Title: Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?
Abstract: Molecular CarcinogenesisVolume 5, Issue 2 p. 91-94 Working Hypothesis Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development? Hirota Fujiki, Corresponding Author Hirota Fujiki Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, JapanNational Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104, JapanSearch for more papers by this author Hirota Fujiki, Corresponding Author Hirota Fujiki Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, JapanNational Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo 104, JapanSearch for more papers by this author First published: 1992 https://doi.org/10.1002/mc.2940050202Citations: 41AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Barbacid M Ras genes. Annu Rev Biochem 56: 779– 827, 1987. 2 Fujiki H, Suganuma M, Nishiwaki S, et al. Specific mechanistic aspects of animal tumor promoters: The okadaic acid pathway. In: R D'Amato, TJ Slaga, W Farland, C Henry (eds), Relevance of Animal Studies to Evaluate Human Cancer Risk. John Wiley & Sons Inc., New York, in press. 3 Suganuma M, Fujiki H, Suguri H, et al. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. Proc Natl Acad Sci USA 85: 1768– 1771, 1988. 4 Hescheler J, Mieskes G, Rüegg JC, Takai A, Trautwein W Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes. Pflüger Arch 412: 248– 252, 1988. 5 Sassa T, Richter WW, Uda N, et al. Apparent “activation” of protein kinases by okadaic acid class tumor promoters. 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Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters. Mol Carcinog 2: 184– 187, 1989. 11 Sakai A, Fujiki H Promotion of BALB/3T3 cell transformation by the okadaic acid class of tumor promoters, okadaic acid and dinophysistoxin-1. Jpn J Cancer Res 82: 518– 523, 1991. 12 Yoshizawa S, Matsushima R, Watanabe MF, et al. Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity. J Cancer Res Clin Oncol 116: 609– 614, 1990. 13 Fujiki H, Matsushima R, Yoshizawa S, et al. Liver tumor promotion through the okadaic acid pathway, inhibition of protein phosphatases 1 and 2A (Abstract). Proceedings of the American Association for Cancer Research 32: 157, 1991. 14 Yu S-Z Drinking water and primary liver cancer. In: ZY Tang, MC Wu, SS Xia (eds), Primary Liver Cancer. China Academic Publishers, Beijing, and Springer-Verlag, Berlin, 1989, pp. 30– 37. 15 Cohen P The structure and regulation of protein phosphatases. Annu Rev Biochem 58: 453– 508, 1989. 16 Brautigan DL, Sunwoo J, Labbe JC, Fernandez A, Lamb NJC Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction. Nature 344: 74– 78, 1990. 17 Mihara K, Cao XR, Yen A, et al. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246: 1300– 1303, 1989. 18 Pallas DC, Shahrik LK, Martin BL, et al. Polyoma small and middle T antigens and SV 40 small T antigen form stable complexes with protein phosphatase 2A. Cell 60: 167– 176, 1990. 19 Walter G, Ruediger R, Slaughter C, Mumby M Association of protein phosphatase 2A with polyoma virus medium tumor antigen. Proc Natl Acad Sci USA 87: 2521– 2525, 1990. 20 Scheidtmann KH, Mumby MC, Rundell K, Walter G Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: Inhibition by small-T antigen. Mol Cell Biol 11: 1996– 2003, 1991. 21 Meek DW, Eckhart W Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells. Mol Cell Biol 8: 461– 465, 1988. 22 Yatsunami J, Fujiki H, Suganuma M, et al. Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid. Biochem Biophys Res Commun 177: 1165– 1170, 1991. 23 Hollstein M, Sidransky D, Vogelstein B, Harris CC p53 mutations in human cancer. Science 253: 49– 53, 1991. Citing Literature Volume5, Issue21992Pages 91-94 ReferencesRelatedInformation
Publication Year: 1992
Publication Date: 1992-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 56
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