A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation

Name: Work Video:
Duration: 3 min 30 s
Carla A. Borgoño; Iacovos P. Michael; Nahoko Komatsu; Arumugam Jayakumar; Ravi Kapadia; Gary L. Clayman; Georgia Sotiropoulou; Eleftherios P. Diamandis
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4154, 4195, 4210, 4222, 4293, 4307, 4317, 4345, 4377], 'KLK7,': [25, 274, 1065], 'are': [26, 275, 839, 1173, 1352, 1525, 1553, 2804, 2962], 'implicated': [27, 276], 'in': [28, 58, 81, 154, 208, 220, 243, 277, 307, 330, 403, 457, 469, 492, 730, 1009, 1055, 1176, 1359, 1406, 1556, 1655, 1731, 1749, 1849, 2044, 2234, 2349, 2352, 2362, 2745, 2805, 2967, 2984, 2995, 3023, 3068, 3169, 3305, 3456, 3486, 3833, 4124, 4166, 4207, 4279, 4326, 4354], 'desquamation': [29, 76, 221, 278, 325, 470, 1058, 1780, 1842, 2831], 'by': [30, 36, 77, 134, 146, 173, 183, 229, 279, 285, 326, 383, 395, 422, 432, 478, 954, 1022, 1247, 1743, 1832, 1846, 1973, 2039, 2838, 3277, 3575, 3593, 3940, 4076, 4103, 4138, 4205, 4214, 4245], 'digestion': [31, 280], '(corneo)desmosomes': [33, 282], 'inhibition': [35, 284, 3590, 4070, 4095], 'desquamation-related': [37, 286, 1527], 'protease': [39, 115, 186, 288, 364, 435, 652, 656, 1007, 1729, 1834, 2047, 2358, 2859, 3578, 4072], 'inhibitors': [40, 289, 1835, 4057], '(SPIs).': [41, 290, 1836], 'However,': [42, 291], 'epidermal': [44, 293, 1532, 2952, 2972, 3011], 'localization': [45, 294, 1533, 2953], 'specificity': [47, 296, 1036, 2950], 'additional': [49, 298], 'KLKs': [50, 194, 217, 299, 443, 466, 1515, 2803, 2815, 2956, 2994, 3260, 3572, 4396, 4410], 'also': [51, 300, 793, 1554, 1747, 2862, 4200], 'supports': [52, 301], 'role': [54, 303, 1054, 2813, 2975], 'for': [55, 165, 237, 304, 414, 486, 1722, 2180, 3610, 3613, 3619, 3623, 3807, 3817, 3856, 3862, 3868, 3872, 3877, 3884, 3891, 3898, 3968, 3976, 4068, 4158, 4163, 4175, 4234, 4275, 4328, 4339, 4363], 'these': [56, 305], 'enzymes': [57, 306, 1172, 1395], 'desquamation.': [59, 308], 'This': [60, 309, 845], 'study': [61, 213, 310, 462, 2998], 'aims': [62, 311], 'to': [63, 75, 123, 312, 324, 372, 592, 1016, 1062, 1243, 1354, 1399, 1514, 2239, 2520, 2740, 2821, 2870, 2987, 3061, 3263, 3458, 3491, 3909, 3924, 4005, 4014, 4052, 4182, 4255, 4265, 4400], 'delineate': [64, 313, 2988], 'probable': [66, 315], 'contribution': [67, 316], 'KLK1,': [69, 318, 3003, 3808, 3885, 4150], 'KLK5,': [70, 138, 319, 387, 1744, 3004, 3614, 3639, 3809, 3873, 4151], 'KLK6,': [71, 139, 320, 388, 3005, 3615, 3865, 3869, 3886, 4152], 'KLK13,': [72, 140, 192, 321, 389, 441, 3006, 3640, 3810, 3888, 4153], 'KLK14': [74, 142, 323, 391, 1719, 1737, 3008, 3156, 3878, 4155], 'examining': [78, 327], 'their': [79, 121, 328, 370, 1531, 2974, 3273], 'interactions,': [80, 329], 'vitro,': [82, 331], 'with:': [83, 332, 3009], '1)': [84, 333, 3010], 'colocalized': [85, 334], 'SPI,': [86, 335, 650], 'lympho-epithelial': [87, 336, 2190], 'Kazal-type-related': [88, 337], 'inhibitor': [89, 187, 338, 436, 657, 2048, 2193, 2860, 2873, 4065], '(LEKTI,': [90, 339, 3013], 'four': [91, 340], 'recombinant': [92, 341, 3474], 'fragments': [93, 342, 3283, 3823], 'containing': [94, 343, 673, 2852, 3284, 3915, 4289], 'inhibitory': [95, 344, 2185, 2249, 2545, 3557, 4099, 4403], 'domains': [96, 99, 106, 110, 345, 348, 355, 359, 2250, 3286, 3289, 3296, 3300, 3561], '1–6': [97, 346, 3287], '(rLEKTI(1–6)),': [98, 347, 3288], '6–8': [100, 349, 3290], 'partial': [102, 351, 3292], 'domain': [103, 352, 672, 2851, 3293], '9': [104, 353, 3294], '(rLEKTI(6–9′)),': [105, 354, 3295], '9–12': [107, 356, 3297], '(rLEKTI(9–12)),': [108, 357, 3298], '12–15': [111, 360, 3301], '(rLEKTI(12–15)),': [112, 361], 'secretory': [113, 184, 362, 433, 646, 2857], 'leukocyte': [114, 185, 363, 434, 647, 2858], 'inhibitor,': [116, 365], 'elafin': [118, 367, 2867, 3447, 3569, 3596, 3830, 3851], '2)': [120, 369, 3018], 'ability': [122, 371, 2732], 'digest': [124, 373, 1401], '(corneo)desmosomal': [126, 375, 3020], 'cadherin,': [127, 376], 'desmoglein': [128, 199, 225, 377, 448, 474], '1.': [129, 378], 'KLK1': [130, 379, 3077, 3863], 'was': [131, 171, 181, 380, 420, 430, 3027, 3053, 3573, 3597, 3998, 4026, 4379], 'not': [132, 381, 2980], 'inhibited': [133, 145, 172, 182, 382, 394, 421, 431, 2837, 4038], 'any': [135, 384], 'SPI': [136, 385, 2182, 3012], 'tested.': [137, 386], 'were': [143, 392, 3041, 3059, 3080, 3157, 3261, 3275, 3303, 3448, 3477, 3512, 3604, 3819, 3906, 3938, 3980, 3990, 4042, 4049, 4058, 4074, 4101, 4122, 4146, 4199, 4203, 4211, 4243, 4263, 4335, 4372, 4411], 'potently': [144, 393], 'rLEKTI(1–6),': [147, 396, 4315], 'rLEKTI(6–9′),': [148, 397], 'rLEKTI(9–12)': [150, 399], 'with': [151, 400, 1034, 2183, 2551, 2964, 3586, 3821, 3853, 3879, 3900, 3954, 4149, 4188, 4248, 4298, 4309, 4342, 4347, 4413], 'Ki': [152, 401], 'values': [153, 402], 'range': [156, 405], '2.3–28.4': [158, 407], 'nm,': [159, 161, 408, 410, 3963], '6.1–221': [160, 409], '2.7–416': [163, 412], 'nm': [164, 413, 3806, 3816], 'each': [166, 415, 3977, 3993], 'respective': [167, 416], 'fragment.': [168, 417], 'Only': [169, 418], 'rLEKTI(12–15)': [174, 423], '(Ki': [175, 424], '=': [176, 425], '21.8': [177, 426], 'nm).': [178, 427], 'No': [179, 428], 'KLK': [180, 245, 429, 494, 1023, 2833], 'or': [188, 207, 437, 456, 3814, 3845, 4142, 4319], 'elafin.': [189, 438], 'Apart': [190, 439], 'from': [191, 440, 841, 3029, 3043, 3055, 3084, 3144, 3450, 3479, 3922, 3992, 4010, 4044, 4055, 4180], 'all': [193, 442], 'digested': [195, 444], 'ectodomain': [197, 446], '1': [200, 226, 449, 475, 3870, 3896, 4276, 4329, 4364], 'within': [201, 450, 526, 2543, 2557, 3927], 'cadherin': [202, 451, 3021], 'repeats,': [203, 452], 'Ca2+': [204, 453], 'binding': [205, 454], 'sites,': [206, 455], 'juxtamembrane': [210, 459], 'region.': [211, 460], 'Our': [212, 461], 'indicates': [214, 463], 'that': [215, 464, 1522, 1718, 2246, 2802, 2828], 'multiple': [216, 465, 2552, 2993, 3571], 'may': [218, 233, 467, 482, 1746, 2829], 'participate': [219, 468, 1748], 'through': [222, 471], 'cleavage': [223, 472], 'regulation': [228, 477], 'LEKTI.': [230, 479], 'These': [231, 480], 'findings': [232, 481], 'have': [234, 483, 1396, 1652, 1715], 'clinical': [235, 484], 'implications': [236, 485], 'treatment': [239, 488], 'skin': [241, 490, 843, 1970, 2824], 'disorders': [242, 491], 'which': [244, 493, 1360, 2187, 4056], 'activity': [246, 495, 1008, 1730, 2528, 3579, 4404], 'elevated.': [248, 497], 'As': [498, 789], 'outermost': [500], 'layer': [501], 'skin,': [504], 'functions': [508], 'as': [509, 2360, 2816, 2864, 2871, 2905, 2907, 2976, 3090, 3167, 3311, 3514, 3599, 3982, 4375], "body's": [511], 'main': [512], 'protective': [513], 'barrier': [514, 1986], 'against': [515, 2531, 3580, 4407], 'physical': [516], 'chemical': [518], 'damage,': [519], 'dehydration,': [520], 'microbial': [522], 'pathogens.': [523], 'Inter-corneocyte': [524], 'cohesion': [525], 'depends': [530], 'primarily': [531], 'on': [532, 1530, 2536, 3267, 3570, 3945, 4381, 4397], 'corneodesmosomes,': [533], 'structurally': [534], 'modified': [535], 'desmosomes': [536], '(1Brody': [537], 'I.': [538, 704, 880, 968, 1793], 'Acta': [539, 1138], 'Derm.': [540], 'Venereol.': [541, 1140], '1968;': [542], '48:': [543], '290-302PubMed': [544], 'Google': [545, 559, 589, 699, 724, 762, 787, 828, 871, 896, 914, 950, 984, 1002, 1049, 1090, 1112, 1132, 1144, 1168, 1200, 1219, 1239, 1268, 1302, 1348, 1390, 1440, 1474, 1510, 1588, 1612, 1639, 1689, 1713, 1777, 1809, 1827, 1883, 1915, 1963, 2016, 2035, 2081, 2118, 2176, 2225, 2286, 2344, 2403, 2433, 2481, 2517, 2608, 2638, 2686, 2728, 2772, 2798, 2903, 2944, 3112, 3140, 3200, 3226, 3258, 3338, 3372, 3404, 3440, 3551, 3703, 3750, 3773], 'Scholar,': [546, 560, 700, 763, 872, 985, 1091, 1133, 1145, 1201, 1220, 1269, 1303, 1441, 1475, 1589, 1613, 1810, 1884, 1916, 2017, 2082, 2119, 2287, 2404, 2434, 2609, 2639, 2687, 2773, 3113, 3201, 3227, 3339, 3373, 3405, 3704, 3725, 3751, 3774], '2Skerrow': [547], 'C.J.': [548, 3239], 'Clelland': [549], 'D.G.': [550], 'Skerrow': [551], 'D.': [552, 927, 1417, 1451, 1924, 1940, 2090, 2258, 2442, 2458, 2647, 2663, 2710, 3249, 3790], 'J.': [553, 579, 818, 859, 876, 888, 905, 936, 964, 976, 990, 1076, 1098, 1158, 1186, 1210, 1227, 1256, 1288, 1334, 1376, 1426, 1460, 1485, 1496, 1574, 1631, 1675, 1763, 1789, 1801, 1815, 1869, 1949, 2002, 2022, 2067, 2098, 2157, 2162, 2211, 2266, 2325, 2330, 2378, 2389, 2419, 2467, 2594, 2624, 2672, 2706, 2712, 2764, 2884, 2889, 2930, 3126, 3186, 3421, 3426, 3532, 3537, 3689, 3706, 3793], 'Cell': [554, 691, 906], 'Sci.': [555, 752], '1989;': [556], '92:': [557], '667-677PubMed': [558], '3Serre': [561], 'G.': [562, 801, 935, 1285, 1331, 1425, 1459, 1493, 1625, 1902, 1934, 2161, 2329, 2386, 2452, 2504, 2591, 2657, 2927, 3094, 3175, 3177, 3183, 3203, 3209, 3213, 3678, 3680, 3686, 3735], 'Mils': [563, 802], 'V.': [564, 803, 3205, 3411, 3522], 'Haftek': [565, 804, 924, 1414], 'M.': [566, 712, 805, 884, 919, 923, 925, 972, 1073, 1095, 1149, 1183, 1273, 1275, 1367, 1409, 1413, 1415, 1447, 1449, 1457, 1487, 1563, 1664, 1698, 1754, 1797, 1858, 1892, 1894, 1922, 1936, 1991, 2056, 2092, 2204, 2260, 2380, 2408, 2440, 2454, 2494, 2496, 2613, 2645, 2659, 2716, 2750, 2754, 2929, 3104, 3125, 3146, 3181, 3353, 3385, 3407, 3518, 3684], 'Vincent': [567, 806], 'C.': [568, 807, 929, 1307, 1309, 1371, 1419, 1443, 1479, 1481, 1491, 1758, 1888, 1890, 2086, 2254, 2372, 2374, 2384, 2490, 2492, 2567, 2569, 2695, 2699, 2714, 3235, 3753], 'Croute': [569, 808], 'F.': [570, 809, 1920, 2438, 2643, 2704, 2708, 3415, 3526], 'Reano': [571, 810], 'A.': [572, 755, 767, 771, 811, 856, 902, 987, 1122, 1135, 1151, 1155, 1271, 1305, 1333, 1489, 1495, 1700, 1812, 1896, 1904, 1906, 1928, 2088, 2100, 2109, 2159, 2256, 2268, 2277, 2327, 2382, 2388, 2446, 2498, 2506, 2508, 2565, 2593, 2651, 2691, 2697, 2718, 2789, 2882, 2925, 3179, 3215, 3329, 3341, 3375, 3417, 3528, 3682, 3727, 3759, 3786], 'Ouhayoun': [573, 812], 'J.P.': [574, 578, 813, 817, 1918, 2436, 2641], 'Bettinger': [575, 814], 'S.': [576, 708, 754, 815, 1281, 1319, 1483, 1595, 1603, 2084, 2123, 2127, 2252, 2291, 2295, 2376, 2579], 'Soleilhavoup': [577, 816], 'Invest.': [580, 819, 860, 991, 1099, 1187, 1228, 1257, 1289, 1335, 1377, 1461, 1497, 1575, 1676, 1764, 1816, 1870, 1950, 2003, 2068, 2163, 2331, 2390, 2420, 2468, 2595, 2625, 2673, 3427, 3538], 'Dermatol.': [581, 820, 861, 889, 977, 992, 1100, 1124, 1139, 1188, 1229, 1258, 1290, 1336, 1378, 1462, 1498, 1576, 1632, 1677, 1765, 1802, 1817, 1871, 1951, 2004, 2025, 2069, 2164, 2332, 2391, 2421, 2469, 2596, 2626, 2674, 2765, 3428, 3539], '1991;': [582, 821, 1126, 1141], '97:': [583, 822], '1061-1072Abstract': [584, 823], 'Full': [585, 824, 865, 942, 944, 996, 1082, 1084, 1104, 1106, 1164, 1192, 1194, 1233, 1262, 1294, 1296, 1340, 1342, 1382, 1384, 1432, 1434, 1466, 1468, 1502, 1504, 1580, 1582, 1681, 1683, 1769, 1771, 1821, 1875, 1877, 1955, 1957, 2008, 2010, 2029, 2073, 2075, 2168, 2170, 2217, 2219, 2336, 2338, 2395, 2397, 2425, 2427, 2473, 2475, 2600, 2602, 2630, 2632, 2678, 2680, 2895, 2897, 2936, 2938, 3132, 3134, 3192, 3194, 3432, 3434, 3543, 3545, 3695, 3697], 'Text': [586, 825, 866, 943, 945, 997, 1083, 1085, 1105, 1107, 1165, 1193, 1195, 1234, 1263, 1295, 1297, 1341, 1343, 1383, 1385, 1433, 1435, 1467, 1469, 1503, 1505, 1581, 1583, 1682, 1684, 1770, 1772, 1822, 1876, 1878, 1956, 1958, 2009, 2011, 2030, 2074, 2076, 2169, 2171, 2218, 2220, 2337, 2339, 2396, 2398, 2426, 2428, 2474, 2476, 2601, 2603, 2631, 2633, 2679, 2681, 2896, 2898, 2937, 2939, 3133, 3135, 3193, 3195, 3433, 3435, 3544, 3546, 3696, 3698], 'PDF': [587, 826, 867, 946, 998, 1086, 1108, 1166, 1196, 1235, 1264, 1298, 1344, 1386, 1436, 1470, 1506, 1584, 1685, 1773, 1823, 1879, 1959, 2012, 2031, 2077, 2172, 2221, 2340, 2399, 2429, 2477, 2604, 2634, 2682, 2899, 2940, 3136, 3196, 3436, 3547, 3699], 'PubMed': [588, 696, 721, 759, 784, 827, 868, 893, 911, 947, 981, 999, 1087, 1109, 1129, 1167, 1197, 1216, 1236, 1265, 1299, 1345, 1387, 1437, 1471, 1507, 1585, 1609, 1636, 1686, 1710, 1774, 1806, 1824, 1880, 1912, 1960, 2013, 2032, 2078, 2115, 2173, 2222, 2283, 2341, 2400, 2430, 2478, 2514, 2605, 2635, 2683, 2725, 2769, 2795, 2900, 2941, 3109, 3137, 3197, 3223, 3255, 3335, 3369, 3401, 3437, 3548, 3700, 3747, 3770], 'Scholar).': [590, 725, 788, 829, 1003, 1050, 1391, 1511, 1690, 1778, 1964, 2177, 2226, 2345, 2945, 3259, 3441, 3552, 3800], 'Akin': [591], 'classical': [593], 'desmosomes,': [594, 791], 'corneodesmosomes': [595, 792], 'maintain': [596], 'integrity': [598], 'mediate': [600], 'cell': [601, 3087, 3308], 'adhesion': [602, 852], 'via': [603], 'calcium-dependent': [604], 'interactions': [605, 3001], 'between': [606, 3002], 'two': [607, 2839], 'families': [608], 'desmosomal': [610], 'cadherins,': [611], 'desmogleins': [613], '(DSG1–4)': [614], '2The': [615], 'abbreviations': [616], 'used': [617, 3598, 3981], 'are:': [618], 'DSG,': [619], 'desmoglein;': [620], 'KLK,': [621, 626], 'gene;': [625], 'protein;': [630, 666, 674], 'LEKTI,': [631, 2822, 4194], 'lymphoepithelial': [632], 'Kazal-type': [633, 2049, 2191], 'related': [634, 2192], 'inhibitor;': [635, 649, 653], 'NE,': [636, 4408], 'neutrophil': [637, 3443, 3666], 'elastase;': [638], 'NS,': [639, 1965], 'Netherton': [640, 1850], 'syndrome;': [641], 'SKALP,': [642], 'skin-derived': [643, 2876], 'antileukoproteinase;': [644], 'SLPI,': [645, 3014, 3567], 'proteinase': [648, 2872], 'SPINK5,': [654], 'kazal-type': [658], '5;': [659], 'TBS-T,': [660, 4327], 'Tris-buffered': [661, 4280, 4343, 4355], 'saline-Tween;': [662, 4356], 'WAP,': [663], 'whey': [664], 'acid': [665, 2849], 'trappin,': [667], 'transglutaminase': [668], 'substrate': [669, 1535, 2845, 2949, 3978, 4387], 'wap': [671, 2847], 'AMC,': [675], '7-Amino-4-methylcoumarin;': [676], 'Boc,': [677], 't-butoxycarbonyl;': [678], 'Bis-Tris,': [679], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol.': [680], 'desmocollins': [682], '1–3': [683], '(4Green': [684], 'K.J.': [685], 'Gaudry': [686], 'C.A.': [687, 1038, 3231, 3776], 'Nat.': [688, 1907, 2110, 2278, 2509], 'Rev.': [689], 'Mol.': [690, 1043, 1604, 2720], 'Biol.': [692, 907, 937, 1077, 1159, 1427, 1705, 2212, 2790, 2890, 2931, 3127, 3187, 3250, 3330, 3690, 3794], '2000;': [693, 1101, 1189, 2112, 2280], '1:': [694], '208-216Crossref': [695], 'Scopus': [697, 722, 760, 785, 869, 894, 912, 948, 982, 1000, 1088, 1110, 1130, 1198, 1217, 1237, 1266, 1300, 1346, 1388, 1438, 1472, 1508, 1586, 1610, 1637, 1687, 1711, 1775, 1807, 1825, 1881, 1913, 1961, 2014, 2033, 2079, 2116, 2174, 2223, 2284, 2342, 2401, 2431, 2479, 2515, 2606, 2636, 2684, 2726, 2770, 2796, 2901, 2942, 3110, 3138, 3198, 3224, 3256, 3336, 3370, 3402, 3438, 3549, 3701, 3748, 3771], '(321)': [698], '5Kurzen': [701], 'H.': [702, 765, 886, 974, 1279, 1287, 1321, 1329, 1799, 2208, 2581, 2589, 2921, 3419, 3425, 3530, 3536], 'Moll': [703, 705], 'R.': [706, 744, 746, 933, 1313, 1423, 1453, 1569, 1621, 1862, 1995, 2060, 2133, 2301, 2412, 2573, 2617], 'Schafer': [707], 'Simics': [709], 'E.': [710, 1311, 1930, 2121, 2139, 2153, 2289, 2307, 2321, 2448, 2571, 2653, 2689, 2886, 2919], 'Amagai': [711], 'Wheelock': [713], 'M.J.': [714, 3098, 3115, 3355, 3383], 'Franke': [715, 747], 'W.W.': [716, 748], 'Differentiation.': [717, 780], '1998;': [718], '63:': [719], '295-304Crossref': [720], '(0)': [723], 'The': [726, 1837, 2526, 3589, 3904, 4018, 4032], 'most': [727, 836], 'abundant': [728], 'isoforms': [729], 'include': [734], 'DSG1,': [735, 1402, 3022], 'DSG4,': [736], 'desmocollin-1': [738, 898], '(6Koch': [739], 'P.J.': [740, 1325, 2585], 'Goldschmidt': [741], 'M.D.': [742], 'Zimbelmann': [743], 'Troyanovsky': [745], 'Proc.': [749], 'Natl.': [750], 'Acad.': [751, 2024], 'U.': [753], '1992;': [756], '89:': [757], '353-357Crossref': [758], '(129)': [761], '7Bazzi': [764], 'Getz': [766], 'Mahoney': [768], 'M.G.': [769], 'Ishida-Yamamoto': [770, 1488, 1895, 2381, 2497, 2924], 'Langbein': [772], 'L.': [773, 1147, 2151, 2198, 2319, 2693, 3409, 3520, 3788], 'Wahl': [774], 'J.K.': [775], 'II': [776], 'I': [777], 'Christiano': [778], 'A.M.': [779], '2006;': [781, 1499, 1707, 1952, 2392, 2470, 2675, 2933, 3796], '74:': [782], '129-140Crossref': [783], '(77)': [786], 'specialized': [790], 'contain': [794], 'unique': [796], 'glycoprotein': [797], 'constituent,': [798], 'corneodesmosin': [799, 917], '(3Serre': [800], 'During': [830], 'normal': [831], 'desquamation,': [834, 2996], 'superficial': [837], 'corneocytes': [838], 'shed': [840], 'surface.': [844], 'process': [846, 1785], 'requires': [847], 'proteolysis': [848], 'corneodesmosomal': [851], 'molecules': [853], 'DSG1': [854], '(8Lundstrom': [855], 'Egelrud': [857, 930, 988, 1074, 1096, 1136, 1156, 1184, 1208, 1225, 1254, 1374, 1420, 1454, 1703, 1761, 1813, 1937, 2455, 2660], 'T.': [858, 931, 989, 1075, 1097, 1120, 1137, 1157, 1185, 1207, 1209, 1226, 1255, 1375, 1421, 1455, 1567, 1597, 1619, 1704, 1762, 1814, 1938, 2456, 2661, 2702, 2748, 3207, 3237], '1990;': [862], '94:': [863], '216-220Abstract': [864], '(97)': [870], '9Suzuki': [873], 'Y.': [874, 962, 1277, 1323, 1373, 1760, 1787, 1900, 2102, 2107, 2270, 2275, 2502, 2583, 2781, 2785, 3321, 3325, 3343, 3345, 3377, 3381], 'Koyama': [875, 963, 1788], 'Moro': [877, 965, 1790], 'O.': [878, 966, 1791, 1864, 1997, 2062, 2414, 2619, 2888], 'Horii': [879, 967, 1792], 'Kikuchi': [881, 969, 1794], 'K.': [882, 970, 1317, 1369, 1571, 1573, 1591, 1593, 1599, 1601, 1617, 1627, 1662, 1672, 1696, 1756, 1795, 1866, 1868, 1999, 2001, 2064, 2066, 2129, 2297, 2416, 2418, 2577, 2621, 2623, 2756, 3347, 3351, 3379, 3392, 3413, 3524], 'Tanida': [883, 971, 1796], 'Tagami': [885, 973, 1798], 'Br.': [887, 975, 1630, 1800, 2763], '1996;': [890, 978, 1803, 2892], '134:': [891, 979, 1804], '460-464Crossref': [892, 980, 1805], '(74)': [895, 983, 1808], 'Scholar),': [897, 915, 1169, 1349, 1640, 1828, 2036, 2518, 2729, 2799], '(10King': [899], 'I.A.': [900, 3100, 3119], 'Tabiowo': [901], 'Fryer': [903], 'P.R.': [904], '1987;': [908], '105:': [909], '3053-3063Crossref': [910], '(16)': [913], '(11Simon': [918, 1408], 'Jonca': [920, 1410, 1444, 2922], 'N.': [921, 1411, 1445, 1561, 1565, 1615, 1623, 1660, 1856, 1860, 1989, 1993, 2054, 2058, 2406, 2410, 2611, 2615, 2923, 3211], 'Guerrin': [922, 1412, 1448, 2928], 'Bernard': [926, 1416, 1450], 'Caubet': [928, 1418], 'Schmidt': [932, 1422, 1452], 'Serre': [934, 1284, 1424, 1458, 2926], 'Chem.': [938, 1078, 1160, 1428, 1706, 2213, 2791, 2891, 2932, 3128, 3188, 3251, 3331, 3691, 3795], '2001;': [939, 1429, 2165, 2333], '276:': [940, 1430], '20292-20299Abstract': [941, 1431], '(153)': [949, 1439], 'Scholar)': [951, 1113, 1240, 1714, 2482, 2904, 3141], 'likely': [952], 'mediated': [953], 'both': [955, 1394, 4323], 'trypsin-like': [956, 1727, 2532, 2553], 'chymotrypsin-like': [958], 'proteases': [960, 1033, 2534, 2556, 2978], '(9Suzuki': [961, 1786], '12Lundstrom': [986, 1811], '1988;': [993, 1818], '91:': [994, 1819], '340-343Abstract': [995, 1820], '(91)': [1001, 1826, 2797, 3337], 'To': [1004], 'date,': [1005], 'has': [1013, 1059, 2979], 'been': [1014, 1060, 1397, 1653, 2981], 'attributed': [1015], 'kallikreins': [1019, 1524], '(KLK;': [1020], 'encoded': [1021], 'genes': [1024], '(EC': [1025], '3.4.21)),': [1026], 'subgroup': [1028], '15': [1030, 2184, 4340], 'secreted': [1031], '(chymo)trypsin-like': [1035, 2948], '(13Borgono': [1037], 'Michael': [1039, 3777], 'I.P.': [1040, 3173, 3676, 3778], 'Diamandis': [1041, 1628, 1673, 3184, 3216, 3246, 3687, 3738, 3762, 3791], 'E.P.': [1042, 1629, 1674, 3185, 3217, 3247, 3688, 3739, 3763, 3792], 'Cancer': [1044], 'Res.': [1045, 1125, 3219, 3742], '2004;': [1046, 1291, 1463, 3398, 3429, 3540, 3767], '2:': [1047], '257-280PubMed': [1048], 'Among': [1051], 'KLKs,': [1052, 4193], 'ascribed': [1061], 'originally': [1066], 'denoted': [1067, 2189], 'tryptic': [1070], 'enzyme': [1071, 1118], '(14Brattsand': [1072], '1999;': [1079, 2214], '274:': [1080, 2215], '30033-30040Abstract': [1081], '(194)': [1089], '15Ekholm': [1092], 'I.E.': [1093, 1181], 'Brattsand': [1094, 1182, 1446, 1697, 1935, 2453, 2658, 2749], '114:': [1102, 1190], '56-63Abstract': [1103, 1191], '(204)': [1111, 1199], 'chymotryptic': [1117], '(16Egelrud': [1119], 'Lundstrom': [1121], 'Arch.': [1123, 3363], '283:': [1127], '108-112Crossref': [1128], '(104)': [1131], '17Lundstrom': [1134], '71:': [1142], '471-474PubMed': [1143], '18Hansson': [1146], 'Stromqvist': [1148], 'Backman': [1150], 'Wallbrandt': [1152], 'P.': [1153, 1477, 1886, 1898, 2200, 2370, 2488, 2500, 2752, 3121, 3241], 'Carlstein': [1154], '1994;': [1161, 1213], '269:': [1162], '19420-19426Abstract': [1163], 'respectively.': [1170], 'Both': [1171], 'maximally': [1174], 'expressed': [1175, 1555, 3081, 4050], 'granulosum': [1179, 1559, 2560], '(15Ekholm': [1180], '19Sondell': [1202], 'B.': [1203, 1222, 1251, 1666, 1702, 2146, 2314], 'Thornell': [1204, 1223, 1252], 'L.E.': [1205, 1224, 1253], 'Stigbrand': [1206], 'Histochem.': [1211], 'Cytochem.': [1212], '42:': [1214], '459-465Crossref': [1215], '(71)': [1218], '20Sondell': [1221], '1995;': [1230, 1259], '104:': [1231, 1260], '819-823Abstract': [1232, 1261], '(87)': [1238, 1267], 'transported': [1242], 'interstices': [1246], 'lamellar': [1248], 'granules': [1249], '(20Sondell': [1250], '21Ishida-Yamamoto': [1270], 'Simon': [1272, 1456], 'Kishibe': [1274, 1893, 2495], 'Miyauchi': [1276], 'Takahashi': [1278, 1320, 2580], 'Yoshida': [1280, 1594], "O'Brien": [1282, 1314, 2574], 'T.J.': [1283, 1315, 2575], 'Iizuka': [1286, 1328, 2588], '122:': [1292, 1464], '1137-1144Abstract': [1293], '(118)': [1301], '22Ishida-Yamamoto': [1304], 'Deraison': [1306, 1478, 1887, 2371, 2489, 2566], 'Bonnart': [1308, 1889, 2491, 2568, 2694], 'Bitoun': [1310, 2570], 'Robinson': [1312, 2572], 'Wakamatsu': [1316, 2576], 'Ohtsubo': [1318, 2578], 'Hashimoto': [1322, 2582], 'Dopping-Hepenstal': [1324, 2584], 'McGrath': [1326, 2586], 'J.A.': [1327, 2587], 'Richard': [1330, 2160, 2328, 2590], 'Hovnanian': [1332, 1494, 1905, 2108, 2158, 2276, 2326, 2387, 2507, 2592, 2717], '2005;': [1337, 1379, 1633, 1678, 1766, 1909, 2511, 2597, 2766, 2792, 3106, 3189, 3252, 3332, 3366, 3692], '124:': [1338, 1380, 1767, 2598], '360-366Abstract': [1339, 2599], '(132)': [1347, 2607], 'where': [1350], 'they': [1351], 'thought': [1353], 'form': [1355], 'proteolytic': [1357], 'cascade': [1358, 1751], 'activates': [1362], 'itself': [1363], 'KLK7': [1365, 2744, 2835, 2961], '(23Brattsand': [1366, 1753], 'Stefansson': [1368, 1692, 1755], 'Lundh': [1370, 1757], 'Haasum': [1372, 1759], '198-203Abstract': [1381, 1768], '(270)': [1389, 1776], 'Once': [1392], 'active,': [1393], 'shown': [1398, 1717], 'concertedly': [1400], 'desmocollin-1,': [1403], 'corneodesmosin,': [1405], 'vitro': [1407, 2746], '24Caubet': [1442], '1235-1244Abstract': [1465], '(419)': [1473], '25Descargues': [1476], 'Prost': [1480, 2106, 2274, 2373], 'Fraitag': [1482, 2375], 'Mazereeuw-Hautier': [1484, 2377, 2705], "D'Alessio": [1486, 2379, 2715], 'Bodemer': [1490, 2085, 2253, 2383, 2713], 'Zambruno': [1492, 1901, 2385, 2503], '126:': [1500, 1953, 2393, 2471, 2676], '1622-1632Abstract': [1501, 2394], '(165)': [1509, 2402], 'In': [1512, 2819, 4131], 'addition': [1513, 2820], '5': [1516, 2050, 3866, 3889], '7,': [1518], 'accumulating': [1519], 'reports': [1520], 'suggest': [1521, 2801], 'other': [1523, 2826, 2957], 'candidate': [1526], 'enzymes,': [1528], 'based': [1529, 2535], 'specificity.': [1536], 'For': [1537, 4238, 4259], 'instance,': [1538], '1,': [1540], '4,': [1541], '6,': [1542, 1643, 2736], '8,': [1543, 1644], '9,': [1544], '10,': [1545, 1645], '11,': [1546, 1646], '13,': [1547, 1647], '14': [1549, 1649], 'transcripts': [1550, 2236], 'and/or': [1551, 3829], 'proteins': [1552, 4262], '(26Komatsu': [1560], 'Takata': [1562, 1857, 1990, 2055, 2407, 2612], 'Otsuki': [1564, 1622, 1859, 1992, 2057, 2409, 2614], 'Toyama': [1566, 1618], 'Ohka': [1568, 1620, 1861, 1994, 2059, 2411, 2616], 'Takehara': [1570, 1626, 1671, 1865, 1998, 2063, 2415, 2620], 'Saijoh': [1572, 1616, 1661, 1867, 2000, 2065, 2417, 2622], '2003;': [1577, 2722, 3220, 3744], '121:': [1578], '542-549Abstract': [1579], '(113)': [1587], '27Kuwae': [1590], 'Matsumoto-Miyai': [1592], 'Sadayama': [1596], 'Yoshikawa': [1598], 'Hosokawa': [1600], 'Shiosaka': [1602], 'Pathol.': [1605], '2002;': [1606, 1872, 2005, 2070, 2422, 2627, 3129], '55:': [1607], '235-241Crossref': [1608], '(38)': [1611], '28Komatsu': [1614], 'Hussack': [1624], '153:': [1634, 2767], '274-281Crossref': [1635], '(121)': [1638], 'protein': [1650, 4241], 'levels': [1651], 'quantified': [1654], '(29Komatsu': [1659], 'Sidiropoulos': [1663], 'Tsai': [1665], 'Levesque': [1667], 'M.A.': [1668, 3102], 'Elliott': [1669], 'M.B.': [1670], '125:': [1679], '1182-1189Abstract': [1680], '(66)': [1688], 'Interestingly,': [1691], 'et': [1693], 'al.': [1694], '(30Stefansson': [1695], 'Ny': [1699], 'Glas': [1701], '387:': [1708], '761-768Crossref': [1709], '(61)': [1712], 'recently': [1716], 'responsible': [1721], '∼50%': [1723], 'total': [1726], 'corneum.': [1734], 'Moreover,': [1735], 'because': [1736], 'can': [1738], 'activate': [1739], 'be': [1741], 'activated': [1742], 'it': [1745, 1829], 'pathway': [1752], 'Because': [1779], 'regulated': [1831], 'protease/SPI': [1839], 'balance': [1840], 'governing': [1841], 'best': [1844], 'illustrated': [1845], 'its': [1847, 2544], 'imbalance': [1848], 'syndrome': [1851], '(NS;': [1852], 'OMIM': [1853], '256500)': [1854], '(31Komatsu': [1855, 1988, 2053], 'Amano': [1863, 1996, 2061, 2413, 2618], '118:': [1873, 2006, 2071, 2423, 2628], '436-443Abstract': [1874, 2007, 2072, 2424, 2629], '(178)': [1882, 2015, 2080, 2432, 2637], '32Descargues': [1885], 'Kreft': [1891, 2493], 'Elias': [1897, 1947, 2465, 2499, 2670], 'Barrandon': [1899, 2101, 2269, 2501], 'Sonnenberg': [1903, 2505], 'Genet.': [1908, 2111, 2279, 2510, 2721], '37:': [1910, 2512], '56-65Crossref': [1911, 2513], '(309)': [1914, 2516], '33Hachem': [1917, 2435, 2640], 'Wagberg': [1919, 2437, 2642], 'Schmuth': [1921, 2439, 2644], 'Crumrine': [1923, 2441, 2646], 'Lissens': [1925, 2443, 2648], 'W.': [1926, 2444, 2649], 'Jayakumar': [1927, 2445, 2650, 2788, 3328, 3416, 3527], 'Houben': [1929, 2447, 2652], 'Mauro': [1931, 2449, 2654], 'T.M.': [1932, 2450, 2655], 'Leonardsson': [1933, 2451, 2656], 'Roseeuw': [1939, 2457, 2662], 'Clayman': [1941, 2459, 2664, 2786, 3326, 3361, 3393, 3422, 3533], 'G.L.': [1942, 2460, 2665, 2787, 3327, 3362, 3394, 3423, 3534], 'Feingold': [1943, 2461, 2666], 'K.R.': [1944, 2462, 2667], 'Williams': [1945, 2143, 2311, 2463, 2668], 'M.L.': [1946, 2142, 2144, 2310, 2312, 2464, 2669], 'P.M.': [1948, 2466, 2671], '1609-1621Abstract': [1954, 2472, 2677], '(149)': [1962, 2480, 2685], 'an': [1966, 2181, 2985], 'autosomal': [1967], 'recessive': [1968], 'ichthyotic': [1969], 'disorder': [1971], 'characterized': [1972], 'hair': [1974], 'shaft': [1975], 'defects,': [1976], 'atopic': [1977], 'features,': [1978], 'overdesquamation': [1979, 2521], 'corneocytes,': [1981], 'severe': [1983], 'dysfunction': [1987], '34Greene': [2018], 'S.L.': [2019], 'Muller': [2020], 'S.A.': [2021], 'Am.': [2023], '1985;': [2026], '13:': [2027, 3221], '329-337Abstract': [2028], '(111)': [2034, 2902], 'caused': [2038], 'frameshift': [2040], 'nonsense': [2042], 'mutations': [2043, 2229], '(SPINK5)': [2051], 'gene': [2052, 2854], '35Chavanas': [2083], 'Rochat': [2087, 2255], 'Hamel-Teillac': [2089, 2257], 'Ali': [2091, 2259], 'Irvine': [2093, 2261], 'A.D.': [2094, 2262, 3708], 'Bonafe': [2095, 2263], 'J.L.': [2096, 2264, 3780], 'Wilkinson': [2097, 2265], 'Taieb': [2099, 2267], 'Harper': [2103, 2271, 2711], 'J.I.': [2104, 2272], 'de': [2105, 2140, 2273, 2308], '25:': [2113, 2281], '141-142Crossref': [2114, 2282], '(703)': [2117, 2285], '36Sprecher': [2120, 2288], 'Chavanas': [2122, 2290], 'DiGiovanna': [2124, 2292], 'J.J.': [2125, 2293], 'Amin': [2126, 2294], 'Nielsen': [2128, 2296], 'Prendiville': [2130, 2298], 'J.S.': [2131, 2299], 'Silverman': [2132, 2300], 'Esterly': [2134, 2302], 'N.B.': [2135, 2303], 'Spraker': [2136, 2304], 'M.K.': [2137, 2305], 'Guelig': [2138, 2306], 'Luna': [2141, 2309], 'Buehler': [2145, 2313], 'Siegfried': [2147, 2315], 'E.C.': [2148, 2316], 'Van': [2149, 2317], 'Maldergem': [2150, 2318], 'Pfendner': [2152, 2320], 'Bale': [2154, 2322], 'S.J.': [2155, 2323], 'Uitto': [2156, 2324], '117:': [2166, 2334], '179-187Abstract': [2167, 2335], '(133)': [2175, 2343, 3749], 'SPINK5': [2178, 2228], 'codes': [2179], 'domains,': [2186, 2546], '(LEKTI)': [2194], '(37Magert': [2195], 'H.J.': [2196, 2762, 3245], 'Standker': [2197], 'Kreutzmann': [2199, 2751], 'Zucht': [2201], 'H.D.': [2202], 'Reinecke': [2203], 'Sommerhoff': [2205], 'C.P.': [2206], 'Fritz': [2207], 'Forssmann': [2209, 2759], 'W.G.': [2210, 2760], '21499-21502Abstract': [2216], '(219)': [2224], 'All': [2227, 3057, 4120], 'introduce': [2230], 'premature': [2231], 'termination': [2232], 'codons': [2233], 'LEKTI': [2235, 2244, 2350, 2530, 2550, 2734, 2807, 3282, 3560, 3822, 3843, 3880, 4135, 4159], 'lead': [2238], 'production': [2241], 'truncated': [2243], 'forms': [2245], 'lack': [2247], 'several': [2248, 3916, 4416], '(35Chavanas': [2251], 'Consequently,': [2346], 'decrease': [2348], 'expression/activity': [2351], 'NS': [2353, 2367], 'causes': [2354], 'unrestricted,': [2355], 'elevated': [2356], 'activity,': [2359, 4073], 'observed': [2361], 'patients': [2368], '(25Descargues': [2369], '31Komatsu': [2405, 2610], 'Spink5–/–': [2485], 'mice': [2486], '(32Descargues': [2487], 'leading': [2519], 'thinning.': [2525], 'predicted': [2527], 'predominance': [2538], 'basic': [2540], 'P1': [2541], 'residues': [2542], 'colocalization': [2548], '(22Ishida-Yamamoto': [2564], '38Bitoun': [2688], 'Micheloni': [2690], 'Lamant': [2692], 'Tartaglia-Polcini': [2696], 'Cobbold': [2698], 'Al': [2700], 'Saati': [2701], 'Mariotti': [2703], 'Boralevi': [2707], 'Hohl': [2709], 'Hum.': [2719], '12:': [2723], '2417-2430Crossref': [2724], '(173)': [2727], '(domains': [2735], '6–9′,': [2737, 3563], '9–12)': [2739], 'inhibit': [2741], '(39Egelrud': [2747], 'Walden': [2753], 'Vitzithum': [2755], 'Marx': [2757, 3389], 'U.C.': [2758, 3390], 'Magert': [2761], '1200-1203Crossref': [2768], '(103)': [2771], '40Schechter': [2774], 'N.M.': [2775, 3315], 'Choi': [2776, 3316], 'E.J.': [2777, 3317], 'Wang': [2778, 3318, 3352, 3384], 'Z.M.': [2779, 3319], 'Hanakawa': [2780, 3320], 'Stanley': [2782, 3322], 'J.R.': [2783, 3323], 'Kang': [2784, 3324, 3342, 3376], '386:': [2793, 3253, 3333], '1173-1184Crossref': [2794, 3334], 'strongly': [2800], 'vivo': [2806], 'targets': [2808], 'further': [2810], 'substantiate': [2811], 'desquamatory': [2817, 2977], 'enzymes.': [2818], 'contains': [2825], 'SPIs': [2827], 'regulate': [2830], 'activity.': [2834], 'trappin': [2843], '(transglutaminase': [2844], '(whey': [2848], 'protein)': [2850, 2853], 'family,': [2855, 2914], 'namely': [2856], '(SLPI;': [2861], 'known': [2863, 4001], 'antileukoprotease)': [2865], '(also': [2868], 'referred': [2869], '3': [2874], 'antileukoprotease': [2877], '(SKALP))': [2878], '(41Franzke': [2879], 'C.W.': [2880], 'Baici': [2881], 'Bartels': [2883], 'Christophers': [2885], 'Wiedow': [2887], '271:': [2893], '21886-21890Abstract': [2894], 'well': [2906], 'novel': [2909], 'member': [2910], 'α2-macroglobulin': [2913], 'α2-macroglobulin-like-1': [2915], '(42Galliano': [2916], 'M.F.': [2917], 'Toulza': [2918], 'Gallinaro': [2920], '281:': [2934], '5780-5789Abstract': [2935], '(64)': [2943], 'Although': [2946], 'many': [2955], 'than': [2958], 'compatible': [2963], 'function': [2966], 'terminal': [2969], 'stages': [2970], 'turnover,': [2973], 'investigated.': [2982], 'Thus,': [2983], 'attempt': [2986], 'possible': [2990], 'involvement': [2991], 'this': [2997], 'examines': [2999], 'elafin/SKALP)': [3016], 'vitro.': [3024], 'Materials—7-Amino-4-methylcoumarin': [3025], '(AMC)': [3026], 'purchased': [3028, 3042, 3449], 'Sigma-Aldrich.': [3030], 'AMC': [3031, 3581, 3918, 3943, 4004, 4011, 4016, 4023, 4028], 'peptide': [3032, 3582, 3919, 3936], 'substrates': [3033, 3058, 3583, 3608], 'Boc-Val-Pro-Arg-AMC': [3034], '(VPR-AMC),': [3035], 'H-Pro-Phe-Arg-AMC': [3036], '(PFR-AMC),': [3037], 'Boc-Gln-Ala-Arg-AMC': [3039], '(QAR-AMC)': [3040], 'Bachem': [3044], 'Bioscience': [3045], '(King': [3046], 'Prussia,': [3048], 'PA),': [3049], 'methoxysuccinyl-Ala-Ala-Pro-Val-AMC': [3051], '(AAPV-AMC)': [3052], 'obtained': [3054, 3478, 3989], 'Calbiochem.': [3056], 'diluted': [3060, 3455, 4324], 'final': [3063, 3460, 3492, 4168], 'concentration': [3064, 3461, 3803, 4066], '80': [3066], 'mm': [3067, 3654], 'Me2SO': [3069], 'stored': [3071, 3466, 3502], 'at': [3072, 3467, 3503, 3839, 3965, 3971, 4128, 4185, 4231, 4272, 4304, 4331, 4366, 4415], '–20': [3073], '°C.': [3074, 3469, 3505, 3973], 'Recombinant': [3075, 3151, 3281, 3442, 3470], 'mature': [3076, 3155], 'KLK6': [3079, 3892], 'purified': [3083, 3262], 'baculovirus/insect': [3086, 3307], 'line': [3088, 3309], 'system': [3089, 3165, 3310, 4221], 'previously': [3091, 3312, 3515], 'described': [3092, 3168, 3516], '(43Laxmikanthan': [3093], 'Blaber': [3095, 3103, 3116, 3124], 'S.I.': [3096, 3117], 'Bernett': [3097], 'Scarisbrick': [3099, 3118], 'Juliano': [3101], 'Proteins.': [3105], '58:': [3107], '802-814Crossref': [3108], '(58)': [3111], '44Bernett': [3114], 'Dhanarajan': [3120], 'Thompson': [3122], 'S.M.': [3123, 3233], '277:': [3130], '24562-24570Abstract': [3131], '(154)': [3139], '(kind': [3142], 'gifts': [3143], 'Dr.': [3145], 'Blaber,': [3147], 'Florida': [3148], 'State': [3149], 'University).': [3150], 'pro-KLK5,': [3152], 'pro-KLK13,': [3153], 'produced': [3158, 3304, 3513], 'using': [3159, 3606, 4000, 4080, 4109, 4216, 4384], 'Easyselect™': [3161], 'Pichia': [3162], 'pastoris': [3163], 'expression': [3164], '(Invitrogen)': [3166], 'detail': [3170], 'elsewhere': [3171], '(45Michael': [3172, 3675], 'Sotiropoulou': [3174, 3677, 3734], 'Pampalakis': [3176, 3208, 3679], 'Magklara': [3178, 3681, 3758], 'Ghosh': [3180, 3683, 3783], 'Wasney': [3182, 3685, 3730, 3760], '280:': [3190, 3693], '14628-14635Abstract': [3191, 3694], '(135)': [3199, 3702], '46Sotiropoulou': [3202], 'Rogakos': [3204], 'Tsetsenis': [3206], 'Zafiropoulos': [3210], 'Simillides': [3212], 'Yiotakis': [3214], 'Oncol.': [3218], '381-391Crossref': [3222], '(44)': [3225], '47Felber': [3228], 'L.M.': [3229], 'Borgono': [3230], 'Cloutier': [3232], 'Kundig': [3234], 'Kishi': [3236], 'Ribeiro': [3238], 'Jichlinski': [3240], 'Gygi': [3242], 'C.M.': [3243], 'Leisinger': [3244], 'Deperthes': [3248], '291-298Crossref': [3254], '(54)': [3257], 'homogeneity': [3264], '(>95%': [3265], 'purity': [3266], 'Coomassie': [3268], 'Blue-stained': [3269], 'polyacrylamide': [3270, 4226], 'gels),': [3271], 'identities': [3274], 'confirmed': [3276], 'tandem': [3278], 'mass': [3279], 'spectrometry.': [3280], 'intact': [3285], '(rLEKTI(12–15))': [3302], 'reported': [3313], '(40Schechter': [3314], '48Jayakumar': [3340], 'Henderson': [3344, 3380], 'Mitsudo': [3346, 3378], 'Liu': [3348], 'X.': [3349], 'Briggs': [3350, 3391], 'Frederick': [3354, 3382], 'El': [3356, 3386], 'Naggar': [3357, 3387], 'A.K.': [3358, 3388], 'Bebok': [3359], 'Z.': [3360], 'Biochem.': [3364, 3740], 'Biophys.': [3365, 3741], '435:': [3367], '89-102Crossref': [3368], '(18)': [3371], '49Jayakumar': [3374], 'Protein': [3395], 'Expr.': [3396], 'Purif.': [3397], '35:': [3399], '93-101Crossref': [3400], '(39)': [3403], '50Raghunath': [3406], 'Tontsidou': [3408, 3519], 'Oji': [3410, 3521], 'Aufenvenne': [3412, 3523], 'Schurmeyer-Horst': [3414, 3525], 'Stander': [3418, 3529], 'Smolle': [3420, 3531], 'Traupe': [3424, 3535], '123:': [3430, 3541], '474-483Abstract': [3431, 3542], '(96)': [3439, 3550], 'elastase': [3444], '(NE)': [3445], 'Calbiochem': [3451], 'Sigma-Aldrich,': [3453], 'respectively,': [3454, 3500, 3964], 'water': [3457], '0.5': [3463, 3495], 'g/liter,': [3464, 3499], '–80': [3468, 3504], 'SLPI': [3471, 3594, 3826, 3849, 3901, 4137, 4143, 4164, 4196, 4398, 4406, 4414], 'DSG1/Fc': [3475], 'chimera': [3476], 'R&D': [3480], 'Systems': [3481], 'Inc.': [3482], '(Minneapolis,': [3483], 'MN),': [3484], 'reconstituted': [3485], 'phosphate-buffered': [3487], 'saline': [3488], '(pH': [3489, 4287], '7.4)': [3490], 'concentrations': [3493, 3920, 4002], 'g/liter': [3496], '0.25': [3498], 'Anti-LEKTI': [3506], 'monoclonal': [3507, 4311], 'antibodies': [3508], '1C11G6': [3509, 4313], '1D6G8': [3511, 4320], '(50Raghunath': [3517], 'Kinetic': [3553], 'Inhibition': [3554], 'Assays—The': [3555], 'putative': [3556], 'effect': [3558], '1–6,': [3562], '9–12,': [3564], '12–15,': [3566], 'assessed': [3574], 'measuring': [3576, 3941, 4401], 'residual': [3577], 'after': [3584], 'incubation': [3585], 'individual': [3587, 4409], 'inhibitors.': [3588], 'NE': [3592, 3813, 3899], 'positive': [3601], 'control.': [3602], 'Assays': [3603], 'performed': [3605, 4123], 'optimal': [3607, 3837, 3913, 4169], '(PFR-AMC': [3609], 'KLK1;': [3611], 'VPR-AMC': [3612], 'KLK13;': [3617], 'QAR-AMC': [3618], 'KLK14;': [3620], 'AAPV-AMC': [3622], 'NE)': [3624], 'buffer': [3626, 3838, 3914, 4170, 4286], 'conditions': [3627, 4230], '(KLK1:': [3628], '0.1': [3629, 3632, 3643, 3656, 4283], 'm': [3630, 3633, 3644, 3657, 3669], 'Tris-HCl,': [3631, 3670], 'NaCl,': [3634, 3658], '0.01%': [3635, 3647, 3671], 'Tween-20,': [3636, 3672], 'pH': [3637, 3650, 3663, 3673], '8.0;': [3638, 3651], 'KLK14:': [3642], 'sodium': [3645], 'phosphate,': [3646], 'Tween': [3648, 4295], '20,': [3649], 'KLK6:': [3652], '50': [3653, 4161], 'Tris,': [3655], '0.2%': [3659], 'bovine': [3660], 'serum': [3661], 'albumin,': [3662], '7.3;': [3664], 'elastase:': [3667], '0.2': [3668], '7.5)': [3674, 4288], '51Chao': [3705], 'Barrett': [3707], 'Rawlings': [3709], 'N.D.': [3710], 'Woessner': [3711], 'J.F.': [3712], '2nd': [3713], 'Ed.': [3714], 'Handbook': [3715], 'Proteolytic': [3717], 'Enzymes.': [3718], '2.': [3719], 'Elsevier': [3720], 'Academic': [3721], 'Press,': [3722], 'London2004:': [3723], '1577-1580Google': [3724], '52Magklara': [3726], 'Mellati': [3728, 3756], 'A.A.': [3729, 3757], 'G.A.': [3731, 3761], 'Little': [3732], 'S.P.': [3733], 'Becker': [3736], 'G.W.': [3737], 'Commun.': [3743], '307:': [3745], '948-955Crossref': [3746], '53Kapadia': [3752], 'Yousef': [3754], 'G.M.': [3755], 'Clin.': [3764], 'Chim.': [3765], 'Acta.': [3766], '339:': [3768], '157-167Crossref': [3769], '(24)': [3772], '54Borgono': [3775], 'Shaw': [3779], 'Luo': [3781], 'L.Y.': [3782], 'M.C.': [3784], 'Soosaipillai': [3785], 'Grass': [3787], 'Katsaros': [3789], '(November': [3797], '16,': [3798], '2006)10.1074/jbc.M608348200Google': [3799], 'Proteases': [3801], '(final': [3802], '12': [3805], 'KLK14,': [3811, 3894], '30': [3815, 3882, 4273], 'KLK6)': [3818], 'preincubated': [3820], '(0–60': [3824], 'nm),': [3825], '(0–1.2': [3827, 3831], 'μm),': [3828], 'μm)': [3832], '10': [3834, 3875], 'μl': [3835, 3911, 4174], '25': [3840], '°C': [3841, 3847, 4187, 4306], '(for': [3842, 3848, 4314, 4321], 'reactions)': [3844, 3852, 4165], '37': [3846, 3972, 4186], 'gentle': [3854], 'agitation': [3855], 'different': [3857, 4176], 'time': [3858, 4177], 'points': [3859, 4178], '(10': [3860, 4140], 'min': [3861, 3867, 3871, 3883, 3890, 3897, 3970, 4236, 4341], 's': [3876], 'fragments;': [3881], 'elafin).': [3903], 'mixtures': [3905, 4242], 'subsequently': [3907, 4212], 'added': [3908], '90': [3910], 'fixed': [3917], 'ranging': [3921, 4179], '4': [3923, 4305], '3000': [3925], 'μm': [3926], 'polystyrene': [3928], 'microtiter': [3929], 'plate': [3930], 'wells.': [3931], 'Initial': [3932], 'rates': [3933, 4007], 'protease-mediated': [3935], 'hydrolysis': [3937], 'monitored': [3939], 'free': [3942, 4015], 'fluorescence': [3944, 4012, 4029, 4378], 'Wallac': [3947], '1420': [3948], 'Victor2TM': [3949], 'fluorometer': [3950], '(PerkinElmer': [3951], 'Life': [3952], 'Sciences)': [3953], 'excitation': [3955], 'emission': [3957], 'filters': [3958], '380': [3960], '480': [3962], '1-min': [3966], 'intervals': [3967], '20': [3969, 4173], 'Protease-free': [3974], 'reactions,': [3975, 4191, 4240, 4261], 'concentration,': [3979], 'negative': [3983], 'controls,': [3984], 'background': [3987], 'counts': [3988], 'subtracted': [3991], 'value.': [3994], 'A': [3995], 'standard': [3996, 4024], 'curve': [3997, 4025], 'constructed': [3999], 'convert': [4006], 'reaction': [4009], 'counts/min': [4013], 'produced/min.': [4017], 'slope': [4019], 'resultant': [4022], '19.184': [4027], 'counts/nm': [4030], 'AMC.': [4031], 'rate': [4033], 'changes': [4034], '(nanomolar': [4035], 'AMC/min)': [4036], 'control': [4040, 4053], 'reactions': [4041], 'determined': [4043, 4075, 4102], 'velocity': [4046], 'plots.': [4047], 'Activities': [4048], 'relative': [4051], 'incubations': [4054], 'excluded.': [4059], 'Average': [4060], 'IC50': [4061], 'values,': [4062], 'i.e.': [4063, 4192], 'required': [4067], '50%': [4069], 'non-linear': [4077, 4106], 'regression': [4078, 4107], 'analysis': [4079, 4108], 'Prism': [4081], '(Version': [4082], '4.0,': [4083], 'GraphPad,': [4084], 'San': [4085], 'Diego,': [4086], 'CA).': [4087, 4393], 'Michaelis-Menten': [4088], 'parameters': [4089], '(Km': [4090], 'Vmax),': [4092], 'equilibrium': [4094], 'constant': [4096], '(Ki),': [4097], 'mechanisms': [4100], 'linear': [4104], 'Enzyme': [4111], 'Kinetics': [4112], 'Module': [4113], '1.1': [4114], '(Sigma': [4115], 'Plot,': [4116], 'SSPS,': [4117], 'Chicago,': [4118], 'IL).': [4119], 'experiments': [4121], 'triplicate': [4125], 'repeated': [4127], 'least': [4129], 'twice.': [4130], 'Vitro': [4132], 'Digestion': [4133], 'KLKs—LEKTI': [4139], 'ng)': [4141, 4145], '(500': [4144], 'incubated': [4147, 4197, 4412], 'separately': [4148], '(1': [4156], 'ng': [4157, 4162], 'reactions;': [4160], 'volume': [4171], '0': [4181], '24': [4183], 'h': [4184, 4330, 4365], 'shaking.': [4189], 'Control': [4190], 'alone,': [4198], 'performed.': [4201], 'Reactions': [4202], 'terminated': [4204], 'freezing': [4206], 'liquid': [4208], 'nitrogen': [4209], 'resolved': [4213], 'SDS-PAGE': [4215], 'NuPAGE': [4218], 'Bis-Tris': [4219], 'electrophoresis': [4220], '4–12%': [4223], 'gradient': [4224], 'pre-cast': [4225], 'gels': [4227], 'under': [4228], 'reducing': [4229], '200': [4232], 'V': [4233, 4274], '45': [4235], '(Invitrogen).': [4237], 'KLK-SLPI': [4239], 'visualized': [4244], 'silver': [4246], 'staining': [4247], 'Silver': [4250], 'Xpress': [4251], 'kit': [4252], '(Invitrogen),': [4253], 'according': [4254], "manufacturer's": [4257], 'instructions.': [4258], 'KLK-LEKTI': [4260], 'transferred': [4264], 'Hybond-C': [4266], 'Extra': [4267], 'nitrocellulose': [4268], 'membrane': [4269], '(Amersham': [4270], 'Biosciences)': [4271], 'h,': [4277], 'blocked': [4278], 'saline-Tween': [4281, 4344], '(TBS-T;': [4282], 'mol/liter': [4284, 4291], 'Tris-HCl': [4285], '0.15': [4290], 'NaCl': [4292], '0.1%': [4294], '20)': [4296], 'supplemented': [4297], '5%': [4299], 'nonfat': [4300], 'dry': [4301], 'milk': [4302], 'overnight': [4303], 'probed': [4308], 'anti-LEKTI': [4310], 'antibody': [4312, 4352], '-(6–9′),': [4316], '-(9–12))': [4318], 'rLEKTI(12–15)),': [4322], '1:1,000': [4325], 'room': [4332, 4367], 'temperature.': [4333, 4368], 'Membranes': [4334], 'washed': [4336, 4373], 'three': [4337], 'times': [4338], 'treated': [4346], 'alkaline': [4348], 'phosphatase-conjugated': [4349], 'goat': [4350], 'anti-mouse': [4351], '(1:10,000': [4353], 'Jackson': [4357], 'ImmunoResearch': [4358], 'Laboratories,': [4359], 'West': [4360], 'Grove,': [4361], 'PA)': [4362], 'Finally,': [4369], 'membranes': [4371], 'again': [4374], 'above,': [4376], 'detected': [4380], 'x-ray': [4382], 'film': [4383], 'chemiluminescent': [4386], '(Diagnostic': [4388], 'Products': [4389], 'Corp.,': [4390], 'Los': [4391], 'Angeles,': [4392], 'Effect': [4394], 'Activity—Prior': [4399], 'molar': [4417], 'ratios': [4418], '(i': [4419]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2015248164', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 21}], 'updated_date': '2024-12-13T12:40:11.512716', 'created_date': '2016-06-24'}
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