X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway

Name: Work Video:
Duration: 3 min 30 s
Jingyu Diao; Aye Aye Khine; Farida Sarangi; Eric C. Hsu; Caterina Iorio; Lee Anne Tibbles; James R. Woodgett; Josef Penninger; Christopher D. Richardson
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1678, 1799, 1819, 1841, 1847, 1853, 1862, 1936, 2088, 2230, 2504, 2654, 2939, 2948, 3143, 3236, 3352, 3735, 3745, 3840, 4012, 4069], 'from': [3, 133, 142, 170, 228, 234, 364, 373, 401, 459, 934, 942, 1459, 1470, 1685, 2135, 2709, 2717, 2786, 2827, 2940, 2966, 3053, 3168, 3211, 3226, 3756, 3816, 3900], 'a': [4, 101, 195, 212, 235, 332, 426, 443, 537, 683, 728, 739, 857, 996, 1028, 1034, 1142, 1285, 1445, 2486, 2667, 2927, 3153, 3473, 3535, 3670, 3777, 4031, 4188, 4369], 'chronic': [5, 236, 868, 944, 1349], 'strain': [6, 237], 'of': [7, 28, 48, 78, 81, 167, 177, 208, 223, 238, 259, 279, 309, 312, 398, 408, 439, 454, 540, 634, 646, 651, 679, 682, 741, 829, 838, 844, 862, 867, 930, 1002, 1032, 1036, 1065, 1149, 1282, 1294, 1322, 1339, 1348, 1447, 1454, 1457, 1466, 1475, 1569, 1577, 1636, 1644, 1751, 1800, 1820, 1842, 1848, 1855, 1863, 1958, 1976, 2039, 2095, 2103, 2488, 2502, 2548, 2618, 2701, 2809, 2862, 2874, 2905, 2914, 2923, 2936, 2952, 3030, 3097, 3102, 3414, 3491, 3628, 3635, 3641, 3704, 3733, 3768, 3847, 3855, 3952, 3985, 3996, 4006, 4060, 4068, 4076, 4155, 4284, 4298, 4305, 4340, 4371, 4373], 'hepatitis': [8, 239, 462, 465, 692, 936, 1350, 2227, 2551], 'B': [9, 240, 463, 466, 503, 527, 534, 583, 2228], 'virus': [10, 241, 464, 467, 509, 535, 614, 941, 1074, 1373, 1669, 1823, 2866], '(HBx)': [11, 242], 'was': [12, 43, 60, 76, 117, 152, 219, 243, 274, 291, 307, 348, 383, 450, 1023, 2655, 2854, 2901, 2930, 2964, 3026, 3109, 3144, 3162, 3196, 3305, 3357, 3384, 3532, 3552, 3708, 3736, 3750, 3762, 3773, 3825, 3834, 3882, 4268, 4277, 4292, 4352], 'determined': [13, 244], 'to': [14, 99, 147, 245, 330, 378, 661, 670, 674, 738, 835, 855, 1026, 1140, 1146, 1180, 1558, 1632, 1659, 1682, 1769, 1968, 2047, 2476, 2505, 2628, 2973, 3055, 3179, 3192, 3219, 3295, 3316, 3354, 3541, 3646, 3747, 3752, 3805, 3812, 3827, 3921, 3990, 4035, 4225, 4253, 4262], 'inhibit': [15, 246, 2506], 'Fas-mediated': [16, 22, 74, 108, 148, 229, 247, 253, 305, 339, 379, 460, 1686, 1757, 2523, 2585, 2629, 2673, 2710], 'apoptosis': [17, 23, 75, 248, 254, 306, 1389, 1579, 1661, 1687, 2507, 2524, 2586, 2630, 2650], 'and': [18, 54, 110, 161, 164, 185, 202, 226, 249, 285, 341, 392, 395, 416, 433, 457, 542, 589, 602, 649, 696, 711, 716, 720, 761, 831, 848, 864, 871, 946, 1038, 1055, 1063, 1070, 1115, 1129, 1380, 1387, 1562, 1575, 1651, 1674, 1859, 1912, 1933, 1985, 2037, 2051, 2114, 2132, 2225, 2231, 2415, 2443, 2508, 2525, 2536, 2545, 2591, 2675, 2688, 2736, 2762, 2781, 2790, 2811, 2841, 2870, 2944, 2971, 3004, 3035, 3060, 3118, 3286, 3307, 3329, 3370, 3397, 3442, 3453, 3478, 3503, 3539, 3561, 3571, 3596, 3607, 3617, 3623, 3638, 3650, 3666, 3730, 3770, 3780, 3852, 3857, 3886, 3888, 3903, 3924, 3935, 3982, 4016, 4027, 4063, 4072, 4097, 4109, 4185, 4193, 4197, 4240, 4265, 4282, 4361], 'promote': [19, 250], 'cell': [20, 37, 251, 268, 507, 521, 640, 652, 1442, 2116, 2129, 2526, 2643, 3038, 3077, 3107, 3589, 3648, 3757, 3817, 3954, 4310], 'survival.': [21, 252], 'is': [24, 255, 994, 1288, 1324, 1556, 2236, 2286, 2680], 'the': [25, 46, 82, 123, 139, 143, 165, 175, 256, 277, 313, 354, 370, 374, 396, 406, 638, 665, 721, 865, 931, 940, 1051, 1071, 1147, 1280, 1292, 1299, 1328, 1342, 1345, 1460, 1471, 1634, 1645, 1667, 1675, 1748, 1760, 1771, 1797, 1817, 1839, 1845, 1850, 1860, 1913, 1926, 1929, 1934, 2040, 2093, 2101, 2104, 2119, 2239, 2283, 2478, 2492, 2495, 2500, 2510, 2546, 2615, 2619, 2646, 2652, 2697, 2718, 2745, 2763, 2791, 2828, 2837, 2863, 2875, 2892, 2906, 2924, 2934, 2937, 2953, 2986, 2992, 3031, 3048, 3095, 3105, 3266, 3308, 3335, 3355, 3361, 3449, 3454, 3479, 3484, 3563, 3597, 3610, 3647, 3661, 3712, 3766, 3786, 3793, 3799, 3829, 3845, 3865, 3901, 3986, 4007, 4036, 4145, 4227, 4231, 4280, 4285, 4306, 4313, 4347], 'major': [26, 257], 'cause': [27, 258, 539], 'hepatocyte': [29, 260, 1983, 2740], 'damage': [30, 261, 619, 2544], 'during': [31, 262, 626, 2550], 'liver': [32, 263, 627, 662, 671, 869, 1343, 2053, 2113, 2543, 2713, 3006, 3064, 3087, 3291], 'disease.': [33, 264], 'Experiments': [34, 265], 'demonstrated': [35, 190, 210, 266, 421, 441, 1553, 2109, 2603], 'that': [36, 67, 71, 114, 158, 191, 211, 267, 298, 302, 345, 389, 422, 442, 704, 734, 1249, 1385, 1554, 2099, 2110, 2213, 2232, 2282, 2408, 2582, 2592, 2608, 2613, 2637, 2678, 2693, 2932, 3425], 'death': [38, 269, 1443, 2527], 'caused': [39, 270, 620], 'by': [40, 45, 271, 276, 621, 1580, 2238, 2289, 2529, 2703, 2730, 2744, 2753, 2816, 2823, 2856, 2903, 3081, 3111, 3115, 3132, 3149, 3164, 3214, 3359, 3483, 3554, 3603, 3668, 3717, 3884, 3890, 3905, 3932, 3937, 4044, 4099, 4199, 4294], 'anti-Fas': [41, 182, 272, 413], 'antibodies': [42, 273, 3122, 3203, 3224, 3804, 4078, 4271], 'blocked': [44, 275, 2584, 3358], 'expression': [47, 278, 861, 2851, 2898, 2962, 4287], 'HBx': [49, 124, 130, 151, 192, 209, 280, 355, 361, 382, 423, 440, 863, 993, 1176, 1250, 1283, 1323, 1555, 1581, 1752, 1861, 2087, 2111, 2224, 2290, 2409, 2446, 2483, 2503, 2583, 2639, 2694, 2704, 2810, 2812, 2842, 2858, 2887, 2907, 2938, 2987, 3103, 3125, 3142, 3186, 3207, 4276], 'in': [50, 63, 87, 120, 174, 281, 294, 318, 351, 405, 546, 587, 630, 744, 948, 1153, 1298, 1341, 1391, 1444, 1639, 1662, 1777, 1962, 1982, 2055, 2092, 2112, 2221, 2491, 2515, 2522, 2542, 2587, 2597, 2604, 2683, 2739, 2767, 2795, 2886, 2985, 3028, 3094, 3104, 3146, 3158, 3199, 3297, 3324, 3343, 3374, 3387, 3430, 3496, 3625, 3660, 3738, 3765, 3844, 3949, 3958, 4057, 4151, 4230, 4245, 4326, 4375], 'human': [51, 282, 505, 1072, 1821, 2589, 3033], 'primary': [52, 283, 2588, 2726, 3032, 3058], 'hepatocytes': [53, 284, 2549, 2590, 2727, 3034, 3059], 'mouse': [55, 64, 127, 286, 295, 358, 517, 2605, 2748, 2783, 3036, 3073, 3090, 4363], 'embryo': [56, 287, 518, 4359], 'fibroblasts.': [57, 288], 'This': [58, 289], 'effect': [59, 290], 'also': [61, 292, 1137, 1657, 1979, 2287, 2624, 2889, 3197, 3790, 3897], 'observed': [62, 293, 2581], 'erythroleukemia': [65, 296, 2606, 2749, 3084, 4364], 'cells': [66, 106, 121, 297, 337, 352, 1684, 2134, 2222, 2607, 2648, 2671, 2684, 2708, 2714, 2750, 2764, 2792, 3003, 3007, 3065, 3292, 3309, 3336, 3356, 3362, 3393, 3469, 3593, 3600, 3614, 3654, 3727, 3916, 4041, 4054, 4087, 4192, 4304, 4365], 'lacked': [68, 299, 2609, 2614], 'p53,': [69, 300, 836, 1452, 1455], 'indicating': [70, 301], 'protection': [72, 89, 227, 303, 320, 458], 'against': [73, 304, 2642, 3124, 3141, 3185, 3234, 3243, 3250, 3258, 3265, 4080, 4273], 'independent': [77, 308], 'p53.': [79, 310, 2610], 'Components': [80, 311], 'signal': [83, 314, 845, 1773, 2096, 2412, 2489, 2511], 'transduction': [84, 315, 846, 1774, 2097, 2413, 2512], 'pathways': [85, 316, 654, 2098, 2490, 2513], 'involved': [86, 317, 2514], 'this': [88, 319, 613, 1174, 1637, 2516, 3169, 3206], 'were': [90, 131, 172, 321, 362, 403, 1679, 1745, 2519, 2602, 2623, 2640, 2715, 2728, 2737, 2751, 2765, 2793, 2821, 2888, 2989, 3011, 3042, 3067, 3079, 3130, 3171, 3209, 3293, 3310, 3319, 3337, 3407, 3434, 3451, 3456, 3470, 3481, 3494, 3514, 3569, 3576, 3581, 3594, 3601, 3615, 3644, 3655, 3728, 3789, 3810, 3896, 3919, 3930, 3947, 3970, 3988, 4009, 4020, 4042, 4055, 4088, 4112, 4149, 4195, 4213, 4233, 4243, 4251, 4260, 4366], 'studied.': [91, 322], 'SAPK/JNK': [93, 224, 324, 455, 1772, 2284, 2660, 3706, 3713, 3755, 3806, 3815], 'pathway': [94, 103, 145, 325, 334, 376, 1775, 2285, 2622, 2661, 2669], 'has': [95, 326, 735, 1004, 1136, 1177, 1246, 1301, 1582, 2044, 2089, 2210, 2447, 2662], 'previously': [96, 327, 2663, 4116], 'been': [97, 328, 656, 736, 1005, 1138, 1178, 1247, 1302, 1583, 1767, 1980, 2045, 2090, 2211, 2448, 2664, 3427], 'suggested': [98, 329, 1139, 2665], 'be': [100, 331, 675, 856, 1027, 1141, 1969], 'survival': [102, 333, 653, 2102, 2596, 2668], 'for': [104, 216, 221, 335, 447, 452, 592, 706, 1336, 2670, 3057, 3062, 3072, 3205, 3326, 3348, 3379, 3394, 3439, 3507, 3525, 3543, 3663, 3864, 3877, 3943, 3976, 3994, 4011, 4094, 4105, 4205, 4219], 'some': [105, 336], 'undergoing': [107, 338, 2672], 'apoptosis,': [109, 149, 340, 380, 1758, 2674, 3492], 'kinase': [111, 342, 473, 476, 483, 488, 489, 490, 526, 1911, 2241, 2621, 3760, 3801, 3860, 3867], 'assays': [112, 343, 2676], 'showed': [113, 157, 344, 388, 2692], 'SAPK': [115, 144, 346, 375, 1938, 1959, 1977, 2049, 2679, 2702, 3871], 'activity': [116, 225, 347, 456, 1254, 2050, 2242, 3707], 'highly': [118, 349, 2681], 'up-regulated': [119, 350, 2220, 2288, 2682], 'expressing': [122, 129, 353, 360], 'protein.': [125, 356], 'Normal': [126, 357, 2635], 'fibroblasts': [128, 137, 359, 368, 519, 2612, 2636, 2784, 3091, 4360], 'protected': [132, 363, 2641], 'death,': [134, 365, 2644], 'whereas': [135, 366, 2645], 'identical': [136, 367], 'lacking': [138, 369], 'SEK1': [140, 371, 2616], 'component': [141, 372, 2617], 'succumbed': [146, 377], 'whether': [150, 381, 2651], 'present': [153, 384, 2496, 2656], 'or': [154, 385, 1462, 1473, 2657, 3013, 3089, 3420, 3999, 4082], 'not.': [155, 386, 2658], 'Assays': [156, 387], 'caspase': [159, 390, 1252, 1476, 3960, 3997, 4000, 4017], '3': [160, 391, 1253, 3395, 3399, 3977, 3998, 4015], '8': [162, 393, 3527, 4001, 4018], 'activities': [163, 394, 4019], 'release': [166, 397, 1469], 'cytochrome': [168, 399, 1467, 4274], 'c': [169, 400, 1468], 'mitochondria': [171, 402], 'inhibited,': [173, 404], 'presence': [176, 407, 1148, 3096, 3767, 3846], 'HBx,': [178, 409], 'following': [179, 410, 4146, 4346], 'stimulation': [180, 411, 843], 'with': [181, 194, 412, 425, 612, 850, 1046, 1182, 1327, 1451, 1560, 1565, 1918, 1964, 1971, 2696, 2775, 2991, 3015, 3044, 3047, 3152, 3176, 3313, 3321, 3332, 3339, 3363, 3391, 3401, 3410, 3446, 3458, 3472, 3517, 3558, 3585, 3609, 3620, 3785, 3837, 3859, 3926, 4046, 4065, 4144, 4235, 4270], 'antibodies.': [183, 414, 3587, 3797, 3928], 'Coprecipitation': [184, 415], 'confocal': [186, 417, 2690, 3476], 'immunofluorescence': [187, 418, 2689, 3119], 'microscopy': [188, 419, 2691], 'experiments': [189, 420], 'localizes': [193, 424, 2695], 'cytoplasmic': [196, 427], 'complex': [197, 428], 'containing': [198, 429, 2223, 2685, 2800, 2883, 3092, 3499, 3591, 3912], 'MEKK1,': [199, 430], 'SEK1,': [200, 431], 'SAPK,': [201, 432], '14-3-3': [203, 217, 434, 448], 'proteins.': [204, 435], 'Finally,': [205, 436, 3448], 'mutational': [206, 437], 'analysis': [207, 438, 4267], 'potential': [213, 444], 'binding': [214, 445, 834, 3268, 3353, 3629], 'region': [215, 446], 'proteins': [218, 449, 714, 1439, 1648, 4259], 'essential': [220, 451], 'induction': [222, 453, 650, 3490], 'apoptosis.': [230, 461, 2711], 'tumor': [468], 'necrosis': [469], 'factor': [470], 'stress-activated': [471], 'c-JUN': [474, 3743, 3771, 3787, 3873, 3881, 3894], 'N-terminal': [475, 2884, 3742], 'enhanced': [477, 2240, 2945], 'green': [478, 495, 2946], 'fluorescent': [479, 496, 2947, 3961, 4023], 'mitogen-activated': [481, 484], 'kinase/extracellular': [486], 'signal-regulated': [487], 'internal': [491, 2954], 'ribosome': [492, 2955], 'entry': [493, 2956], 'site': [494, 2957], 'reverse': [498], 'transcriptase-polymerase': [499], 'chain': [500, 2825], 'reaction': [501, 3761], 'tetramethylrhodamine': [502], 'isothiocyanate': [504, 513], 'T': [506, 1672], 'lymphotrophic': [508], 'phosphate-buffered': [510], 'saline': [511], 'fluorescein': [512], 'polyacrylamide': [514], 'gel': [515, 3538, 3564, 3902], 'electrophoresis': [516, 3542, 4254], 'fluorescence-activated': [520], 'sorter': [522], 'phosphatidylinositol': [523, 2479], '3-kinase': [524, 2480], '7-amino-actinomycin': [528], 'D': [529], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine': [530], 'glutathione': [531], 'S-transferase': [532], 'Hepatitis': [533, 582], '(HBV)1is': [536], 'leading': [538, 660], 'cirrhosis': [541], 'hepatocellular': [543, 872], 'carcinoma': [544, 873], '(reviewed': [545, 743, 1390, 1776], 'Refs.': [547, 745, 1392], '1Ganem': [548], 'D.': [549, 906, 1211, 1727, 2389], 'Fields': [550, 556], 'B.N.': [551], 'Knipe': [552], 'D.M.': [553], 'Howley': [554], 'P.M.': [555], 'Virology.': [557], '2.': [558], 'Lippincott-Raven,': [559], 'Philadelphia1996:': [560], '6881-6886Google': [561], 'Scholar,': [562, 577, 778, 789, 801, 814, 898, 915, 978, 1090, 1103, 1199, 1222, 1407, 1421, 1493, 1511, 1534, 1602, 1705, 1725, 1880, 2019, 2156, 2175, 2193, 2257, 2306, 2347, 2359, 2381], '2Hildt': [563, 746], 'E.': [564, 747, 1008, 1228, 1305, 1589, 1729], 'Hofschneider': [565, 748, 1009, 1306, 1590, 2337], 'P.H.': [566, 749, 1010, 1307, 1591, 2338, 2565], 'Urban': [567, 750, 1011, 1206, 1308, 1592], 'P.': [568, 751, 763, 900, 1012, 1309, 1593, 1604, 1697, 1715, 2008, 2361], 'Semin.': [569, 752, 1013, 1310, 1399, 1410, 1594], 'Virol.': [570, 753, 972, 986, 1014, 1120, 1193, 1236, 1311, 1360, 1400, 1505, 1595, 1874, 1891, 2300, 2317, 2353, 2375], '1996;': [571, 754, 1015, 1194, 1312, 1596, 1721, 1875, 2301, 2354, 2376, 3695], '7:': [572, 755, 1016, 1313, 1597], '333-347Crossref': [573, 756, 1017, 1314, 1598], 'Scopus': [574, 757, 775, 786, 811, 822, 895, 1018, 1100, 1111, 1125, 1219, 1275, 1315, 1404, 1418, 1433, 1548, 1599, 1628, 1737, 1791, 1813, 1896, 1952, 2016, 2033, 2082, 2153, 2172, 2190, 2205, 2254, 2274, 2322, 2344, 2434, 2472, 2575, 4140], '(27)': [575, 758, 1019, 1316, 1600], 'Google': [576, 600, 759, 777, 788, 800, 813, 824, 897, 914, 927, 977, 991, 1020, 1089, 1102, 1113, 1127, 1170, 1198, 1221, 1241, 1277, 1317, 1365, 1406, 1420, 1435, 1492, 1510, 1533, 1550, 1601, 1630, 1704, 1724, 1739, 1793, 1815, 1837, 1879, 1898, 1954, 2018, 2035, 2084, 2155, 2174, 2192, 2207, 2256, 2276, 2305, 2324, 2346, 2358, 2380, 2405, 2436, 2474, 2577, 3699, 4142], '3Koshy': [578], 'R.': [579, 956, 1203, 1495, 1888, 2181, 2314, 2383], 'Caselmann': [580], 'W.H.': [581], 'Virus:': [584], 'Molecular': [585, 4327], 'Mechanisms': [586], 'Disease': [588], 'Novel': [590], 'Strategies': [591], 'Therapy.': [593], 'Imperial': [594], 'College': [595], 'Press,': [596], 'River': [597], 'Edge,': [598], 'NJ1998Crossref': [599], 'Scholar),': [601, 1816, 1838, 2036], 'currently': [603], 'more': [604, 2444, 2626], 'than': [605, 2631], '400': [606, 3940], 'million': [607], 'people': [608], 'are': [609, 1649, 1656, 2219], 'chronically': [610], 'infected': [611, 1761, 4367], 'worldwide.': [615], 'Multiple': [616], 'factors': [617, 1058, 2538], 'including': [618, 826, 1449], 'inflammatory': [622], 'cytokines,': [623], 'mutations': [624, 1340], 'incurred': [625], 'regeneration,': [628], 'defects': [629], 'DNA': [631, 636, 687, 841, 938, 1329, 1368, 2806, 2859, 2908, 3040, 3550, 3556], 'repair,': [632, 842], 'integration': [633], 'viral': [635, 830, 937, 1037, 1438, 1646, 1764, 2653], 'into': [637, 4300], 'host': [639, 642, 1039], 'genome,': [641], 'genomic': [643], 'instability,': [644], 'activation': [645, 1568, 1576, 2094], 'cellular': [647, 832, 1972], 'oncogenes,': [648], 'have': [655, 1552, 1766, 1978, 2108], 'implicated': [657, 1981, 2091], 'as': [658, 1284, 1371, 2666, 3068, 3070, 3229, 3583, 3862, 4114], 'causes': [659], 'cancer.': [663], 'However,': [664, 1279, 1572], 'exact': [666], 'molecular': [667], 'events': [668], 'progressing': [669], 'carcinogenesis': [672], 'remain': [673], 'elucidated.': [676], 'genome': [678, 2234], 'HBV': [680, 1068, 1864, 2233, 2840], 'consists': [681], 'partially': [684], 'double-stranded': [685], 'circular': [686], 'spanning': [688], '3200': [689], 'nucleotides.': [690], 'Mammalian': [691], 'viruses': [693, 1369], '(human,': [694], 'woodchuck,': [695], 'ground': [697], 'squirrel)': [698], 'encode': [699], '4': [700, 3444, 3821, 3980, 4095, 4209, 4223], 'overlapping': [701], 'reading': [702, 2844], 'frames': [703], 'code': [705], 'surface': [707], 'glycoproteins': [708], '(PreS1,': [709], 'PreS2,': [710], 'S),': [712], 'core': [713], '(C': [715], 'PreC),': [717], 'polymerase': [718, 2824], '(P),': [719], '(HBx).': [724], 'Thex': [725], 'gene': [726, 933, 1040, 1134, 1383, 1915, 1931, 2988], 'encodes': [727], '17-kDa': [729], '(154': [730], 'amino': [731], 'acid)': [732], 'attributed': [737], 'number': [740, 2487, 2848], 'functions': [742], 'Scholar': [760, 1114, 1128], '4Arbuthnot': [762], 'Capovilla': [764], 'A.': [765, 1161, 1209, 1262, 1623, 1825, 2000, 2064, 2077, 2148, 2167, 2397], 'Kew': [766, 903], 'M.': [767, 904, 1258, 1260, 1423, 1483, 1616, 1695, 1870, 1886, 2006, 2177, 2296, 2312, 2363, 2367, 2371, 3685, 4320], 'J.': [768, 795, 804, 886, 971, 982, 985, 1084, 1093, 1118, 1185, 1187, 1192, 1235, 1263, 1359, 1497, 1499, 1504, 1730, 1832, 1866, 1873, 1889, 1990, 2139, 2158, 2185, 2269, 2292, 2299, 2315, 2352, 2374, 2422, 2460, 2568, 2788, 3683, 4118, 4128], 'Gastroenterol.': [769], 'Hepatol.': [770, 887], '2000;': [771, 2463], '15:': [772, 889, 1545], '357-368Crossref': [773], 'PubMed': [774, 785, 810, 821, 894, 913, 976, 990, 1099, 1110, 1124, 1197, 1218, 1240, 1274, 1364, 1417, 1432, 1509, 1547, 1627, 1736, 1790, 1812, 1878, 1895, 1951, 2015, 2032, 2081, 2152, 2171, 2189, 2204, 2253, 2273, 2304, 2321, 2343, 2357, 2379, 2404, 2433, 2471, 2574, 3698, 4139], '(177)': [776, 2083], '5Koike': [779], 'K.': [780, 902, 1165, 1256, 1521, 1542, 4122], 'Intervirology.': [781, 817, 1106], '1995;': [782, 910, 1506, 1530, 1701, 2168, 2186, 2571], '38:': [783], '134-142Crossref': [784], '(76)': [787], '6Feitelson': [790], 'M.A.': [791, 803, 921, 1080, 1092, 1481, 2068], 'Duan': [792, 1081, 1484], 'L.X.': [793, 1082, 1485], 'Am.': [794, 1083], 'Pathol.': [796, 1085], '1997;': [797, 1086, 1544, 1624, 2201, 2250, 4136], '150:': [798, 1087], '1141-1157PubMed': [799, 1088], '7Feitelson': [802, 1091], 'Cell.': [805, 1094, 1783, 1807, 1944, 2011, 2199, 2248, 2399], 'Physiol.': [806, 1095], '1999;': [807, 818, 1096, 1107, 1237, 1787, 1948, 2270, 2401], '181:': [808, 1097], '188-202Crossref': [809, 1098], '(98)': [812, 1101], '8Murakami': [815, 1104], 'S.': [816, 954, 1105, 1157, 1207, 1398, 1536, 1606, 1622, 1829, 1992, 1996, 2025, 2058, 2076, 2147, 2166, 2755], '42:': [819, 1108], '81-99Crossref': [820, 1109], '(140)': [823, 1112], 'Scholar)': [825, 1551, 1631, 2406, 2437, 2475, 4143], 'transcriptional': [827, 1567], 'transactivation': [828], 'genes,': [833], 'inhibition': [837, 1465, 1574], 'nucleotide': [839], 'excision': [840], 'pathways,': [847, 1464, 1755, 2414], 'interference': [849], 'proteosome': [851], 'activity.': [852, 1477, 4002], 'There': [853], 'appears': [854, 1967], 'close': [858], 'correlation': [859], 'between': [860, 2868, 2910, 4279], 'development': [866, 2054], 'disease': [870], '(9Diamantis': [874], 'I.D.': [875], 'McGandy': [876], 'C.E.': [877], 'Chen': [878], 'T.J.': [879, 1191, 1234], 'Liaw': [880], 'Y.F.': [881], 'Gudat': [882], 'F.': [883, 980, 1868, 1882, 2294, 2308, 2349], 'Bianchi': [884], 'L.': [885, 1994, 2060, 2334, 2567], '1992;': [888, 1121], '400-403Abstract': [890], 'Full': [891, 1269, 1271, 2428, 2430, 2466, 2468], 'Text': [892, 1270, 1272, 2429, 2431, 2467, 2469], 'PDF': [893, 1273, 2432, 2470], '(63)': [896], '10Paterlini': [899], 'Poussin': [901], 'Franco': [905], 'Brechot': [907, 1212, 2394], 'C.': [908, 984, 1213, 1501, 1614, 2265, 2369, 2387, 2391, 2393, 2395], 'Hepatology.': [909, 2028], '21:': [911], '313-321Crossref': [912], '11Wang': [916], 'W.L.': [917, 2451], 'London': [918, 1486], 'W.T.': [919, 1487], 'Feitelson': [920], 'Cancer': [922, 1528, 2758], 'Res.': [923, 1529], '1991;': [924], '51:': [925], '4971-4977PubMed': [926], 'Scholar).': [928, 992, 1021, 1171, 1242, 1278, 1318, 1366, 1436, 1740, 1794, 1899, 1955, 2085, 2208, 2277, 2325, 2578, 3700, 4338], 'Removal': [929], 'x': [932, 2229], 'woodchuck': [935, 2226], 'prevents': [939], 'establishing': [943], 'infections': [945], 'tumors': [947], 'experimental': [949], 'animals': [950], '(12Chen': [951], 'H.S.': [952], 'Kaneko': [953], 'Girones': [955], 'Anderson': [957], 'R.W.': [958], 'Hornbuckle': [959], 'W.E.': [960], 'Tennant': [961], 'B.C.': [962], 'Cote': [963], 'P.J.': [964], 'Gerin': [965], 'J.L.': [966], 'Purcell': [967], 'R.H.': [968, 970, 1803], 'Miller': [969], '1993;': [973, 1489, 2340], '67:': [974], '1218-1226Crossref': [975], '13Zoulim': [979], 'Saputelli': [981], 'Seeger': [983], '1994;': [987, 1167, 2149], '68:': [988], '2026-2030Crossref': [989], 'clearly': [995], 'multifunctional': [997, 1650], 'protein,': [998], 'but': [999, 1655, 2216, 3066], 'its': [1000, 1044, 1154, 1325, 2941], 'mechanism': [1001], 'action': [1003], 'controversial': [1006, 1290], '(2Hildt': [1007, 1304, 1588], 'It': [1022, 2209], 'initially': [1024], 'described': [1025, 4115], '"promiscuous': [1029], 'transactivator"': [1030], 'capable': [1031], 'stimulating': [1033], 'variety': [1035, 1446], 'promoters': [1041], 'indirectly': [1042], 'through': [1043], 'interaction': [1045, 1450, 1638], 'transcription': [1047, 1057], 'factors.': [1048], 'These': [1049, 1437, 1795], 'included': [1050], 'proto-oncogenes': [1052], '(c-myc,': [1053], 'N-myc,': [1054], 'c-jun),': [1056], '(AP-1,': [1059], 'NF-κB,': [1060], 'ATF/CREB,': [1061], 'ERCC3,': [1062], 'RPB5': [1064], 'RNA': [1066], 'polymerase),': [1067], 'enhancers,': [1069], 'immunodeficiency': [1073, 1822], 'long': [1075, 1346], 'terminal': [1076], 'repeat': [1077], '(see': [1078], 'Refs.6Feitelson': [1079], '14Rossner': [1116], 'M.T.': [1117], 'Med.': [1119, 2570], '36:': [1122], '101-117Crossref': [1123], '(190)': [1126], 'references': [1130], 'therein).': [1131], 'product': [1135, 1916], 'protease': [1143, 1151, 1286], 'inhibitor': [1144, 1287], 'due': [1145], 'serpin-like': [1150, 1296], 'domains': [1152, 1297], 'sequence': [1155], '(15Takada': [1156], 'Kido': [1158], 'H.': [1159, 1201, 1519, 2021, 2385, 2557, 2559], 'Fukutomi': [1160], 'Mori': [1162], 'T.': [1163, 1693, 1713, 2023, 2066], 'Koike': [1164, 1541], 'Oncogene.': [1166, 1214, 1488, 1543, 1700], '9:': [1168, 1415, 2013], '341-348PubMed': [1169], 'To': [1172], 'support': [1173, 2100], 'hypothesis,': [1175], 'found': [1179], 'associate': [1181], 'proteosomes': [1183], '(16Huang': [1184], 'Kwong': [1186], 'Sun': [1188], 'E.C.': [1189, 3689], 'Liang': [1190, 1233], '70:': [1195, 1876, 2302, 2355, 2377], '5582-5591Crossref': [1196], '17Sirma': [1200], 'Weil': [1202], 'Rosmorduc': [1204], 'O.': [1205, 1230], 'Israel': [1208, 2396], 'Kremsdorf': [1210, 2388], '1998;': [1215, 1266, 1361, 1401, 1414, 1429, 1733, 1809, 1834, 1892, 2012, 2029, 2078, 2318, 2425], '16:': [1216], '2051-2063Crossref': [1217], '(101)': [1220], '18Hu': [1223], 'Z.': [1224, 1226], 'Zhang': [1225], 'Doo': [1227], 'Coux': [1229], 'Goldberg': [1231], 'A.L.': [1232, 2457], '73:': [1238], '7231-7240Crossref': [1239], 'More': [1243], 'recently': [1244, 1680, 2445], 'it': [1245, 2439, 2593], 'proposed': [1248], 'inhibits': [1251], '(19Gottlob': [1255], 'Fulco': [1257], 'Levrero': [1259, 1615, 2370], 'Graessmann': [1261], 'Biol.': [1264, 1413, 1732, 1808, 2010, 2200, 2249, 2400, 2423, 2461], 'Chem.': [1265, 2424, 2462], '273:': [1267, 2426], '33347-33353Abstract': [1268], '(117)': [1276], 'role': [1281], 'still': [1289], 'since': [1291, 2532], 'existence': [1293], 'true': [1295], 'disputed': [1303], 'Another': [1319], 'intriguing': [1320], 'property': [1321], 'association': [1326], 'repair': [1330], 'DDBP1/XPE,': [1332], 'which': [1333], 'could': [1334], 'account': [1335], 'an': [1337, 2975], 'accumulation': [1338], 'over': [1344], 'course': [1347], '(20Becker': [1351], 'S.A.': [1352], 'Lee': [1353], 'T.H.': [1354], 'Butel': [1355], 'J.S.': [1356], 'Slagle': [1357], 'B.L.': [1358], '72:': [1362], '266-272Crossref': [1363], 'Most': [1367], 'such': [1370, 1902], 'simian': [1372, 1668], '40,': [1374], 'polyomavirus,': [1375], 'papillomaviruses,': [1376], 'poxviruses,': [1377], 'retroviruses,': [1378], 'baculoviruses,': [1379], 'herpesviruses': [1381], 'contain': [1382, 2974], 'products': [1384], 'block': [1386, 1441, 1660], 'reduce': [1388, 2048], '21Miller': [1393], 'L.K.': [1394], 'Kaiser': [1395], 'W.J.': [1396, 2555], 'Seshagiri': [1397], '18:': [1402, 1810, 2271], '445-452Crossref': [1403], '(26)': [1405], '22Hardwick': [1408], 'J.M.': [1409], 'Cell': [1411, 1718, 1731, 3968], 'Dev.': [1412], '339-349Crossref': [1416], '(92)': [1419], '23Barry': [1422], 'McFadden': [1424], 'G.': [1425, 1608, 1711, 1998, 2373, 2561, 2967], 'Curr.': [1426], 'Opin.': [1427], 'Immunol.': [1428, 1833], '10:': [1430], '422-430Crossref': [1431], '(73)': [1434], 'can': [1440, 1563, 1652, 2484], 'ways': [1448], 'degradation': [1453], 'subversion': [1456], 'components': [1458], 'TNF': [1461], 'Fas': [1463, 2534, 3274, 3586, 3927, 4081], 'mitochondria,': [1472], 'reduction': [1474], 'Several': [1478, 2106], 'laboratories': [1479], '(24Feitelson': [1480], 'Zhu': [1482], '8:': [1490], '1109-1117PubMed': [1491], '25Truant': [1494], 'Antunovic': [1496], 'Greenblatt': [1498], 'Prives': [1500], 'Cromlish': [1502], 'J.A.': [1503], '69:': [1507], '1851-1859Crossref': [1508], '26Wang': [1512], 'X.W.': [1513], 'Gibson': [1514, 3692], 'M.K.': [1515], 'Vermeulen': [1516], 'W.': [1517, 2563], 'Yeh': [1518], 'Forrester': [1520], 'Sturzbecher': [1522], 'H.W.': [1523], 'Hoeijmakers': [1524], 'J.H.': [1525], 'Harris': [1526], 'C.C.': [1527], '55:': [1531, 1788, 1949], '6012-6016PubMed': [1532], '27Takada': [1535], 'Kaneniwa': [1537], 'N.': [1538, 1540, 1689, 1707, 2179], 'Tsuchida': [1539], '1895-1901Crossref': [1546], '(83)': [1549], 'able': [1557, 1658], 'interact': [1559], 'p53': [1561, 1654], 'interfere': [1564], 'p53-mediated': [1566, 1578], 'other': [1570, 1663, 2279, 2327], 'genes.': [1571], 'both': [1573, 2533], 'reported,': [1584], 'causing': [1585], 'many': [1586, 1643, 1919], 'investigators': [1587], '28Chirillo': [1603], 'Pagano': [1605], 'Natoli': [1607, 2372], 'Puri': [1609, 2364], 'P.L.': [1610, 2365], 'Burgio': [1611], 'V.L.': [1612], 'Balsano': [1613, 2368], 'Proc.': [1617, 2071, 2142, 2161], 'Natl.': [1618, 2072, 2143, 2162], 'Acad.': [1619, 2073, 2144, 2163], 'Sci.': [1620, 1786, 1947, 2074, 2145, 2164], 'U.': [1621, 2075, 2146, 2165, 2332], '94:': [1625], '8162-8167Crossref': [1626], '(193)': [1629], 'question': [1633], 'significance': [1635], 'vivo.': [1640], 'In': [1641, 2494], 'addition,': [1642], 'anti-apoptotic': [1647], 'bind': [1653, 3828], 'ways.': [1664], 'For': [1665, 3798], 'example,': [1666], '40': [1670], 'large': [1671], 'antigen': [1673], 'adenovirus': [1676, 1801], 'E1B/19K': [1677, 1798], 'shown': [1681, 1768, 2046, 2449], 'protect': [1683], '(29Rouquet': [1688], 'Allemand': [1690, 1708], 'I.': [1691, 1709], 'Molina': [1692, 1712], 'Bennoun': [1694], 'Briand': [1696, 1714], 'Joulin': [1698, 1716], 'V.': [1699, 1717, 3548], '11:': [1702], '1061-1067PubMed': [1703], '30Rouquet': [1706], 'Grimber': [1710], 'Death': [1719], 'Differ.': [1720], '3:': [1722], '91-96PubMed': [1723], '31Perez': [1726], 'White': [1728], '141:': [1734], '1255-1266Crossref': [1735], '(103)': [1738], 'With': [1741], 'these': [1742, 3212], 'precedents,': [1743], 'we': [1744, 2498], 'intrigued': [1746], 'about': [1747, 3526], 'possible': [1749], 'effects': [1750, 2601], 'upon': [1753], 'apoptotic': [1754], 'particularly': [1756], 'within': [1759], 'cell.': [1762, 2105], 'Many': [1763], 'oncogenes': [1765, 1901], 'up-regulate': [1770], 'Ref.': [1778], '32Tibbles': [1779], 'L.A.': [1780, 1941], 'Woodgett': [1781, 1942], 'J.R.': [1782, 1943], 'Mol.': [1784, 1806, 1945, 2009, 2198, 2247, 2398], 'Life': [1785, 1946], '1230-1254Crossref': [1789, 1950], '(554)': [1792, 1953], 'include': [1796], '(33See': [1802], 'Shi': [1804], 'Y.': [1805, 2027, 2062, 2421], '4012-4022Crossref': [1811], '(28)': [1814], 'TAT': [1818], '(34Kumar': [1824], 'Manna': [1826], 'S.K.': [1827], 'Dhawan': [1828], 'Aggarwal': [1830], 'B.B.': [1831], '161:': [1835], '776-781PubMed': [1836], 'LMP1': [1840], 'Epstein-Barr': [1843], 'virus,': [1844, 1858], 'TAX': [1846], 'HTLV-1,': [1849], 'angiogenic': [1851], 'G': [1852, 3824, 4070], 'receptor': [1854, 2120], 'Kaposi': [1856], 'sarcoma': [1857, 2865], '(35Benn': [1865, 2291], 'Su': [1867, 2293], 'Doria': [1869, 2295], 'Schneider': [1871, 2140, 2159, 2182, 2196, 2245, 2266, 2297, 2350], 'R.J.': [1872, 2004, 2141, 2160, 2183, 2197, 2246, 2267, 2298, 2351], '4978-4985Crossref': [1877, 2303], '36Henkler': [1881, 2307], 'Lopes': [1883, 2309], 'A.R.': [1884, 2310], 'Jones': [1885, 2311, 4131], 'Koshy': [1887, 2313], 'Gen.': [1890, 2316], '79:': [1893, 2319], '2737-2742Crossref': [1894, 2320], '(30)': [1897, 2323], 'Cellular': [1900], 'asTPL2': [1903], '(tumor': [1904], 'progression': [1905], 'locus': [1906], '2': [1907, 3054, 3544, 4106], 'protein)': [1908], 'andBCR-ABL': [1909], 'tyrosine': [1910, 2121], 'HER2/NEU': [1914], 'associated': [1917, 1970, 3784], 'breast': [1920], 'tumors,': [1921], 'epidermal': [1922], 'growth': [1923, 1984, 2537], 'factor-stimulated': [1924], 'proliferation,': [1925], 'RET': [1927], 'oncoprotein,': [1928], 'MAS': [1930], 'product,': [1932], 'MET': [1935], 'increase': [1937], 'levels': [1939, 1975], '(32Tibbles': [1940], 'Clearly': [1956, 2482], 'up-regulation': [1957], 'activity,': [1960], 'often': [1961], 'parallel': [1963], 'increased': [1965], 'MAPK,': [1966], 'transformation.': [1973], 'Higher': [1974], 'regeneration': [1986, 2547], '(37Auer': [1987], 'K.L.': [1988], 'Contessa': [1989], 'Brenz-Verca': [1991], 'Pirola': [1993], 'Rusconi': [1995], 'Cooper': [1997], 'Abo': [1999], 'Wymann': [2001], 'M.P.': [2002], 'Davis': [2003], 'Birrer': [2005], 'Dent': [2007], '561-573Crossref': [2014], '(114)': [2017], '38Mitsui': [2020], 'Maruyama': [2022], 'Kimura': [2024], 'Takuwa': [2026], '27:': [2030], '1362-1367Crossref': [2031], '(32)': [2034], 'deletion': [2038, 2813], 'upstream': [2041], 'kinase,': [2042], 'Sek1,': [2043], 'impair': [2052], 'mice': [2056], '(39Ganiatsas': [2057], 'Kwee': [2059], 'Fujiwara': [2061], 'Perkins': [2063], 'Ikeda': [2065], 'Labow': [2067], 'Zon': [2069], 'L.I.': [2070], '95:': [2079], '6881-6886Crossref': [2080], 'Recently': [2086], 'reports': [2107, 2280], 'fibroblast': [2115, 3037, 3074], 'lines': [2117, 3078, 3108], 'stimulates': [2118, 2410], 'kinase-Ras-Raf-MAPK': [2122], 'pathway,': [2123], 'activates': [2124, 2440], 'c-FOS/c-JUN-mediated': [2125], 'transcription,': [2126], 'favors': [2127], 'G0/S': [2128], 'cycle': [2130], 'transition,': [2131], 'protects': [2133], 'serum': [2136, 2530, 3368, 4164], 'starvation': [2137], '(40Benn': [2138], '91:': [2150], '10350-10354Crossref': [2151], '(404)': [2154], '41Benn': [2157], '92:': [2169], '11215-11219Crossref': [2170], '(266)': [2173], '42Doria': [2176], 'Klein': [2178], 'Lucito': [2180], 'EMBO': [2184, 2268], '14:': [2187], '4747-4757Crossref': [2188], '(275)': [2191], '43Klein': [2194], 'N.P.': [2195, 2244, 2259], '17:': [2202, 2251], '6427-6436Crossref': [2203, 2252], '(219)': [2206, 2255], 'reported': [2212], 'Src': [2214], 'kinases,': [2215], 'not': [2217], 'Ras,': [2218], 'replication': [2235], 'stimulated': [2237], '(43Klein': [2243], '44Klein': [2258], 'Bouchard': [2260], 'M.J.': [2261], 'Wang': [2262, 4133], 'L.H.': [2263], 'Kobarg': [2264], '5019-5027Crossref': [2272], '(104)': [2275], 'Two': [2278], 'indicate': [2281], 'Still': [2326], 'findings': [2328], '(45Kekule': [2329], 'A.S.': [2330], 'Lauer': [2331], 'Weiss': [2333], 'Luber': [2335], 'B.': [2336], 'Nature.': [2339], '361:': [2341], '742-745Crossref': [2342], '(335)': [2345], '46Su': [2348], '4558-4566Crossref': [2356], '47Chirillo': [2360], 'Falco': [2362], 'Artini': [2366], '641-646Crossref': [2378], '48Weil': [2382], 'Sirma': [2384], 'Giannini': [2386], 'Bessia': [2390], 'Dargemont': [2392], '19:': [2402], '6345-6354Crossref': [2403], 'suggest': [2407], 'NFκB': [2411], 'another': [2416], 'group': [2417], '(49Lee': [2418], 'Y.H.': [2419], 'Yun': [2420], '25510-25515Abstract': [2427], '(212)': [2435], 'suggests': [2438], 'JAK1-STAT': [2441], 'signaling,': [2442], '(50Shih': [2450], 'Kuo': [2452], 'M.L.': [2453], 'Chuang': [2454], 'S.E.': [2455], 'Cheng': [2456], 'Doong': [2458], 'S.L.': [2459], '275:': [2464, 4137], '25858-25864Abstract': [2465], '(174)': [2473], 'activate': [2477], 'pathway.': [2481], 'modulate': [2485], 'cytoplasm.': [2493], 'study,': [2497], 'explored': [2499], 'ability': [2501], 'dissected': [2509], 'protection.': [2517], 'We': [2518, 2579], 'primarily': [2520], 'interested': [2521], 'induced': [2528], 'starvation,': [2531], 'ligand': [2535], 'play': [2539], 'important': [2540], 'roles': [2541], '(51Galle': [2552], 'P.R.': [2553], 'Hofmann': [2554], 'Walczak': [2556], 'Schaller': [2558], 'Otto': [2560], 'Stremmel': [2562], 'Krammer': [2564], 'Runkel': [2566], 'Exp.': [2569], '182:': [2572], '1223-1230Crossref': [2573], '(679)': [2576], 'first': [2580], 'supported': [2594], 'their': [2595], 'culture.': [2598], 'same': [2600, 2893], 'Mouse': [2611, 4358], 'stress': [2620], 'much': [2625], 'sensitive': [2627], 'wild': [2632, 2838], 'type': [2633, 2839], 'cells.': [2634, 3612], 'contained': [2638], 'SEK1-deficient': [2647], 'underwent': [2649], 'show': [2677], 'HBx.': [2686], 'Immunoprecipitation': [2687], 'SAPK-JNK': [2698], 'complex.': [2699], 'Up-regulation': [2700], 'may': [2705], 'help': [2706], 'rescue': [2707], 'Chang': [2712, 3005, 3063, 3086, 3290], 'purchased': [2716], 'American': [2719], 'Type': [2720, 2833], 'Culture': [2721, 2834], 'Collection': [2722], '(Manassas,': [2723], 'VA).': [2724], 'Human': [2725], 'supplied': [2729, 3046, 3131], 'Clonetics': [2731], 'Corp.': [2732], '(San': [2733], 'Diego,': [2734], 'CA)': [2735, 3025], 'grown': [2738, 3294, 3572, 3920], 'culture': [2741], 'medium': [2742, 2799, 4062], 'provided': [2743, 2752, 3716, 3957], 'company.': [2746], 'DP-16-1': [2747], 'Dr.': [2754, 2787], 'Benchimol': [2756], '(Ontario': [2757], 'Institute,': [2759, 2981], 'Toronto,': [2760, 2982], 'Canada),': [2761], 'propagated': [2766], 'minimum': [2768], "Eagle's": [2769, 2798], 'medium-α': [2770], '(Life': [2771, 3019, 4048], 'Technologies,': [2772, 3020, 4049], 'Inc.)': [2773], 'supplemented': [2774, 3858], '10%': [2776, 2801], 'fetal': [2777, 2802], 'calf': [2778, 2803], 'serum.': [2779, 2804], 'sek1−/−': [2780], 'sek1+/+': [2782], 'came': [2785, 3225], 'Woodgett,': [2789], 'cultured': [2794], "Dulbecco's": [2796], 'modified': [2797, 2972], 'coding': [2807], 'regions': [2808], 'mutant': [2814], 'flanked': [2815], 'engineered': [2817], 'restriction': [2818], 'enzyme': [2819], 'sites': [2820, 2873, 2913], 'generated': [2822, 2990, 3157, 3198, 4293], 'reactions': [2826], 'plasmid': [2829], 'pAM6': [2830], '(45020D)': [2831], '(American': [2832], 'Collection)': [2835], 'harboring': [2836], 'open': [2843], 'frame': [2845], '(GenBankTM': [2846], 'accession': [2847], 'X51970).': [2849], 'vector': [2852, 2877, 2899, 2915, 2963], 'pRBK-HBx': [2853, 3093], 'constructed': [2855, 2902], 'inserting': [2857], 'fragments': [2860, 2909, 3557], 'downstream': [2861], 'Rous': [2864], 'promoter': [2867], 'theNheI': [2869], 'XhoI': [2871, 4283], 'cloning': [2872, 2912], 'pRBK': [2876], '(Invitrogen,': [2878], 'Carlsbad,': [2879], 'CA).': [2880, 2920, 3001, 3137, 3967], 'Expression': [2881, 3101], 'vectors': [2882], 'deletions': [2885], 'made': [2890], 'using': [2891, 3017, 3173, 3217, 3460, 3675, 3776, 3795, 4022, 4030, 4187, 4312], 'insert': [2894], 'sites.': [2895], 'bicistronic': [2897, 2928], 'pIRES-EGFP-HBx': [2900], 'ligation': [2904], 'theEcoRV-EcoRI': [2911], 'pIRES-EGFP': [2916], '(CLONTECH,': [2917, 3964], 'Palo': [2918, 3965], 'Alto,': [2919, 3966], 'Through': [2921], 'use': [2922], 'cytomegalovirus': [2925], 'promoter,': [2926], 'mRNA': [2929], 'transcribed': [2931], 'directs': [2933], 'synthesis': [2935], 'own': [2942], 'AUG': [2943], '(EGFP)': [2949], 'under': [2950, 3565], 'control': [2951, 4084], '(IRES).': [2958], 'pBMN': [2960], 'retroviral': [2961, 4286], 'obtained': [2965], 'Nolan': [2968, 4321], '(Stanford': [2969], 'University)': [2970], 'IRES-GFP': [2976], 'element': [2977], '(J.': [2978], 'Ruland,': [2979], 'Amgen': [2980], 'Canada).': [2983], 'Mutations': [2984], 'QuickChangeTM': [2993], 'XL': [2994], 'site-directed': [2995], 'mutagenesis': [2996], 'kit': [2997, 4038], '(Stratagene,': [2998], 'La': [2999], 'Jolla,': [3000], 'Erythroleukeima': [3002], 'at': [3008, 3345, 3376, 3403, 3436, 3510, 3522, 3546, 3657, 3820, 3874, 3939, 3972, 3979, 4091, 4101, 4201, 4208, 4216, 4222, 4354, 4368], '50–70%': [3009], 'confluency': [3010, 3296, 3923], 'transfected': [3012], 'cotransfected': [3014], 'plasmids,': [3016], 'LipofectAMINE': [3018], 'Inc.).': [3021, 4050], 'SuperFect': [3022], '(Qiagen,': [3023], 'Valencia,': [3024], 'used': [3027, 3737, 3751, 3811, 3826, 3863], 'transfections': [3029, 3041], 'lines.': [3039, 3075], 'performed': [3043, 3435, 4269], 'protocols': [3045], 'reagents.': [3049], 'Transfection': [3050], 'efficiencies': [3051], 'ranged': [3052], '4%': [3056, 3322], '60%': [3061], 'high': [3069, 4341], '80%': [3071, 3577, 3922], 'Stable': [3076], 'selected': [3080], 'culturing': [3082], 'DP-16': [3083, 4362], 'cells,': [3085, 3088], 'hygromycin': [3098], '(270': [3099], 'μg/ml).': [3100], 'various': [3106], 'verified': [3110], 'RT-PCR,': [3112], 'immunoprecipitation': [3113], 'followed': [3114], 'immunoblot': [3116, 3781, 4266], 'analysis,': [3117], 'microscopy.': [3120], 'Monoclonal': [3121], 'directed': [3123, 3140, 3184, 4079, 4272], 'peptide': [3126, 3187, 3208, 4024], '(amino': [3127, 3188], 'acids': [3128, 3189], '50–88)': [3129], 'Chemicon': [3133], 'International': [3134], 'Inc.': [3135], '(Temecula,': [3136], 'Polyclonal': [3138], 'antiserum': [3139, 3170], 'produced': [3145], 'our': [3147, 3200], 'laboratory': [3148], 'immunizing': [3150], 'rabbits': [3151], 'maltose-binding': [3154], 'protein-HBx': [3155], 'fusion': [3156, 3744, 3839], 'Escherichia': [3159], 'coli.': [3160], 'Protein': [3161, 3823], 'purified': [3163, 3172, 3210], 'affinity': [3165, 3174, 3215], 'chromatography.': [3166], 'Antibodies': [3167], 'chromatography': [3175, 3216], 'HBx-(His6)': [3177], 'coupled': [3178, 3191], 'nickel-Sepharose.': [3180], 'Rabbit': [3181], 'polyclonal': [3182, 3232, 3241, 3256], 'antisera': [3183, 3213], '2–21)': [3190], 'keyhole': [3193], 'limpet': [3194], 'hemocyanin': [3195], 'laboratory.': [3201], 'specific': [3204, 3796, 3803], 'peptide-conjugated': [3218], 'Affi-Gel': [3220], '10': [3221, 3349, 3853, 3944, 4220, 4296, 4374], '(Bio-Rad).': [3222], 'Other': [3223], 'commercial': [3227], 'sources': [3228], 'follows:': [3230], 'rabbit': [3231, 3240, 3255], 'antibody': [3233, 3242, 3249, 3257, 3264, 3383, 3412, 3779], '14-3-3β': [3235], '(Santa': [3237, 3252], 'Cruz': [3238, 3253], 'Biotechnology),': [3239, 3254], 'MKK4/SEK1': [3244], '(Upstate': [3245, 3260], 'Biotechnology,': [3246, 3261], 'Inc.),': [3247, 3262], 'monoclonal': [3248, 3263], 'MEKK1': [3251], 'SAPK1/JNK': [3259], 'phospho-14-3-3': [3267], 'motif': [3269], '(New': [3270, 3807, 3841], 'England': [3271, 3719, 3808, 3842], 'Biolabs),': [3272], 'anti-mouse': [3273, 3279, 3417], '(PharMingen,': [3275], 'San': [3276], 'Diego),': [3277], 'goat': [3278, 3282, 3416, 3421], 'TRITC': [3280, 3418], '(Sigma),': [3281, 3285], 'anti-rabbit': [3283, 3422], 'FITC': [3284, 3423], 'anti-hamster': [3287], 'Ig': [3288], '(PharMingen).': [3289, 3631], '8-well': [3298], 'chamber': [3299, 3918], 'slides': [3300, 3455], '(Nalge': [3301], 'Nunc': [3302], 'International).': [3303], 'Medium': [3304], 'removed,': [3306, 3452], 'washed': [3311, 3330, 3398, 3443, 3618], 'once': [3312, 3331], 'PBS': [3314, 3325, 3344, 3402, 3622], 'prior': [3315], 'fixation.': [3317], 'Cells': [3318, 3406, 3568, 3929, 4148], 'fixed': [3320, 3392], 'paraformaldehyde': [3323], '15': [3327, 3664], 'min': [3328, 3509, 3665, 3978, 4207, 4221], 'PBS.': [3333, 3447], 'Subsequently': [3334], 'permeabilized': [3338], '0.2%': [3340], 'Triton': [3341, 3372, 3501], 'X-100': [3342, 3373, 3502], 'room': [3346, 3404, 3658], 'temperature': [3347, 3659], 'min.': [3350, 3381, 3879, 3945, 4107], 'Nonspecific': [3351], 'incubating': [3360], 'blocking': [3364, 3388, 3431], 'solution': [3365], '(1%': [3366], 'bovine': [3367, 4163], 'albumin': [3369], '0.1%': [3371], 'PBS)': [3375], '37': [3377, 3437, 3511, 3523, 4092], '°C': [3378, 3524, 3876, 4093, 4224], '30': [3380, 3508, 3875, 3878], 'Primary': [3382], 'diluted': [3385, 3428], '1:50': [3386, 3429], 'solution,': [3389], 'incubated': [3390, 3409, 3836, 4064], 'h,': [3396], 'times': [3400, 3445], 'temperature.': [3405], 'subsequently': [3408, 3515], 'secondary': [3411], 'consisting': [3413, 4154], 'either': [3415, 4073], '(Sigma)': [3419, 3424, 4071], 'had': [3426], 'buffer.': [3432, 4249], 'Incubations': [3433], 'oC': [3438], '1': [3440, 3848, 3913], 'h': [3441, 3545, 4096, 4356], 'chambers': [3450], 'mounted': [3457], 'coverslips': [3459], 'Fluorescent': [3461], 'Mounting': [3462], 'Solution': [3463], '(Dako,': [3464], 'Hiroshima,': [3465], 'Japan).': [3466], 'Fluorescently': [3467], 'labeled': [3468], 'viewed': [3471], 'Zeiss': [3474], 'LSM510': [3475, 3485], 'microscope,': [3477], 'images': [3480], 'analyzed': [3482, 3667], 'image': [3486], 'browser': [3487], 'software.': [3488], 'Following': [3489], '104cells': [3493], 'lysed': [3495], 'Tris-EDTA': [3497], 'buffer': [3498, 3630, 3861, 3956, 4153], '1%': [3500], 'RNase': [3504], '(10': [3505], 'μg/ml)': [3506], '°C.': [3512, 3822, 4210], 'Lysates': [3513], 'treated': [3516, 3582, 3925], 'proteinase': [3518], 'K': [3519], '(0.5': [3520], 'mg/ml)': [3521], 'h.': [3528], 'entire': [3530], 'lysate': [3531], 'loaded': [3533], 'onto': [3534], '2%': [3536], 'agarose': [3537], 'subjected': [3540, 4252], '65': [3547], 'ladder': [3551], 'visualized': [3553], 'staining': [3555], 'ethidium': [3559], 'bromide': [3560], 'examining': [3562], 'UV': [3566], 'light.': [3567], 'plated': [3570], 'overnight': [3573, 3819], 'until': [3574], 'they': [3575, 3580], 'confluent': [3578], 'when': [3579], 'indicated': [3584], 'Subsequently,': [3588, 3632], 'media': [3590], 'detached': [3592, 3611], 'collected,': [3595], 'remaining': [3598, 4004], 'adherent': [3599], 'released': [3602], 'trypsinization': [3604], '(1': [3605, 4167, 4171], 'min)': [3606], 'combined': [3608], 'Collected': [3613], 'centrifuged': [3616, 3971, 4215], 'twice': [3619], 'cold': [3621, 3850, 3953, 4152], 'resuspended': [3624, 3948], '100': [3626, 3950], 'μl': [3627, 3634, 3640, 3951, 3984], '5': [3633, 3639, 3724, 4051, 4066, 4074, 4180, 4206, 4301], 'Annexin': [3636], 'V-PE': [3637], '7-AAD': [3642], '(PharMingen)': [3643], 'added': [3645], 'suspension': [3649], 'mixed': [3651], 'gently.': [3652], 'stained': [3656], 'dark': [3662], 'on': [3669, 3711, 3792, 4255], 'Becton': [3671], 'Dickinson': [3672], 'fluorescence': [3673], 'cytometer': [3674], 'CellQuest': [3676], 'software': [3677], '(52Philpott': [3678], 'N.J.': [3679], 'Turner': [3680], 'A.J.': [3681], 'Scopes': [3682], 'Westby': [3684], 'Marsh': [3686], 'J.C.': [3687], 'Gordon-Smith': [3688], 'Dalgleish': [3690], 'A.G.': [3691], 'F.M.': [3693], 'Blood.': [3694], '87:': [3696], '2244-2251Crossref': [3697], 'A': [3701, 4170], 'nonradioactive': [3702, 3866], 'method': [3703, 4317], 'measuring': [3705], 'employed': [3709], 'based': [3710], 'Assay': [3714], 'Kit': [3715], 'New': [3718], 'Biolabs': [3720], '(Beverly,': [3721], 'MA).': [3722], 'Briefly,': [3723], '×': [3725, 3914, 3941, 3974, 4052, 4103, 4203, 4302, 4380], '106': [3726, 3915, 4053, 4303], 'lysed,': [3729], '250': [3731, 4156], 'μg': [3732, 4297], 'total': [3734], 'each': [3739], 'reaction.': [3740], 'An': [3741], 'bound': [3746], 'Sepharose': [3748], 'beads': [3749, 3788], 'pull': [3753], 'down': [3754], 'lysates.': [3758], 'carried': [3763], 'out': [3764, 3899], 'ATP,': [3769], 'phosphorylation': [3772], 'selectively': [3774, 3814], 'measured': [3775, 4021], 'phospho-c-JUN': [3778], 'analysis.': [3782, 3892], 'Proteins': [3783, 4229], 'detected': [3791, 3887], 'immunoblots': [3794], 'radioactive': [3800], 'assay,': [3802], 'Biolabs)': [3809, 3843], 'immunoprecipitate': [3813, 3833], 'lysates': [3818, 3969], 'immunocomplexes.': [3830], 'resulting': [3832], 'then': [3835], 'c-JUN-(1–89)': [3838], 'mm': [3849, 4157, 4160, 4181], 'ATP': [3851], 'mCi': [3854], '[γ-32P]ATP': [3856], 'assay;': [3868], 'immunoprecipitated': [3869], 'active': [3870], 'phosphorylated': [3872], 'Phosphorylated': [3880], 'separated': [3883], 'SDS-PAGE': [3885], 'quantitated': [3889, 3904], 'PhosphorImager': [3891], 'bands': [3895], 'cut': [3898], 'liquid': [3906], 'scintillation': [3907], 'assays.': [3908], '6-Well': [3909], 'microtiter': [3910, 3992, 4377], 'plates': [3911, 3993, 4378], 'per': [3917], 'suspended': [3931, 4043, 4056, 4150], 'trypsin': [3933, 4047], 'treatment': [3934, 4045], 'collected': [3936, 4098], 'centrifugation': [3938, 4100, 4200], 'g': [3942, 3975, 4104, 4204], 'Pellets': [3946], 'lysis': [3955], 'ApoAlert': [3959, 4037], 'assay': [3962], 'kits': [3963], '18,000': [3973], '°C,': [3981], '50': [3983], 'supernatants': [3987, 4008, 4212, 4232], 'transferred': [3989, 4261], '96-well': [3991], 'detection': [3995], 'portions': [4005], 'assayed': [4010], 'concentration.': [4013], 'Caspase': [4014], 'substrates': [4025], '(DEVD-AFC': [4026], 'IETD-AFC,': [4028], 'respectively)': [4029], 'Wallac': [4032], 'fluorimeter': [4033], 'according': [4034], 'instructions.': [4039], 'Adherant': [4040], '0.5': [4058, 4159], 'ml': [4059], 'serum-free': [4061], 'μg/ml': [4067, 4075], 'hamster': [4077, 4083], 'IgG.': [4085], 'gently': [4089], 'shaken': [4090], '600': [4102, 4202], 'Mitochondria': [4108], 'cytosol': [4110], 'fractions': [4111], 'prepared': [4113], '(53Yang': [4117], 'Liu': [4119], 'X.': [4120, 4134], 'Bhalla': [4121], 'Kim': [4123], 'C.N.': [4124], 'Ibrado': [4125], 'A.M.': [4126], 'Cai': [4127], 'Peng': [4129], 'T.I.': [4130], 'D.P.': [4132], 'Science.': [4135], '1129-1132Crossref': [4138], '(4410)': [4141], 'modifications.': [4147], 'mannitol,': [4158], 'EGTA,': [4161], '0.1%(w/v)': [4162], 'albumin,': [4165], 'leupeptin': [4166], 'μg/ml),': [4168, 4172, 4175], 'pepstatin': [4169], 'antipain': [4173], '(50': [4174], 'phenylmethylsulfonyl': [4176], 'fluoride': [4177], '(0.1': [4178], 'mm),': [4179], 'HEPES,': [4182], 'pH': [4183], '7.2,': [4184], 'disrupted': [4186], 'Dounce': [4189], 'homogenizer.': [4190], 'Unbroken': [4191], 'nuclei': [4194], 'sedimented': [4196], 'removed': [4198], 'further': [4214], '12,000': [4217], '×g': [4218], 'sediment': [4226], 'mitochondria.': [4228], 'denatured': [4234], '4×': [4236], 'SDS': [4237, 4247], 'sample': [4238, 4248], 'buffer,': [4239], 'mitochondrial': [4241], 'pellets': [4242], 'solubilized': [4244], '1×': [4246], 'Samples': [4250], '10–20%': [4256], 'acrylamide/Tricine-buffered': [4257], 'gels;': [4258], 'nitrocellulose': [4263], 'membranes,': [4264], 'c.': [4275], 'inserted': [4278], 'EcoRI': [4281], 'vector,': [4288], 'pBMN-IRES-GFP.': [4289], 'Recombinant': [4290, 4350], 'retrovirus': [4291, 4351], 'introducing': [4295], 'pBMN-HBx-IRES-GFP': [4299], 'ecotropic': [4307], 'packaging': [4308], 'Phoenix': [4309], 'line': [4311], 'calcium': [4314], 'phosphate': [4315], 'transfection': [4316], '(54Pear': [4318], 'W.S.,': [4319], 'G.P.': [4322], 'Robbins': [4323], 'P.D.': [4324], 'Methods': [4325], 'Medicine:': [4328], 'Gene': [4329], 'Therapy': [4330], 'Protocols.': [4331], 'Humana': [4332], 'Press': [4333], 'Inc.,': [4334], 'Totowa,': [4335], 'NJ1997:': [4336], '41-57Google': [4337], 'Generation': [4339], 'titer,': [4342], 'helper-free': [4343], 'retroviruses': [4344], 'occurred': [4345], 'transient': [4348], 'transfection.': [4349], 'harvested': [4353], '48': [4355], 'post-transfection.': [4357], 'multiplicity': [4370], 'infection': [4372], '6-well': [4376], '(5': [4379], '105cells/chamber)': [4381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2015464799', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-09T00:32:05.648422', 'created_date': '2016-06-24'}
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