issn': ['0196-9781', '1873-5169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079087297', 'display_name': 'I Lagny-Pourmir', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'I Lagny-Pourmir', 'raw_affiliation_strings': ['INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005187287', 'display_name': 'Anne-Marie Lorinet', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'A.M Lorinet', 'raw_affiliation_strings': ['INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053594587', 'display_name': 'Noboru Yanaihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'N Yanaihara', 'raw_affiliation_strings': ['Laboratory of Bio-organic Chemistry, University of Shizuoka School of Pharmaceutical Sciences, Oshika, Shizuoka 422, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Bio-organic Chemistry, University of Shizuoka School of Pharmaceutical Sciences, Oshika, Shizuoka 422, Japan', 'institution_ids': ['https://openalex.org/I150240954']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076634867', 'display_name': 'Marc Laburthe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'M Laburthe', 'raw_affiliation_strings': ['INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U178, Unité de Recherches sur la Différenciation et la Neuroendocrinologie de Cellules Digestives, Bâtiment INSERM 16 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France', 'institution_ids': ['https://openalex.org/I154526488']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3460, 'currency': 'USD', 'value_usd': 3460, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.926, 'has_fulltext': False, 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.726259, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '10', 'issue': '4', 'first_page': '757', 'last_page': '761'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Role of Neuropeptides in Physiology and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Calcineurin-NFAT Signaling in Transcriptional Regulation', 'score': 0.9741, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.5511411}, {'id': 'https://openalex.org/keywords/calcitonin-gene-related-peptide', 'display_name': 'Calcitonin Gene-Related Peptide', 'score': 0.483031}], 'concepts': [{'id': 'https://openalex.org/C19519825', 'wikidata': 'https://www.wikidata.org/wiki/Q417867', 'display_name': 'Galanin', 'level': 4, 'score': 0.77893764}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6555882}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.5511411}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5048278}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46941125}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4660341}, {'id': 'https://openalex.org/C118303440', 'wikidata': 'https://www.wikidata.org/wiki/Q419968', 'display_name': 'Neuropeptide', 'level': 3, 'score': 0.44663543}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4112725}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37016293}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3691963}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27439088}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.09587747}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011964', 'descriptor_name': 'Receptors, Gastrointestinal Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000596', 'descriptor_name': 'Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019004', 'descriptor_name': 'Galanin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007457', 'descriptor_name': 'Iodine Radioisotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007515', 'descriptor_name': 'Islets of Langerhans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044088', 'descriptor_name': 'Receptors, Galanin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011964', 'descriptor_name': 'Receptors, Gastrointestinal Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0196-9781(89)90109-5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S120382301', 'display_name': 'Peptides', 'issn_l': '0196-9781', 'issn': ['0196-9781', '1873-5169'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2479930', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1896296706', 'https://openalex.org/W1968136188', 'https://openalex.org/W1968513661', 'https://openalex.org/W1968908922', 'https://openalex.org/W1980070975', 'https://openalex.org/W1988681212', 'https://openalex.org/W1992043179', 'https://openalex.org/W1992976741', 'https://openalex.org/W2030350982', 'https://openalex.org/W2033158972', 'https://openalex.org/W2057212749', 'https://openalex.org/W2086962416', 'https://openalex.org/W2091972078', 'https://openalex.org/W2100322140', 'https://openalex.org/W2123092430', 'https://openalex.org/W2128635872', 'https://openalex.org/W2412282877', 'https://openalex.org/W3027184292', 'https://openalex.org/W4240550939', 'https://openalex.org/W4243857271', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W4389173712', 'https://openalex.org/W3208011488', 'https://openalex.org/W3025837361', 'https://openalex.org/W2789974351', 'https://openalex.org/W2584680835', 'https://openalex.org/W2339356172', 'https://openalex.org/W2069800100', 'https://openalex.org/W2061180318', 'https://openalex.org/W2049160758', 'https://openalex.org/W204194975'], 'abstract_inverted_index': {'The': [0, 88], 'binding': [1, 46], 'activity': [2], 'of': [3, 56, 76], 'several': [4], 'galanin': [5, 45, 77], 'fragments': [6], 'and': [7, 18, 38, 47], 'analogs': [8], 'was': [9, 32, 70], 'measured': [10], 'on': [11], 'specific': [12], 'receptors': [13], 'present': [14], 'in': [15, 92, 96], 'rat': [16, 20], 'brain': [17], 'the': [19, 52, 73], 'pancreatic': [21], 'beta': [22], 'cell': [23], 'line': [24], 'Rin': [25], 'm': [26], '5F.': [27], 'In': [28], 'both': [29], 'tissues': [30], 'it': [31], 'observed': [33], 'that:': [34], '1)': [35], 'galanin(3–29),': [36], 'galanin(10–29)': [37], '[Ile2]-galanin': [39], 'were': [40], 'ineffective': [41], 'for': [42, 81], 'inhibiting': [43], '[125I]': [44], '2)': [48], 'active': [49], 'peptides': [50], 'had': [51], 'following': [53], 'rank': [54], 'order': [55], 'potency:': [57], 'galanin(1–29)': [58], '>': [59, 61, 63, 65, 67], '[Ac-Trp2]-galanin(2–29)': [60], 'galanin(2–29)': [62], 'galanin(1–15)': [64], '[Phe2]-galanin': [66], '[Tyr2]-galanin.': [68], 'It': [69], 'concluded': [71], 'that': [72], 'N-terminal': [74], 'portion': [75], 'is': [78], 'very': [79], 'important': [80], 'interaction': [82], 'with': [83], 'central': [84], 'or': [85], 'peripheral': [86], 'receptors.': [87], 'aromatic': [89], 'amino': [90], 'acid': [91], 'position': [93], '2': [94], '(Trp': [95], 'native': [97], 'galanin)': [98], 'plays': [99], 'a': [100], 'crucial': [101], 'role.': [102]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2015891968', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-08-15T05:46:11.893485', 'created_date': '2016-06-24'}